Clinical trials: ARDS: Acute Respiratory Distress Syndrome
ARDS (Acute Respiratory Distress Syndrome)
Free for Weaning ECMO vs Respiratory Driven Study
In its most severe form, Acute Respiratory Distress Syndrome (ARDS) may require the use of veno-venous ECMO (vvECMO). While the criteria for vvECMO indication, ECMO settings, and ventilator management are relatively well-defined…
- Trial name
- FORWARD (NCT06876415)
- Testing
- P0.1 and delta Poeso integration into the decanulation decision
- Where
- 4 sites in France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
COVID-19 Acute Respiratory Distress Syndrome, Cytokine Release Syndrome
Tazemetostat for the Treatment of Moderate to Severe COVID-19 Infection
The purpose of this study is to assess the safety and efficacy of repurposing tazemetostat for the treatment of Acute Respiratory Distress Syndrome (ARDS) or Systemic Cytokine Release Syndrome (SCRS) in COVID-19 patients.
- Trial name
- IST (NCT05018975)
- Testing
- Tazemetostat
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Acute Respiratory Distress Syndrome (ARDS), COVID-19
Impact of Intravenous Lidocaine on Clinical Outcomes of Patients With ARDS During COVID-19 Pandemia
The purpose of our prospective monocentric, randomized, controlled trial is to evaluate the effects of intravenous lidocaine on gas exchange and inflammation in acute respiratory distress syndrome (ARDS) due or not to Covid-19…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), COVID-19, Corona Virus Infection
- Trial name
- LidoCovid (NCT04609865)
- Testing
- Lidocaine 2%, Control
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Strasbourg, France
COVID-19, COVID-19 Acute Respiratory Distress Syndrome
Characteristics and Outcome of Patients With COVID-19 in ICUs in South Tyrol
The investigators retrospectively investigate the epidemiology, clinical characteristics and therapeutic interventions of patients with COVID-19 associated respiratory failure admitted to the intensive care units in South Tyrol…
- Trial name
- NCT05077319
- Where
- Italy
- Volunteers
- 550 people
- Sponsor
- Institute of Mountain Emergency Medicine
Acute Respiratory Distress Syndrome
Lung Open Ventilation to Decrease Mortality in the Acute Respiratory Distress Syndrome
A multinational, randomized trial comparing two lung protecting strategies of respiratory life support among critically ill patients with severe lung injury.
- Trial name
- LOVS (NCT00182195)
- Testing
- Control Ventilation Strategy
- Where
- Canada
- Volunteers
- 980 people
- Sponsor
- Hamilton Health Sciences Corporation
Respiratory Distress Syndrome, Adult
Mesenchymal Stem Cell in Patients With Acute Severe Respiratory Failure
Although the advent of advanced medical support for respiratory failure, the mortality rate of acute severe respiratory failure is still high and the life quality is frequently compromised from pulmonary fibrosis.
- Trial name
- STELLAR (NCT02112500)
- Testing
- Mesenchymal Stem Cell
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Asan Medical Center
Acute Respiratory Distress Syndrome (ARDS), Acute Brain Injury
Contribution of Transthoracic and Transcranial Ultrasonography to the Titration of PEEP in Patients With ARDS and ABI
The present study will investigate whether the combined use of lung and brain ultrasonography is useful in selecting the optimal positive end-expiratory pressure in mechanically ventilated critically ill patients with acute…
- Trial name
- NCT07248995
- Testing
- Stepwise Positive End-Expiratory Pressure (PEEP) Increase Protocol
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Theodoros Schizodimos
Influenza, Acute Lung Injury
Immuno-virological Characterization of Severe H1N1v Influenza Infection in Bronchoalveolar Lavage
The influenza A/H1N1v pandemic virus causes severe pneumonia that can lead to acute respiratory distress syndrome and death even in healthy young individuals.
- Conditions
- Influenza, Acute Lung Injury, Acute Respiratory Distress Syndrome
- Trial name
- FluBAL (NCT01089400)
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Mild to Moderate Acute Respiratory Distress Syndrome
Post-Market Study of Low-flow ECCO2R Using PrismaLung+
PrismaLung+ is intended to provide extracorporeal carbon dioxide removal (ECCO2R) as a standalone therapy or in combination with continuous renal replacement therapy (CRRT).
- Trial name
- NCT04617093
- Testing
- PrismaLung+
- Where
- 10 sites in France
- Volunteers
- 63 people
- Sponsor
- Vantive Health LLC
Acute Respiratory Distress Syndrome
Mechanical Ventilation With Neurally-Adjusted Ventilatory Assist in Patients With ARDS
Neurally-Adjusted Ventilatory Assist (NAVA) is a ventilatory mode that uses the electrical activity of the diaphragm to control the mechanical ventilator, offering inspiratory assistance in proportion to respiratory effort to…
- Trial name
- NCT01519258
- Testing
- Pressure Support ventilation, NAVA
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Respiratory Distress Syndrome (ARDS)
Low Dose Lung CT Scan for Quantitative Analysis in ARDS Patients
We aimed to assess the accuracy of visual and quantitative analysis performed on low radiation dose lung CT scan (30-60 mAs)compared with that performed on standard radiation dose lung CT scan (110 mAs), in ARDS patients.
- Trial name
- NCT01926093
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- Policlinico Hospital
Respiratory Distress Syndrome, Acute, Severe Community-Acquired Pneumonia
Multimodal Database and Large Language Model for ARDS
The goal of this observational study is to integrate existing clinical cohorts from the research team to establish dedicated cohorts for ARDS and high-risk ARDS patients (primarily SCAP patients), then systematically collect…
- Trial name
- NCT06973733
- Testing
- Clinical data and biospecimen collection
- Volunteers
- 6,500 people
- Sponsor
- China-Japan Friendship Hospital
Critical Illness, Acute Respiratory Distress Syndrome
TelePORT Pilot Study
Although more than 50% of survivors of critical illness experience one or more post-intensive care syndrome (PICS) problems, there are still no validated interventions for the management of PICS.
- Conditions
- Critical Illness, Acute Respiratory Distress Syndrome, Septic Shock
- Trial name
- TelePORT (NCT03926533)
- Testing
- Telehealth
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Vanderbilt University
COVID19 ARDS
Efficacy of Infusions of MSC From Wharton Jelly in the SARS-Cov-2 (COVID-19) Related Acute Respiratory Distress Syndrome
Mesenchymal stem cells (MSCs) are of potential help in acute respiratory distress syndrome (ARDS), due to their anti-inflammatory properties.
- Trial name
- MSC-COVID19 (NCT04625738)
- Testing
- Ex vivo expanded Wharton's Jelly Mesenchymal Stem Cells
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Central Hospital, Nancy, France
Acute Respiratory Distress Syndrome
ART-2 Pilot - Driving Pressure Limited Ventilation for Patients With ARDS
This is a multicenter randomized controlled pilot trial to investigate the feasibility of a driving pressure limited mechanical ventilation strategy compared to the ARDS Clinical Network strategy (conventional strategy) in…
- Trial name
- ART2pilot (NCT02365038)
- Testing
- Driving pressure limited ventilation, Conventional ventilation
- Volunteers
- 20 people
- Sponsor
- Hospital do Coracao
Respiratory Distress Syndrome, Adult
Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome
This is a Phase 2b, randomized, double-blind, placebo-controlled, multi-center study to assess the safety and efficacy of a single dose of Allogeneic Bone Marrow-derived Human Mesenchymal Stromal Cells (hMSCs) infusion in…
- Trial name
- STAT (NCT03818854)
- Testing
- Human Mesenchymal Stromal Cells, Cell Reconstitution Media
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- Michael A. Matthay
ARDS
Impact of Belt Position on the Results of PEEP Titration by EIT During ARDS
ARDS is a frequent reason for hospitalization in intensive care. In order to improve its management, doctors seek to limit the mechanical ventilation-induced injuries (VILI) that can occur.
- Trial name
- REPEIT (NCT06541522)
- Testing
- EIT
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
Acute Respiratory Distress Syndrome (ARDS), ARDS
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)
This is a Phase 2 multicenter, randomized, double-blinded, placebo-controlled study that will evaluate the safety and efficacy of host-directed therapeutics in hospitalized adults diagnosed with Acute Respiratory Distress…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome
- Trial name
- NCT06703073
- Testing
- Cohort A: vilobelimab, Cohort B: paridiprubart, Cohort C: bevacizumab
- Where
- 41 sites in United States
- Volunteers
- 600 people
- Sponsor
- PPD Development, LP
Video-assisted Thoracoscopic Surgery (VATS), Lung Cancer (Diagnosis)
Intraoperative Paravertebral Block and Postoperative Complications
This study aims to evaluate the clinical association between intraoperative paravertebral block and the reduction of postoperative complications following thoracic surgery.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Lung Cancer (Diagnosis), Pulmonary Infections, Respiratory Failure Without Hypercapnia
- Trial name
- IPVB and POCs (NCT07211529)
- Testing
- Paravertebral Block (PVB)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Chemical Injury, Chemicals; Intoxication
The Medical Management in Patients Exposed to Weapons of Mass Destruction
Observation study measuring medical response in contaminated environment.
- Conditions
- Chemical Injury, Chemicals; Intoxication, Acute Respiratory Distress Syndrome, Distress Respiratory Syndrome
- Trial name
- CBRNEObs (NCT05026645)
- Testing
- Clinical interventions performed in acute settings (contaminated environment), Protection (clinician and patient), Decontamination (clinician and patient)
- Where
- 15 sites in United States, Canada and 4 more
- Volunteers
- 1,000 people
- Sponsor
- St. Justine's Hospital
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