Clinical trials: Abnormalities, Jaw
Clift Lip, Cleft Palate
Description of Pain in Pediatric Patients With Cleft Lip and Palate Undergoing Alveolar Grafting Using Two Surgical Strategies: Stem Cells and Autogenous Iliac Crest Bone (Pain Evaluation in Children Undergoing Alveolar Grafting: Stem Cells vs. Iliac Crest Bone)
Study Objective The objective of this study was to evaluate and compare postoperative pain and hospital costs in pediatric patients with cleft lip and palate undergoing alveolar bone grafting surgery.
- Conditions
- Clift Lip, Cleft Palate, Alveolar Bone Loss, Postoperative Pain
- Trial name
- NCT07734974
- Testing
- Autogenous Iliac Crest Bone Grafting, Bioengineered Alveolar Grafting (SHED + Scaffold)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital Sirio-Libanes
Class II Malocclusion, Mandibular Deficiency
Dentoskeletal Effects of 3D-Printed Fixed Twin Block Versus MARA Appliances in Management of Skeletal Class II
Objective: to evaluate the dentoskeletal effects of CAD/CAM 3D-Printed fixed twin block versus MARA appliances in the management of skeletal class II due to Mandibular Deficiency in Preadolescence Class II malocclusion is…
- Trial name
- NCT07340242
- Testing
- MARA appliance, fixed twin block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Neoplastic Syndrome, Non-melanomatous Skin Cancer
Topical Sirolimus in Patients With Basal Cell Nevus Syndrome and in Healthy Participants
RATIONALE: Studying samples of blood and tissue from patients with basal cell nevus syndrome and from healthy participants in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers…
- Trial name
- NCT00433485
- Testing
- sirolimus, comparative genomic hybridization, gene expression analysis
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Yale University
Cleft Palate
Acellular Dermal Matrix in Primary Palatoplasty
The goal of the present study is to definitely determine whether the use of acellular dermal matrix (ADM) during primary cleft palate repair decreases the rate of fistula formation.
- Trial name
- NCT01867632
- Testing
- Acellular Dermal Matrix
- Where
- Canada
- Volunteers
- 131 people
- Sponsor
- Mirko S. Gilardino
Infants, Difficult Airway
Oxygen Insuflation and ArterialDesaturation During Tracheal Intubation in Children
Infants (0-1 yr.) with anticipated difficult airways will be enrolled in the study. Specifically, we will include infants with cleft palate, Pierre Robin, Treacher Collins, trisomy 21, or similar congenital malformations.
- Trial name
- NCT01664234
- Testing
- laryngoscopy with oxygen, laryngoscopy without oxygen
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- Medical University of Vienna
Cleft Palate
Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate
Cell therapy appears to be an alternative to treat bone defects. Scientific advances have shown in animal models and in humans that mesenchymal stem cells were good candidates to support cellular bone regeneration after…
- Trial name
- NCT02900014
- Testing
- sampling mesenchymal stem cells
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Heart Failure With Preserved Ejection Fraction, Prognathism
Effect of Bilirubin on Prognosis in Heart Failure With Preserved Ejection Fraction
Factors influencing the prognosis of patients with heart failure with preserved ejection fraction (HFpEF) have been extensively studied.
- Trial name
- NCT06379152
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Chongqing Medical University
Cleft Lip and Palate
Unilateral Cleft Repair in One Surgery With Pure Primary Healing
Retrospective analysis of the current surgical method to repair unilateral cleft lip and palate malformations at our centre
- Trial name
- NCT04108416
- Testing
- Cleft lip and palate repair
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- University Hospital, Basel, Switzerland
Cleft Palate, Orofacial Cleft
Neural Network to Calculate Morphology of the Cleft Palate to Reduce Cleft Lip and Palate Treatment Burden.
This study is to develop a neural network to compute palatal three dimensional (3D) geometry by using routinely taken intraoral/palatal photographs and palatal casts of infants with cleft lip and palate deformity for reducing…
- Trial name
- NCT04342234
- Testing
- data collection of palatal casts and palatal images of cleft patients routinely treated at the institution
- Where
- Switzerland
- Volunteers
- 450 people
- Sponsor
- University Hospital, Basel, Switzerland
Orthodontic Appliance Complication, Dental Malocclusion
Changes in the Upper Airway Volume After Rapid Maxillary Expansion in Adults Using Pure Skeletal Anchorage
The objective of this study is to evaluate the effect of bone-anchored rapid maxillary expansion (RME) in the volume of the right maxillary sinus, left maxillary sinus and nasal and maxillary sinus airway complex, through bone…
- Conditions
- Orthodontic Appliance Complication, Dental Malocclusion, Bone Anchored Rapid Maxillary Expansion, Maxillary Hypoplasia
- Trial name
- NCT05831722
- Testing
- Rapid Maxillary Expansion
- Where
- 3 sites in Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Orthodontic Appliance Design, Retrognathism
Effect of the Innovated Seifi's Functional Appliance on Skeletal and Dentoalveolar Changes of Class II/ 1, Deep Bite
For improving the appearance of protruded upper front teeth when lower front teeth may touch palatal mucosa or have proximity to that; the innovated Seifi's Functional Appliance may be used.
- Conditions
- Orthodontic Appliance Design, Retrognathism, Malocclusion, Angle Class II, Deepbite
- Trial name
- Seifi-Fx (NCT00688233)
- Testing
- Seifi's Functional
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Cherubism
Natural History of Cherubism Observational Study
To observe the natural history of cherubism.
- Trial name
- NCT01916772
- Testing
- no interventions
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Mandibular Retrognathism, Mandibular Hypoplasia
Twin Block Appliance in Incremental Versus Maximum Bite Advancement in Skeletal Class II
The aim of this study is to compare to different protocols to treat Class II malocclusion in growing subjects using the twin block appliance
- Trial name
- NCT04562545
- Testing
- Modified Twin Block, Twin Block Appliance set to maximum bite
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Basal Cell Nevus Syndrome
Nivolumab With Vismodegib in Patients With Basal Cell Nevus Syndrome
This is a single-arm, phase II study to assess the efficacy of combined SMO and PD-1 inhibition with Vismodegib (SMO inhibitor) and Nivolumab (anti-PD-1 antibody) in BCNS patients (target enrollment of 22 patients), with a…
- Trial name
- NCT03767439
- Testing
- Vismodegib, Nivolumab, Ipilimumab
- Sponsor
- Columbia University
Maxillary Hypoplasia
Skeletal and Dental Changes with Hyrax-type Rapid Maxillary Expander Anchored to Permanent Versus Deciduous Molars
The aim of the study is to compare the skeletal and dental maxillary expansion obtained with an Hyrax tooth-borne expander anchored either on the 2nd deciduous molars (V) or on the 1st permanent molars (6)
- Trial name
- DENTHYRAX (NCT05773573)
- Testing
- Experimental group, Control group
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Montpellier
Cleft Palate, Cleft Lip
Articulation and Phonology in Children With Unilateral Cleft Lip and Palate
The purpose of the study is to assess if there are any differences in the articulatory and phonological competence in pre-school children with unilateral cleft lip and palate (UCLP) who are treated with different surgical methods…
- Trial name
- APCLP (NCT00829101)
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Region Skane
Musculoskeletal Complications
Levocarnitine in Treating Patients With Vismodegib-Associated Muscle Spasms
This randomized clinical trial studies levocarnitine in treating patients with vismodegib-associated muscle spasms. Levocarnitine may decrease muscle spasms caused by vismodegib.
- Trial name
- NCT01893892
- Testing
- levocarnitine, questionnaire administration
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Cleft Lip and Cleft Palate, Cleft Lip Palate
Early Intervention in Infants With Unrepaired Cleft Palate: Language, Palatal Function, and Articulation.
The goal of this clinical trial is to learn if teaching speech skills to infants with cleft palates, prior to palate repair, will help them to develop speech and language skills.
- Conditions
- Cleft Lip and Cleft Palate, Cleft Lip Palate, Cleft Lip and/or Palate, Cleft Palate
- Trial name
- NCT07219901
- Testing
- Early intervention for language, articulation and palatal function skills
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Old Dominion University
Buccal Fat Pad, Cleft Palate
Evaluating Salivary α - Amylase Levels Following Trigona Sp Honey Application To Post Palatoplasty Patients: A Pilot Randomized Clinical Study
Palatoplasty is a surgical procedure performed to restore palatal continuity and improve velopharyngeal function in patients with cleft palate.
- Conditions
- Buccal Fat Pad, Cleft Palate, Honey, Salivary Alpha Amylase
- Trial name
- NCT07610993
- Testing
- Trigona sp honey with the buccal fat pad technique, framicetyn sulfate dressing with the buccal fat pad technique, Trigona sp. honey dressing without the buccal fat pad technique
- Where
- Indonesia
- Volunteers
- 24 people
- Sponsor
- Hasanuddin University
Cleft Palate, Jaw Abnormalities
Improving Informed Consent for Cleft Palate Repair
To determine if providing a written document in addition to the standard oral discussion of surgical risks improves risk recall for the parents/guardians of a child seen in consultation for cleft palate surgery, and if this has…
- Conditions
- Cleft Palate, Jaw Abnormalities, Maxillofacial Abnormalities, Mouth Abnormalities
- Trial name
- NCT02595307
- Testing
- Pamphlet
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- IWK Health Centre