Clinical trials: AMI
Microvascular Coronary Artery Disease, STEMI
Clinical Trial for Evaluating the Effectiveness and Safety of Online caIMR in STEMI Patients
Despite the success of restoration of epicardial blood flow by the primary percutaneous coronary intervention (PPCI), approximately a half of patients with ST-segment elevation myocardial infarction (STEMI) have failed myocardial…
- Trial name
- FlashIV (NCT06118450)
- Testing
- Non-intervention
- Where
- 8 sites in China
- Volunteers
- 335 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Myocardial Infarction, Acute
RAPID-POP a Randomized Controlled Trial
Efficacy of the Pressure Optimization Protocol (POP) versus Conventional Stent Deployment Strategy during Primary PCI: An Open Label Randomized Clinical Trial The investigators will compare conventional rapid stent…
- Trial name
- NCT06430892
- Testing
- Primary Percutaneous Coronary Intervention (PPCI)
- Where
- Pakistan
- Volunteers
- 400 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Cardiogenic Shock
HEROIC (Heparin Requirement in Counterpulsation)
Patients with intra-aortic balloon pumps (catheters placed in the groin connected to a pump which assists the heart by opening and closing a balloon in the aorta, thereby decreasing the work of the heart and improving blood flow…
- Trial name
- HEROIC (NCT00445211)
- Testing
- Heparin, Without Heparin
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Corewell Health East
Myocardial Infarction
Myocardial Infarction Rates Overview During COVID-19 Pandemic In France: MODIF Study
In late December 2019, an emerging disease due to a novel coronavirus (named SARS-CoV-2) rapidly spread in China and outside. France is currently facing the COVID-19 wave with more than 131 863 confirmed cases and almost 25 201…
- Trial name
- MODIF (NCT04357314)
- Where
- France
- Volunteers
- 6,332 people
- Sponsor
- French Cardiology Society
Severe Cardiomyopathy, Angina, Unstable
Hemodynamics During the Soccer Championship 2012
The purpose of this study is to determine in soccer fans whether and to which extend positive or negative emotions during the European soccer Championship affects Central Hemodynamics, Arterial Stiffness, Heartrate and…
- Conditions
- Severe Cardiomyopathy, Angina, Unstable, Myocardial Infarction, Angina, Stable
- Trial name
- NCT01617863
- Where
- 4 sites in Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Complication, Postoperative
Perioperative Fluid Management: Goal-directed Versus Restrictive Strategy
There is no ideal "cookbook recipe" for fluid prescription that would fit every surgical patient. In this study, the investigators working hypothesis is that the adoption of an integrative algorithm for perioperative fluid and…
- Trial name
- NCT02625701
- Testing
- Goal-directed therapy, Restrictive fluid therapy
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Geneva
ISCHEMIC CARDIOMYOPATHY
Clinical Trial of Manganese-Enhanced MRI (MEMRI) to Assess Peri-Infarct Injury
The purpose of this study is to evaluate the safety and tolerance of a new intravenous diagnostic agent, SeeMore or EVP 1001-1, in patients with Cardiovascular Disease (MEMRI scan).
- Trial name
- NCT02933034
- Testing
- Manganese-enhanced MRI contrast reagent, Gadolinium-enhanced MRI contrast reagent
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Stanford University
Extracorporeal Membrane Oxygenation Complication
Distal Perfusion Timing, Early or Conservative, to Prevent Limb Ischemia During Peripheral VA-ECMO
Peripheral VA-ECMO is widely used in refractory cardiogenic shock patients as a salvage therapy. In most cases, the femoral artery and vein are used for the vascular approach.
- Trial name
- DECIDE-ECMO (NCT05698628)
- Testing
- Distal perfusion catheterization
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Min-Seok Kim
Acute Coronary Syndrome, Myocardial Ischemia
Shared Care Rehabilitation After Acute Coronary Syndrome
Cardiac rehabilitation is an individual adapted multidisciplinary intervention for people suffering from Heart Disease. It involves; Dietary counseling, Exercise training, Psychosocial support, Physician smoking cessation Patient…
- Conditions
- Acute Coronary Syndrome, Myocardial Ischemia, Acute Myocardial Infarction: Rehabilitation Phase
- Trial name
- SHARED-REHAB (NCT01522001)
- Testing
- Shared Care model
- Where
- 3 sites in Denmark
- Volunteers
- 212 people
- Sponsor
- University of Aarhus
Platelet Indices, White Blood Cell
Beyond Platelet Indices, WBC-to-MPV Ratio in Myocardial Infarction With Non-Obstructive Coronary Arteries (MINOCA) Correlate With Short-Term Rather Than In-Hospital Outcomes
This study aims to evaluate the role of platelet indices and the [White blood cell (WBC) /mean platelet volume (MPV)] ratio in correlation with angiographic profiles of patients diagnosed with myocardial infarction with…
- Conditions
- Platelet Indices, White Blood Cell, Mean Platelet Volume, Myocardial Infarction
- Trial name
- NCT07076732
- Testing
- Coronary Angiography, SYNTAX Score
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Sohag University
Myocardial Infarction
Impact on Physical Activity of Coronary Patients in Phase 3 of a Therapeutic Consolidation Educational Program Involving a "Patient Partner" Associated With a Healthcare Professional.
Following myocardial infarction, cardiac rehabilitation has undeniable benefits on criteria such as cardiovascular mortality and coronary recurrence. Cardiac rehabilitation consists of 3 phases: 1.
- Trial name
- P-HEARTNER (NCT05927363)
- Testing
- Therapeutic educational consolidation program in Phase 3 of cardiac rehabilitation associating a patient & caregiver partnership, Teleconsultation at 2 months, Teleconsultation at 4 months
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication
Efficacy and Clinical Outcomes of Levosimendan in E-CPR
Treatment of refractory cardiac arrest requiring cardiopulmonary resuscitation (CPR) may be augmented with Extracorporeal membrane oxygenation (ECMO) to re-establish perfusion in the absence of return of spontaneous circulation.
- Trial name
- ECPR (NCT05730907)
- Testing
- Levosimendan
- Where
- Qatar
- Volunteers
- 100 people
- Sponsor
- Hamad Medical Corporation
Anterior Wall Acute Myocardial Infarction
Evaluation of Intracoronary Hyperoxemic Oxygen Therapy in Anterior Acute Myocardial Infarction Patients (IC-HOT)
The primary objective of the study is to collect confirmatory data supporting the safety and effectiveness of SSO2 Therapy in treatment of anterior acute myocardial infarction (AMI) patients who have undergone successful…
- Trial name
- IC-HOT (NCT02603835)
- Testing
- SSO2 Therapy
- Where
- 15 sites in United States
- Volunteers
- 100 people
- Sponsor
- TherOx
Acute Myocardial Infarction
Sex Differences in Relative Survival and Excess Mortality Following Acute Myocardial Infarction
The aim of this study was to estimate the impact of sex on relative survival and excess mortality following acute myocardial infarction (AMI) using a population-based cohort within a relative survival framework.
- Trial name
- NCT02952417
- Testing
- Excess mortality
- Volunteers
- 180,000 people
- Sponsor
- University of Leeds
HIV, Cardiovascular Diseases
Evaluating the Use of Pitavastatin to Reduce the Risk of Cardiovascular Disease in HIV-Infected Adults
People with HIV are at risk for cardiovascular disease (CVD). This study evaluated the use of pitavastatin to reduce the risk of CVD in adults with HIV on antiretroviral therapy (ART).
- Trial name
- REPRIEVE (NCT02344290)
- Testing
- Pitavastatin
- Where
- 137 sites in United States, Botswana and 11 more
- Volunteers
- 7,769 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
ST-Elevation Myocardial Infarction, Primary Percutaneous Coronary Intervention
Bivalirudin/Prasugrel Versus Abciximab/Clopidogrel in Patients Presenting With STEMI
In the setting of ST elevation myocardial infarction newer therapies has been recently studied and, following encouraging results, introduced into the clinical practice.
- Trial name
- NCT01158846
- Testing
- prasugrel/bivalirudin, clopidogrel/abciximab
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
ST-Elevation Myocardial Infarction (STEMI), Heart Failure With Preserved Ejection Fraction (HFpEF)
Platelet Derived Growth Factor Receptor ß (PDGFRß) Imaging in Cardiac Fibrosis
An observational, cross-sectional, longitudinal, microdosing Position Emission Tomography (PET) imaging study to investigate platelet derived growth factor receptor beta (PDGFRß) expression in the heart of patients with high or…
- Trial name
- PARIS (NCT06956560)
- Testing
- PET/MRI or separate PET/CT and MRI
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Heart Diseases
Evaluation of CCR2 in Patients Post Myocardial Infarction
To determine the feasibility of 64Cu-DOTA-ECL1i, an investigational PET imaging drug, at the cellular level in the myocardium for individuals who have suffered a heart attack or who have other inflammatory heart disease.
- Trial name
- NCT05107596
- Testing
- 64Cu-DOTA-ECL1i
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Atrial Fibrillation (AF), Cerebral Vascular Accident (CVA)
Pilot Study to Determine the Optimal Protocol for Preoperative Transcutaneous Vagal Neurostimulation
Post-operative atrial fibrillation (POAF) is a frequent complication of surgical aortic valve replacement, affecting 38 to 63% of patients, and increasing risks of stroke, heart failure, and long-term mortality.
- Conditions
- Atrial Fibrillation (AF), Cerebral Vascular Accident (CVA), Heart Failure, Myocardial Infarction (MI)
- Trial name
- VAGASTIMA-PILT (NCT07891390)
- Testing
- tVNS session on the left earlobe
- Where
- 3 sites in France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
ST Elevation Myocardial Infarction, HF - Heart Failure
Diagnostic Values of Galectin-3, Soluble ST2 and BNP in Predicting the Clinical Outcome of ST-Segment Elevation Myocardial Infarction Patients
An acute ST-elevation myocardial infarction occurs due to occlusion of one or more coronary arteries, causing transmural myocardial ischemia which in turn results in myocardial injury or necrosis.
- Conditions
- ST Elevation Myocardial Infarction, HF - Heart Failure, Stable Angina
- Trial name
- NCT05246215
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University