Clinical trials: ARDS
Covid19
Tableted COVID-19 Therapeutic Vaccine
Safety and immunogenicity one-month study in healthy individuals administered once-daily pill of therapeutic vaccine made from heat-inactivated plasma from donors with COVID-19.
- Trial name
- COVID-19 (NCT04380532)
- Testing
- V-SARS
- Where
- 2 sites in Canada, Mongolia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Immunitor LLC
Corona Virus Infection, ARDS
Microbiota in COVID-19 Patients for Future Therapeutic and Preventive Approaches
In light of the rapidly emerging pandemic of SARS-CoV-2 infections, the global population and health care systems are facing unprecedented challenges through the combination of transmission and the potential for severe disease.
- Conditions
- Corona Virus Infection, ARDS, Coinfection
- Trial name
- MICRO-COV (NCT04410263)
- Testing
- Sampling (EDTA blood, pharyngeal and nose swabs, bronchoalveolar lavage ,urine)
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University of Zurich
Respiratory Distress Syndrome
Diaphragm Dysfunction in ARDS Patients With V-V ECMO
Use of veno-venous extracorporeal oxygenation membrane is a therapeutic option for the management of the most severe patients with acute respiratory distress syndrome (ARDS).
- Trial name
- DD-ECMO (NCT04613752)
- Testing
- diaphragmatic function measurements and diaphragmatic ultrasound
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prematurity, Low Birth Weight
Paternal Involvement in Nursing Guidance and Breastfeeding Self-Efficacy in Mothers of High-Risk Newborns
This study aims to evaluate whether a structured nursing guidance program that increases fathers' participation in the care of hospitalized high-risk newborns improves maternal outcomes compared with routine nursing care.
- Conditions
- Prematurity, Low Birth Weight, Respiratory Distress Syndrome, Newborn, Neonatal Hyperbilirubinemia
- Trial name
- NCT07834008
- Testing
- step-by-step parent education, active father participation in breastfeeding support
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Acute Respiratory Distress Syndrome
Inflammation During ECMO Therapy and ECMO Weaning
The goal of this interventional clinical trial is to compare patients who undergo ECMO therapy for treatment of acute respiratory distress syndrome (ARDS) and a randomized into one of two possible weaning strategy groups.
- Trial name
- ECMOWean (NCT05640635)
- Testing
- Ventilator weaning first, ECMO weaning first
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Tuebingen
ARDS, Fluid Management
Cardiometry Versus Fluid and Catheter Treatment Trial (FACTT Lite) on Fluid Management in Acute Respiratory Distress Syndrome Patients
The aim of this study will be to compare the fluid management in acute respiratory distress syndrome ARDS guided by electrical cardiometry (EC) versus the guidance with simplified conservative fluid protocol, Fluid and Catheter…
- Conditions
- ARDS, Fluid Management, Cardiometry
- Trial name
- NCT04219150
- Testing
- Electrical cardiometry, Fluid and Catheter Treatment Trial "FACTT Lite"
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Acute Respiratory Distress Syndrome
Low-Flow CO2 Removal for Mild to Moderate ARDS With PRISMALUNG
This pilot observational study will assess changes in pH /PaO2 /PaCO2, Respiratory Rate and device CO2 clearance in the first 24 hours of Extracorporeal CO2 removal (ECCO2R) following tidal volume (Vt), and plateau pressure…
- Trial name
- NCT02606240
- Testing
- CO2 removal with PRISMALUNG in ARDS
- Where
- 5 sites in France
- Volunteers
- 20 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Covid-19
Bicentric Study on the Use of ECMO-VV or VA for Severe ARDS Associated With Covid-19
Describes the cohort of patients receiving ECMO-VV or ECMO-VA in the management of severe ARDS refractory to SARS-CoV-2 in the Strasbourg and Louvain centres
- Trial name
- ECMO-SL-CoV-2 (NCT04446286)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Infant, Premature, Diseases, Bronchopulmonary Dysplasia
Forced Oscillometry in Infants With Bronchopulmonary Dysplasia
The purpose of this study is to use forced oscillometry technique (FOT) to measure pulmonary mechanics and function in in term infants and premature infants with bronchopulmonary dysplasia (BPD)
- Conditions
- Infant, Premature, Diseases, Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
- Trial name
- NCT04270045
- Testing
- Non-invasive forced airway oscillometry
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Winston Manimtim
COVID-19, ARDS, Human
Curosurf® in Adult Acute Respiratory Distress Syndrome Due to COVID-19
Surfactant replacement therapy (SRT) improves oxygenation and survival in NRDS and some infant ARDS. SRT was tried in adult ARDS with conflicting results.
- Trial name
- Caards-1 (NCT04384731)
- Testing
- poractant alfa
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Dr Christophe LENCLUD
Acute Respiratory Distress Syndrome (ARDS), ARDS
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: Bevacizumab
This is a Phase 2 multicenter, randomized, double-blinded, placebo-controlled study that will evaluate the safety and efficacy of host-directed therapeutics in hospitalized adults diagnosed with Acute Respiratory Distress…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome
- Trial name
- NCT06701656
- Testing
- Cohort C: bevacizumab
- Where
- 41 sites in United States
- Volunteers
- 200 people
- Sponsor
- PPD Development, LP
Respiration, Artificial, Respiratory Distress Syndrome, Adult
Weaning From Mechanical Ventilation Using Permissive Hypercarbia
Some patients receiving mechanical ventilation have difficulty weaning off the ventilator because of physiological factors such as pre-existing lung disease, respiratory distress syndrome, and trauma among others.
- Trial name
- NCT00357929
- Testing
- Permissive hypercarbia
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Milton S. Hershey Medical Center
Sepsis, Acute Lung Injury
Effects of TNX-832 (Sunol cH36) in Subjects With Acute Lung Injury/Acute Respiratory Distress Syndrome
This Phase I/IIa, multi-center, randomized, placebo-controlled, single-blinded dose-escalation study evaluated TNX-832 (also referred to as ALT-836 and Sunol cH36) in subjects with suspected or proven bacteria-induced ALI/ARDS.
- Conditions
- Sepsis, Acute Lung Injury, Acute Respiratory Distress Syndrome
- Trial name
- NCT01438853
- Testing
- TNX-832
- Where
- 7 sites in United States, Canada
- Volunteers
- 18 people
- Sponsor
- Altor BioScience
Acute Respiratory Failure, ARDS
V/Q Matching in Pressure Support Ventilation
The aim of this study is to describe the effects of different levels of pressure support on ventilation-perfusion matching in patients recovering from ARDS, using electrical impedance tomography.
- Conditions
- Acute Respiratory Failure, ARDS, Electrical Impedance Tomography
- Trial name
- NCT05781802
- Testing
- Level of pressure support
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo
Preterm Delivery
Betamethasone Dosing Interval - 12 or 24 Hours?
The purpose of this study is to determine if there may be a benefit to the newborn if betamethasone is given 12 hours apart instead of 24 hours apart.
- Trial name
- NCT00453141
- Testing
- dosing of Betamethasone
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Cooper Health System
Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Pulmonary Complication
FSTL1 and PPCs on Pediatric Within LDLT:a Prospective Cohort Analysis
The goal of this observational study is to identify the association between FSTL1 elevation and acute lung injury (ALI) after pediatric liver transplantation.The main questions it aims to answer what the risk factors are for ALI…
- Conditions
- Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Pulmonary Complication, Liver Transplant; Complications
- Trial name
- NCT05807802
- Volunteers
- 400 people
- Sponsor
- Tianjin First Central Hospital
Acute Respiratory Distress Syndrome
Early Use of Airway Pressure Release Ventilation (APRV) in ARDS
Airway pressure release ventilation (APRV) is a time-cycled, pressure controlled, intermittent mandatory ventilation mode with extreme inverse I:E ratios. Currently it is considered as a non-conventional ventilatory mode.
- Trial name
- NCT04221737
- Testing
- APRV. General Electric Healthcare Engstrom ventilator system, Conventional. General Electric Healthcare Engstrom ventilator system
- Where
- Mexico
- Volunteers
- 150 people
- Sponsor
- Hospital Civil de Guadalajara
ARDS
Eit in ArdS for Tcav Setting (EAST Study)
Acute respiratory distress syndrome (ARDS) is a severe form of acute respiratory failure. The therapeutic management is currently based on the treatment of the cause of ARDS, and on mechanical ventilation with positive expiratory…
- Trial name
- EAST (NCT06408272)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Central Hospital, Nancy, France
Respiratory Distress Syndrome, Adult
Effects of Positive End-expiratory Pressure and Tidal Volume on Fluid Responsiveness of Acute Respiratory Distress Syndrome
Fluid responsiveness (FR)refers to the ability of heart to increase its stroke volume in response to volume load.Low tidal volume and high PEEP exerts contrast effect on the prediction of fluid responsiveness, the aim of this…
- Trial name
- NCT01716962
- Testing
- Infusion of 6% tetrastarch for a total of 500 ml
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Mechanical Ventilation, Acute Respiratory Distress Syndrome
Ventilation's Parameters Applied in Emergency Medicine. A Prospective Observational Study
To prospectively assess the mechanical ventilation management when its provided by Emergency Physicians in French Hospital, and to assess complications and outcome of these patients.
- Conditions
- Mechanical Ventilation, Acute Respiratory Distress Syndrome, Protective Ventilation, Survival
- Trial name
- PARAVENT (NCT03351920)
- Testing
- mechanical ventilation
- Where
- 7 sites in France
- Volunteers
- 229 people
- Sponsor
- Poitiers University Hospital