Clinical trials: ARDS: Acute Respiratory Distress Syndrome
Acute Respiratory Failure
Physiological Effects of a New Interface on Lung Ventilation and Gas Distribution
Hypoxemic Acute Respiratory Failure (hARF) is a common reason of admission to Intensive Care. Different modalities can be used to administer oxygen, which is the first supportive treatment in these patients.
- Trial name
- NCT04619641
- Testing
- High Flow Nasal Cannula (HFNC), Continuous Positive Airway Pressure (CPAP)
- Volunteers
- 15 people
- Sponsor
- University Magna Graecia
Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication
Cerebral Bleeding in COVID-19 ARDS Patients on Veno-venous ECMO
Critically ill patients with severe acute respiratory distress syndrome (ARDS) sometimes require treatment with veno-venous extracorporeal membrane oxygenation (ECMO) to support gas exchange.
- Conditions
- Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication, Corona Virus Infection
- Trial name
- NCT04853953
- Testing
- Incidence of bleeding complications in ARDS patients on veno-venous ECMO
- Volunteers
- 400 people
- Sponsor
- University of Zurich
Acute Respiratory Distress Syndrome (ARDS)
Multicentric, Randomized Study to Assess Safety and Efficacy of Centhaquine in Patients With ARDS
Acute respiratory distress syndrome (ARDS) is a life-threatening condition with a diffuse, inflammatory form of lung injury, causing pulmonary infiltration and respiratory failure leading to poor oxygenation.
- Trial name
- NCT05241067
- Testing
- Normal Saline, Centhaquine
- Volunteers
- 80 people
- Sponsor
- Pharmazz, Inc.
Ventilator-Induced Lung Injury, Acute Respiratory Distress Syndrome
Comparing Mechanical Power in Different Inspiratory Times
We aimed to compare mechanical power and energy values using geometric methods at varying inspiratory rise times.
- Trial name
- NCT06413472
- Testing
- Mechanical ventilator adjustment for PCV, Mechanical ventilator adjustment for VCV
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Respiratory Distress Syndrome, Adult
Viral-Related Neutrophil Response and Condition Severity in People With ARDS
Acute respiratory distress syndrome (ARDS) is a severe lung condition that can result from a bacterial infection in the lungs. Viral infections may impair the body's immune system response to bacteria, which may lead to more…
- Trial name
- NCT00548795
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- National Jewish Health
Respiratory Distress Syndrome, Adult
Evaluating a Web-Based Ventilator Management Educational Program for Clinicians (The Lung Injury Knowledge Network [LINK] Study)
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a severe lung condition that causes respiratory failure. Individuals with ALI/ARDS often require the use of a respirator or artificial breathing machine, known…
- Trial name
- LINK (NCT00542737)
- Testing
- Web-Based Educational Program
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
COVID-19 Pneumonia, Acute Lung Injury
Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury
The study is a prospective, randomized, placebo-controlled, double-blind phase 2 clinical study of the efficacy and safety of CERC-002, a potent inhibitor of LIGHT (Lymphotoxin-like, exhibits Inducible expression, and competes…
- Conditions
- COVID-19 Pneumonia, Acute Lung Injury, ARDS
- Trial name
- NCT04412057
- Testing
- CERC-002
- Where
- 11 sites in United States
- Volunteers
- 88 people
- Sponsor
- Aevi Genomic Medicine, LLC, a Cerecor company
ARDS
The Evaluation of NETs, Caspase-1 and Cytokines in ARDS Patients
1. enrollment criteria and clinical data collection: follow the principles of medical ethics, the development of inclusion and exclusion criteria, select 90 cases of ARDS patients, in the active treatment at the same time…
- Trial name
- NCT03227107
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Early Prediction for Sepsis Induced Acute Lung Injury
Radiomics Markers to Predict Sepsis Induced Acute Respiratory Distress Syndrome
Introduction: Sepsis-induced acute respiratory distress syndrome(SI-ARDS) is a common complication of severe sepsis and is an independent contributor to poor prognosis of patients.
- Trial name
- NCT04541264
- Testing
- radiomic of chest CT
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Acute Respiratory Distress Syndrome
Airway Pressure Release Ventilation (APRV) Protocol Early Used in Acute Respiratory Distress Syndrome
The aim of this study is to assess the effects and safety of the early application of BILEVEL-APRV protocol and conventional ventilation strategy that used low tidal volume and adequate PEEP level in ARDS patients .
- Trial name
- NCT02639364
- Testing
- Nellcor Puritan Bennett 840 ventilator system
- Where
- China
- Volunteers
- 200 people
- Sponsor
- West China Hospital
Acute Respiratory Distress Syndrome
Early Versus Late Initiation of ECMO (Extracorporal Membrane Oxygenation) Trial (ELIEO-Trial)
This trial is a prospective randomized multicenter trial that assigns patients to either a treatment for Acute Respiratory Distress Syndrome (ARDS) with an Extracorporal Membrane Oxygenation (ECMO) immediately after admission to…
- Trial name
- ELIEO (NCT04208126)
- Testing
- ECMO
- Where
- Germany
- Volunteers
- 508 people
- Sponsor
- University Hospital Tuebingen
ICU Patients, Healthy Lung
Effects of End-expiratory Positive Pressure Optimization in Intubated Patients With Healthy Lung or Acute Respiratory Distress Syndrome
PEEP titration is a recommended during invasive mechanical ventilation of ICU patients. However, little is known about the right way to conduct this titration.
- Conditions
- ICU Patients, Healthy Lung, Positive End-Expiratory Pressure, ARDS
- Trial name
- PEEP-Réa (NCT04503876)
- Testing
- Increasing PEEP setting, Decreasing PEEP setting
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Clermont-Ferrand
ARDS
Cerebrovascular Hemodynamics in Patients With ARDS.
The acute respiratory distress syndrome (ARDS) is a life-threatening disease with functional impairment of the lung. It is characterized by an excessive inflammatory response of lung tissue, capillaries, and blood vessels and is…
- Trial name
- NCT03949738
- Testing
- Near-infrared spectroscopy-based assessement of cerebral autoregulation.
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure
The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS
Acute respiratory distress syndrome (ARDS) in its moderate to severe forms is associated with high mortality. Mechanical ventilation (MV) remains the cornerstone of ARDS management but carries a significant risk of…
- Conditions
- Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure, Mechanical Ventilation, Electrical Impedance Tomography (EIT)
- Trial name
- PEEP (NCT06733168)
- Testing
- electrical impedance tomography, Non-EIT
- Where
- Vietnam
- Volunteers
- 76 people
- Sponsor
- Vietnam Military Medical University
Respiratory Distress Syndrome, Adult
Abnormalities in Lung Computed Tomography and Physiological Alterations in Patients With Acute Respiratory Distress Syndrome
The objective of the study is to determine the correlation between the physiological variables and the degree of consolidation in lung computed tomography in patients with acute respiratory distress syndrome
- Trial name
- NCT02799940
- Where
- Argentina
- Volunteers
- 29 people
- Sponsor
- Hospital Regional Rio Gallegos
COVID-19
COVID-19 : Study of INFLAmmasome and PLAtelets Functions
COVID-19 pandemic is a severe viral sepsis characterized by the occurrence of Acute respiratory distress syndrome (ARDS) whose pathophysiology is little described
- Trial name
- CO-QUETTES (NCT04397822)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 61 people
- Sponsor
- University Hospital, Toulouse
Acute Respiratory Distress Syndrome
Platform Adaptive Embedded Trial for Acute Respiratory Distress Syndrome
Platform adaptive embedded trial for acute respiratory distress syndrome (PETARDS) is a randomized, embedded, multifactorial, adaptive platform trial for ARDS.
- Trial name
- PETARDS (NCT05658692)
- Testing
- protective ventilation, prone position ventilation, glucocorticoid therapy
- Where
- 11 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Tocilizumab for Patients With Cancer and COVID-19 Disease
This phase II expanded access trial will study how well tocilizumab works in reducing the serious symptoms including pneumonitis (severe acute respiratory distress) in patients with cancer and COVID-19.
- Conditions
- Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Pneumonia, Pneumonitis
- Trial name
- NCT04370834
- Testing
- Tocilizumab
- Where
- 5 sites in United States
- Volunteers
- 1 people
- Sponsor
- National Cancer Institute (NCI)
SARS-CoV-2, Covid19
Pathological Findings of Fatal COVID-19
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new coronavirus discovered in December 2019 in Wuhan, China and currently responsible of a worldwide outbreak and the death of more than 55,000 patients in…
- Conditions
- SARS-CoV-2, Covid19, Pathology, Intensive Care Units
- Trial name
- HISTOCOVID (NCT04675281)
- Testing
- 2 post-mortem transcutaneous lung biopsies (1 anterior ; 1 posterior) using anatomical landmarks
- Where
- 44 sites in France
- Volunteers
- 170 people
- Sponsor
- Nantes University Hospital
COVID-19 Infection, COVID-19-Associated Acute Respiratory Distress Syndrome
Study of Cord Blood Derived Mesenchymal Stem Cells for Treatment of Moderate, Severe or Critical Pneumonia
This is a phase I trial followed by a phase II randomized trial. The purpose of phase I study is the feasibility of treating patients with acute respiratory distress syndrome (ARDS) related to COVID-19 infection (COVID-19) with…
- Conditions
- COVID-19 Infection, COVID-19-Associated Acute Respiratory Distress Syndrome, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT04565665
- Testing
- Best Practice, Mesenchymal Stem Cell
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- M.D. Anderson Cancer Center
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