Clinical trials: Abscess, open to volunteers
Liver Abscess, Amoebic Liver Abscess
Efficacy of Diloxanide Furoate as Additional Luminal Agent Along With Metronidazole for the Treatment of Amoebic Liver Abscess
Liver abscess is a common cause of presentation to medical emergency. Among the various causes of liver abscess, Amoebic liver abscess (ALA) is a frequent cause that can resemble pyogenic infections in tropical regions.
- Trial name
- DFALA RCT (NCT07807150)
- Testing
- Diloxanide furoate
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Crohn's Disease
Exclusive Enteral Nutrition Therapy for Active and Complicated Crohn's Disease
The goal of this observational study is to evaluate the effectiveness and safety of exclusive enteral nutrition (EEN) in adults with active Crohn's disease (CD), particularly in patients with complicated disease such as…
- Trial name
- EEN-CD (NCT07504510)
- Testing
- Exclusive Enteral Nutrition
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Brain Abscess
Circulating Cell-Free DNA for Brain Abscess Diagnosis: A Pilot Study
Brain abscess is a severe intracranial infection associated with significant morbidity and mortality. Standard management combines neurosurgical intervention, when feasible, with prolonged intravenous antibiotic therapy.
- Trial name
- METABCES-PoC (NCT07479225)
- Testing
- Plasma Microbial Cell-Free DNA Metagenomic Sequencing
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Grenoble
Abscess
Efficacy of Methylene Blue Photodynamic Therapy for Treatment of Deep Tissue Abscesses
The objective of this Phase 2 study is to evaluate the efficacy of methylene blue photodynamic therapy (MB-PDT) performed at the time of percutaneous abscess drainage for disinfection of deep tissue abscesses.
- Trial name
- NCT06052956
- Testing
- Methylene Blue, Lipid Emulsion, Insertion of optical fiber
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Rochester
Pilonidal Cyst and Sinus Without Abscess, Pilonidal Sinus Disease
The Effect of Local Anesthesia Techniques on Postoperative Pain After Laser Treatment of Pilonidal Sinus
"Assessment of postoperative pain with conventional and tumescent local anesthesia in the laser treatment of pilonidal sinus." The aim of this study is to: examine the possible difference in postoperative pain between two local…
- Conditions
- Pilonidal Cyst and Sinus Without Abscess, Pilonidal Sinus Disease, Pilonidal Sinus Treatment, Laser Ablation
- Trial name
- NCT07408414
- Testing
- local anesthesia using 2% lidocaine, SiLaC, Questionnaire and physical examination
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- Opća županijska bolnica Požega
Peritonsillar Abscess, Peritonsillar Cellulitis
Transoral Ultrasound Versus no Transoral Ultrasound in Diagnostic Workup of Peritonsillar Abscess
Peritonsillar abscess (PTA) is a collection of pus between the palatine tonsil and the constrictor muscle. PTA is detected by recognizing characteristics during clinical examination: redness, pain, malaise, trismus, and…
- Conditions
- Peritonsillar Abscess, Peritonsillar Cellulitis, Tonsillitis
- Trial name
- NCT07577232
- Testing
- Transoral Ultrasound
- Where
- 3 sites in Denmark
- Volunteers
- 368 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pilonidal Cyst Without Abscess
Laser Coagulation of Pilonidal Sinus With/Without Intraoperative Ultrasound Control
LASER COAGULATION OF THE PILONIDAL SINUS WITH INTRAOPERATIVE US CONTROL: PROTOCOL FOR A PROSPECTIVE MULTICENTER RANDOMIZED CLINICAL STUDY.
- Trial name
- LCPSwUsC (NCT07829315)
- Testing
- LASER COAGULATION OF THE PILONIDAL SINUS, LASER COAGULATION OF THE PILONIDAL SINUS WITH ULTRASONIC CONTROL
- Volunteers
- 310 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Perforated Appendicitis
APPI-Cost Trial for Perforated Appendicitis
The purpose of this study to assess the clinical effectiveness and cost-effectiveness of povidone-iodine (PVI) irrigation in perforated appendicitis, to investigate barriers and facilitators to future implementation of PVI…
- Trial name
- NCT06705842
- Testing
- PVI, Usual Care
- Where
- United States
- Volunteers
- 346 people
- Sponsor
- The University of Texas Health Science Center, Houston
Breast Abscess
Evaluation of Non-Surgical Treatment of Breast Abscess
Breast abscess is a localized suppurative complication of breast infection commonly managed by ultrasound-guided needle aspiration combined with antibiotic therapy.
- Trial name
- NCT07777783
- Testing
- Ultrasound-guided needle aspiration and antibiotics
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Brain Abscess, Cerebral Abscess
Partial Oral Antibiotic Treatment for Bacterial Brain Abscess
The investigators aim to determine if oral antibiotics are clinically acceptable as treatment of brain abscess. Following 2 weeks of standard intravenous antibiotic therapy, half of patients will continue with this treatment for…
- Trial name
- ORAL (NCT04140903)
- Testing
- Early transition to oral antibiotics, Standard treatment of intravenous antibiotics
- Where
- 4 sites in Denmark
- Volunteers
- 400 people
- Sponsor
- Henrik Nielsen
Acute, Perforated Appendicitis
Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized Study
The purpose of this study is to determine the effect of intra-abdominal irrigation with povidone-iodine (PVI) versus usual care on the rate of 30-day postoperative intra-abdominal abscesses (IAA) and to determine the effect of…
- Trial name
- PAPPA (NCT04200729)
- Testing
- Irrigation with PVI, Usual care
- Where
- United States
- Volunteers
- 1,750 people
- Sponsor
- The University of Texas Health Science Center, Houston
Perianal Abscess
Study on Dynamic Multimodal Analgesia Regimen Integrated With Traditional Chinese and Western Medicine After Perianal Abscess Surgery
Background:Perianal abscess is a common acute anorectal pyogenic disease (8%-25% of anorectal illnesses), mainly seen in men aged 20-40.
- Trial name
- NCT07744594
- Testing
- TCM sitz bath
- Where
- China
- Volunteers
- 147 people
- Sponsor
- The Affiliated Hospital of Putian University
Central Nervous System Infections, Bacterial Meningitis
Central Nervous System Infections in Denmark
The Danish Study Group of Infections of the Brain is a collaboration between all departments of infectious diseases in Denmark. The investigators aim to monitor epidemiological trends in central nervous system (CNS) infections by…
- Conditions
- Central Nervous System Infections, Bacterial Meningitis, Viral Meningitis, Aseptic Meningitis
- Trial name
- DASGIB (NCT03418441)
- Testing
- Community-acquired CNS infections
- Where
- 8 sites in Denmark
- Volunteers
- 1,900 people
- Sponsor
- Aalborg University Hospital
Chronic Apical Periodontitis, Necrosis of Pulp
Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth
This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (A-PRF+) and i-PRF in…
- Conditions
- Chronic Apical Periodontitis, Necrosis of Pulp, Acute Apical Periodontitis of Pulpal Origin, Periapical Abscess
- Trial name
- NCT07192289
- Testing
- Using advanced platelet-rich fibrin (A-PRF+) or injectable platelet-rich fibrin (i-PRF) in regenerative endodontic treatment in mature permanent teeth.
- Where
- Vietnam
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Perianal Abscess, Anal Fistulas
Multicenter Study for Diagnosis and Treatment of Perianal Abscesses
Drainage of perianal abscesses is a well established treatment. Traditionally its been done in general anesthesia after the swelling has been localised its been drained with a knife.
- Conditions
- Perianal Abscess, Anal Fistulas, Incontinence
- Trial name
- NCT02306382
- Testing
- Perianal abscess drainage, 3D ultrasonography
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- University Hospital, Umeå
Liver Abscess
Empirical Intravenous Beta-Lactam Plus Metronidazole Vs Oral Cefixime Plus Metronidazole for the Treatment of Liver Abscess
Liver abscess (LA) is potentially life threatening medical emergency requiring prompt medical intervention. The backbone of therapy is prompt empirical antimicrobial with or without percutaneous drainage/ aspiration of the…
- Trial name
- NCT06847126
- Testing
- Intravenous beta-lactam antimicrobial for 2 weeks Plus Intravenous Metronidazole (750 mg q 8 hourly) for 2 weeks, Tablet Cefixime (200 mg q 12 hourly) for 2 weeks Plus Tablet Metronidazole (800 mg q 8 hourly) for 2 weeks, Standard medical care
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Lung Adenocarcinoma, Lung Abscess
Evaluation of Different Sizes of Left-Sided Double-Lumen Tubes for Thoracic Surgery in a Tertiary Level Teaching Hospital
Double lumen tubes (DLT) have become standard of care for one lung ventilation in thoracic and esophageal surgeries. Selection of accurate size of DLT is important to achieve proper one lung ventilation, prevent trauma to airway…
- Trial name
- NCT07373171
- Testing
- Intubation of patients undergoing thoracic surgery with left sided double lumen tube
- Where
- Nepal
- Volunteers
- 60 people
- Sponsor
- Tribhuvan University, Nepal
Hidradenitis Suppurativa (Acne Inversa)
HS ABSCESSES: I&D VS PUNCH DEBRIDEMENT
This randomized-control trial is designed to determine the recurrence rate of HS abscesses following drainage via two methods: I\&D with a linear incision and PD with an 8mm punch biopsy.
- Trial name
- HSPUNCH (NCT06731309)
- Testing
- Punch Debridement, Incision and Drainage
- Where
- Netherlands
- Volunteers
- 72 people
- Sponsor
- Erasmus Medical Center
Cerebral Toxoplasmosis
Study of a Cohort of Non-HIV Immunocompromised Patients With Toxoplasmosis at the Strasbourg University Hospital
Toxoplasmosis in HIV-positive individuals is well-studied and has a codified management protocol, which is not the case for other immunodeficiencies, except for recent recommendations in the context of hematopoietic stem cell…
- Trial name
- TOXO (NCT07299500)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Appendicitis
Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon
The investigators aim to determine if early operative intervention is superior to non-operative management for adult patients with computerized tomography (CT)-proven complicated appendicitis with phlegmon or abscess.
- Trial name
- NCT04168866
- Testing
- Operative management, Drainage or antibiotics
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Yale University