Clinical trials: ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION
Anterior Cruciate Ligament Reconstruction
Proprioceptive Training for Gait and Knee Function After Anterior Cruciate Ligament Reconstruction
Anterior cruciate ligament reconstruction (ACLR) is commonly performed to restore knee stability after injury, but many patients continue to experience gait abnormalities and reduced knee function during rehabilitation.
- Trial name
- NCT07268651
- Testing
- Standard Rehabilitation, Proprioceptive Training
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Universiti Sains Malaysia
ACL Tear
Psychological Factors Influencing the Patient-reported and Functional Outcome of ACL Reconstruction and Their Sex-specific Differences
Psychological parameters among patients undergoing ACL reconstruction and their impact on the patient-reported and functional outcome of reconstruction will be prospectively evaluated
- Trial name
- NCT06156501
- Testing
- ACL Reconstruction
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Anterior Cruciate Ligament Reconstruction, Total Hip Arthroplasty (THA)
Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery
After orthopedic surgeries like knee or hip replacement, some patients struggle to fully activate their muscles due to a condition called Arthrogenic Muscle Inhibition (AMI).
- Conditions
- Anterior Cruciate Ligament Reconstruction, Total Hip Arthroplasty (THA), Total Knee Arthroplasty, Hip Arthroscopy
- Trial name
- iBrainTechRCT (NCT07020312)
- Testing
- Visualization training with neurofeedback, Standard post-surgical rehabilitation therapy
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Rush University Medical Center
Anterior Cruciate Ligament
Evaluation of Outpatient Surgery in the Anterior Cruciate Ligament Reconstructions With Hamstring Hospital
Care in ambulatory surgery (CA) is growing in France, despite lagging behind other countries in North or US Europe. Arthroscopic knee surgery is a minimally invasive surgery eligible for CA.
- Trial name
- DIDTGENOU (NCT02895607)
- Testing
- Ambulatory care among eligible patients
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Anterior Cruciate Ligament Injuries, Knee Injuries
Effects of Early Rehabilitation Using Blood Flow Restriction and/or Surface Electromyography Biofeedback on Quadriceps Activation and Strength After Anterior Cruciate Ligament Reconstruction: A Multicenter Randomized Controlled Trial
Many patients experience quadriceps inhibition after anterior cruciate ligament (ACL) reconstruction, delaying strength recovery, hindering return to sport, and potentially increasing the risk of re-injury.
- Conditions
- Anterior Cruciate Ligament Injuries, Knee Injuries, Muscle Weakness
- Trial name
- NCT07145606
- Testing
- Standard Rehabilitation, Blood Flow Restriction (BFR) Training, sEMG Biofeedback
- Where
- 4 sites in France, Switzerland
- Volunteers
- 200 people
- Sponsor
- Haute Ecole ARC Sante
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
SEQUAR SEmitendinosus vs QUadriceps in Anterior Cruciate Ligament Reconstruction
Randomized control trial comparing two different Anterior Cruciate Ligament (ACL) grafts in Anterior Cruciate Ligament Reconstruction: the semitendinosus hamstrings graft and the quadriceps graft.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- SEQUAR (NCT04295148)
- Testing
- ACL Reconstruction with Semitendinosus graft, ACL Reconstruction with Quadriceps tendon-bone graft
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Anterior Cruciate Ligament Injury
Therapeutic Effects of Cryotherapy on Arthrogenic Muscle Inhibition in Patients With Cruciate Ligament Reconstruction
Anterior cruciate ligament(ACL) injury is one of the most common sport injuries. The major problem after ACL reconstruction or rehabilitation program is quadriceps weakness.
- Trial name
- NCT01273649
- Testing
- cryotherapy
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Anterior Cruciate Ligament Injury, Osteoarthritis
Safety and Efficacy Study of MSB-CAR001 in Subjects 6 Weeks Post an Anterior Cruciate Ligament Reconstruction
The purpose of this study is to evaluate safety and preliminary efficacy of MSB-CAR001 in subjects who have recently undergone an Anterior Cruciate Ligament Reconstruction
- Trial name
- NCT01088191
- Testing
- MSB-CAR001 Combined With Hyaluronan, Hyaluronan
- Where
- Australia
- Volunteers
- 17 people
- Sponsor
- Mesoblast, Ltd.
Rupture of Anterior Cruciate Ligament
Stability of the Knee Joint After Single and Double Bundle Anterior Cruciate Ligament Reconstruction
The purpose of this prospective study is to evaluate the influence of both bundles on the knee stability - anterior-posterior translation, internal and external rotations after the double-bundle reconstruction of Anterior…
- Trial name
- NCT01391650
- Testing
- 'biomechanic of the knee'
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Hospital Znojmo
Anterior Cruciate Ligament (ACL) Tear, Arthroscopic Anterior Cruciate Ligament Reconstruction
Intraoperative Periarticular Injection in Arthroscopic Anterior Cruciate Ligament Reconstruction Surgery
In this prospective, assessor-blinded, single-surgeon clinical trial, the goal was to validate the efficacy of PAI in aACLR surgery with a reduced opioid dose, while achieving similar pain relief with few adverse events.
- Trial name
- PAI in ACLR (NCT06630520)
- Testing
- Periarticular injection
- Where
- Taiwan
- Volunteers
- 288 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Anterior Cruciate Ligament Reconstruction
Intraarticular Injection of Tranexamic Acid Reduced Postoperative Hemarthrosis in Arthroscopic Anterior Cruciate Ligament Reconstruction
Post-anterior cruciate ligament reconstruction (ACLR) hemarthrosis may result in increased pain thus delaying postoperative rehabilitation, which may eventually lead to arthrofibrosis and a functional deficit.
- Trial name
- NCT03580018
- Testing
- Tranexamic Acid Powder, Post-anterior cruciate ligament reconstruction (ACLR)
- Where
- Taiwan
- Volunteers
- 320 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Anterior Cruciate Ligament Reconstruction, Athrogenic Muscle Responses
The Effects of Cognitive Dual-Tasking in Later Stages of Rehabilitation After ACL Reconstruction
Anterior cruciate ligament (ACL) injuries are common in sports and often require a long and challenging rehabilitation process. Athletes who sustain these injuries typically engage in pivoting and cutting sports, where these…
- Conditions
- Anterior Cruciate Ligament Reconstruction, Athrogenic Muscle Responses, ACL Injury
- Trial name
- AMIRA (NCT06206200)
- Testing
- Cognitive dual task training (intervention group), Standard of care physiotherapy (control group)
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- University Ghent
Anterior Cruciate Ligament Injuries
The Impact of Germanium-Embedded Knee Brace on Patient Recovery After ACL Reconstruction
Anti-inflammatory brace technology has demonstrated superior clinical outcomes in the management of knee osteoarthritis and accelerate recovery time for Major League Soccer players.
- Trial name
- NCT05068297
- Testing
- Incrediwear Germanium-Embedded Knee Brace following ACL reconstruction, Replica Knee Brace
- Volunteers
- 100 people
- Sponsor
- Total Sports Medicine & Orthopedics
ACL Injury
Continuous Vs Single Shot Block After ACL
The investigators will be randomizing patients to either receive an adductor canal block in the operating room postoperatively as single shot of 20-30cc bupivacaine or to have a catheter inserted into the adductor canal which…
- Trial name
- NCT04101682
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Anterior Cruciate Ligament Reconstruction
The Impact of Superimposed Vibration on the Recovery of Muscle Strength and Function Following Anterior Cruciate Ligament Surgery
Restoring muscle strength following knee ligament reconstruction (of the anterior cruciate ligament, ACL) is a major challenge for the functional success of rehabilitation.
- Trial name
- VIBRA-LCA (NCT07555613)
- Testing
- Vibramoov, Techno Concept, Mane, France, No device
- Volunteers
- 62 people
- Sponsor
- Centre orthopédique de Dracy-le-Fort
Anterior Cruciate Ligament Reconstruction, Volumetric Muscle Loss
Blood Flow Restriction Training in Rehabilitation Patients
Occlusion training, resistance exercise performed with a specialized venous tourniquet, leads to beneficial changes in muscle at low resistance and minimal stress on the nearby joint.
- Conditions
- Anterior Cruciate Ligament Reconstruction, Volumetric Muscle Loss, Chronic Thigh Muscle Weakness, Knee Arthroscopy
- Trial name
- NCT02174770
- Testing
- Blood Flow Restriction (BFR) Training, Standard ACSM-guided strength training
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Brooke Army Medical Center
Anterior Cruciate Ligament Injuries
Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy Trial
Several attempts have been made to reduce these failure rates and improve return to sports rates in high-risk populations, and one of these approaches has been postoperative bracing.
- Trial name
- BRACE (NCT06942754)
- Testing
- post-surgical functional bracing
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Wake Forest University Health Sciences
Ligament Rupture
Anterior Cruciate Ligament Reconstruction
This study evaluates the effectiveness of a pre-habilitation stay via digital monitoring on patients' short-term post-operative anxiety, compared with conventional management.
- Trial name
- Préhab-LCA (NCT06099600)
- Testing
- Reconstructive surgery of the anterior cruciate ligament
- Where
- France
- Volunteers
- 84 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
ACL
LIVing Donor Allograft for Anterior Cruciate Ligament Reconstruction Study
The Anterior Cruciate Ligament (ACL) is a major stabiliser of the knee. ACL rupture is being increasingly identified in children and skeletally immature patients.
- Trial name
- LivD_ACLR (NCT05395767)
- Testing
- Endoscopic Anterior Cruciate Ligament reconstruction using living donor hamstring allograft from a parent donor
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maidstone & Tunbridge Wells NHS Trust
ACL Injury, Meniscus Tear
MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)
This is a multicenter randomized, placebo-controlled trial to assess whether a 6-month course of oral montelukast after ACL reconstruction reduces systemic markers of inflammation and biochemical and imaging biomarkers of…
- Conditions
- ACL Injury, Meniscus Tear, Post-traumatic Osteoarthritis
- Trial name
- MOCHA (NCT04572256)
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Austin V Stone