Clinical trials: ARDS
Respiratory Distress Syndrome, Newborn, Continuous Positive Airway Pressure
Neotech RAM Cannula Versus Conventional Binasal Prong Continuous Positive Airway Pressure (CPAP) to Treat Respiratory Distress in Low Birth Weight Neonates
The purpose of this study is to determine if the RAM cannula is as effective as conventional binasal prongs to deliver CPAP to low birth weight infants with respiratory distress.
- Conditions
- Respiratory Distress Syndrome, Newborn, Continuous Positive Airway Pressure, Low Birth Weight Infants
- Trial name
- NCT02168257
- Testing
- RAM Cannula, Binasal Prong CPAP
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Respiratory Disease, Respiratory Distress Syndrome
Oxygenation Efficacy of "Intrinseque Health" Non-Rebreathing Mask ("IHNRM")
Based on early bench-testing data and subsequent clinical case studies in the U.S., "Intrinseque Health" non-rebreathing mask (IHNRM) has delivered virtual elimination of air entrainment and preferential delivery of all available…
- Conditions
- Respiratory Disease, Respiratory Distress Syndrome, Respiratory Failure
- Trial name
- NCT06310629
- Testing
- High Flow Nasal Cannula, "Intrinseque Health" Non-Rebreathing Mask ("IHNRM")
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- China Medical University Hospital
Respiratory Distress Syndrome, Newborn, Pulmonary Surfactants
Echography-guided Surfactant THERapy (ESTHER) For Preterm Infants With Respiratory Failure
Point-of-care ultrasound (POCUS) is the use of ultrasound by the bedside provider in real time to answer a specific question and guide medical management.
- Conditions
- Respiratory Distress Syndrome, Newborn, Pulmonary Surfactants, Intensive Care Units, Neonatal
- Trial name
- NCT06446453
- Testing
- Echography-guided Surfactant THERapy (ESTHER)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Connecticut Children's Medical Center
ARDS, Human
Feasabilty and Physiological Effects of a Ventilation Strategy Combining PEEP and Tidal Volume Titration According to Inspiratory and Expiratory Transpulmonary Pressures in ARDS Patients.
Expiratory or inspiratory transpulmonary pressures have been proposed to optimize ventilator settings in patients with ARDS. The aim of this study is to assess the feasibility and the physiological effects of a new method based…
- Trial name
- PULMOESO (NCT05337059)
- Testing
- PEEP and Tidal Volume Titration
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Angers
Acute Respiratory Distress Syndrome, Diaphragm Injury
Re-Evaluation of Systemic Early Neuromuscular Blockade and Transthoracic Ultrasound Assessment of the Diaphragm
ROSETTA is a multi-centre study evaluating the time course of diaphragm thickness and function following exposure to neuromuscular blockade or control in patients with acute respiratory distress.
- Conditions
- Acute Respiratory Distress Syndrome, Diaphragm Injury, Neuromuscular Blockade
- Trial name
- ROSETTA (NCT03132896)
- Where
- 6 sites in United States
- Sponsor
- University Health Network, Toronto
Respiratory Insufficiency, Pressure Injury
Effectiveness of Platform-Based Lateralization Therapy in Reducing Interface Pressure Between The Patient And The Support Surface
Pressure injury (PI) is characterized as damage to the skin and/or underlying tissues resulting from sustained pressure or a combination of pressure and shear forces between the patient and the support surface.
- Conditions
- Respiratory Insufficiency, Pressure Injury, Intensive Care Medicine, ARDS
- Trial name
- PREVENT-ICU (NCT06819943)
- Testing
- Automated Lateral Rotation Therapy
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Respiratory Failure
Epidemiology of Respiratory Insufficiency in Critical Care
Acute respiratory failure is a common entity in intensive care units nowadays and is associated with significant morbidity and mortality, thus representing a major health problem.
- Trial name
- ERICC (NCT01268410)
- Where
- Brazil
- Volunteers
- 773 people
- Sponsor
- Hospital Sirio-Libanes
Respiratory Distress Syndrome, Adult, Gastrointestinal Hemorrhage
INR-Triggered Transfusion In GI Bleeders From ER
Transfusion-related acute lung injury (TRALI) is the most common cause of transfusion-related morbidity and mortality in the United States.
- Conditions
- Respiratory Distress Syndrome, Adult, Gastrointestinal Hemorrhage, Liver Diseases, Transfusion Related Lung Injury
- Trial name
- I-TRIGER (NCT01461889)
- Testing
- Transfuse plasma to High INR target, Transfuse plasma to Low INR target
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Acute Respiratory Distress Syndrome, Acute Lung Injury
Non-invasive Vagal Neurostimulation (nVNS) for Traumatic Brain Injury (TBI)-Induced Acute Respiratory Distress
This is a prospective, randomized, two-arm, controlled 30-day investigational pilot trial using the gammaCore Sapphire S non-invasive vagus nerve stimulation (nVNS) device + standard of care (SOC) in newly-hospitalized patients…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Traumatic Brain Injury
- Trial name
- NCT04935697
- Testing
- nVNS, SOC
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
ARDS, Human, Mechanical Ventilation Pressure High
Lung Protection in ARDS Using Neurally Adjusted Ventilatory Assist
The aim of this study is to investigate the use neurally adjusted ventilatory assist (NAVA) as lung protective strategy in patients with acute respiratory distress syndrome (ARDS).
- Trial name
- NAVA (NCT03868982)
- Testing
- Neurally adjusted ventilatory assist
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Fu Jen Catholic University
Acute Respiratory Distress Syndrome
Pediatric Acute Respiratory Distress Syndrome Ventilation Bundle
Mortality rates in children with pediatric acute respiratory distress syndrome (PARDS) are higher in Asia compared to other regions.
- Trial name
- NCT03504176
- Testing
- Ventilation bundle
- Where
- Singapore
- Volunteers
- 134 people
- Sponsor
- KK Women's and Children's Hospital
ARDS, Human
LIght Sedation Pressure Support
Sedation may have many drawbacks in ICU patients: cardiovascular, neurologic, muscular. Light sedation and Pressure Support ventilation is feasible in ARDS patients.
- Trial name
- LIPS (NCT03783468)
- Testing
- decrease of sedation doses and switch of ventilator settings
- Sponsor
- University Hospital, Lille
ARDS Associated With COVID-19
Flow Controlled Ventilation in ARDS Associated With COVID-19
The pandemic of a newly upcoming viral disease which is associated with COVID-19 puts the whole world's health system under pressure.
- Trial name
- NCT04399317
- Testing
- Flow controlled ventilation (Evone-ventilator)
- Where
- Qatar
- Volunteers
- 20 people
- Sponsor
- Hamad Medical Corporation
Viral Pneumonia, Acute Respiratory Distress Syndrome (ARDS)
Mucosal Associated Invariant T Cell During Viral Pneumonia and Acute Respiratory Distress Syndrome
Viral pneumonia, including SARS-CoV-2 and influenza A virus (IAV), can culminate in acute respiratory distress syndrome (ARDS), a severe form of respiratory failure with high mortality.
- Trial name
- MAIT-VECTORS (NCT06720818)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Tours
Transient Tachypnea of Newborn and Fetal Acidosis
Impact Of Maternal Spinal Anesthesia-Induced Hypotension At Scheduled Cesarean Delivery On Risk Development Of Transient Tachypnea Of Newborn And Fetal Acidosis
We will evaluate the association between transient tachypnea of newborns and fetal acidosis development to the degree and duration of maternal hypotension and anesthesia to delivery time during spinal anesthesia at scheduled…
- Trial name
- NCT06383624
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Benha University
COVID, ARDS
Prone Positioning and High-flow Nasal Cannula in COVID-19 Induced ARDS
Prone position (PP) has been proved to be effective in severe ARDS patients. On the other hand, High flow nasal cannula (HFNC) may prevent intubation in hypoxemic Acute respiratory failure (ARF) patients.
- Conditions
- COVID, ARDS, Acute Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- NCT04391140
- Testing
- Prone position
- Where
- Spain
- Volunteers
- 248 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Respiratory Distress Syndrome
Etiology and Outcomes of Tropical Acute Respiratory Distress Syndrome
This is a prospective observational study done to know the etiology and outcomes of Acute Respiratory Distress Syndrome.
- Trial name
- NCT01450527
- Where
- India
- Volunteers
- 64 people
- Sponsor
- All India Institute of Medical Sciences
Coronavirus Disease 2019, Disease Caused by Severe Acute Respiratory Syndrome Coronavirus 2
Study of Varespladib in Patients Hospitalized With Severe COVID-19
This is a 2-part, multi-center, randomized, double-blind, placebo-controlled, phase 2 study designed to evaluate the safety, tolerability, and efficacy of oral varespladib, in addition to standard of care, in patients…
- Trial name
- STAIRS (NCT04969991)
- Testing
- Varespladib
- Where
- 7 sites in United States
- Volunteers
- 18 people
- Sponsor
- Ophirex, Inc.
Acute Respiratory Distress Syndrome, Lung Diseases
ARDS - Clinical Epidemiology and the Role of the Inflammatory Response - SCOR in Acute Lung Injury
To investigate the epidemiology of adult respiratory distress syndrome (ARDS) and the evolution of the inflammatory process in patients with acute lung injury.
- Trial name
- NCT00005318
- Sponsor
- University of Minnesota
Acute Respiratory Distress Syndrome, Prone Position
Early Verticalization of the Patient With Acute Respiratory Distress Syndrome: Assessment of Feasibility and Safety.
Acute Respiratory Distress Syndrome (ARDS) is defined according to the Berlin definition (1) as diffuse lung damage occurring in patients with a predisposing risk factor.
- Trial name
- STAND_ARDS1 (NCT04472260)
- Testing
- Verticalization and Prone position
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Centre Hospitalier Régional d'Orléans