Clinical trials: Abortion Early, active
Miscarriage, Early Pregnancy Loss
Cohort of Patients Presenting Unexplained Recurrent Miscarriages and Identification of Early Miscarriage Recidivism Factors
About 1 to 3% of women of childbearing age suffer repeated early spontaneous miscarriages (RCF) defined by at least 3 fetal losses before 14 weeks of gestation.
- Trial name
- FALCO (NCT05557201)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Early Pregnancy Loss
Optimal Time Interval Between Mifepristone and Misoprostol Administration for Early Pregnancy Loss
A prospective cohort study to explore the optimal time interval between mifepristone and misoprostol administration for medical management of early pregnancy loss.
- Trial name
- TIME (NCT07506512)
- Testing
- 200mg mifepristone and 800mg misoprostol
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania
PGT-A, PCOS
PIMS vs PGT-A in Infertile PCOS Patients
This experiment has become a serious issue for two reasons: DNA methylation plays an important role during embryogenesis, global abnormal methylome reprogramming often occurs in human embryos, and DNA methylome pattern is…
- Conditions
- PGT-A, PCOS, PIMS
- Trial name
- NCT06887881
- Testing
- PIMS screening, PGT-A screening
- Where
- China
- Volunteers
- 766 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Pregnancy Loss, Pregnancy Loss, Early
Efficacy of Progesterone and Low Molecular Weight Heparin in Recurrent Pregnancy Loss
This prospective, single-centre, open-label, randomized Phase III superiority trial will enroll approximately 268 women aged 18-40 years with at least two consecutive unexplained miscarriages and a singleton intrauterine…
- Trial name
- PREMISE (NCT07796737)
- Testing
- Vaginal Micronized Progesterone (Progesterone Besins), Enoxaparin (Clexane)
- Where
- Czechia
- Volunteers
- 268 people
- Sponsor
- General University Hospital, Prague
Infertility, Assisted Reproductive Technology
Microbiome and Metabolome Profiles in Couples Undergoing IVF and Reproductive Outcomes
This prospective observational cohort study investigates the role of the microbiome and metabolome in couples undergoing in vitro fertilization.
- Conditions
- Infertility, Assisted Reproductive Technology, Pregnancy Complications, Pregnancy Loss, Early
- Trial name
- Mi IVF (NCT07532629)
- Where
- 3 sites in Sweden
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Miscarriage
Interest of a Short Early Psychological Care in Women With Miscarriage
Miscarriage is a very common complication of pregnancy, accounting for 15.3% (95% CI 12.5-18.7%) of diagnosed pregnancies. Miscarriage would affect one in ten women during her lifetime.
- Trial name
- MisTher (NCT05653414)
- Testing
- short early psychological care associated with encouragement of early support consultation with generalist practitioner or midwife, encouragement of early support consultation with generalist practitioner or midwife
- Volunteers
- 932 people, healthy volunteers welcome
- Sponsor
- Université de Reims Champagne-Ardenne
Early Pregnancy Loss, Spontaneous Miscarriage
Interest of Simulation Training on the Announcement of Early Pregnancy Loss on the Psychological Impact of the Patients
Early pregnancy loss (or spontaneous miscarriage) is the loss of a pregnancy before 14 weeks of amenorrhea. Its incidence is estimated at between 10 and 15%, and increases with maternal age.
- Trial name
- MISC-TRAIN (NCT06647849)
- Testing
- centers whose interns receive simulation training in the announcement of early spontaneous miscarriage between the 2 inclusion phases, centers with standard in-house management of spontaneous miscarriage/pregnancy arrested in the emergency department
- Where
- 28 sites in France
- Volunteers
- 607 people
- Sponsor
- University Hospital, Angers
Infertility, Female, Miscarriage
Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?
This study aims to explore the potential correlation between decreased ovarian reserve and previous history of early miscarriage.
- Conditions
- Infertility, Female, Miscarriage, Miscarriage, Recurrent, IVF
- Trial name
- NCT05969574
- Testing
- Transvaginal ultrasound, Blood test AMH
- Where
- 3 sites in United Arab Emirates
- Volunteers
- 2,059 people
- Sponsor
- ART Fertility Clinics LLC
Pregnancy, Abortion Early
Assessment of Early Pregnancy MAB Completion
This is a prospective study to evaluate if successful completion of a medication abortion in patients with very early pregnancy can be detected with a urine pregnancy test at 2 weeks instead of 4 weeks.
- Trial name
- NCT06893484
- Testing
- Weekly high-sensitivity urine pregnancy tests
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Washington
Menstrual Cycles, Conception
Factors Influencing Fertility or Pregnancy Health
Background: The North Carolina Early Pregnancy Study (EPS) was held from 1982 to 1986. Women who were trying to get pregnant took part in the study. They collected urine samples. They kept diaries. They filled out surveys.
- Conditions
- Menstrual Cycles, Conception, Early Pregnancy Loss, Pregnancy Outcomes
- Trial name
- NCT04595760
- Where
- United States
- Volunteers
- 231 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Preeclampsia, Premature Birth
Cohort Study on the Levels of Placental Growth Factor and Nucleosomes in Early Pregnancy and Adverse Pregnancy Outcomes
Objective: This study aims to investigate the association between maternal serum placental growth factor (PLGF) and nucleosome levels in early pregnancy and adverse pregnancy outcomes, and to evaluate their predictive value for…
- Conditions
- Preeclampsia, Premature Birth, Fetal Growth Restriction, Recurrent Miscarriage
- Trial name
- NCT07841197
- Testing
- Measurement of plasma nucleosome and placental growth factor (PLGF) levels
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Early Abortion, Pregnancy Loss, Early
Comparison of Surgical Management of Early Pregnancy Loss by Suction Curettage Versus Hysteroscopy in Patients Undergoing In-vitro Fertilization (IVF)
Early pregnancy loss occurs in ~15% of pregnancies. The treatment options include surgical uterine evacuation by suction curettage, medical management with misoprostol, or conservative management without interventions.
- Trial name
- NCT07143578
- Testing
- Operative hysteroscopy using tissue removal device, suction curettage
- Where
- 2 sites in Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Early Pregnancy
Conversational AI Platform for Early Pregnancy Care City-wide Recruitment: A Feasibility Study
This study seeks to determine pregnant patients in the Philadelphia area can be recruited to a conversational AI texting platform.
- Trial name
- CIRCA (NCT07197892)
- Testing
- CIRCA Texting Platform
- Where
- United States
- Volunteers
- 2,637 people
- Sponsor
- University of Pennsylvania
Missed Abortion, Early Pregnancy Failure
A Real-World Study Comparing the Efficacy of Different Treatment Regimens for Early Missed Abortion
At present, there is no unified standard for the treatment of missed abortion in clinical practice. This study intends to collect clinical data of this type of disease to compare the efficacy of different treatments, and on this…
- Trial name
- NCT07422506
- Testing
- Control group, Conventional dose of estrogen, High-dose estrogen
- Where
- China
- Volunteers
- 580 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Missed Abortion, Early Pregnancy Loss
GPT-Based Digital Assistant Support During Treatment for Induced Abortion or Missed Abortion
We have developed a digital assistant based on GPT (Generative Pre-trained Transformer) technology, trained specifically to provide empathetic, medically accurate, and guideline-based responses in Hebrew, tailored to the clinical…
- Conditions
- Missed Abortion, Early Pregnancy Loss, Abortion in First Trimester, Abortion, Medical
- Trial name
- NCT07856940
- Testing
- GPT-Based Digital Assistant
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Wolfson Medical Center
Miscarriage in First Trimester, Prenatal Genetic Diagnosis
GRACE - Genetic Insights Into Early pRegnancy Loss Using Cell-free fEtal DNA
The aim of this study is to assess the impact of non-invasive prenatal testing right after an early isolated miscarriage on mental health and on the patient's subsequent care in the year following the miscarriage
- Trial name
- GRACE (NCT07639333)
- Testing
- Non invasive prenatal test
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Rennes University Hospital
Abortion, Spontaneous
Vitamin D and Angiogenic Markers in Odense Child Cohort 1
The Vitamin D and Angiogenic Marker Study 1: Vitamin D and angiogenic markers in early pregnancy. Epidemiology and associations to early-pregnancy miscarriage
- Trial name
- VITAM (NCT02434900)
- Where
- Denmark
- Volunteers
- 2,874 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Abortion in First Trimester, Abortion Early
Research on Equity in Abortion Care by TeleHealth
This study will examine the ways in which telehealth for reproductive healthcare affects timing, costs, and follow-up care; whether telehealth reaches people in areas with greater health inequities; and the attributes of…
- Conditions
- Abortion in First Trimester, Abortion Early, Abortion; Attempted
- Trial name
- REACH (NCT06787274)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Early Pregnancy Loss, Intrauterine Adhesion
Operative Hysteroscopy Versus Suction Curettage for Surgical Termination of Early Pregnancy Loss (Miscarriage)
Non-blinded prospective randomized study. 100 women diagnosed with early pregnancy loss up to 10 gestational weeks who opted for surgical management (after being offered the options of conservative management and medical…
- Trial name
- NCT06309927
- Testing
- Operative hysteroscopy (by tissue removal device), Suction curettage
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Early Pregnancy, Early Pregnancy Loss
EARLY-PREG: A Preconception Cohort Study Based on Counterfactuals to Study Maternal-Embryonic Molecular Interactions
EARLY-PREG is an open-cohort clinical study with a preconception, longitudinal, bidirectional and counterfactual design. The aim of this cohort is to investigate the proteomic signatures of maternal-embryonic communication by…
- Conditions
- Early Pregnancy, Early Pregnancy Loss, Childbirth, Healthy
- Trial name
- EARLY-PREG (NCT07358026)
- Testing
- EMBRYO EXPOSURE
- Where
- Chile
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- MELISA Institute Genomics & Proteomics Research SpA