Clinical trials: ASA III, active
Colon Cancer, Adjuvant Therapy
A Trial of Aspirin on Recurrence and Survival in Colon Cancer Patients
The purpose of this study is to determine whether acetylsalicylic acidis effective on the recurrence and survival of colon cancer patients.
- Trial name
- ASPIRIN (NCT02301286)
- Testing
- Acetylsalicylic acid
- Where
- 32 sites in Netherlands
- Volunteers
- 770 people
- Sponsor
- Leiden University
Patients Scheduled for Elective Lower Extremity Surgery, Ages 18-80
Parasacral Ischial Plane Block in Lower Extremity Surgery
The parasacral ischial plane block is a novel fascial plane approach targeting the sacral plexus. This technique is technically less challenging and eliminates the requirement for direct visualization of the sacral plexus.
- Conditions
- Patients Scheduled for Elective Lower Extremity Surgery, Ages 18-80, ASA I-III, Patients Operated on Under Regional Anesthesia
- Trial name
- NCT07594197
- Testing
- Parasacral Ischial Plan Block, Sacral plexus block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Metastatic Colorectal Cancer
Regorafenib With Low-dose Chemotherapies and Aspirin Followed by Standard Chemotherapies in Metastatic Colorectal Cancer
This study evaluates the interest of regorafenib in combination of metronomic chemotherapies and low-dose aspirin as a 2 months induction therapy before chemotherapy initiation in the second-line metastatic colorectal carcinoma
- Trial name
- REPROGRAM-02 (NCT05462613)
- Testing
- quality of life questionnaires, Blood sample, Regorafenib
- Where
- 14 sites in France
- Volunteers
- 446 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8
Aspirin and Rintatolimod With or Without Interferon-alpha 2b in Treating Patients With Prostate Cancer Before Surgery
This phase II trial studies how well enteric-coated (EC) aspirin and rintatolimod with or without interferon-alpha 2b work in treating patients with prostate cancer before surgery.
- Conditions
- Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage IIA Prostate Cancer AJCC v8
- Trial name
- NCT03899987
- Testing
- EC Aspirin, Radical Prostatectomy, Recombinant Interferon Alfa-2b
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Roswell Park Cancer Institute
Colon Cancer
ASPIRIN Trial Belgium
The purpose of this study is to determine whether acetylsalicylic acid is effective on the recurrence and survival of colon cancer patients.
- Trial name
- ASPIRIN (NCT03464305)
- Testing
- acetylsalicylic acid
- Where
- 29 sites in Belgium
- Volunteers
- 148 people
- Sponsor
- University Hospital, Antwerp
Colorectal Cancer
Study on Aspirin Versus Placebo in Resected Colon Cancer With PI3K Mutation Stage III or II High Risk
Four retrospective studies were recently published on efficacy of aspirin in patients with surgically resected colon cancer. Two of these studies strongly suggested that aspirin used in low doses (100 mg/d) after surgical…
- Trial name
- ASPIK French (NCT02945033)
- Testing
- aspirin intake, Surgical resection of colonic adenocarcinoma stage III or II high risk, Molecular analysis of exon 9 and 20 of PI3K
- Where
- France
- Volunteers
- 264 people
- Sponsor
- University Hospital, Rouen
Cancer, Breast Cancer
Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours
Add-Aspirin aims to assess whether regular aspirin use after standard curative therapy can prevent recurrence and improve survival in individuals with non-metastatic common tumours.
- Conditions
- Cancer, Breast Cancer, Prostate Cancer, Colorectal Cancer
- Trial name
- NCT02804815
- Testing
- Aspirin 100mg, Aspirin 300mg
- Where
- 82 sites in Ireland, United Kingdom
- Volunteers
- 11,000 people
- Sponsor
- University College, London
Hypotension Drug-Induced, Spinal Aneshtesia
Effect of Lateral Decubitus Position After Spinal Anesthesia on Hemodynamic Stability in High-Risk Geriatric Patients
Spinal anesthesia is a common and preferred anesthetic technique for lower extremity orthopedic surgery in elderly patients. However, it can cause a significant drop in blood pressure (hypotension), especially in high-risk older…
- Conditions
- Hypotension Drug-Induced, Spinal Aneshtesia, Geriatric, Orthopedic Surgery Patients
- Trial name
- NCT07597148
- Testing
- Lateral Decubitus Positioning, Immediate Supine Positioning
- Volunteers
- 70 people
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Tuberculous Meningitis
Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis
INTENSE-TBM is randomized controlled, phase III, multicenter, 2 x 2 factorial plan superiority trial assessing the efficacity of two interventions to reduce mortality from tuberculous meningitis (TBM) in adolescents and adults…
- Trial name
- INTENSE-TBM (NCT04145258)
- Testing
- Aspirin, WHO TBM treatment, Intensified TBM treatment
- Where
- 13 sites in Côte d’Ivoire, Madagascar and 2 more
- Volunteers
- 768 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Diabetic Nephropathy Type 2
Study of the Protective Effect of Low-dose Aspirin on Renal Function in Patients With Early Diabetic Nephropathy
This is a multicenter, randomized, placebo-controlled study to evaluate the effectiveness and safety of low-dose aspirin (50 mg/day) in renal and cardiac function protection in people with diabetic nephropathy.
- Trial name
- NCT06068439
- Testing
- Acetylsalicylic Acid
- Volunteers
- 355 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
ASA III, Elective Prosthetic Surgery
How to Prevent Post-surgery Infections
Evaluation of the effectiveness in reducing the bacterial load on the skin of bedridden opatients through the use of two different cleaning and washing systems (swash bathing gloves vs pre-soaped sponges).
- Conditions
- ASA III, Elective Prosthetic Surgery, Patient Bedridden After Surgery
- Trial name
- Bundle (NCT07848269)
- Testing
- Swab for cleaning, used as first comparator. For this group we want, during these three days and each day, measure skin pH before and after, Coltural exam before and after and time for cleaning
- Where
- Italy
- Volunteers
- 164 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Pre-term Birth
Efficacy and Safety of Aspirin and Lansoprazole for Prevention of Preterm Birth in High-Risk Pregnant Women: A Biomarker-Enriched Trial
This protocol describes a seamless Phase II/III, randomized, double-blind clinical trial evaluating the efficacy and safety of daily low-dose aspirin (81 mg) plus lansoprazole (30 mg) in pregnant individuals at high risk for…
- Trial name
- NCT07337655
- Testing
- Low-Dose Aspirin Dose: 81 mg & Lansoprazole Dose: 30 mg, Standard of Care
- Where
- United States
- Volunteers
- 670 people
- Sponsor
- Stanford University
Periodontal Disease, Periodontitis (Stage 3)
Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis
This randomized double-blind placebo-controlled clinical trial aims to evaluate the clinical and biochemical effects of omega-3 fatty acids combined with low-dose aspirin as an adjunct to scaling and root planing (SRP) in smoker…
- Conditions
- Periodontal Disease, Periodontitis (Stage 3), Smoking Behaviors
- Trial name
- OASP (NCT07673185)
- Testing
- Omega-3 Fatty Acids (EPA plus DHA) plus low dose aspirin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Prostate Cancer
Trial of Acetylsalicylic Acid and Atorvastatin in Patients With Castrate-resistant Prostate Cancer
This is a 2x2 factorial randomized, multicenter, international, open phase III trial. The primary objective is to evaluate the benefit of acetylsalicylic acid and atorvastatin on overall survival (OS) (main endpoint) for patients…
- Trial name
- PEACE-4 (NCT03819101)
- Testing
- Acetylsalicylic acid, Atorvastatin
- Where
- 30 sites in Czechia, France and 4 more
- Volunteers
- 1,210 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Hepatocellular Carcinoma, ASA I-III Patients
Phase II Trial of Immunonutrition in Hepatectomy
A randomised open labelled study to evalaute the impact of immunonutrition in Patients Undergoing Hepatectomies for Liver Tumors
- Trial name
- NCT07395635
- Testing
- Immunonutrition
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Tata Memorial Centre