Clinical trials: Abdominal Cancer Patients
Mesothelin Positive, Mesothelin-Expressing Tumors
A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer or Malignant Peritoneal Mesothelioma
Participants will have a sample of their white blood cells, called T cells, collected using a procedure called leukapheresis. The collected T cells will be sent to a laboratory at Memorial Sloan Kettering to be changed (modified)…
- Conditions
- Mesothelin Positive, Mesothelin-Expressing Tumors, Esophageal Adenocarcinoma, Esophageal Adenocarcinomas
- Trial name
- NCT06623396
- Testing
- M28z1XXPD1DNR CAR
- Where
- 7 sites in United States
- Volunteers
- 32 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
ColoRectal Cancer
Perioperative Immunonutrition in Colorectal Cancer Patients Undergoing Abdominal Surgery
The immune system plays an important role in helping to kill and prevent cancers. Cells of the immune system, such as natural killer (NK) cells and T cells, do not work as well following surgery.
- Trial name
- PERIOP-02 (NCT02987296)
- Testing
- Immunonutrition with arginine, Immunonutrition without Arginine
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Ottawa Hospital Research Institute
Heart Failure
Levosimendan for Cardiac Patients Undergoing Major Abdominal Cancer Surgeries
The objective of this pilot study is to evaluate the efficacy and safety of preoperative administration of levosimendan in patients with chronic heart failure scheduled for major abdominal cancer surgery assuming the reduction of…
- Trial name
- NCT03557255
- Testing
- Levosimendan, Saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Peritoneal Carcinomatosis
Representation of the Body for Patients With Cancer
The project aims to understand better how patients live the event of cancer and live its consequences on their bodily representations.
- Trial name
- CORCAN (NCT01560533)
- Testing
- Interviews
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Hospices Civils de Lyon
Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
Heated Mitomycin and Cisplatin During Surgery in Treating Patients With Stomach or Gastroesophageal Cancer
This phase II trial studies how well heated mitomycin and cisplatin during surgery work in treating patients with stomach or gastroesophageal cancer.
- Conditions
- Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Peritoneal Carcinomatosis
- Trial name
- NCT02891447
- Testing
- Cisplatin, Hyperthermic Intraperitoneal Chemotherapy, Mitomycin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Patients With Biliary Stricture Treated During ERCP With Available MRCP and Abdominal CT Scan
Preclinical Development of a 3D Bili-MRI Reconstruction Tool and an Artificial Intelligence Algorithm to Assist Endoscopists in Performing Endoscopic Retrograde Cholangiopancreatography (ERCP)
ERCP is a complex interventional endoscopic procedure based on 2D visualization of the biliary tract. 3D modeling and AI are promising solutions to improve navigation and safety during ERCP.
- Trial name
- MAAGIE (NCT07401485)
- Testing
- retrospective study based on data already collected during routine care (no intervention)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intubation, Surgery
Water Method Colonoscopy in Patients With Prior Surgery
Water method with water exchange has been shown to reduce medication requirement and pain experienced during colonoscopy. It increases the success rate of cecal intubation in sedated and unsedated patients undergoing screening…
- Conditions
- Intubation, Surgery, Adenoma, Pain
- Trial name
- NCT01485133
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Air Force Military Medical University, China
Carcinoma, Ovarian Epithelial, Ovarian Neoplasms
AB-1015, an Integrated Circuit T (ICT) Cell Therapy in Patients With Platinum Resistant Epithelial Ovarian Cancer
This is a multi-center, open-label phase 1 dose escalation trial that uses a modified 3+3 design to identify a recommended phase 2 dose (RP2D) of AB-1015 cell product.
- Conditions
- Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Fallopian Tube Neoplasms, Peritoneal Neoplasms
- Trial name
- NCT05617755
- Testing
- AB-1015
- Where
- 8 sites in United States
- Volunteers
- 19 people
- Sponsor
- Arsenal Biosciences, Inc.
Peritoneal Neoplasms, Postoperative Recovery
Remimazolam Versus Propofol for Early Recovery After Cytoreductive Surgery
The REPAIR Trial is a single-center, prospective, randomized, parallel-group superiority trial enrolling 320 adults scheduled for elective cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy…
- Trial name
- REPAIR (NCT07785557)
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Abdominal Malignancy, Pelvic Malignancy
Intraoperative Radiation Therapy for Locally Advanced or Recurrent Abdomino-pelvic Solid Tumors With the CivaSheet
This study is a pilot study of the CivaSheet, a new type of intraoperative radiation therapy (IORT) device that offers several advantages over existing techniques of performing IORT.
- Trial name
- NCT02902107
- Testing
- CivaSheet, Brachytherapy, surgical resection
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Patients With an Indication for Myomectomy or Polymyomectomy
Hyaluronic Acid for the Prevention of Endocavitary Synechiae After Myomectomy
PREVENDO is a prospective, multicenter, pilot, and randomized study in 2 parallel arms and single blind, evaluating the proportion of endometrial synechiae 6 weeks after surgery in patients undergoing abdominal myomectomy or…
- Trial name
- PREVENDO (NCT04702399)
- Testing
- GEL GROUP
- Volunteers
- 76 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastric Cancers, Colorectal Cancer
Predictive Effect of Abdominal Fat and Muscle Area Calculated Based on Abdominal CT on Gastric Cancer Patients
This study aims to create a clinical prediction model. Abdominal fat and muscle area also play an important role in the prediction of surgical outcomes in colorectal cancer.
- Conditions
- Gastric Cancers, Colorectal Cancer, Sarcopenia, Obesity and Overweight
- Trial name
- NCT06606912
- Testing
- Skeletal muscle, subcutaneous fat and visceral fat area
- Where
- 3 sites in China
- Volunteers
- 4,000 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Post Operative Pain, Gynecologic Cancer
Pilot: Intraoperative TAP Block and Post-operative Pain Control for Minimally Invasive Hysterectomy for Endometrial Cancer
Modern postoperative pain management aims to optimizing pain relief while minimizing opiate usage. While opiates are effective for pain relief, they result in common adverse effects such as nausea, constipation, and urinary…
- Trial name
- NCT05763667
- Testing
- Liposomal bupivacaine, Bupivacain
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Tufts Medical Center
Peritoneal Carcinomatosis, Gastrointestinal Peritoneal Carcinomatosis
Patient Derived Vascularized MicroTumor Model of Gastrointestinal Peritoneal Carcinomatosis
This is a pilot study gathering and using samples and data from patients with gastrointestinal peritoneal carcinomatosis. Participants will be asked for permission to provide blood and ascites/peritoneal wash fluid, tumor samples…
- Trial name
- NCT05844865
- Testing
- Biospecimen Collection (Blood, Ascites/Peritoneal Wash Fluid and/or Tumor Samples)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Irvine
Colorectal Carcinomatosis
Perioperative Chemotherapy With Bevacizumab for Colorectal Carcinomatosis French Part of the Main Bev-IP Study
Selected patients with peritoneal carcinomatosis (PC) from colorectal cancer (CRC) benefit from cytoreductive surgery (CRS) combined with intraperitoneal chemoperfusion (IPC).
- Trial name
- NCT03161041
- Testing
- Cytoreductive surgery combined with HIPEC, bevacizumab and HIPEC (Oxaliplatin 360 mg/m2).
- Sponsor
- Hospices Civils de Lyon
Abdominal Pain
Effect of tDCS on Chronic Abdominal Visceral Pain in HCC Patients
To evaluate the effect of transcranial direct current stimulation (tDCS) applied to the motor cortex to reduce chronic abdominal visceral pain in a group of participants with hepatocellular carcinoma
- Trial name
- NCT02928237
- Testing
- transcranial direct current stimulation tDCS
- Volunteers
- 40 people
- Sponsor
- Assiut University
Immune System Suppression
Effect of Intrathecal Morphine, Dexmedetomidine or Both in Combination to Bupivacaine on Immunity
this work aims to investigate the effect of intrathecal administration of Morphine, Dexmedetomidine or both in combination on cellular immunity and cytokine production in patients undergoing major abdominal cancer surgeries.
- Trial name
- NCT03024957
- Testing
- Morphine Sulfate, Dexmedetomidine, Bupivacaine
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Peritoneal (Metastatic) Cancer, Peritoneal Carcinomatosis
Heated Versus Aerosol-based Laparoscopic Chemotherapy for Cancer That Has Spread to the Peritoneum (Abdominal Lining)
This research study aims to improve the treatment of Peritoneal Carcinomatosis (PC), a condition where cancer spreads within the abdomen. Patients with PC often experience significant pain and nutritional problems.
- Conditions
- Peritoneal (Metastatic) Cancer, Peritoneal Carcinomatosis, Abdominal Cancer, Abdominal Cancer Patients
- Trial name
- Charlie-2 (NCT07282834)
- Testing
- Heated intra-peritoneal chemotherapy, Aerosolized intra-peritoneal chemotherapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Patrick Wagner, MD, FACS
Rectal Cancer
Minimally Invasive Sphincter Sparing Total Mesorectal Excision for Ultra-low Rectal Cancer After Initial Chemo-radiotherapy (MISS-TRICR).
A prospective study is planned for management of low rectal cancer with the aim of sphincter preservation and improving the oncological outcome of the patients, through comparing of both approaches minimally invasive techniques…
- Trial name
- MISS-TRICR (NCT02488707)
- Testing
- laparoscopic intersphincteric resection (LISR group), Transanal minimally invasive Total mesorectal excision (TAMIS group)
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Mansoura University
Peritoneal Carcinomatosis
Flat Dose vs. Weight-based IP Chemotherapy for CRS/HIPEC
Peritoneal carcinomatosis from advanced gastro-intestinal malignancy has historically been associated with poor overall survival (≤ 12 months) with few treatment options.
- Trial name
- NCT04779554
- Testing
- Mitomycin C, flat dose 40 mg, Mitomycin C, weight-based dose 12.5 mg/m2
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Prakash Pandalai