Clinical trials: Ablation of Atrial Fibrillation
Atrial Fibrillation
Comparison of RF and crYoballoon ablatiOn Therapy of AF（CRYO-AF）
It's a multi-center, prospective, randomized, controlled clinical trial of cryoballoon versus radiofrequency ablation for paroxysmal atrial fibrillation.
- Trial name
- CRYO-AF (NCT03044951)
- Testing
- cryoballoon ablation, radiofrequency ablation
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Ruijin Hospital
Atrial Fibrillation
Safety and Efficacy Study of The Combined Ablation Procedure To Treat Longstanding Persistent Atrial Fibrillation
This is a multi-center, prospective open label, feasibility study evaluating the safety and efficacy of the combined ablation procedure for the treatment of longstanding persistent atrial fibrillation.
- Trial name
- CAPstopsLSPAF (NCT01103661)
- Testing
- Numeris®-AF Guided Coagulation System with VisiTrax®
- Where
- 4 sites in United States
- Volunteers
- 7 people
- Sponsor
- nContact Surgical Inc.
Atrial Fibrillation Paroxysmal
Zero-fluoroscopic Cryoballoon Ablation
This study aimed to investigate safety and efficacy of intracardiac echocardiography (ICE)-guided zero-fluoroscopic cryoballoon ablation (CBA) in patients with paroxysmal atrial fibrillation.
- Trial name
- NCT05711589
- Testing
- CBA was performed under intracardiac echocardiography guidance without fluoroscopy, cryoablation (CBA) was performed under fluoroscopic guidance
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Pusan National University Hospital
Atrial Fibrillation
PVAC GOLD Versus Irrigated RF Single Tip Catheter With Contact FORCE Ablation of the Pulmonary Veins for Treatment of Drug Refractory Symptomatic Paroxysmal and Persistent Atrial Fibrillation
The GOLD FORCE trial investigates the differences between treatment with a Contact Force single-tip catheter against the PVAC GOLD multielectrode catheter in cardiac ablation procedures in patients with paroxysmal atrial…
- Trial name
- GOLD-FORCE (NCT02463851)
- Testing
- PVAC GOLD multielectrode catheter, Contact Force single-tip ablation catheter
- Where
- 3 sites in Germany, Netherlands
- Volunteers
- 212 people
- Sponsor
- L.V.A. Boersma
Atrial Fibrillation
Comparison of Expandable and Fixed Size Cryoballoon for the Treatment of Paroxysmal Atrial Fibrillation
The goal of this clinical trial is to compare two different, market approved, cryoballoon devices for the treatment of paroxysmal atrial fibrillation (AF).
- Trial name
- NCT06183879
- Testing
- cryoballoon pulmonary vein isolation (Medtronic 4th gen balloon), cryoballoon pulmonary vein isolation (Boston 2nd gen balloon)
- Where
- 2 sites in Croatia
- Volunteers
- 150 people
- Sponsor
- University of Zagreb
Atrial Fibrillation
the Study of STABLE_SR for Persistent Atrial Fibrillation
Background:the ablation outcomes for the treatment of persistent atrial fibrillation are not as satisfactory as paroxsymal AF. The successful rate ranges from 30%-55%.
- Trial name
- STABLE-SR (NCT01761188)
- Testing
- Ablation
- Where
- China
- Volunteers
- 220 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Coagulation; Intravascular
Randomized Comparison of Continuous and Intermittent Heparin Infusion During Catheter Ablation of Atrial Fibrillation
Optimal anticoagulation using heparin with close attention to maintain therapeutic dosing during the procedure is important. Randomized comparison of continuous and intermittent heparin infusion during catheter ablation of Atrial…
- Trial name
- COHERE (NCT01935557)
- Testing
- Continuous heparin infusion, Intermittent heparin infusion
- Where
- South Korea
- Volunteers
- 296 people
- Sponsor
- Yong Seog Oh
Paroxysmal Atrial Fibrillation
IMPACT: A Safety and Feasibility Study of the IOWA Approach Cardiac Ablation System
IMPACT is a prospective, single-arm, multi-center, safety and feasibility study evaluating the IOWA Approach Cardiac Ablation System (FARAPULSE, Inc.) for the treatment of paroxysmal atrial fibrillation.
- Trial name
- IMPACT (NCT03700372)
- Testing
- IOWA Approach Cardiac Ablation System
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Boston Scientific Corporation
Patients With Atrial Fibrillation Undergoing Catheter Ablation
Comparison of Patients' Satisfaction Between Dexmedetomidine and Remimazolam Anesthesia in Patients With Atrial Fibrillation Undergoing Catheter Ablation
The primary purpose of this study was to investigate whether remimazolam administration for sedation had a positive effect on patients' satisfaction compared to dexmedetomidine administration in patients with atrial fibrillation…
- Trial name
- NCT05864404
- Testing
- remimazolam-remifentanil, dexmedetomidine-remifentanil
- Where
- South Korea
- Volunteers
- 142 people
- Sponsor
- Yonsei University
Atrial Fibrillation, Atrial Flutter
A Comparative Study Evaluating the Vein of MArshall Ethanol Infusion Ablation Using an Over-the-wire (OTW) Balloon Versus a microcatHeter in Patients With Atrial Fibrillation
The goal of this study is to compare OTW balloon with microcatheter in the Marshall vein alcohol ablation study. The main questions it aims to answer are: • Is there a difference in the effectiveness and safety of OTW balloon and…
- Trial name
- NCT06460831
- Testing
- Microcatheter, OTW
- Where
- 5 sites in China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Heart Failure, Atrial Fibrillation
Comparison of His Bundle Pacing and Bi-Ventricular Pacing in Heart Failure With Atrial Fibrillation
This study is a multicenter, prospective, randomized cross-over study to compare His Bundle Pacing (HBP) with Bi-Ventricular Pacing (BiVP) in HF Patients with AF who need atrial-ventricular node ablation.
- Trial name
- NCT02805465
- Testing
- CRT Device and Bi-ventricular pacing, CRT Device and His-bundle Pacing
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Atrial Fibrillation
The Relationship Between Left Atrial Pressure and Cardiac Function After Atrioventricular Node Ablation
Effects of left atrial pressure-guided ventricular rate changes on cardiac function after atrioventricular node ablation combined with left bundle branch pacing
- Trial name
- LAP-TOP (NCT05449158)
- Testing
- left atrial pressure regulation
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Shanghai 10th People's Hospital
Atrial Fibrillation (AF)
Acupuncture for Preventing Atrial Arrhythmia Recurrence After Ablation
This study aims to evaluate whether acupuncture can reduce the recurrence of atrial arrhythmias after catheter ablation in patients with persistent atrial fibrillation.
- Trial name
- NCT07487532
- Testing
- Electroacupuncture, Standard Medical Therapy
- Volunteers
- 120 people
- Sponsor
- Shanghai Zhongshan Hospital
Atrial Fibrillation, Persistent or Longstanding Persistent Atrial Fibrillation
Pivotal Study Of A Dual Epicardial & Endocardial Procedure (DEEP) Approach
The objective of this study is to establish the safety and effectiveness of a dual epicardial and endocardial ablation procedure for patients presenting with Persistent Atrial Fibrillation or Longstanding Persistent Atrial…
- Trial name
- DEEP (NCT02393885)
- Testing
- AtriCure Bipolar System and AtriClip® PRO LAA Exclusion System, Endocardial Ablation
- Where
- 17 sites in United States, Belgium and 1 more
- Volunteers
- 90 people
- Sponsor
- AtriCure, Inc.
Atrial Fibrillation
Radiofrequency Ablation of Atrial Fibrillation Under Totally Thoracoscope
Atrial fibrillation (AF) is a common supraventricular arrhythmia, the incidence of which increases with age. The aim of treatment of atrial fibrillation is to restore sinus rhythm and return the heart to atrioventricular…
- Trial name
- NCT00844584
- Testing
- epicardial radiofrequency ablation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xijing Hospital
Atrial Fibrillation
Non - Invasive Evaluation of the Left Atrium Anatomy and Function
The aim of the study is to evaluate the accuracy and reproducibility of the left atrium (LA) anatomy and function in different populations and in patients with atrial fibrillation who have undergone cryoballoon ablation.
- Trial name
- NCT03551158
- Testing
- Echocardiography
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Atrial Fibrillation
The Ablate-by-LAW Study
Of all the determinants of lesion creation during atrial fibrillation (AF) ablation, left atrial wall thickness (LAWT), as measured with multi-detector cardiac tomography (MDCT) is one key element that has been evaluated in some…
- Trial name
- NCT04218604
- Testing
- Personalized atrial fibrillation ablation
- Where
- 5 sites in Germany, Italy and 1 more
- Volunteers
- 106 people
- Sponsor
- Centro Medico Teknon
Intraoperative Awareness
Measurement of Bispectral Index and Awareness in Patients Undergoing Electrophysiology Studies With Isoproterenol
Isoproterenol is used as a cardiac stimulant in electrophysiology studies (EP). Preliminary data suggests that administration of isoproterenol increases the Bispectral index (BIS).
- Trial name
- NCT01377636
- Testing
- Isoproterenol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Atrial Fibrillation
Timing of Direct Current Cardioversion (DCC) in Patients Undergoing Ablation of Persistent/Permanent Atrial Fibrillation
The purpose of this study is to compare which strategy is superior in patients with persistent/permanent atrial fibrillation (AF) undergoing ablation, direct current cardioversion (DCC) prior to empirical pulmonary vein isolation…
- Trial name
- NCT02429648
- Testing
- DCC first then PVI, PVI then DCC after
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- The Cleveland Clinic
Atrial Fibrillation
CONVERGE CAP Study-For The Treatment Of Symptomatic Persistent or Long-standing Persistent AF
The objective of this clinical study is to collect additional data on the safety and effectiveness of the EPi- Sense®-AF Guided Coagulation System with VisiTrax® to treat symptomatic persistent or long-standing persistent Atrial…
- Trial name
- CAP (NCT04239534)
- Testing
- Convergence Of Epicardial And Endocardial RF Ablation
- Where
- 10 sites in United States, United Kingdom
- Sponsor
- AtriCure, Inc.