Clinical trials: Abdominal Site
Obesity, Gastric Cancer
Effect of Obesity on Surgical Outcomes and Survival for Gastric Cancer
As the number of obesity continues to increase, surgical oncologist pay more attention to the effect of obesity on surgical outcomes and survival of digestive systemin cancers.
- Trial name
- NCT02800005
- Testing
- AFA group (successive patients), BMI group (successive patients)
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Jian-Kun Hu
Colorectal Cancer With a Resected Minimal Synchronous PC, Ovarian Metastases
Trial Comparing Simple Follow-up to Exploratory Laparotomy Plus "in Principle" (Hyperthermic Intraperitoneal Chemotherapy) HIPEC in Colorectal Patients
Multicentric randomised trial. Patients with a high risk of developing colorectal Peritoneal Carcinomatosis (PC) after resection of their primary will be informed, will sign the consent and will be pre-registered.
- Conditions
- Colorectal Cancer With a Resected Minimal Synchronous PC, Ovarian Metastases, Tumour Rupture in the Abdominal Cavity
- Trial name
- ProphyloCHIP (NCT01226394)
- Testing
- laparotomy plus HIPEC
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Adenocarcinoma, Stomach Neoplasms
Elimination of Peritoneal Tumor Cells With Extensive Peritoneal Lavage During Surgery in Patients With Gastric Cancer
A Japanese study showed that the additional use of an "Extensive Intraperitoneal Lavage" (EIPL), i.e. an extensive washing of the abdominal cavity with water, during surgery for gastric cancer can lead to a significant increase…
- Trial name
- EIPL (NCT01476553)
- Testing
- Extensive Intraperitoneal Lavage (EIPL)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Universitätsmedizin Mannheim
Epithelial Ovarian Cancer, Fallopian Tube Neoplasms
SUROVA - Surgery in Ovarian Cancer, Comparing Primary and Interval Cytoreductive Surgery
An international worldwide retrospective cohort observational study comparing primary cytoreductive surgery with neoadjuvant chemotherapy and interval cytoreductive surgery in patients with carcinoma of the ovary, fallopian…
- Conditions
- Epithelial Ovarian Cancer, Fallopian Tube Neoplasms, Peritoneal Neoplasms
- Trial name
- SUROVA (NCT06223763)
- Testing
- Cytoreductive surgery, Neoadjuvant chemotherapy, Adjuvant chemotherapy
- Where
- Spain
- Volunteers
- 5,000 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Surgical Wound Infection
Closed Incision Negative Pressure Wound Therapy for the Prevention of Surgical Site Infections in Abdominal Surgery
Surgical site infections (SSI) are a frequent complication in abdominal surgery. SSI lead to worse outcomes for the affected patients and significantly higher healthcare costs.
- Trial name
- CISSI (NCT06068517)
- Testing
- Closed incision negative pressure wound therapy, Standard dressing
- Where
- Switzerland
- Volunteers
- 654 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
High Risk Polycythemia Vera, High Risk Essential Thrombocythemia
Pegylated Interferon Alfa-2a Salvage Therapy in High Risk Polycythemia Vera (PV) or Essential Thrombocythemia (ET)
The aim of this research is to look at two conditions, Essential Thrombocythemia (ET) and Polycythemia Vera (PV). ET causes people to produce too many blood cells called platelets and PV causes too many platelets and red blood…
- Trial name
- NCT01259817
- Testing
- PEGASYS, Aspirin
- Where
- 21 sites in United States, Italy
- Volunteers
- 135 people
- Sponsor
- Ronald Hoffman
Esophageal Squamous Cell Carcinoma Abdominal Stage 0
PD-1 Antibody Combined With mXELIRI Versus mXELIRI in the Second-line Setting for ESCC
This trial is a prospective, multicenter, randomized controlled trial. The sample size was 380. Patients with advanced or metastatic esophageal squamous cell carcinoma will be randomized to receive PD1 antibody combined with…
- Trial name
- Escape (NCT05737563)
- Testing
- PD-1 Inhibitors, Irinotecan, Capecitabine tablets
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Sun Yat-sen University
Ovarian Cancer
Phase I Low Dose WART in Combination With Weekly Paclitaxel for Platinum Resistant Ovarian Cancer
Background: Epithelial Ovarian Cancer is the most lethal amongst the gynecologic malignancies and is the fifth leading cause of cancer death in women in the United States.1 Despite initial high response rates, 50% to 75% of women…
- Trial name
- NCT02545010
- Testing
- Paclitaxel, LDWART (Low Dose Whole Abdominal Radiation Therapy)
- Where
- Singapore
- Volunteers
- 24 people
- Sponsor
- National University Hospital, Singapore
Gastric Cancer, Peritoneal Carcinomatosis
Phase II Study of the Effects of Laparoscopic Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients With Advanced Gastric Cancer
To assess if PD-L1 expression can be upregulated in peritoneal metastases from gastric cancer after the administration of HIPEC with greater frequency compared to systemic chemotherapy alone
- Trial name
- NCT04107077
- Testing
- Cisplatin, Mitomycin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Chicago
Postoperative Pain
Effect of Local Anesthetic Infiltration for Postoperative Pain Control in Laparoscopic Abdominal Surgery: A Prospective Randomized Study
Brief Summary Postoperative pain remains a common problem after laparoscopic abdominal surgery despite the minimally invasive nature of these procedures.
- Trial name
- NCT07747584
- Testing
- Bupivacaine, Standard Perioperative Analgesia
- Where
- Pakistan
- Volunteers
- 166 people
- Sponsor
- Allied Hospital Faisalabad
Pancreatic Cancer
EUS-guided Celiac Plexus Neurolysis for the Treatment of Abdominal Pain in Pancreatic Cancer
Studies have shown that injecting local anesthetics in areas rich in blood vessels increases the risk of drug injection into blood vessels by mistake and increases the systemic absorption of drugs, which may increase the…
- Trial name
- NCT03940027
- Testing
- EUS-guided celiac plexus neurolysis
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Changhai Hospital
Prostatic Neoplasms, Exosomes
Prognostic Study of Via Dynamic Change of PCA3 mRNA in Drainage Fluid After Radical Prostatectomy
This study investigates the prognostic value of dynamic changes in PCA3 mRNA levels found in the abdominal cavity drainage fluid after radical prostatectomy.
- Trial name
- NCT06707961
- Volunteers
- 100 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Pseudomyxoma Peritonei, Colorectal Cancer
HIPEC Using High Intra-abdominal Pressure
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising therapy for peritoneal carcinomatosis (PC) of various origins.
- Trial name
- HIPEC-IAP (NCT02949791)
- Testing
- Cytoreductive surgery, Low Intra abdominal pressure HIPEC, High Intra abdominal pressure HIPEC
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Peritoneal Carcinomatosis, Ovarian Cancer
Study of Radspherin® in Recurrent Ovarian Cancer Subjects With Peritoneal Carcinomatosis
RAD-18-001 is a First-In-Man, Dose Escalation study conducted at 2 sites. The dose escalation will be performed based on a 3 + 3 design. Increasing dose levels starting at 1 MBq will be followed by 2, 4 and 7 MBq.
- Trial name
- NCT03732768
- Testing
- Radspherin
- Where
- 4 sites in Belgium, Norway and 1 more
- Volunteers
- 21 people
- Sponsor
- Oncoinvent Solutions AS
Cervical Cancer
German-funded Laparoscopic Approach to Cervical Cancer
The G-LACC trial is a prospective, interventional, multicenter, open-label, randomized and controlled non-inferiority operative trial.
- Trial name
- G-LACC (NCT06489795)
- Testing
- Laparoscopic or robot-assisted radical/simple hysterectomy, Abdominal radical/simple hysterectomy
- Where
- 14 sites in Germany
- Volunteers
- 756 people
- Sponsor
- Hannover Medical School
Cervical Cancer
Laparoscopic or Abdominal Radical Hysterectomy for Cervical Cancer(Stage IB1,IB2,IIA1)
The purpose of this study is to confirm whether there is a difference between laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH) in patient survival for Cervical Cancer (Stage IB1, IB2, IIA1).
- Trial name
- LAUNCH 2 (NCT04929769)
- Testing
- Total Laparoscopic or Robotic Radical Hysterectomy, Total Abdominal Radical Hysterectomy
- Where
- China
- Volunteers
- 780 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Gastric Cancers, Colorectal Cancer
Predictive Effect of Abdominal Fat and Muscle Area Calculated Based on Abdominal CT on Gastric Cancer Patients
This study aims to create a clinical prediction model. Abdominal fat and muscle area also play an important role in the prediction of surgical outcomes in colorectal cancer.
- Conditions
- Gastric Cancers, Colorectal Cancer, Sarcopenia, Obesity and Overweight
- Trial name
- NCT06606912
- Testing
- Skeletal muscle, subcutaneous fat and visceral fat area
- Where
- 3 sites in China
- Volunteers
- 4,000 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Fallopian Tube Cancer, Peritoneal Neoplasms
OVATURE (OVArian TUmor REsponse) A Phase III Study of Weekly Carboplatin With and Without Phenoxodiol in Patients With Platinum-Resistant, Recurrent Epithelial Ovarian Cancer
The purpose of this project is to see if weekly carboplatin compared with phenoxodiol in combination with weekly carboplatin, is effective against late stage ovarian cancer and to see what, if any, side-effects of treatment may…
- Conditions
- Fallopian Tube Cancer, Peritoneal Neoplasms, Ovarian Cancer
- Trial name
- OVATURE (NCT00382811)
- Testing
- phenoxodiol, carboplatin
- Where
- 70 sites in United States, Australia and 5 more
- Volunteers
- 142 people
- Sponsor
- MEI Pharma, Inc.
Tumor Motion, "Continuous Positive Airway Pressure"
Evaluation of Continuous Positive Airway Pressure for Tumor Motion Management in Radiotherapy
This is a clinical study on patients to compare the effects of CPAP on lung volume diaphragm motion, heart position and tumor motion compared to free breathing.
- Conditions
- Tumor Motion, "Continuous Positive Airway Pressure", Lung Cancer, Breast Cancer
- Trial name
- NCT02324530
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Wound Infection, Cicatrization
Comparison of the Impact of Electric Scalpels Versus Cold Scalpels
Surgical site infection (SSI) is the second commonest hospital infection, despite advances in prevention that have been achieved.
- Trial name
- SCL01 (NCT01410175)
- Testing
- Conventional scalpel
- Where
- Brazil
- Volunteers
- 163 people
- Sponsor
- Barretos Cancer Hospital