Clinical trials: ART
HIV Infections
Highly Active Antiretroviral Therapy (HAART) Adherence Interventions
This study proposes a 4-armed factorial randomized clinical trial in Nairobi, Kenya to determine the effect of cognitive and behavioral interventions on HAART adherence.
- Trial name
- NCT00273780
- Testing
- Adherence counseling, Alarm device
- Where
- Kenya
- Volunteers
- 400 people
- Sponsor
- University of Washington
Malaria
Safety and Efficacy of Methylene Blue Combined With Artesunate or Amodiaquine for Malaria Treatment in Children of Burkina Faso: a Pilot Study
The primary objective of this trial is to study the safety of the combination methylene blue (MB)-artesunate (AS) and MB-amodiaquine (AQ) in treating malaria among children compared to the safety of an AS-AQ regimen.
- Trial name
- NCT00354380
- Testing
- Methylene blue, Artesunate, Amodiaquine
- Where
- Burkina Faso
- Sponsor
- Heidelberg University
HIV (Human Immunodeficiency Virus), AIDS (Acquired Immune Deficiency Syndrome)
Antiretroviral Therapy and Inflammatory and Coagulation Biomarkers: iMACS Study
The aim of this study is to develop and follow a cohort of human immunodeficiency virus (HIV)-infected adults who are starting HIV drugs at health facilities in Kenya.
- Conditions
- HIV (Human Immunodeficiency Virus), AIDS (Acquired Immune Deficiency Syndrome), Tuberculosis, Non-communicable Diseases (NCD)
- Trial name
- iMACS (NCT02027480)
- Where
- 9 sites in Kenya
- Volunteers
- 685 people
- Sponsor
- Columbia University
Malaria
Efficacy of Three ACTs for the Treatment of Falciparum Malaria in Maradi Niger
Study treatments: Artemether-lumefantrine Artesunate-amodiaquine Dihydroartemisinin-piperaquine Location: Maradi, Niger Principal Objective: To measure the clinical and parasitological efficacy of the three artemisinin…
- Trial name
- NCT01755559
- Testing
- Artesunate-amodiaquine, Dihydroartemisinin-piperaquine, Artemether-lumefantrine
- Where
- Niger
- Volunteers
- 663 people
- Sponsor
- Epicentre
Fertility Disorders
Effect of Oocyte Denudation Time and Intracytoplasmic Sperm Injection Time on Embryo Quality
An observational analytic retrospective study was conduct using cross-sectional study. The subject were oocytes from in-vitro fertilization procedures using the ICSI method at the assisted reproductive technology clinic in a…
- Trial name
- NCT05448859
- Testing
- intracytoplasmic sperm injection
- Volunteers
- 200 people
- Sponsor
- Universitas Padjadjaran
HIV Infections
Cohort Study of HIV-positive People, Treated With Long Acting Antiretroviral Therapy
Systematic, continuative collection of clinical and laboratory data on patients followed at lnfectious Diseases Unit of the IRCCS San Raffaele Hospital in Milan, receiving long-acting ART (Phase IV, single-center, prospective…
- Trial name
- SCohoLART (NCT05663580)
- Testing
- Cabotegravir 600mg/3mL, Rilpivirine 900mg/3mL
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Castagna Antonella
Patient Satisfaction, Vascular Access Complication
Radial vs. State-Of-The-Art Femoral Access for Bleeding and Access Site Complication Reduction in Cardiac Catheterization (REBIRTH)
This is a phase IV, prospective, open label, randomized-controlled study that will compare radial access with state-of-the-art femoral access in patients without ST-segment elevation acute myocardial infarction undergoing cardiac…
- Trial name
- REBIRTH (NCT04077762)
- Testing
- Radial Access, State-of-the-art femoral access with 18 gauge needle, State-of-the-art femoral access with 21 gauge needle
- Where
- 6 sites in United States
- Volunteers
- 3,266 people
- Sponsor
- Minneapolis Heart Institute Foundation
Malaria
A Trial of the Efficacy of Artesunate and Three Quinine Regimens in the Treatment of Severe Malaria in Children at the Ebolowa Regional Hospital - Cameroon
The purpose of the study is to evaluate and compare the efficacy of parenteral artesunate with three quinine regimens in the treatment of severe malaria in children at the Ebolowa Regional Hospital located in the South region of…
- Trial name
- NCT02563704
- Testing
- Artesunate, Quinine
- Volunteers
- 238 people
- Sponsor
- University of Yaounde 1
Human Immunodeficiency Virus, HIV Infections
Adjusting Antiretroviral Therapy Dosage Using Therapeutic Drug Monitoring
Background Low concentrations of protease inhibitors (PIs) or nonnucleoside reverse transcriptase inhibitors (NNRTIs) are associated with an increased risk of virological failure.
- Trial name
- TDM (NCT00836212)
- Testing
- Reducing dose of Lopinavir, Reducing dose of efavirenz
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University Hospital, Geneva
Aneuploidy, Infertility
Nuclear Magnetic Resonance for Embryo Ploidy Selection
This study aims to validate the embryo culture medium analysis by nuclear magnetic resonance spectroscopy, as a faster and less-costly alternative to preimplantation genetic test for aneuploidy which could significantly enhance…
- Trial name
- NCT05488236
- Testing
- Nuclear magnetic resonance analysis of embryo culture medium
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidade de Lisboa
Recreational Drug Use
Chemsex Engagement and HIV Biomedical Prevention in MSM
HIV biomedical prevention through treatment-as-prevention (TasP) and pre-exposure prophylaxis (PrEP) is highly efficacious for reducing HIV transmission risk.
- Trial name
- NCT05031832
- Testing
- HIV test
- Where
- Hong Kong
- Volunteers
- 733 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
HIV
Observational, Retrospective, Multicenter Study to Describe the Reasons for the Change of the Regimen of Antiretroviral Therapy in HIV Patients
The study aims to describe the changes of combination antiretroviral therapy and the causes that motivated them.
- Trial name
- SWITCHART (NCT02039921)
- Where
- 12 sites in Spain
- Volunteers
- 250 people
- Sponsor
- Fundacion SEIMC-GESIDA
HIV-1-infection
Efficacy and Safety of Doravirine in the Rapid Initiation
Protocol title: "Efficacy and safety of doravirine in the rapid initiation of highly active antiretroviral therapy (HAART) in HIV-1positive patients without prior treatment."
- Trial name
- RapiDO (NCT07357584)
- Testing
- Doravirine / lamivudine/ Tenofovir Disoproxil Oral Tablet
- Where
- 2 sites in Argentina
- Volunteers
- 100 people
- Sponsor
- Fundación Huésped
Malaria,Falciparum
Pyronaridine-artesunate With Low Dose Primaquine for Preventing P. Falciparum Transmission
The purpose of this study is to assess the gametocytocidal and transmission reducing activity of pyronaridine-artesunate (PA) and dihydroartemisinin-piperaquine (DP) with and without a single low dose of primaquine (PQ…
- Trial name
- NECTAR1 (NCT04049916)
- Testing
- Pyronaridine Tetraphosphate/Artesunate, Dihydroartemisinin/Piperaquine, Primaquine Diphosphate
- Where
- 2 sites in Mali, Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Dental Caries
Glass-ionomer Cement Containing Chlorhexidine for ART
This study evaluated the clinical and microbiological long-term effects of 1.25% CHX associated with GIC applied in primary molars using Atraumatic Restorative Treatment (ART) technique.
- Trial name
- NCT02459730
- Testing
- ART with GIC containing 1.25% CHX., ART with GIC.
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Mindfulness, Meditation
My Mindful Moments: A Mindfulness Meditation and Digital Art Activity
The purpose of this evidence-based practice project is to evaluate the feasibility of providing a relaxation mindfulness meditation and an expressive digital arts activity among clinical staff at Dana Farber Cancer Institute .
- Trial name
- NCT04557033
- Testing
- Mindfulness intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
HIV
Preferences for Services in a Patient's First Six Months on Antiretroviral Therapy for HIV in Zambia
With the advent of universal eligibility for HIV treatment ("treat all") and same-day and community-based antiretroviral therapy (ART) initiation, retention in care after a patient has started ART remains the main challenge to…
- Trial name
- PREFER-Zambia (NCT05454852)
- Testing
- Survey, Focus group
- Where
- 2 sites in South Africa, Zambia
- Volunteers
- 771 people
- Sponsor
- Boston University
Sterility, Infertility
Oral Versus Vaginal Progesterone in the Luteal Support in Cryo-warmed Embryo Transfer Cycles
In IVF/ICSI cycles, the progesterone levels induced by ovarian stimulation are low, therefore the luteal phase is supported by progesterone.
- Trial name
- NCT03619707
- Testing
- Progesterone
- Where
- Lebanon
- Volunteers
- 157 people
- Sponsor
- American University of Beirut Medical Center
Postpartum Hemorrhage
Prevention of Postpartum Hemorrhage With Tranexamic Acid
Postpartum hemorrhage is a significant contributor to maternal morbidity and mortality and is worldwide. TXA has recently been proven to reduce mortality when given to women in setting of diagnosed PPH.
- Trial name
- NCT03287336
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- George Washington University
Infertility
CONSORT Randomized Controlled Trial in Assisted Reproductive Technology
The overall objective of this trial is to compare the ovarian response in assisted reproductive technology (ART) subjects administered GONAL f® according to the 'Consistency in recombinant follicle stimulating hormone [r-FSH]…
- Trial name
- NCT00829244
- Testing
- GONAL f® prefilled pen
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Merck KGaA, Darmstadt, Germany