Clinical trials: Abortion Early
Menstrual Cycles, Conception
Factors Influencing Fertility or Pregnancy Health
Background: The North Carolina Early Pregnancy Study (EPS) was held from 1982 to 1986. Women who were trying to get pregnant took part in the study. They collected urine samples. They kept diaries. They filled out surveys.
- Conditions
- Menstrual Cycles, Conception, Early Pregnancy Loss, Pregnancy Outcomes
- Trial name
- NCT04595760
- Where
- United States
- Volunteers
- 231 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Gestational Age, Time to Pregnancy
A Follow-up of the Early Pregnancy Study Cohort.
Background: The purpose of the 1982 1986 North Carolina Early Pregnancy Study was to determine how often pregnancy loss occurs before women know they are pregnant.
- Conditions
- Gestational Age, Time to Pregnancy, Early Pregnancy Loss
- Trial name
- NCT01132924
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Missed Abortion, Early Pregnancy Failure
A Real-World Study Comparing the Efficacy of Different Treatment Regimens for Early Missed Abortion
At present, there is no unified standard for the treatment of missed abortion in clinical practice. This study intends to collect clinical data of this type of disease to compare the efficacy of different treatments, and on this…
- Trial name
- NCT07422506
- Testing
- Control group, Conventional dose of estrogen, High-dose estrogen
- Where
- China
- Volunteers
- 580 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Placenta; Implantation
The Accuracy of Ultrasound in the Detection of Placenta Site in the First Trimester.
The investigators speculate that ultrasound examination in the first trimester can accurately detect placental location. By performing both transabdominal ultrasound and later hysteroscopy on women with a first trimester missed…
- Trial name
- NCT04579796
- Testing
- ultrasound exam, hysteroscopy diagnostic
- Where
- Israel
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Missed Abortion, Early Pregnancy Loss
GPT-Based Digital Assistant Support During Treatment for Induced Abortion or Missed Abortion
We have developed a digital assistant based on GPT (Generative Pre-trained Transformer) technology, trained specifically to provide empathetic, medically accurate, and guideline-based responses in Hebrew, tailored to the clinical…
- Conditions
- Missed Abortion, Early Pregnancy Loss, Abortion in First Trimester, Abortion, Medical
- Trial name
- NCT07856940
- Testing
- GPT-Based Digital Assistant
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Wolfson Medical Center
Miscarriage, Breast Feeding
The Relationship Between Breastfeeding During Early Pregnancy and Miscarriage
Breastfeeding provides various health and psychological benefits to mothers and their babies. It also acts as an effective method of natural contraception when applied strictly for up to six months after birth.
- Trial name
- NCT05461963
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Siirt University
Pregnancy Early, Miscarriage
Gonadotropin Releasing Hormone Agonist (GnRHa) Versus Estrogen and Progesterone for Luteal Support in High Responders
Gonadotropin Releasing Hormone agonist (GnRHa) triggering is used as an alternative to human chorionic gonadotropin (hCG) in GnRH antagonist protocol to eliminate the risk of ovarian hyperstimulation syndrome (OHSS).
- Conditions
- Pregnancy Early, Miscarriage, Ovarian Hyperstimulation Syndrome
- Trial name
- NCT04797338
- Testing
- Synarel, 0.2 Mg/Inh Nasal Spray, Estrofem, Utrogestan
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Abortion Early, Pregnancy Related
Improving Access to Abortion in the Republic of Georgia
In the Republic of Georgia, the medical abortion regimen involves three in-person visits. This study aims to pilot and evaluate a simplified medical abortion service delivery model that will reduce the number of in-person visits…
- Trial name
- NCT04458558
- Testing
- Mifepristone
- Where
- 3 sites in Georgia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Center for Information and Counseling on Reproductive Health - Tanadgoma
Abortion, Spontaneous, Abortion in First Trimester
Effect of Paracervical Block Volume on Pain Control for Dilation and Curettage.o
The investigators are conducting a study on pain control for dilation and curettage (D\&C). Participants are eligible to enroll if they are a planning to have a D\&C in a participating clinic.
- Conditions
- Abortion, Spontaneous, Abortion in First Trimester, Pain Uterus, Abortion Early
- Trial name
- NCT03636451
- Testing
- 40cc buffered 0.5% lidocaine with 2 units of vasopressin paracervical block, 20cc 1% lidocaine with 2 units of vasopressin paracervical block
- Where
- 2 sites in United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Early Pregnancy Loss, Intrauterine Adhesion
Operative Hysteroscopy Versus Suction Curettage for Surgical Termination of Early Pregnancy Loss (Miscarriage)
Non-blinded prospective randomized study. 100 women diagnosed with early pregnancy loss up to 10 gestational weeks who opted for surgical management (after being offered the options of conservative management and medical…
- Trial name
- NCT06309927
- Testing
- Operative hysteroscopy (by tissue removal device), Suction curettage
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Anesthesia, Abortion Early
Remimazolam Versus Propofol for Painless Abortion
The goal of this clinical trial is to compare the efficacy and safety of propofol vs. remimazolam in combine use of esketamine in women with early pregnancy undergoing painless abortion.
- Trial name
- NCT05635955
- Testing
- Remimazolam, Propofol, Esketamine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Maternal and Child Health Hospital of Hubei Province
Early Pregnancy Failure
Comparing Two Medical Treatments for Early Pregnancy Failure.
This study aims to compare whether a combination of two drugs (Mifepristone and misoprostol) are superior compared to using only one of these drugs (Misoprostol) as medical treatment for a miscarriage.
- Trial name
- Triple M (NCT03212352)
- Testing
- Mifepristone, Misoprostol
- Where
- 13 sites in Netherlands
- Volunteers
- 342 people
- Sponsor
- Radboud University Medical Center
Abortion Early, Pregnancy Related
Mail Order Mifepristone Study
This study aims to evaluate the feasibility, acceptability, and effectiveness of dispensing mifepristone via a mail-order pharmacy.
- Trial name
- NCT03913104
- Testing
- Mifepristone
- Where
- 11 sites in United States
- Volunteers
- 536 people, healthy volunteers welcome
- Sponsor
- Daniel Grossman, MD
Infertility, Female, Miscarriage
Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?
This study aims to explore the potential correlation between decreased ovarian reserve and previous history of early miscarriage.
- Conditions
- Infertility, Female, Miscarriage, Miscarriage, Recurrent, IVF
- Trial name
- NCT05969574
- Testing
- Transvaginal ultrasound, Blood test AMH
- Where
- 3 sites in United Arab Emirates
- Volunteers
- 2,059 people
- Sponsor
- ART Fertility Clinics LLC
Spontaneous Abortion
Comparative Effectiveness of Pregnancy Failure Management Regimens
The purpose of the study is to compare the effectiveness of combination treatment (mifepristone premedication plus single-dose misoprostol) to single-dose misoprostol (standard of care) for the management of early pregnancy…
- Trial name
- PreFaiR (NCT02012491)
- Testing
- Misoprostol, Mifepristone
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Pennsylvania
Abortion Early, Abortion in First Trimester
Delivery of Audiovisual Information on Early Medical Abortion
The majority of abortions in the United Kingdom (UK) are performed before 9 weeks (63 days) gestation using a method known as Early Medical Abortion (EMA).
- Trial name
- EMAVID (NCT03417362)
- Testing
- Animation
- Where
- 3 sites in France, Sweden and 1 more
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Early Abortion
Advance Provision of Medication Abortion
This mixed-methods study follows a prospective cohort of participants receiving Mifeprex® (mifepristone) by a clinician in advance of a potential unintended pregnancy.
- Trial name
- NCT03829696
- Testing
- Mifeprex® (Mifepristone 200 mg), Misoprostol 800 mcg, ella® (ulipristal acetate emergency contraception 30 mg)
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Abortion Early, Abortion in First Trimester
Using Telemedicine to Improve Early Medical Abortion at Home
The investigators plan a trial comparing telephone consultations for women requesting early medical abortion (EMA - under 10 weeks pregnant) to regular face-to-face consultations.
- Trial name
- UTAH (NCT04139382)
- Testing
- Telephone Consultation, Face-to-Face Consultation
- Where
- United Kingdom
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Incomplete Abortion, Intrauterine Contraception
Ideal Timing of Intrauterine Contraception Insertion After Medical Management of First Trimester Incomplete Abortion
Background: Unintended pregnancies continue to cause a public health threat in Low and Middle Income countries yet with restrictive abortion laws.
- Conditions
- Incomplete Abortion, Intrauterine Contraception, Misoprostol
- Trial name
- PAIC (NCT05343546)
- Testing
- Use of either copper T380A or Levonorgestrel LNG 52 IUS after medical management of first trimester incomplete abortion
- Where
- Uganda
- Volunteers
- 2,076 people
- Sponsor
- Makerere University
Recurrent Pregnancy Loss
Establishment of Special Disease Cohort for RPLand Study of Impact Mechanism of Early Embryo Development
Recurrent pregnancy loss (RPL) is a refractory disease with diverse etiologies, complex pathogenesis and limited therapeutic options. Current tests and treatments lack uniform specifications.
- Trial name
- NCT05186207
- Testing
- abnormal pre-pregnancy test results that need clinical intervention
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University