Clinical trials: ARTHROPLASTY, REPLACEMENT
Knee Pain Chronic, Rheumatoid Arthritis
Cemented vs Cementless Persona Keel RCT
The main objective of this study is to evaluate the safety, performance, and clinical benefits of the Persona Keel cementless and cemented knee.
- Conditions
- Knee Pain Chronic, Rheumatoid Arthritis, Osteoarthritis, Traumatic Arthritis
- Trial name
- NCT05630053
- Testing
- Cementless Persona Knee System, Cemented Persona Knee System
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Zimmer Biomet
Arthroplasty, Replacement, Hip
Secur-Fit Advanced Outcomes Study
The goal of this study is to evaluate the Secur-Fit Advanced Hip Stem in primary total hip replacement surgery.
- Trial name
- NCT01917929
- Testing
- Secur-Fit Advanced Hip Stem
- Where
- 8 sites in United States
- Volunteers
- 326 people
- Sponsor
- Stryker Orthopaedics
Osteoarthritis
Comparison of Two Minimally Invasive Surgical Techniques for Hip Replacement
Comparison of the clinical effectiveness and cost-effectiveness of the MIS anterolateral approach (MIS Watson Jones, G3) versus anterolateral mini or posterolateral mini approaches in primary total hip arthroplasty
- Trial name
- NCT00175461
- Testing
- hip surgery
- Where
- Canada
- Volunteers
- 156 people
- Sponsor
- University of British Columbia
Total Hip Arthroplasty, Total Hip Replacement
Total Hip Replacement With Ceramic on Ceramic Bearing- Clinical Follow-up Study
The pain and severe wear of hip joints caused by osteoarthritis, rheumatoid arthritis, avascular necrosis and trauma can be subjected to total hip replacement (THR).
- Trial name
- NCT04256291
- Where
- Taiwan
- Volunteers
- 160 people
- Sponsor
- National Taiwan University Hospital
Spinal Anesthesia
The Bupivacaine Dose Sparing Effect of Intrathecal Epinephrine
Intrathecal epinephrine has been known to increase the duration of spinal anesthesia, or increase the quality of anesthesia. However, there is still a controversy, and the mechanism of epinephrine is recently suggested as a…
- Trial name
- NCT01261078
- Testing
- epinephrine 25, Epinephrine 50, epinephrine 100
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Seoul Medical Center
Arthritis Knee
Trial to Compare Femoral Nerve Block With Local Anaesthetic Injection for Post-operative Pain After Knee Replacement.
Pain after a knee replacement can impair recovery and use of the new knee. Having an injection to numb the femoral nerve is known to give good pain relief after the operation but may lead to slower mobilisation as it also…
- Trial name
- LIFT (NCT02288923)
- Testing
- Femoral nerve block, Local Infiltration Analgesia, Sub arachnoid analgesia
- Where
- United Kingdom
- Volunteers
- 199 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Osteoarthritis, Knee, Obesity
Effect Of The Use Of Navigation In The Alignment Obtained When Performing A Total Knee Arthroplasty In Obese Patients
NAOBE is a randomized, open and prospective clinical trial that evaluates the accuracy to achieve an adequate mechanical axis of the lower extremity in obese patients after total knee replacement.
- Conditions
- Osteoarthritis, Knee, Obesity, Arthropathy of Knee
- Trial name
- NCT03865524
- Testing
- Total knee arthroplasty implanted with GPS navigation system, Total knee arthroplasty implanted with standard guides.
- Where
- 2 sites in Spain
- Volunteers
- 159 people
- Sponsor
- Pedro-José Torrijos-Garrido
Pain Management, Function
Evaluation of Post Hospital Administration of Celecoxib Following Minimally Invasive Knee Replacement Surgery
This study will evaluate the benefits of continuing celecoxib through six weeks of total knee arthroplasty recovery. This is a randomized, double blind study with a group of approximately 130 primary total knee patients.
- Conditions
- Pain Management, Function, Minimally Invasive Total Knee Arthroplasty, Celecoxib
- Trial name
- NCT00474773
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- St. Louis Joint Replacement Institute
Knee Osteoarthritis, Rehabilitation
Preoperative Rehabilitation in Greek Patients Undergoing Total Knee Arthroplasty
Purpose: The purpose of this study was to investigate the efficacy of a 6-week supervised high-intensity preoperative training program on muscle strength, functional performance and patient-reported outcomes in patients…
- Trial name
- NCT04911205
- Testing
- Preoperative training program
- Volunteers
- 88 people
- Sponsor
- National and Kapodistrian University of Athens
Prosthetic Joint Infection, Surgical Skin Infection
Efficacy of InteguSeal for Surgical Skin Preparation in Patients Undergoing Total Joint Replacement
This study is being conducted to investigate the potential benefits of using a special type of fluid that can be applied to the skin (Integuseal) in addition to standard surgical skin preparation in patients undergoing total hip…
- Trial name
- NCT00829556
- Testing
- Integuseal
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Rothman Institute Orthopaedics
Non-inflammatory Degenerative Joint Disease
Metal Ion Release From an FDA-Approved Metal-on-Metal Total Hip Replacement Implant
This is a multi-center, randomized study to compare blood and urine cobalt, chromium, and titanium ion levels of a metal-on-metal articular bearing coupled with two different head sizes to that of a conventional…
- Trial name
- NCT00962351
- Testing
- Total Hip Replacement
- Where
- 2 sites in United States, Canada
- Volunteers
- 120 people
- Sponsor
- Anderson Orthopaedic Research Institute
Rehabilitation, Telerehabilitation
Does Rehabilitation After Total Hip Or Knee Arthroplasty Work (DRAW2)
Overall frame: The overall or "parent" DRAW-project is a large-scale project run in Denmark that aims to provide substantial level 1A evidence-data related to the question: Does rehabilitation after total hip and knee…
- Conditions
- Rehabilitation, Telerehabilitation, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Trial name
- DRAW2 (NCT04960241)
- Testing
- Homebased telerehabilitation, Homebased rehabilitation, No physical rehabilitation
- Where
- Denmark
- Volunteers
- 169 people
- Sponsor
- Troels Mark Christensen
Knee Osteoarthritis, Arthroplasty, Replacement, Knee
Implementation of Indication Criteria for Total Knee Replacement in Osteoarthritis (Value-based TKR)
The aim of this trial is to investigate the effect of a medical decision aid (EKIT-Tool) on decision quality for knee arthroplasty.
- Trial name
- NCT04837053
- Testing
- Digital decision aid for physicians and patients, Routine care
- Where
- Germany
- Volunteers
- 1,092 people
- Sponsor
- Technische Universität Dresden
Osteoarthritis, Traumatic Arthritis
A Clinical Investigation of the Vanguard™ Complete Knee System
The purpose of this prospective clinical data-collection is to document the performance and clinical outcomes of the Vanguard™ Complete Knee System.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Rheumatoid Arthritis, Lower Limb Deformity
- Trial name
- NCT00698854
- Testing
- Vanguard™ Complete Knee System, Vanguard™ Patient-Specific Femur
- Where
- 8 sites in United States
- Volunteers
- 552 people
- Sponsor
- Zimmer Biomet
Hip Fractures, Arthroplasty, Replacement, Hip
PENG Block + LIA For Endoprosthesis Surgery
The goal of this clinical trial is to learn if a new local anesthesia technique can control pain as well as the standard spinal anesthesia for adults having hip endoprosthesis surgery.
- Conditions
- Hip Fractures, Arthroplasty, Replacement, Hip, Pain, Postoperative, Anesthesia and Analgesia
- Trial name
- PENG 360° (NCT07239817)
- Testing
- Pericapsular Nerve Group Blocks with Local Infiltration Analgesia, spinal anesthesia
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- ASST Gaetano Pini-CTO
Arthropathy of Knee, Arthropathy of Hip
Nirvana Super Pro Supplementation in Orthopedic Surgery Patients
The purpose of this study is to investigate orthopedic patients undergoing either a total hip replacement (THR) or total knee arthroplasty (TKR) using two dietary supplements, PREPARE and RECOVER, and their recovery times…
- Trial name
- NCT06203691
- Testing
- Supplementation with Nirvana Super Pro Liquid Supplements, Non-Supplementation Group
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nirvana Water Sciences Corp
Osteoarthritis, Knee
Comparison of Mobile-Bearing and Fixed-Bearing All-Polyethylene Tibia Total Knee Designs
This study will be designed to compare prospectively, in a randomized fashion, the clinical, functional, and radiographic results of a nonmodular (all-polyethylene tibi/AP) fixed-bearing posterior cruciate substituting design…
- Trial name
- NCT00894361
- Testing
- TKA surgery with the rotating platform mobile-bearing knee design, TKA surgery with the all-polyethylene tibia knee design
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Persistent Postsurgical Pain, Arthritis Knee
Persistent Pain After Knee Replacement
This study is a nationwide cross-sectional survey on pain and satisfaction after knee arthroplasty (KA). Please find the full protocol uploaded at ClinicalTrials.gov The goal of this observational study is to study pain and…
- Conditions
- Persistent Postsurgical Pain, Arthritis Knee, Neuropathic Pain, Opioid Use
- Trial name
- NCT05900791
- Testing
- Primary knee arthroplasty
- Where
- Denmark
- Volunteers
- 3,710 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Osteoarthritis, Hip
Is Drainage Necessary After Total Hip Replacement?
The goal of this study was to compare early results of Total Hip Replacement (THR) in 2 groups of patients: with and without closed suction drainage (CSD). Patients were followed for 3 months post operatively.
- Trial name
- NCT02562586
- Testing
- Closed Suction Drainage System
- Where
- Brazil
- Volunteers
- 92 people
- Sponsor
- University of Sao Paulo
Total Knee Arthroplasty
REST-Knee: A Pilot RCT of 72-Hour Knee Immobilization and Pain Outcomes
Postoperative pain following total knee arthroplasty (TKA) is often difficult to manage, particularly with the increasing use of outpatient surgery where patients recover at home.
- Trial name
- REST-Knee (NCT07511842)
- Testing
- Knee Extension Brace (Zimmer-type), Early Mobilization (Standard Care)
- Where
- Canada
- Volunteers
- 106 people
- Sponsor
- Université de Sherbrooke