Clinical trials: Abscess, active
Brain Abscess, Cerebral Abscess
Partial Oral Antibiotic Treatment for Bacterial Brain Abscess
The investigators aim to determine if oral antibiotics are clinically acceptable as treatment of brain abscess. Following 2 weeks of standard intravenous antibiotic therapy, half of patients will continue with this treatment for…
- Trial name
- ORAL (NCT04140903)
- Testing
- Early transition to oral antibiotics, Standard treatment of intravenous antibiotics
- Where
- 4 sites in Denmark
- Volunteers
- 400 people
- Sponsor
- Henrik Nielsen
Abdominal Abscess
Abdominal aBscess Catheter Sclerotherapy (ABCS)
This is a single center, two arm phase I/II clinical trial exploring the use of chemical sclerosants (ethanol and povidone iodine) in decreasing the time needed for catheter drainage for patients with non-fistulous intraabdominal…
- Trial name
- ABCS (NCT06906029)
- Testing
- Catheter Sclerotherapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Lung Adenocarcinoma, Lung Abscess
Evaluation of Different Sizes of Left-Sided Double-Lumen Tubes for Thoracic Surgery in a Tertiary Level Teaching Hospital
Double lumen tubes (DLT) have become standard of care for one lung ventilation in thoracic and esophageal surgeries. Selection of accurate size of DLT is important to achieve proper one lung ventilation, prevent trauma to airway…
- Trial name
- NCT07373171
- Testing
- Intubation of patients undergoing thoracic surgery with left sided double lumen tube
- Where
- Nepal
- Volunteers
- 60 people
- Sponsor
- Tribhuvan University, Nepal
Spinal Epidural Abscess
Prospective Analysis of Spinal Epidural Abscess
This is a prospective study involving all patients treated at the University of Kentucky for spinal epidural abscess over a 2-year period.
- Trial name
- SEA (NCT05464251)
- Testing
- Prospective chart review of subjects diagnosed with spinal epidural abscess
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Francis Farhadi
Intervention Studies, ASA Physical Status I
Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases
The aim of this clinical trial is to evaluate anti-inflammatory effect of various intracanal medications: 1. Calcium Hydroxide Slurry mixed with 3% Sodium Hypochlorite 2. Calcium Silicate 3.
- Conditions
- Intervention Studies, ASA Physical Status I, Intracanal Medication, Periapical Abscess
- Trial name
- RCT (NCT07641933)
- Testing
- Calcium Silicate Intracanal Medication, Calcium Hydroxide Slurry mixed with Sodium Hypochlorite Intracanal Medication, Calcium Hydroxide (Ca(OH)2) Intracanal Medication
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Laparoscopy, Discharge Planning
Post-discharge Monitoring Initiative on Outcomes of Post-surgical Patients
The investigators are conducting a prospective study to evaluate the SKH@Home programme, a post-discharge monitoring initiative for surgical patients.
- Trial name
- SKH@home (NCT06980402)
- Testing
- Early post-surgical discharge with post-surgical home based monitoring, Standard inpatient care until deemed suitable for discharge
- Volunteers
- 1,000 people
- Sponsor
- Sengkang General Hospital
Periappendicular Abscess
The Treatment of Periappendicular Abscess After the Acute Phase
The PeriAPPAC trial is a prospective randomised study comparing interval laparoscopic appendectomy with follow-up MRI in patients with initially successfully treated periappendicular abscess.
- Trial name
- PeriAPPAC (NCT03013686)
- Testing
- Interval appendectomy, Follow-up with MRI
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Acute Complicated Appendicitis With Peri-appendiceal Abscess or Phlegmon
Peri-appendiceal Abscess and Phlegmon in Acute Complicated Appendicitis Patients
This study aim to analyze the clinical data of patients who underwent emergency appendectomy for acute complicated appendicitis with peri-appendiceal abscess or phlegmon, identify factors influencing the post-operative length of…
- Trial name
- NCT06490185
- Testing
- Clinical data collection
- Volunteers
- 150 people
- Sponsor
- Shanghai Zhongshan Hospital
Breast Abscess
A Phase 2 Study of Methylene Blue Photodynamic Therapy for Treatment of Breast Abscesses
The objective of this Phase 2 study is to evaluate the efficacy of methylene blue photodynamic therapy (MB-PDT) performed at the time of percutaneous breast abscess drainage for disinfection of breast abscesses.
- Trial name
- NCT07179003
- Testing
- Standard of care breast abscess drainage, Methylene Blue, Lipid Emulsion
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Rochester
Brain Abscess
Circulating Cell-Free DNA for Brain Abscess Diagnosis: A Pilot Study
Brain abscess is a severe intracranial infection associated with significant morbidity and mortality. Standard management combines neurosurgical intervention, when feasible, with prolonged intravenous antibiotic therapy.
- Trial name
- METABCES-PoC (NCT07479225)
- Testing
- Plasma Microbial Cell-Free DNA Metagenomic Sequencing
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Grenoble
Intracranial Abscess
Transcranial Sonographic Evaluation of Preterm Neonates Presenting With Seizures and Its Association With IA
This study aimed to evaluate preterm neonates presenting with seizures using transcranial sonography (cranial ultrasound) to detect intracranial abnormalities.
- Trial name
- NCT07051382
- Testing
- Transcranial Sonographic Examination (Cranial Ultrasound)
- Where
- Pakistan
- Volunteers
- 122 people
- Sponsor
- Superior University
Liver Abscess
Empirical Intravenous Beta-Lactam Plus Metronidazole Vs Oral Cefixime Plus Metronidazole for the Treatment of Liver Abscess
Liver abscess (LA) is potentially life threatening medical emergency requiring prompt medical intervention. The backbone of therapy is prompt empirical antimicrobial with or without percutaneous drainage/ aspiration of the…
- Trial name
- NCT06847126
- Testing
- Intravenous beta-lactam antimicrobial for 2 weeks Plus Intravenous Metronidazole (750 mg q 8 hourly) for 2 weeks, Tablet Cefixime (200 mg q 12 hourly) for 2 weeks Plus Tablet Metronidazole (800 mg q 8 hourly) for 2 weeks, Standard medical care
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Pulp Disease, Dental, Pulp Necrosis
Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial
The treatment of pulpal diseases in primary teeth represents a significant challenge in public health, particularly in emergency dental care settings, where factors such as limited clinical time, low child cooperation, and…
- Conditions
- Pulp Disease, Dental, Pulp Necrosis, Pulp Therapy in Primary Molars, Primary Teeth
- Trial name
- CTZ- emergency (NCT07542639)
- Testing
- CTZ Paste, ZOE Pulpectomy
- Volunteers
- 110 people
- Sponsor
- University of Sao Paulo
Wrist-Ankle Acupuncture
Application Effects of Wrist-Ankle Acupuncture in Patients With Different Types of Pain Following Perianal Surgery
This study is a prospective clinical observation designed to evaluate the analgesic effect of wrist-ankle acupuncture in patients with different types of pain after perianal surgery, as well as its applicability.
- Trial name
- NCT07340307
- Testing
- wrist-ankle acupuncture
- Where
- China
- Volunteers
- 58 people
- Sponsor
- The Affiliated Hospital of Putian University
Lung Abscess
Transthoracic Drainage of Lung Abscesses. A National Randomized Trial.
This study aims to investigate if early drainage of lung abscesses, in addition to standard antibiotic treatment, leads to shorter length of hospital stay. Study Design This is a randomized, controlled clinical trial.
- Trial name
- TOLA (NCT07247461)
- Testing
- Transthoracic drainage
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- University of Aarhus
Appendix Abscess, Appendicitis
The Prevalence of Appendiceal Tumours in Periappendicular Abscess
Complicated and uncomplicated appendicitis follow different epidemiological trends also suggesting different pathophysiology behind these two different forms of appendicitis.
- Conditions
- Appendix Abscess, Appendicitis, Appendix Mass, Appendix Cancer
- Trial name
- PeriAPPAC-T (NCT04634448)
- Testing
- Interval appendectomy, Follow-up MRI at 1 year
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Surgical Wound Infection, Traumatic Wound Infection
A Study of Amicidin-β Topical Solution for Patients With a Contaminated or Infected Surgical or Traumatic Wound or Cutaneous Abscess
The goal of this Phase 1 clinical trial is to learn about the safety profile of Amicidin-β topical solution applied directly into contaminated or infected surgical or traumatic wounds or cutaneous abscess during a surgical…
- Conditions
- Surgical Wound Infection, Traumatic Wound Infection, Cutaneous Abscess
- Trial name
- NCT07379684
- Testing
- Amicidin-β topical solution - 15 mL, Amicidin-β topical solution - 50 mL, Standard of Care (SOC)
- Where
- 5 sites in United States
- Volunteers
- 44 people
- Sponsor
- Macro Biologics, Inc.
Pilonidal Cyst Without Abscess
Laser Coagulation of Pilonidal Sinus With/Without Intraoperative Ultrasound Control
LASER COAGULATION OF THE PILONIDAL SINUS WITH INTRAOPERATIVE US CONTROL: PROTOCOL FOR A PROSPECTIVE MULTICENTER RANDOMIZED CLINICAL STUDY.
- Trial name
- LCPSwUsC (NCT07829315)
- Testing
- LASER COAGULATION OF THE PILONIDAL SINUS, LASER COAGULATION OF THE PILONIDAL SINUS WITH ULTRASONIC CONTROL
- Volunteers
- 310 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Primary Spondylodiscitis, Pyogenic Spondylodiscitis
One Year Results of Managing Primary Spondylodiscitis
Primary spondylodiscitis is a severe infectious condition involving the spinal discs and adjacent vertebrae. It often causes significant back pain and requires careful management, typically involving long-term antibiotics and…
- Conditions
- Primary Spondylodiscitis, Pyogenic Spondylodiscitis, Spinal Infection
- Trial name
- NCT07509983
- Volunteers
- 50 people
- Sponsor
- Assiut University
Autoimmune Hepatitis, Primary Sclerosing Cholangitis
Liver-gut Axis Study Through Identification of Liver Disease-specific Microbiome
In this study, we aim to identify gut microbiomes specific to patients with chronic refractory liver disease and to conduct a gut-liver axis study on the pathogenesis and disease progression.
- Conditions
- Autoimmune Hepatitis, Primary Sclerosing Cholangitis, Non-Alcoholic Fatty Liver Disease, Liver Abscess
- Trial name
- LGAS (NCT06519162)
- Where
- South Korea
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chungnam National University Hospital