Clinical trials: Abortion, Recurrent
Cervical Insufficiency
Cerclage vs Cervical Pessary in Women With Cervical Incompetence
Cervical insufficiency (CI), responsible for 8% of preterm births (PB), is used to describe painless cervical dilation leading to recurrent second-trimester pregnancy losses/births of otherwise normal pregnancies.
- Trial name
- CEPEIC (NCT02405455)
- Testing
- Cerclage, Cervical pessary
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Maternal-Infantil Vall d´Hebron Hospital
Recurrent Abortion
Folic Acid vs 5-methyltetrahydrofolate (5MTHF) in Recurrent Abortion
Recent data indicates that 5 methyltetrahydrofolate (5MTHF) can reduce serum homocystein level more efficiently than folic acid.
- Trial name
- NCT01976676
- Testing
- 5-methyltetrahydrofolate, folic Acid
- Volunteers
- 220 people
- Sponsor
- National Nutrition and Food Technology Institute
Obese, Overweight
Efficacy of a Structured Weight Loss Program in Overweight Women With a History of Recurrent Pregnancy Loss
Overweight and obesity has been associated with a number of adverse pregnancy outcomes in women of reproductive age, including infertility and early pregnancy loss.
- Conditions
- Obese, Overweight, Miscarriage, Recurrent Pregnancy Loss
- Trial name
- NCT01325805
- Testing
- Structured Weight Loss Program, Routine Weight Loss Counseling
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Stanford University
Recurrent Pregnancy Loss
Genomic Predictors of Recurrent Pregnancy Loss
The overall goals of this proposal are to determine the genetic architecture of recurrent pregnancy loss (RPL) and to discover genomic predictors of RPL.
- Trial name
- GPRPL (NCT05444283)
- Where
- 10 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yale University
Recurrent Pregnancy Loss
The Novel Immunomodulatory and Anticoagulant Therapies for Recurrent Pregnancy Loss
In this clinical cohort study, the investigators are going to observe the efficacy of anti-coagulation and immune therapy in the treatment of recurrent pregnancy loss with a prospective randomized controlled trial.
- Trial name
- NCT02990403
- Testing
- Aspirin, Heparin, Prednisone
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Recurrent Miscarriage, Spontaneous Abortion
Low Plasma Mannose Binding Lectin (p-MBL) Level is a Risk Factor for Recurrent Pregnancy Loss (RPL)
The present study is based on the hypothesis, that recurrent pregnancy loss (RPL) is associated with abnormal plasma mannose binding lectin (p-MBL) level.
- Conditions
- Recurrent Miscarriage, Spontaneous Abortion, Mannose-Binding Lectin Deficiency, Habitual Abortion
- Trial name
- NCT04017754
- Where
- Denmark
- Volunteers
- 452 people
- Sponsor
- Aalborg University Hospital
Recurrent Pregnancy Loss
Association of HY-restricting HLA Class II Alleles, Sex of Firstborn Child, and Pregnancy Outcome in RPL Patients
This cross-sectional and prospective cohort study will investigate if sRPL patients with a first born boy who carry ≥1 HY-restricting (HY-r) HLA class II alleles are associated with a lower chance for a succesful reproductive…
- Trial name
- NCT05342948
- Where
- Denmark
- Volunteers
- 583 people
- Sponsor
- Aalborg University Hospital
Chromosome Translocation, Genetic Disorders in Pregnancy
Investigation and Diagnosis of the Chromosome Variation in Donated/abandoned Blastocyst
Blastocysts derived from patients seeking infertility treatment were generated by in vitro fertilization and embryo culture as previously described, and were evaluated using the Gardner system.
- Conditions
- Chromosome Translocation, Genetic Disorders in Pregnancy, Recurrent Miscarriage
- Trial name
- NCT05216068
- Testing
- NGS
- Where
- Taiwan
- Volunteers
- 57 people
- Sponsor
- Chang Gung Memorial Hospital
Recurrent Miscarriage
Distinct Alterations in Gut Microbiota Composition Among Women of Reproductive Age With Elevated Homocysteine Levels.
The goal of this observational study is to test the alterations of gut microbiota composition among women of reproductive age with elevated homocysteine levels.
- Trial name
- NCT06001060
- Where
- China
- Volunteers
- 38 people
- Sponsor
- First People's Hospital of Hangzhou
First Trimester Pregnancy, Fetal Heart Activity Absent
Markers of Oxidative Stress in a Early Week Miscarriage: Ischemia of Modified Albumin
The finding that ischemia-modified albumin (IMA) is increased in pre-eclamptic pregnancy suggests a role for IMA as a potential biomarker for abnormal placental development related to miscarriage.This study was undertaken to…
- Conditions
- First Trimester Pregnancy, Fetal Heart Activity Absent, Absence of Fetal Pole on Ultrasonographic Examination.
- Trial name
- IMA (NCT01988740)
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Recurrent Abortion
Sildenafil Citrate and Recurrent Abortion
Two groups of unexplained recurrent spontaneous abortion, each included 65 participants. scheduled randomly into; the study group received Sildenafil Citrate and Placebo group.
- Trial name
- NCT03475160
- Testing
- Sildenafil Citrate vaginal suppositories, Uterine artery Doppler before treatment, Uterine artery Doppler after treatment
- Volunteers
- 130 people
- Sponsor
- Benha University
Recurrent Miscarriage
Obstetrics , Prenatal Outcomes in Recurrent Miscarriage
The effect of recurrent miscarriage on the outcome of the current pregnancy and if there's a relation between it and adverse out come
- Trial name
- OBPORPL (NCT06356792)
- Where
- Egypt
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Assiut University
Spontaneous Abortion
Composition of the Intestinal Microbiome in Patients With Recurrent Spontaneous Abortions.
Up to 50% of all women suffer of a spontaneous abortion. Having two/three or more spontaneous abortions is one of the main reasons of unwanted childlessness.
- Trial name
- NCT07246486
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Dr. Natascha Köstlin-Gille
Recurrent Miscarriage
Genetic Abnormalities and Oxidative Stress in Sperm as Cause of Recurrent Miscarriage.
In recurrent miscarriage, the male factor has been poorly evaluated. In fact, in the vast majority of clinical protocols of recurrent miscarriage, the sperm is not considered or assessed.
- Trial name
- NCT00447395
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Male Infertility, Unexplained Infertility
Impact of Sperm DNA Integrity on In Vitro Cycles
Sperm DNA integrity will be measured via the Toluidine Blue Assay (TBA) for patients undergoing In Vitro Fertilization (IVF); the study will determine correlations, if any, between IVF success and sperm DNA integrity.
- Conditions
- Male Infertility, Unexplained Infertility, Abortion, Habitual
- Trial name
- TBA on IVF (NCT01232465)
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Northwell Health
Infertility Female, Recurrent Miscarriage
Study on the Association Between SXCI and RM and the Possible Genetic Mechanism
To determine whether there is higher incidence of skewed X chromosome inactivation(SXCI) in the recurrent miscarriage(RM) population compared with normal population, and verify the existing hypothesis of the possible genetic…
- Trial name
- NCT02504281
- Where
- China
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Recurrent Pregnancy Loss
Uterine Artery Doppler Changes After Vaginal Administration of Isosorbide Mononitrate In Patients With URPL
compare uterine artery blood flow before and after the administration of Isosorbide mononitrate as a nitric oxide donor during mid secretory phase of menstrual cycle for patients with unexplained recurrent pregnancy loss.
- Trial name
- NCT05341856
- Testing
- isosorbide mononitrate
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Recurrent Spontaneous Abortion
Difference Between Mean Gestational Sac Diameter and Crown-rump Length as a Marker of First-trimester Pregnancy Outcome in Patients With Recurrent Spontaneous Abortion
Objective: To determine the effect and predictive value of the difference between the mean gestational diameter (mGSD) sac and crown-rump length (CRL) of the first trimester on the pregnancy outcomes of patients with recurrent…
- Trial name
- mGSD-CRL& RSA (NCT06081556)
- Testing
- ultrasonic testing
- Where
- China
- Volunteers
- 256 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Abortion in First Trimester
Progesterone and Doppler in Recurrent Abortion
Recurrent pregnancy loss is classically defined as the occurrence of three or more consecutive pregnancy loss. The American Society of Reproductive Medicine has recently redefined recurrent pregnancy loss as two or more pregnancy…
- Trial name
- NCT03267771
- Testing
- Progesterone Suppositories Vaginal, Dydrogesterone Oral Tablet, doppler ultrasound
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cervical Incompetence (Complicating Pregnancy)
Pregnancy Outcomes According to Cervical Cerclage Indications and Factors Affecting Pregnancy Duration and Outcomes
This study aimed to asses predictive factors associated with successful cervical cerclage and poor pregnancy outcomes in all indications.129 pregnant women who underwent cerclage at 12-25 weeks gestation in a perinatal medical…
- Trial name
- CCERCIAFAO (NCT06443112)
- Testing
- transvaginal cervical cerclage by Mc Donald technique
- Where
- Turkey (Türkiye)
- Volunteers
- 129 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital