Clinical trials: Absorption
Healthy Participants
A Study to Assess the Mass Balance and ADME of [14C]AZD5004 and the Absolute Bioavailability of AZD5004
This study in healthy volunteers aims to answer these questions: Does the test medicine cause any important side effects? What are the blood levels of the test medicine and how quickly does the body get rid of it? How much of the…
- Trial name
- NCT06857695
- Testing
- AZD5004 film-coated tablet, [14C]AZD5004 Solution for Infusion, [14C]AZD5004 Oral Solution
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
HCV
Radiolabel ADME (Absorption, Distribution, Metabolism, and Excretion) Study Of [14C] PF-00868554 In Healthy Adult Male Subjects
This is a phase 1 study to assess the routes of elimination of a single oral dose of [14C] PF-00868554 and to characterize the metabolic profile following single dose administration.
- Trial name
- NCT00823745
- Testing
- [14C]-PF-00868554
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Volunteers in Fed and Fasted State
Fed-Fast Crossover Study to Assess the Effect of Food With CTx-1301 in Healthy Subjects
The primary purpose of this study is to assess the effect of food on the rate and extent of absorption and the overall bioavailability of a single dose of CTx-1301 25 mg trimodal tablets in healthy adult volunteers.
- Trial name
- Fed-Fast (NCT04449250)
- Testing
- Dexmethylphenidate
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Cingulate Therapeutics
Muscle, Skeletal
Protein Ingestion and Muscle Carnitine Uptake
The purpose of this study is to assess the effects of a protein-carbohydrate beverage on the absorption of an orally ingested bolus of L-carnitine, compared to flavoured water and carbohydrate-only controls, and to determine…
- Trial name
- NCT02535897
- Testing
- Flavoured water, Flavoured water + carbohydrate, Flavoured water + carbohydrate + protein
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy
Phospholipid Absorption of a Milk Phospholipid
The aim of the study is to investigate parameters of the lipid metabolism in plasma and feces of healthy subjects after a dietary supplementation of different dosages of milk phospholipids.
- Trial name
- NCT01327430
- Testing
- Milk phospholipid
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Jena
Healthy
Imaging the Effect of Experimental Stress on Small and Large Bowel Water During Fructose Absorption
The investigators have been developing new, non-invasive magnetic resonance imaging (MRI) techniques to image the small bowel. Building on those studies the investigators want to study, in healthy volunteers, the effects of…
- Trial name
- NCT01763281
- Testing
- CRH
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy
Study of the Effects of ITCA 650 on Gastric Emptying and Interaction of ITCA 650 on 4 Commonly Studied Drugs
A Phase 1, Fixed-Sequence, Open-label Study in Healthy Subjects to Estimate the Effects of ITCA 650 on Gastric Emptying and on the Absorption Pharmacokinetics of Each of 4 Commonly Studied DDI Probe Compounds.
- Trial name
- NCT02641899
- Testing
- ITCA 650 20/60 mcg/day, Acetaminophen, Atorvastatin
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Intarcia Therapeutics
Diabetes Mellitus Type 1
Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study
Physiology studies will be performed in patients with type 1 diabetes to define during a standardized mixed meal test: 1. The relationship between fast insulin analogue administration by i.v.
- Trial name
- NCT01800734
- Testing
- Clamp-Mixed Meal Arm
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Obesity
Evaluation of the Absorption Rate From Different Oral Fe-supplements in Obese Volunteers Pre- and Post-RYGB
Obese volunteers who have scheduled a gastric bypass (RYGB) in UZ Leuven will be asked to participate in a cross-over study using commercial available iron supplements.
- Trial name
- NCT02569593
- Testing
- Iron supplements, more specific Ferrodyn and Vista Ferrum
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- KU Leuven
Smoking
Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 Menthol (THS 2.2 Menthol).
The primary objective of this clinical study is to evaluate the pharmacokinetic (PK) profile (rate and amount of nicotine absorbed) following a single use of the THS 2.2 Menthol (mTHS), a candidate Modified Risk Tobacco Product…
- Trial name
- NCT01967706
- Testing
- mTHS, mCC, NRT
- Where
- Japan
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Mechanically Ventilated Neonates, Painful Procedures in Newborns
Codeine in Mechanically Ventilated Neonates
The purpose of this study is to determine the absorption and bioavailability of codeine in relation to postnatal (PNA) and postconceptional (PCA) age; determine the parent drug (codeine), its active metabolites, their formation…
- Trial name
- NCT01322204
- Testing
- Codeine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Healthy Female Participants
A Study to Evaluate the Metabolism, the Routes and Extent of Elimination, and Drug Levels of [14C]Navlimetostat (BMS-986504) in Healthy Female Participants
The purpose of this study is to evaluate the metabolism, the routes and extent of elimination, and drug levels of [14C]Navlimetostat (BMS-986504) in healthy female participants
- Trial name
- NCT07777133
- Testing
- Navlimetostat, [14C]Navlimetostat
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Malnourished Children
Zinc Absorption From Zinc Biofortified Rice
a. To measure the amount of zinc absorbed from ZnBfR compared with the amount absorbed from CR and from CR fortified with added zinc, using the triple stable isotope tracer ratio technique in young children.
- Trial name
- NCT01346722
- Testing
- Diet-ZnBfR, Diet- CR, CR + Zn
- Where
- Bangladesh
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Prediabetes, Obesity & Overweight
Postprandial Glucose Kinetics After Carbohydrate Restriction
The goal of this study is to test whether a low-carbohydrate diet (LCD), comparred with a Mediterranean diet (MED) producing similar weight loss, differentially affects fasting and postprandial glucose metabolism in individuals…
- Conditions
- Prediabetes, Obesity & Overweight, Diet Interventions, Carbohydrate Metabolism
- Trial name
- NCT07802275
- Testing
- Low-carbohydrate diet, Mediterranean Diet
- Where
- Italy
- Volunteers
- 29 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Healthy Subjects, Pharmacokinetics of YM178
A Study to Assess Pharmacokinetic Interaction of Multiple Dose Ketoconazole on Single Dose YM178 Oral Controlled Absorption System (OCAS) in Healthy Adult Volunteers
The purpose of this study is to assess the pharmacokinetic interaction of multiple-dose ketoconazole on single-dose YM178 OCAS and the safety and tolerability of YM178 OCAS alone and in combination with ketoconazole in healthy…
- Trial name
- NCT01476800
- Testing
- YM178 OCAS, Ketoconazole
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Refeeding Syndrome, Cancer of the Head and Neck
Absorption of Orally Ingested Phosphate in Refeeding Syndrome
A phosphate supplement is part of the treatment of patients with the refeeding syndrome (RFS). It is not known, if the generalized edema also affects the intestine to decrease absorption.
- Trial name
- NCT02880072
- Testing
- phosphate orally
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Jens Rikardt Andersen
Cataract
Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs
Based on previous results with eyes without filtering blebs, the aqueous concentrations of ofloxacin and levofloxacin will exceed the concentration of ciprofloxacin after either topical or topical plus oral administration.
- Trial name
- NCT00392275
- Testing
- Ofloxacin 0.3%, Ciprofloxacin 0.3%, Levofloxacin 0.5%
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Indiana University
Prevention of Surgical Site Infections
Tumescent Antibiotic Delivery Pharmacokinetics
Tumescent Antibiotic Delivery (TAD) is a technique for improving the prevention of surgical site infections (SSI). TAD involves the subcutaneous infiltration of tumescent local anesthesia (TLA) containing water soluble…
- Trial name
- NCT01046981
- Testing
- Tumescent Antibiotic Delivery of cefazolin with or without metronidazole, Intravenous Antibiotic Delivery
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Klein, Jeffrey A., M.D.
Glaucoma Open-Angle Primary, Ocular Hypertension
Open-Label Study of Safety of H1337 in Healthy Volunteers
The trial will evaluate the safety of one dose regimen of H-1337 [1% twice daily (b.i.d.)] in both eyes in healthy volunteers.
- Trial name
- NCT06572397
- Testing
- H-1337 1.0%
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- D. Western Therapeutics Institute, Inc.
Osteoporosis
A Study to Estimate the Effect of Formulation on the Relative Absorption of SB-751689 Administered to Healthy Women
This study will examine the effects of formulation on the relative bioavailability of SB-751689 (400 mg) administered to healthy postmenopausal women.
- Trial name
- NCT00540878
- Testing
- SB-751689 oral tablets (400 mg)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline