Clinical trials: ASA III
Cerebrovascular Accident
JASAP: Japanese Aggrenox Stroke Prevention vs. Aspirin Programme
Phase III study to compare the preventive effect of recurrent brain infarction and safety of Aggrenox (combination drug containing sustained-release dipyridamole 200 mg/acetylsalicylic acid 25 mg) twice daily vs.
- Trial name
- NCT00311402
- Testing
- Aggrenox capsule, Acetylsalicylic Acid (ASA)
- Where
- 151 sites in Japan
- Volunteers
- 1,295 people
- Sponsor
- Boehringer Ingelheim
Prostate Cancer
Trial of Acetylsalicylic Acid and Atorvastatin in Patients With Castrate-resistant Prostate Cancer
This is a 2x2 factorial randomized, multicenter, international, open phase III trial. The primary objective is to evaluate the benefit of acetylsalicylic acid and atorvastatin on overall survival (OS) (main endpoint) for patients…
- Trial name
- PEACE-4 (NCT03819101)
- Testing
- Acetylsalicylic acid, Atorvastatin
- Where
- 30 sites in Czechia, France and 4 more
- Volunteers
- 1,210 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Colon Cancer, Adjuvant Therapy
A Trial of Aspirin on Recurrence and Survival in Colon Cancer Patients
The purpose of this study is to determine whether acetylsalicylic acidis effective on the recurrence and survival of colon cancer patients.
- Trial name
- ASPIRIN (NCT02301286)
- Testing
- Acetylsalicylic acid
- Where
- 32 sites in Netherlands
- Volunteers
- 770 people
- Sponsor
- Leiden University
Diabetic Nephropathy Type 2
Study of the Protective Effect of Low-dose Aspirin on Renal Function in Patients With Early Diabetic Nephropathy
This is a multicenter, randomized, placebo-controlled study to evaluate the effectiveness and safety of low-dose aspirin (50 mg/day) in renal and cardiac function protection in people with diabetic nephropathy.
- Trial name
- NCT06068439
- Testing
- Acetylsalicylic Acid
- Volunteers
- 355 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Recurrent Prostate Carcinoma, Stage I Prostate Cancer
Metformin Hydrochloride and Aspirin in Treating Patients With Hormone-Dependent Prostate Cancer That Has Progressed After Surgery or Radiation Therapy
This randomized phase II trial studies how well metformin hydrochloride and aspirin work in treating patients with hormone-dependent prostate cancer that has progressed after surgery or radiation therapy.
- Conditions
- Recurrent Prostate Carcinoma, Stage I Prostate Cancer, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer
- Trial name
- PRIMA (NCT02420652)
- Testing
- Aspirin, Laboratory Biomarker Analysis, Metformin Hydrochloride
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Rutgers, The State University of New Jersey
Anesthesia, General, Neuromuscular Blockade
Comparison of 2.0 mg/kg Sugammadex and Neostigmine at Reappearance of T2 in Chinese and European Subjects (Study 19.4.324)(P05768AM1)(COMPLETED)
The present trial was set up to evaluate the efficacy and safety of 2.0 mg.kg-1 sugammadex compared to neostigmine administered at reappearance of T2 in Chinese and Caucasian subjects for registration purposes in China.
- Trial name
- NCT00825812
- Testing
- Sugammadex, neostigmine
- Volunteers
- 308 people
- Sponsor
- Merck Sharp & Dohme LLC
ASA III, Elective Prosthetic Surgery
How to Prevent Post-surgery Infections
Evaluation of the effectiveness in reducing the bacterial load on the skin of bedridden opatients through the use of two different cleaning and washing systems (swash bathing gloves vs pre-soaped sponges).
- Conditions
- ASA III, Elective Prosthetic Surgery, Patient Bedridden After Surgery
- Trial name
- Bundle (NCT07848269)
- Testing
- Swab for cleaning, used as first comparator. For this group we want, during these three days and each day, measure skin pH before and after, Coltural exam before and after and time for cleaning
- Where
- Italy
- Volunteers
- 164 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Esophageal Cancer
Low-dose Aspirin Therapy for Esophageal Cancer
The aim of this study is to evaluate the survival benefit of low-dose aspirin use for stage II-III esophageal cancer patients.
- Trial name
- NCT02326779
- Testing
- Acetylsalicylic acid
- Sponsor
- Zhejiang University
Stroke
Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS)
This is a study in patients who recently had a brain attack (stroke) and in whom no clear cause of the stroke could be identified.
- Trial name
- NAVIGATE ESUS (NCT02313909)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Acetylsalicylic acid (Aspirin, BAY1019036)
- Where
- 454 sites in United States, Argentina and 29 more
- Volunteers
- 7,213 people
- Sponsor
- Bayer
Esophageal Cancer, Precancerous Condition
A Phase III, Randomized, Study of Aspirin and Esomeprazole Chemoprevention in Barrett's Metaplasia
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of esomeprazole and aspirin may prevent esophageal cancer in patients with Barrett's metaplasia.
- Trial name
- AspECT (NCT00357682)
- Testing
- Esomeprazole, Aspirin
- Volunteers
- 2,557 people
- Sponsor
- University of Oxford
Prostate Cancer
Dexamethasone, Aspirin, and Diethylstilbestrol in Treating Patients With Locally Advanced or Metastatic Prostate Cancer
RATIONALE: Giving dexamethasone together with aspirin and diethylstilbestrol may be effective in lowering prostate-specific antigen levels and may slow or stop the growth of prostate cancer.
- Trial name
- NCT00316927
- Testing
- acetylsalicylic acid, dexamethasone, diethylstilbestrol
- Where
- 15 sites in United Kingdom
- Volunteers
- 260 people
- Sponsor
- St. Bartholomew's Hospital
Adenocarcinoma of the Lung, Recurrent Non-small Cell Lung Cancer
Low-Dose Acetylsalicylic Acid in Treating Patients With Stage I-III Non-Small Cell Lung Cancer
This pilot clinical trial studies low-dose acetylsalicylic acid in treating patients with stage I-III non-small cell lung cancer.
- Conditions
- Adenocarcinoma of the Lung, Recurrent Non-small Cell Lung Cancer, Stage IA Non-small Cell Lung Cancer, Stage IB Non-small Cell Lung Cancer
- Trial name
- NCT01707823
- Testing
- acetylsalicylic acid, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Patients With ASA Status I-III Scheduled for Elective Surgery
The Air Test: A New Simple, Non-invasive Method to Diagnose Anesthesia-induced Atelectasis
Anesthesia-induced atelectasis persist in the postoperative period but are not usually diagnosed because imaging techniques are required.
- Trial name
- NCT02650037
- Testing
- Air Test
- Where
- Spain
- Volunteers
- 181 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Metastatic Colorectal Cancer
Regorafenib With Low-dose Chemotherapies and Aspirin Followed by Standard Chemotherapies in Metastatic Colorectal Cancer
This study evaluates the interest of regorafenib in combination of metronomic chemotherapies and low-dose aspirin as a 2 months induction therapy before chemotherapy initiation in the second-line metastatic colorectal carcinoma
- Trial name
- REPROGRAM-02 (NCT05462613)
- Testing
- quality of life questionnaires, Blood sample, Regorafenib
- Where
- 16 sites in France
- Volunteers
- 446 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Hypotension Drug-Induced, Spinal Aneshtesia
Effect of Lateral Decubitus Position After Spinal Anesthesia on Hemodynamic Stability in High-Risk Geriatric Patients
Spinal anesthesia is a common and preferred anesthetic technique for lower extremity orthopedic surgery in elderly patients. However, it can cause a significant drop in blood pressure (hypotension), especially in high-risk older…
- Conditions
- Hypotension Drug-Induced, Spinal Aneshtesia, Geriatric, Orthopedic Surgery Patients
- Trial name
- NCT07597148
- Testing
- Lateral Decubitus Positioning, Immediate Supine Positioning
- Volunteers
- 70 people
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Colitis, Ulcerative
Budesonide Capsules Versus Mesalazine Granules in Active Ulcerative Colitis (UC)
The purpose of this study is to prove the therapeutic equivalence and safety of once-daily 9 mg budesonide versus 3 g mesalazine in a 8-week treatment in patients with active ulcerative colitis.
- Trial name
- NCT00747110
- Testing
- budesonide, mesalazine
- Where
- Germany
- Volunteers
- 343 people
- Sponsor
- Dr. Falk Pharma GmbH
ASA Class III/IV Patients, Surgery
Artificial Intelligence-augmented Perioperative Clinical Decision Support
The study investigates a novel anaesthesiological clinical decision support (CDS) application, that integrates risk evaluation tools and updated clinical guidelines guided by artificial intelligence in the setting of preoperative…
- Conditions
- ASA Class III/IV Patients, Surgery, Clinical Decision Support Systems
- Trial name
- KIPeriOP (NCT05284227)
- Testing
- Electronic Clinical Decision Support Application
- Where
- Germany
- Volunteers
- 210 people
- Sponsor
- Wuerzburg University Hospital
Node Positive HER2 Negative Breast Cancer
Aspirin in Preventing Recurrence of Cancer in Patients With HER2 Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy
This randomized phase III trial studies how well aspirin works in preventing the cancer from coming back (recurrence) in patients with human epidermal growth factor receptor 2 (HER2) negative breast cancer after chemotherapy…
- Trial name
- NCT02927249
- Testing
- Aspirin
- Where
- 1,452 sites in United States, Canada and 2 more
- Volunteers
- 3,021 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Colon Cancer
Adjuvant Aspirin Treatment for Colon Cancer Patients
Following complete resection of their primary tumor, potentially eligible stage II or stage III colon cancer patients will undergo central PIK3CA testing.
- Trial name
- NCT02467582
- Testing
- Aspirin
- Where
- 60 sites in Belgium, Germany and 2 more
- Volunteers
- 1,040 people
- Sponsor
- Swiss Cancer Institute
Colorectal Cancer
Comparison of Sulindac, Aspirin, and Ursodiol in Preventing Colorectal Cancer
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. It is not yet known whether sulindac, aspirin, or ursodiol is more effective in preventing colorectal…
- Trial name
- NCT00062023
- Testing
- Acetylsalicylic acid (Aspirin), Sulindac, Ursodiol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center