Clinical trials: ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION
Ligamentoplasty, Anterior Cruciate Ligament (ACL)
A Study Aiming to Demonstrate That the Addition of Intravenous (IV) Tranexamic Acid-Compared to Placebo-During Anterior Cruciate Ligament (ACL) Reconstruction Results in Reduced Blood Loss and Postoperative Pain.
Various reconstruction and graft harvesting techniques are used for ACL reconstruction. The most common techniques involve harvesting one or more hamstring tendons.
- Trial name
- EXACYLCA (NCT07753161)
- Testing
- ACL reconstruction
- Where
- France
- Volunteers
- 100 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Anterior Cruciate Ligament, Anterior Cruciate Ligament (ACL) Tear
ACB vs no Block for Pediatric ACL Reconstruction
The goal of this randomized controlled feasibility clinical trial is to assess the feasibility of conducting a randomized trial of adding a perioperative single-shot adductor canal block to standard of care general anesthesia…
- Trial name
- NCT06875427
- Testing
- Ropivacaine 2-2.5mg/kg + dexmedetomidine 1 mcg/kg delivered via a single-shot adductor canal block under ultrasound guidance
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- Isabella Jaramillo
Anterior Cruciate Ligament Injuries
Society for Pediatric Anesthesia Improvement Network- Anterior Cruciate Ligament Reconstruction Outcomes Project
The primary objective is to create a multicenter registry which captures information relating to the perioperative anesthesia course and management of children undergoing anterior cruciate ligament reconstruction and to examine…
- Trial name
- SPAIN-ACL (NCT04329117)
- Where
- 2 sites in United States
- Volunteers
- 526 people
- Sponsor
- Boston Children's Hospital
Anterior Cruciate Ligament Injuries
Arthroscopic Anterior Cruciate Ligament Repair Versus Reconstruction for Acute Anterior Cruciate Ligament Injury
Background: Arthroscopic anterior cruciate ligament(ACL) reconstruction is so far the gold standard for the treatment of ACL ruptures, but this technique still suffers from problems of tendon-bone healing, bone tunnel…
- Trial name
- NCT05584020
- Testing
- ACL Repair, ACL Reconstruction
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
ACL Injury
Continuous Vs Single Shot Block After ACL
The investigators will be randomizing patients to either receive an adductor canal block in the operating room postoperatively as single shot of 20-30cc bupivacaine or to have a catheter inserted into the adductor canal which…
- Trial name
- NCT04101682
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Anterior Cruciate Ligament Injuries
Neuromuscular Training on Lower Extremity in Post-operative Anterior Cruciate Ligament Reconstruction
The objective of the study was to determine the effectiveness of neuromuscular physical Therapy as compared to strength training after ACL reconstruction in terms of pain, function, quality of life, strength and power of…
- Trial name
- ENTACLR (NCT04355078)
- Testing
- Neuromuscular Training, Strength Training
- Where
- Pakistan
- Volunteers
- 84 people
- Sponsor
- Riphah International University
Knee Injuries
Non- vs Partial Controlled Weightbearing After Multiple Knee Ligament Reconstruction
This is a prospective randomized controlled trial with the purpose to determine if patients undergoing isolated posterior cruciate ligament (PCL) reconstruction, or isolated medial collateral ligament (MCL) reconstruction, or…
- Trial name
- NCT05073276
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Twin Cities Orthopedics
Anterior Cruciate Ligament Rupture, Rehabilitation After ACL Reconstruction
Effect of the Hockey Slideboard Training Combined With Blood Flow Restriction (BFR) in the Rehabilitation Following Anterior Cruciate Ligament Surgical Reconstruction (ACL-R)
ACL injuries represent a major health and economic burden. The overall incidence of ACL injuries has increased and is likely to continue to increase, in part due to increased sports participation.
- Trial name
- NCT06955026
- Testing
- Hockey slideboard combined with BFR training, Hockey slideboard
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- Spitalul Municipal Odorheiu Secuiesc
Anterior Cruciate Ligament Injuries
Infection Rates Between Using of Vancomycin Versus Gentamycin in Primary ACLR
The purpose of the study is to compare the efficacy of Vancomycin versus Gentamycin , in reducing infection rates following Anterior Cruciate Ligament Reconstruction .
- Trial name
- ACLR (NCT06050785)
- Testing
- Vancomycin
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Assiut University
Anterior Cruciate Ligament Injury, Knee Injury
Comparison of Quadriceps and Semitendinosus Grafts in ACL Reconstruction Using Data From the Danish Knee Ligament Reconstruction Registry (DKRR)
This study looks at two different types of tendon (tissue) used in knee surgery to repair a torn anterior cruciate ligament (ACL), which is a common injury in active people.
- Conditions
- Anterior Cruciate Ligament Injury, Knee Injury, Ligament Reconstruction, Sports Injuries
- Trial name
- NCT06980285
- Where
- Denmark
- Volunteers
- 2,500 people
- Sponsor
- Abdirahman Hassan Omar
Cruciate Ligament Rupture
Reconstruction of the Anterior Cruciate Ligament(ACL-R) in the 30+-Year Old Assessed by Patient Reported Outcome Measures(PRO) Using the Nationwide Danish Knee Ligament Reconstruction Registry
The purpose of the study is to evaluate the efficacy of primary ACL-R in patients 30 years of age or older using PRO. The PRO used are Knee Osteoarthritis Outcome Score(KOOS) and Tegner score.
- Trial name
- NCT04592367
- Testing
- Patient age at time of procedure of reconstruction of ACL
- Where
- Denmark
- Volunteers
- 30,487 people
- Sponsor
- Region Zealand
Strength, Range of Motion
Low-Load Blood Flow Restriction Training vs Traditional Resistance Training Exercises Following ACLR Surgery
The main objective/s of the study is to compare the effectiveness of low load blood flow restriction training (LL-BFR) with traditional resistance training exercises (T-RT) at improving skeletal muscle hypertrophy, strength…
- Conditions
- Strength, Range of Motion, Pain-Knee, Skeletal Muscle Hypertrophy
- Trial name
- NCT06480032
- Testing
- Blood Flow Restriction band
- Where
- Pakistan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Abasyn University Peshawar
Post Operative Pain
The Effect of Platelet Rich Plasma (PRP) on Post Operative Pain in Anterior Cruciate Ligament Reconstruction
The purpose of this research study is to investigate whether or not platelet rich plasma (PRP) may help to improve tendon healing and decrease post operative pain in patients undergoing anterior cruciate ligament (ACL)…
- Trial name
- NCT01765712
- Testing
- Anterior Cruciate ligament reconstruction bone patellar tendon bone autograft, Platelet Rich Plasma
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brian Walters
ACL Tear
ACL Bone Health and Loading Study
The purpose of this study is to look at the effects of bone density on lower extremity loading mechanics using Blood Flow Restriction (BFR) to provide the control group for bone health.
- Trial name
- ACLBONE (NCT04682392)
- Testing
- Delfi's PTS Personalized Tourniquet System for Blood Flow Restriction Group, Standard ACL rehab
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Candice Dunkin, MS, LAT, ATC
Anterior Cruciate Ligament Reconstruction
The Effect of Contralateral Limb Training on Functional Outcomes in Patients With ACL Reconstruction
Quadriceps and hamstring muscle strenghts have important role in returning to sport after ACL reconstruction and one of the main focus of rehabilitation is to improve strenght of these muscles.
- Trial name
- NCT03304561
- Testing
- Traditional rehabilitation, Cross-over training
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Hacettepe University
Anterior Cruciate Ligament Tear
Tunnel Widening in Augmented ACL Integration Via PrP Enriched Collected Autologous Bone vs Standard ACL Technique
The purpose of this clinical study is to compare the outcomes of two surgical techniques for reconstruction of the anterior cruciate ligament (ACL) after a single, primary ACL rupture.
- Trial name
- NCT05953051
- Testing
- ACL reconstruction with bone/PrP-composite, ACL reconstruction (Standard)
- Where
- Switzerland
- Volunteers
- 107 people
- Sponsor
- Schulthess Klinik
Physical Activity
Clinical and Functional Outcomes at 2 Years of 4-strand Versus 5-strand Hamstring Autograft in Anterior Cruciate Ligament Reconstruction
This study aims to study differences in clinical and functional outcomes at 2 years based on hamstring graft size after single bundle anatomic ACL reconstruction using either 4-strand or 5-strand hamstring grafts.
- Trial name
- NCT03171532
- Testing
- Strands of Hamstring Autograft in ACL reconstruction
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- National University Hospital, Singapore
ACL Injury
ACL Reconstruction: Clinical Outcome
The study is intended to include all patients who will undergo surgical reconstruction of the anterior cruciate ligament (ACL). The patients will be monitored and evaluated preoperatively and also at 6 months and 1, 2 and 5 years…
- Trial name
- RIC-ACL (NCT03441659)
- Testing
- ACL reconstruction
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Stefano Zaffagnini
Knee Injuries, ACL Tear
ACL Reconstruction With Simple and Double Bundle Technique Using Two Different Implants for Graft Fixation
In this study our objective is to compare two tibial ACL graft fixation systems in patients undergoing two different reconstructions technique (with simple and double bundle) in terms of tendon graft osteointegration…
- Conditions
- Knee Injuries, ACL Tear, ACL Injury, Sports Injury
- Trial name
- NCT04550299
- Testing
- Surgical technique combined with a specific choice of the material for the ligament reconstruction
- Where
- Brazil
- Volunteers
- 112 people
- Sponsor
- Vita Care
PEEK Interference Screw; Fixation; Anterior Cruciate Ligament Reconstruction
The Safety and Effectiveness of PEEK Interference Screws in Anterior Cruciate Ligament Reconstruction
Anterior cruciate ligament (ACL) rupture is one of the most common injuries in sports medicine. ACL reconstructions are usually performed to restore the stability of knee joint and prevent the secondary meniscal and chondral…
- Trial name
- NCT03342222
- Testing
- Interference Screws
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Central South University