Clinical trials: Abdominal Site
Peritoneal Mesothelioma, Peritoneal Carcinomatosis
Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies
Background: Cytoreductive surgery (CRS) removes tumors in the abdomen. HIPEC is hyperthermic (heated) chemotherapy that washes the inside of the abdomen. CRS with HIPEC may help people with peritoneal carcinomatosis.
- Conditions
- Peritoneal Mesothelioma, Peritoneal Carcinomatosis, Ovarian Cancer, Gastrointestinal Cancer
- Trial name
- NCT04847063
- Testing
- Sodium Thiosulfate, 5-Fluorouracil, Oxaliplatin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute (NCI)
Postoperative Cognitive Dysfunction
Risk Factors for Early POCD in the Patients With PSM Undergoing CRS-HIPEC
Objectives to investigate the incidence and associated factors for early postoperative cognitive dysfunction in the patients with peritoneal surface malignancies undergoing cytoreductive surgery and hyperthermic intraperitoneal…
- Trial name
- NCT02462564
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Wuhan University
Ovarian Carcinoma, Peritoneal Neoplasms
Clinical Trial of Docetaxel in Combination With Gemcitabine in Platinum-Resistant Ovarian Cancer and Primary Peritoneal Carcinoma
This study is for patients with advanced ovarian cancer that has reappeared after treatment with conventional therapy. The purpose of this study is to determine if the combination of docetaxel and gemcitabine will be effective in…
- Trial name
- NCT00183794
- Testing
- Docetaxel and Gemcitabine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Appendix Cancer, Pseudomyxoma Peritonei
The Appendix Cancer PMP Research Foundation Natural History Study/Patient Registry
ACPMP's first-ever patient-powered global patient registry/natural history study collects patient and caregiver information and data to fuel clinical trials and drive breakthroughs for appendix cancer and PMP.
- Trial name
- NCT07769346
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Appendix Cancer Pseudomyxoma Peritonei Research Foundation
Ovarian Cancer, Fallopian Tube Cancer
Relacorilant in Combination With Different Treatment Regimens in Patients With Gynecological Cancers
This is a Phase 2, open-label, global, multi-arm study to evaluate efficacy and safety of relacorilant in combination with other treatments in patients with gynecological cancers.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Neoplasms, Endometrial Cancer
- Trial name
- NCT06906341
- Testing
- Relacorilant 150 mg once daily (QD), Nab-paclitaxel 80 mg/m^2, Bevacizumab 10 mg/kg
- Where
- 49 sites in United States, Belgium and 6 more
- Volunteers
- 270 people
- Sponsor
- Corcept Therapeutics
Pancreatic Ductal Adenocarcinoma (PDAC)
Intraperitoneal Paclitaxel With NALIRIFOX for Pancreatic Ductal Adenocarcinoma With Peritoneal Carcinomatosis
This goal of this clinical trial is to learn whether the drug combination of intraperitoneal paclitaxel (chemotherapy given directly into the abdominal cavity) and intravenous NALIRIFOX (chemotherapy given into a vein, including…
- Trial name
- NCT07030283
- Testing
- Paclitaxel, NALIRIFOX
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Rectal Cancer
Completely Abdominal Approach Laparoscopic Partial Intersphincteric Resection for Rectal Cancer
The conventional intersphincteric resection (ISR) for low rectal cancer requires a combined abdominal and perineal approach, and followed with a handsewn coloanal anastomosis, which is time consuming and difficult to accomplish.
- Trial name
- NCT04481659
- Testing
- Lap partial ISR, NCRT+Lap partial ISR
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhongnan Hospital
Colorectal Cancer
Resorbable Barrier for the Prevention of Abdominal and Peri-hepatic Adhesion Formation
The purpose of this study is to evaluate the efficiency of a resorbable barrier membrane for the prevention of abdominal and peri-hepatic adhesion in patients with colorectal cancer requiring two-stage surgery for the resection…
- Trial name
- SEPRAC2T (NCT01262417)
- Testing
- - use of resorbable membrane Seprafilm, without resorbable barrier (seprafilm)
- Where
- 17 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Leon Berard
Systemic Immune Activation, Cancer Gi
The Effect of Anesthesia on Systemic Inflammatory Immune Index in Major Abdominal Cancer Surgeries
The effects of different anesthesia methods on the immune system are variable. In this study, we investigated the effect of inhalation anesthesia and total intravenous anesthesia on the SII value in major abdominal cancer…
- Conditions
- Systemic Immune Activation, Cancer Gi, Cancer of Endometrium
- Trial name
- NCT04891146
- Testing
- Systemic inflammatory immmune index
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Peritoneal Carcinomatosis
A Study of GL-ONC1, an Oncolytic Vaccinia Virus, in Patients With Advanced Peritoneal Carcinomatosis
The purpose of this study is to determine whether GL-ONC1, an attenuated vaccinia virus, is safe when administered to patients with peritoneal carcinomatosis via an infusion within the abdominal cavity through an implanted…
- Trial name
- NCT01443260
- Testing
- GL-ONC1
- Where
- Germany
- Volunteers
- 9 people
- Sponsor
- Genelux GmbH
Hepatocellular Carcinoma
Evaluation of 11 C-Choline PET-CT for Detection of Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC)is the most frequent primitive tumour of the liver. Recently, several research studies reported that 11C-choline PET has shown a high detection rate of well differentiated HCC, which is an early…
- Trial name
- CHOLPET (NCT01377220)
- Testing
- 11C-Choline
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Commissariat A L'energie Atomique
Delirium in Old Age, Hernia, Inguinal
Effect of Bilateral RSB on Postoperative Delirium in Elderly Patients Undergoing Laparoendoscopic Single-site Surgery
Postoperative delirium is a common complication in clinical surgery. It has been reported that it can increase postoperative morbidity and mortality and lead to decreased functional and cognitive abilities.
- Conditions
- Delirium in Old Age, Hernia, Inguinal, Cholecystolithiasis
- Trial name
- NCT05280860
- Testing
- ultrasound-guided bilateral rectus sheath block
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Affiliated Hospital of Nantong University