Clinical trials: Abdominal Site
Peritoneal Carcinomatosis, Gastric Cancer
Clinical Trial at Neoadjuvant Peritoneal and Systemic Chemotherapy Plus HIPEC in Gastric Carcinomatosis
Implementation of a curative strategy of treatment in peritoneal carcinomatosis of gastric cancer. The goal is to get 1C level of evidence (patient died with "standard" treatment, with this treatment some of them survive) in…
- Trial name
- HIPEC (NCT01342653)
- Testing
- Intraperitoneal and systemic chemotherapy plus maximum cytoreduction plus HIPEC
- Where
- 3 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Post-Operative Hematoma at Operative Site (Diagnosis), Post-Operative Hemorrhage
Ultrasound for Assessment of Intra-Abdominal Blood Loss After Gynecological Surgery
This is a prospective cohort study designed to assess intra-abdominal blood volume and hemodynamic status by measuring the diameter of the inferior vena cava (IVC) using 3D and Doppler ultrasound within 24 hours after…
- Trial name
- NCT06953141
- Testing
- Ultrasound
- Where
- Israel
- Volunteers
- 250 people
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Cervical Cancer
Laparoscopic or Abdominal Radical Hysterectomy for Cervical Cancer(Stage IA1 With LVSI, IA2)
The purpose of this study is to confirm whether there is a difference between laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH) in patient survival for Cervical Cancer (Stage IA1 with LVSI, IA2)
- Trial name
- LAUNCH 1 (NCT04934982)
- Testing
- Total Laparoscopic or Robotic Radical Hysterectomy, Total Abdominal Radical Hysterectomy
- Where
- China
- Volunteers
- 690 people
- Sponsor
- Hua Jiang
Inguinal Hernia
A Multi-site Randomized Controlled Trial Comparing Regional and General Anesthesia for Effects on Neurodevelopmental Outcome and Apnea in Infants
The primary purpose of the GAS study is to determine whether different types of anesthesia (Regional versus General) given to 720 infants undergoing inguinal hernia repair results in equivalent neurodevelopmental outcomes.
- Trial name
- GAS (NCT00756600)
- Testing
- Regional Anesthesia, General Anesthesia
- Where
- 30 sites in United States, Australia and 5 more
- Volunteers
- 643 people
- Sponsor
- Boston Children's Hospital
Peritoneal Carcinomatosis
FloSeal in CRS and HIPEC
Introduction Modern treatment of peritoneal carcinomatosis (PC) combines an aggressive cytoreductive surgery (CRS) of all macroscopic disease and hyperthermic intraperitoneal chemotherapy (HIPEC) performed at the time of surgery.
- Trial name
- NCT01957852
- Testing
- FloSeal
- Where
- Canada
- Volunteers
- 86 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Incisional Hernia, Ventral Hernia
Risk Factors for Mesh Infection After Abdominal Wall Reconstruction
Abdominal wall reconstruction (AWR) with mesh is the standard repair for ventral, incisional, parastomal and complex abdominal wall defects, but mesh-related infection remains one of its most serious complications - prolonging…
- Conditions
- Incisional Hernia, Ventral Hernia, Parastomal Hernia, Abdominal Wall Defect
- Trial name
- NCT07725718
- Where
- Egypt
- Volunteers
- 420 people
- Sponsor
- Minia University
Abdominal Donor-site
Reinforcement of the Abdominal Wall After Breast Reconstruction With the Pedicled TRAM-flap
The purpose of this study is to compare two methods for reinforcement of the abdominal donor-site after breast reconstruction with the pedicled TRAM-flap.
- Trial name
- NCT02076724
- Testing
- Biological mesh, Synthetic mesh
- Where
- Denmark
- Volunteers
- 29 people
- Sponsor
- Aarhus University Hospital
Prostatic Neoplasm, Genital Neoplasms, Male
Glivec in Prostate Cancer Patients With Rising PSA Following Radical Prostectomy
To investigate the ability of 600 mg of Glivec®, given once daily by mouth to patients with rising PSA following radical prostatectomy, to produce a sustained biochemical response during the first 6 months of treatment.
- Conditions
- Prostatic Neoplasm, Genital Neoplasms, Male, Neoplasms, Abdominal, Urogenital Neoplasms
- Trial name
- NCT01316458
- Testing
- STI571 (Glivec®)
- Where
- 13 sites in Germany
- Volunteers
- 51 people
- Sponsor
- Novartis Pharmaceuticals
Small Cell Lung Carcinoma, Carcinoma, Squamous Cell of Head and Neck
Durvalumab and Tremelimumab in Combination With First-Line Chemotherapy in Advanced Solid Tumors
Durvalumab and Tremelimumab in combination with first-line chemotherapy in the following indications: Ovarian/peritoneal/fallopian tube cancer, SCCHN, TNBC, SCLC and gastric/GEJ cancer, PDAC, ESCC.
- Conditions
- Small Cell Lung Carcinoma, Carcinoma, Squamous Cell of Head and Neck, Stomach Neoplasms, Triple Negative Breast Neoplasms
- Trial name
- NCT02658214
- Testing
- paclitaxel + carboplatin, carboplatin + etoposide, gemcitabine + carboplatin
- Where
- 6 sites in Japan, South Korea
- Volunteers
- 32 people
- Sponsor
- AstraZeneca
Healthy Male Participants
A Study to Evaluate Single Subcutaneous Doses of NXT007 Among Injection Sites Abdomen, Upper Arm, and Thigh in Healthy Male Participants
This is a Phase I, open-label, non-randomized, parallel-group, single-dose study in healthy adult male participants. The aim is to investigate the relative bioavailability (rBA) of NXT007 among subcutaneous (SC) injection sites…
- Trial name
- NCT06189508
- Testing
- NXT007
- Where
- 2 sites in New Zealand
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Acute Abdomen, Ileus
Rectus Sheath Catheters Following Midline Laparotomy
Rectus sheath catheters (RSC) are used for postoperative analgesia following midline laparotomies. Local anesthetics are applied to the posterior rectus sheath via the RSC.
- Conditions
- Acute Abdomen, Ileus, Colorectal Carcinoma
- Trial name
- NCT07099924
- Testing
- Ropivacaine 0.2%, Saline 0.9%
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Asklepios Kliniken Hamburg GmbH
Malignant Neoplasm of Stomach, Secondary Malignant Neoplasm of Peritoneum
Cytoreductive Surgery (CRS) With/Without HIPEC in Gastric Cancer With Peritoneal Carcinomatosis
Patients with histological proven gastric cancer (including cancer of the esophagogastric junction (AEG)) and synchronous peritoneal carcinomatosis, who fulfill the inclusion and exclusion criteria, can be recruited in this…
- Conditions
- Malignant Neoplasm of Stomach, Secondary Malignant Neoplasm of Peritoneum, Secondary Malignant Neoplasm of Other and Unspecified Sites
- Trial name
- GASTRIPEC (NCT02158988)
- Testing
- HIPEC
- Where
- Germany
- Volunteers
- 105 people
- Sponsor
- Charite University, Berlin, Germany
Impaired Cognition, Quality of Life
The Assessment of the Feasibility of a Home Based Exercise Programme in the Older Patient Following Major Surgery
The primary aim of this study is to establish if it is possible for patients who have undergone major body surgery to complete a home based exercise training program and complete the assessments required to measure physical and…
- Conditions
- Impaired Cognition, Quality of Life, Surgery, Delirium
- Trial name
- POETold (NCT03064308)
- Testing
- Exercise Programme
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Nottingham
Epithelial Ovarian Cancer, Peritoneal Neoplasms
Birinapant for Advanced Ovarian, Fallopian Tube, and Peritoneal Cancer
Background: Birinapant is an experimental cancer treatment drug. It removes certain proteins in cells, which helps to kill the cells.
- Conditions
- Epithelial Ovarian Cancer, Peritoneal Neoplasms, Fallopian Tube Neoplasms
- Trial name
- NCT01681368
- Testing
- Birinapant (TL32711)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Bacterial Translocation, Surgical Site Infection
Plastic Wound Retractors and Bacterial Translocation in Abdominal Surgery
Hypothesis: Plastic wound retractors reduce passage of bacteria from the abdomen to the surgical incision site in abdominal surgery Currently, plastic wound retractors are used in abdominal surgery to facilitate access to the…
- Conditions
- Bacterial Translocation, Surgical Site Infection, Abdominal Surgery, Wound Infection
- Trial name
- NCT01007487
- Where
- 2 sites in Ireland
- Volunteers
- 250 people
- Sponsor
- St Vincent's University Hospital, Ireland
Fallopian Tube Cancer, Peritoneal Neoplasms
Predictors of Relapse of Ovarian, Peritoneal, and Fallopian Tube Cancers
This study will develop a blood test that can be used to predict a relapse of ovarian, peritoneal, or fallopian tube cancer. The type of testing is called proteomics, or the study of proteins in living cells.
- Conditions
- Fallopian Tube Cancer, Peritoneal Neoplasms, Epithelial Ovarian Cancer
- Trial name
- NCT00086567
- Where
- 11 sites in United States
- Volunteers
- 119 people
- Sponsor
- National Cancer Institute (NCI)
Malnourishment, Gastrointestinal Tumors
The Impact of Preoperative Oral Glutamine Intake on the Immunocompetence and Outcomes of Malnourished Patients Undergoing Major Abdominal Surgery Due to Malignancies
Malnutrition occurs in up to 50% of patients requiring elective surgery for neoplastic diseases. It exerts a detrimental influence on outcome of surgery, because it can suppress immune function, exaggerate stress response and…
- Trial name
- Glutaminprojec (NCT01552291)
- Testing
- Glutamine
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Ovarian Cancer, Fallopian Tube Neoplasms
Comparing Two Treatments for Ovarian Cancer: Standard Chemotherapy Plus Enzastaurin, or Placebo ("Sugar Pill")
Participants with ovarian cancer usually get the drugs carboplatin and paclitaxel as initial treatment. In many participants the tumor will shrink, or even disappear, after treatment with these drugs.
- Conditions
- Ovarian Cancer, Fallopian Tube Neoplasms, Peritoneal Neoplasm
- Trial name
- NCT00391118
- Testing
- enzastaurin, carboplatin, paclitaxel
- Where
- 15 sites in Belgium, Germany and 3 more
- Volunteers
- 153 people
- Sponsor
- Eli Lilly and Company
Chronic Pancreatitis
Viokase 16, Viokase16 Plus Nexium and Nexium Alone
Our primary hypothesis is that the addition of Nexium to Viokase 16 will decrease the chronic abdominal pain in patients with small duct chronic pancreatitis in a superior fashion compared to Viokase 16 plus placebo or to Nexium…
- Trial name
- AZ (NCT01142128)
- Testing
- Nexium (esomeprazole magnesium), Viokase 16 (pancrelipase) + Nexium
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Florida
Peritoneal Carcinomatosis
Clinical Pharmacology of Platinum-based Hyperthermic Intraperitoneal Chemotherapy
Currently, there is a lack of knowledge on the effect of additional flushing after HIPEC on tumour platinum exposure, systemic platinum exposure and platinum concentration in drain exudate and thereby personal exposure.
- Trial name
- GUTOX (NCT03364907)
- Testing
- HIPEC with flushing afterwards, HIPEC without flushing afterwards
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center