Clinical trials: Abortion Early
Termination of Pregnancy
Obstetric & Pediatric Evolution Following Parental Refusal for Early Termination of Pregnancy Despite Fetal Risk
More and more parents decide to maintain pregnancy which could have been interrupted because of serious fetal pathologies. In this observational study, the investigators examine obstetrical and pediatric evolution of these…
- Trial name
- NCT03393455
- Testing
- not accurate
- Where
- France
- Volunteers
- 211 people
- Sponsor
- University Hospital, Montpellier
Recurrent Pregnancy Loss, Early Pregnancy Failure
Ultrasound Predictors of Early Pregnancy Failure in Patients With Recurrent Pregnancy Loss
evaluation of the role of ultrasonographic parameters (mean gestational sac diameter, yolk sac diameter, crown rump length, embryonic heart rate and uterine artery Doppler) in predicting early pregnancy failure in patients with…
- Trial name
- NCT03178682
- Testing
- ultrasound parameters
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Early Miscarriage
Identification of Histories of Pregnancy Termination, Particularly Early Miscarriage, in General Medical Records
Early miscarriage (EM) is defined as the spontaneous expulsion of an intrauterine pregnancy of less than 14 weeks' duration. Early miscarriage is a very common complication, affecting more than 10% of pregnancies.
- Trial name
- NCT07406776
- Where
- France
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Université de Reims Champagne-Ardenne
Pregnancy, Abortion Early
Assessment of Early Pregnancy MAB Completion
This is a prospective study to evaluate if successful completion of a medication abortion in patients with very early pregnancy can be detected with a urine pregnancy test at 2 weeks instead of 4 weeks.
- Trial name
- NCT06893484
- Testing
- Weekly high-sensitivity urine pregnancy tests
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Washington
Threatened Miscarriage, Early Pregnancy Bleeding
Comparison of Dydrogesterone Alone Versus Dydrogesterone Plus HCG in Threatened Miscarriage
This randomized controlled trial aims to compare the efficacy of Dydrogesterone alone versus Dydrogesterone combined with human chorionic gonadotrophin (HCG) in the treatment of threatened miscarriage in first trimester…
- Trial name
- DYD-HCG (NCT07608133)
- Testing
- Dydrogesterone, Human chorionic gonadotrophin (hCG)
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Pakistan Air Force (PAF) Hospital Islamabad
Early Pregnancy Loss, Early Pregnancy
Conversational Artificial Intelligence (AI) to Improve PeRiconception Care Access
The goal of this project, Conversational Artificial Intelligence (AI) to Improve PeRiconception Care Access (CIRCA), is to engage patients in care early in pregnancy (before prenatal care starts) and safely triage concerns to…
- Trial name
- CIRCA (NCT06618144)
- Testing
- Texting platform
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Pennsylvania
Abortion, Spontaneous
Vitamin D and Angiogenic Markers in Odense Child Cohort 1
The Vitamin D and Angiogenic Marker Study 1: Vitamin D and angiogenic markers in early pregnancy. Epidemiology and associations to early-pregnancy miscarriage
- Trial name
- VITAM (NCT02434900)
- Where
- Denmark
- Volunteers
- 2,874 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
First Trimester Abortion
Early Pregnancy Ultrasound Measurements and Prediction of First Trimester Pregnancy Loss.
Ultrasound measurements of fetus during first trimester may be an indicator of first trimester pregnancy loss. Investigators took 4 measurements of the fetus on 2 intervals during first trimester to confirm this hypothesis.
- Trial name
- NCT06540092
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Infertility, Assisted Reproductive Technology
Microbiome and Metabolome Profiles in Couples Undergoing IVF and Reproductive Outcomes
This prospective observational cohort study investigates the role of the microbiome and metabolome in couples undergoing in vitro fertilization.
- Conditions
- Infertility, Assisted Reproductive Technology, Pregnancy Complications, Pregnancy Loss, Early
- Trial name
- Mi IVF (NCT07532629)
- Where
- 3 sites in Sweden
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Unwanted Pregnancies
Comparing Methotrexate Followed by Misoprostol to Misoprostol Alone for Early Abortion
Background: In most countries in which abortion is legal, medical abortions are induced with mifepristone and misoprostol. Since mifepristone is expensive and unavailable in many countries, it is important to find other regimens.
- Trial name
- NCT00129506
- Testing
- methotrexate + misoprostol, misoprostol
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Wiebe, Ellen, M.D.
Early Pregnancy Loss, Delayed Pregnancy Loss
CCT-102 or Expectant Management in Delayed Pregnancy Loss
A Phase 3, multi-center clinical trial of a CCT-102 regimen or expectant management to promote uterine evacuation in first trimester non-progressing Delayed Pregnancy Loss (DPL).
- Trial name
- MERMAID (NCT06121063)
- Testing
- CCT-102 A and CCT-102 B
- Where
- 15 sites in United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Conceptra Biosciences, LLC
Recurrent Miscarriage
Low-dose Interleukin-2 in Women With Unexplained Miscarriages
The purpose of this study is to demonstrate the ability of low dose IL-2 to stimulate peripheral blood Tregs of women with unexplained repeated early spontaneous miscarriages for development of a therapy to prevent fetal…
- Trial name
- FaCIL-2 (NCT03970954)
- Testing
- low-dose IL-2
- Where
- 3 sites in France
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Early Abortion, Pregnancy Loss, Early
Comparison of Surgical Management of Early Pregnancy Loss by Suction Curettage Versus Hysteroscopy in Patients Undergoing In-vitro Fertilization (IVF)
Early pregnancy loss occurs in ~15% of pregnancies. The treatment options include surgical uterine evacuation by suction curettage, medical management with misoprostol, or conservative management without interventions.
- Trial name
- NCT07143578
- Testing
- Operative hysteroscopy using tissue removal device, suction curettage
- Where
- 2 sites in Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
RECURRENT PREGNANCY LOSS
Sperm DNA Fragmentation in Recurrent Pregnancy Loss
In human, 2% of couples experimented Recurrent pregnancy loss (RPL). Currently, while etiological investigations were performed, 40 to 50 % of RPL were unexplained.
- Trial name
- PARTHOM (NCT02572154)
- Testing
- Blood and sperm samples
- Where
- 3 sites in France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Lactation Suppressed
Cabergoline for Lactation Inhibition After Early Second-Trimester Abortion or Pregnancy Loss
Breast pain following second-trimester abortion is common. Breast engorgement and milk leakage following second-trimester perinatal loss and abortion can cause both physical pain and emotional distress.
- Trial name
- eLISTA (NCT06029673)
- Testing
- Cabergoline 1 MG
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Stanford University
Abortion Early
Medication Abortion With Autonomous Self-Assessment Project
In this study, the investigators propose to create and pilot-test an asynchronous medication abortion provision service.
- Trial name
- MA-ASAP (NCT05278780)
- Testing
- Screening for eligibility
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Spontaneous Abortion
Comprehensive Assessment of Risks for Miscarriage.
This study aims to determine the role of serum biomarkers and placental bloodflow in the comprehensive evaluation of the risk for spontaneous abortion
- Trial name
- MIS-CARE (NCT04456660)
- Testing
- Markers of ultrasound, Immunologic factors, Serum factors
- Where
- Bulgaria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Orthogyn Medical Center, Bulgaria
Early Pregnancy Bleeding, Abdominal Pain
Pelvic Examination in Pregnancy
This study is designed to determine whether the pelvic examination (including bimanual and speculum examination) is necessary in patients with first trimester vaginal bleeding/ lower abdominal pain when an intra-uterine pregnancy…
- Trial name
- PEP (NCT01570413)
- Testing
- No Pelvic Exam, Pelvic Examination
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Boston Medical Center
Polycystic Ovary Syndrome
Effect of Metformin on Early Pregnancy Loss in Pregnant Women With Polycystic Ovarian Syndrome
The aim of this work is to study the effect of metformin use for reducing early pregnancy loss in pregnant patients with Polycystic ovary syndrome (PCOS).
- Trial name
- MIP (NCT02498522)
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pregnancy of Unknown Location, Ectopic Pregnancy
Assessment of Biomarkers in Pregnancy on Unknown Location and Ectopic Pregnancy
To further develop the patient care pathway for women classified with a pregnancy of unknown location (PUL) and ectopic pregnancy (EP).
- Conditions
- Pregnancy of Unknown Location, Ectopic Pregnancy, Early Pregnancy, Early Pregnancy Loss
- Trial name
- ABPEP (NCT04738370)
- Testing
- Sample collection
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London