Clinical trials: Abortion Early
Spontaneous Abortion in First Trimester
Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss
First trimester miscarriages are common. When the failed pregnancy does not pass spontaneously on its own, it is called a missed abortion.
- Trial name
- NCT02141555
- Testing
- Vaginal Misoprostol, Buccal Misoprostol
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Early Pregnancy Failure, Miscarriage
MiMi: A Randomized Trial of Mifepristone and Misoprostol for Treatment of Early Pregnancy Failure
The purpose of this study is to compare two combinations of drugs (mifepristone and misoprostol versus placebo and misoprostol) used for medical treatment for early pregnancy failure.
- Conditions
- Early Pregnancy Failure, Miscarriage, Fetal Demise, Anembryonic Pregnancy
- Trial name
- MiMi (NCT00468299)
- Testing
- Mifepristone and misoprostol
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boston University
Fertility, Infertility
Internet-based Study of Fertility and Early Pregnancy (PEEPS)
The purpose of this study is to assess the feasibility of conducting an Internet-based prospective pregnancy study with preconception enrollment with women completing daily journals for up to 12 months while trying to conceive…
- Conditions
- Fertility, Infertility, Pregnancy, Abortion, Spontaneous
- Trial name
- PEEPS (NCT01904669)
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Courtney D.Lynch, PhD MPH
Pregnancy Loss, Pregnancy Loss, Early
Efficacy of Progesterone and Low Molecular Weight Heparin in Recurrent Pregnancy Loss
This prospective, single-centre, open-label, randomized Phase III superiority trial will enroll approximately 268 women aged 18-40 years with at least two consecutive unexplained miscarriages and a singleton intrauterine…
- Trial name
- PREMISE (NCT07796737)
- Testing
- Vaginal Micronized Progesterone (Progesterone Besins), Enoxaparin (Clexane)
- Where
- Czechia
- Volunteers
- 268 people
- Sponsor
- General University Hospital, Prague
Preeclampsia, Premature Birth
Cohort Study on the Levels of Placental Growth Factor and Nucleosomes in Early Pregnancy and Adverse Pregnancy Outcomes
Objective: This study aims to investigate the association between maternal serum placental growth factor (PLGF) and nucleosome levels in early pregnancy and adverse pregnancy outcomes, and to evaluate their predictive value for…
- Conditions
- Preeclampsia, Premature Birth, Fetal Growth Restriction, Recurrent Miscarriage
- Trial name
- NCT07841197
- Testing
- Measurement of plasma nucleosome and placental growth factor (PLGF) levels
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Preeclampsia, Pregnancy Loss
Early Pregnancy Antioxidant Supplementation in the Prevention of Preeclampsia
Use of Juice Plus+ food supplements, when initiated in the first trimester and used continuously thereafter, will result in a lower incidence of preeclampsia and pregnancy complications.
- Trial name
- NCT00583635
- Where
- United States
- Volunteers
- 684 people
- Sponsor
- University of Mississippi Medical Center
Retained Products of Conception, Intrauterine Adhesion
Hysteroscopy Assisted Suction Curettage for Early Pregnancy Loss
Retained products of conception (RPOC) and intrauterine adhesions (IUA) may occur following suction curettage for early miscarriage and cause secondary infertility, recurrent pregnancy loss and pregnancy complications.
- Trial name
- NCT04637373
- Testing
- Hysteroscopy
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Pre-Eclampsia
Low Dose Aspirin for Prevention of Early Pregnancy Loss
Preeclampsia is a pregnancy-specific, multisystem disorder affecting 3% to 8% of pregnancies and remains a significant cause of maternal and neonatal morbidity and mortality worldwide.
- Trial name
- NCT06261203
- Testing
- Aspirin
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Egymedicalpedia
Abortion Early
Auriculotherapy During Medication Abortion
This randomized trial will evaluate the effect of adding auriculotherapy (i.e. acupuncture applied to the ear) using either gold beads or Pyonex needles in addition to usual care for the relief of pain and anxiety during…
- Trial name
- NCT03900728
- Testing
- Auriculotherapy with needles, Auriculotherapy with beads
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Columbia University
Abortion Early
The California Home Abortion by Telehealth (CHAT) Study
This study aims to assess efficacy and safety outcomes of a telehealth model of abortion care. The study will compare efficacy of this model to usual in-clinic care based on published rates.
- Trial name
- CHAT (NCT04432792)
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 6,020 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy Loss, Early, Major Depression
Effect of Participating in a Study of Causes of Pregnancy Loss on Mental Health Outcomes: A Target Trial Emulation Using the COPL Cohort and Danish National Registries
Pregnancy loss is the most common severe pregnancy complication and is associated with significant mental health sequelae, including depression and anxiety.
- Conditions
- Pregnancy Loss, Early, Major Depression, Anxiety, Stress (Psychology)
- Trial name
- NCT07684677
- Testing
- COPL participation
- Where
- Denmark
- Volunteers
- 30,000 people
- Sponsor
- Amager Hospital
Missed Abortion, Anembryonic Pregnancy
Ulipristal Acetate for Use in Early Pregnancy Loss
The investigators will study the feasibility of using 90mg ulipristal acetate, a selective progesterone receptor agonist, as an adjunct to 800mcg vaginal misoprostol for the medical management of early pregnancy loss.
- Conditions
- Missed Abortion, Anembryonic Pregnancy, Non-Viable Pregnancy
- Trial name
- NCT05216952
- Testing
- Ulipristal Acetate Tablets, Misoprostol Pill
- Where
- 4 sites in United States
- Volunteers
- 3 people
- Sponsor
- University of North Carolina, Chapel Hill
Early Pregnancy Bleeding, Recurrent Pregnancy Loss
Maternal and Newborn Safety Profile of Progestogens in EARLY Pregnancy
This multinational, prospective, active surveillance, registry study following two cohorts will include study participants who are pregnant and seeking any type of medical treatment, including dydrogesterone and other…
- Trial name
- PEARLY (NCT05186779)
- Testing
- Progestagen
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Center for Epidemiology and Health Research, Germany
Infertility
Incidence of Early Pregnancy Loss in Patients With Unexplained Infertility
Unexplained fertility could be partly caused by a higher incidence of early pregnancy loss in this group. 65 women with unexplained infertility and 65 healthy controls will collect daily urine samples form the luteal phase.
- Trial name
- UNEXPLAINED (NCT01015690)
- Where
- Netherlands
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Medical Abortion
Effectiveness of Pregnancy Tests as an Assessment Tool to Identify Continuing Pregnancy
This randomized study will examine the effectiveness of two types of pregnancy tests (a semi-quantitative test and a high sensitivity test) to identify continuing pregnancy at home at various time points after early medical…
- Trial name
- NCT01856777
- Testing
- Semi-quantitative panel test, High sensitivity urine pregnancy test
- Where
- 2 sites in Vietnam
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Pregnant Women Less Than 14 Weeks of Gestation
Accuracy of eDiagEPU, a Medical Computerized Tool for EPU
In a recently published study, a poor knowledge of guidelines in the field of early pregnancy was observed in France, Belgium and Switzerland.
- Trial name
- eDiagEPU (NCT03993015)
- Testing
- Help to diagnosis software
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Uterine Evacuation
The Impact of Doulas in Early Pregnancy Management
The purpose of the study is to examine the impact of doula support for women undergoing a manual vacuum aspiration (MVA) for an early pregnancy failure or undesired pregnancy.
- Trial name
- NCT02165540
- Testing
- Doula
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Abortion Early
The Relation of High Sensitivity C Reactive Protein and Total Leucocytic Count Levels in Threatened Abortion
to identify the relation between maternal serum high sensitivity C reactive protein and total and differential leucocytic count values in healthy pregnant women with threatened abortion and the outcome of pregnancy
- Trial name
- NCT05986357
- Testing
- maternal serum C reactive protein, total leucocytic count levels, differential leucocytic count levels
- Where
- Egypt
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Pregnancy Related, Abortion Early
Medication Abortion Via Pharmacy Dispensing
This mixed-methods study follows a prospective cohort of patients receiving Mifeprex ® (mifepristone) for medication abortion dispensed by pharmacists after undergoing standard clinical evaluation.
- Trial name
- NCT03320057
- Testing
- Mifepristone, Training on mifepristone dispensing
- Where
- 6 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Daniel Grossman
Early Pregnancy Loss
Optimal Time Interval Between Mifepristone and Misoprostol Administration for Early Pregnancy Loss
A prospective cohort study to explore the optimal time interval between mifepristone and misoprostol administration for medical management of early pregnancy loss.
- Trial name
- TIME (NCT07506512)
- Testing
- 200mg mifepristone and 800mg misoprostol
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania