Clinical trials: Abuse, Drug
Marijuana Use, Opioid Use
Reinforcing Effects of Marijuana and Opioids
The primary goals of this study are to examine 1) marijuana modulation of oxycodone self-administration and 2) oxycodone modulation of marijuana self-administration, under controlled conditions and across a range of doses for…
- Trial name
- NCT05485012
- Testing
- Marijuana, Opioid
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Shanna Babalonis, PhD
Alzheimer's Disease, Huntington's Disease
A Study To Evaluate The Abuse Potential Of Single Oral Doses Of Dimebon (Latrepirdine) In Healthy Recreational Polydrug Users
Dimebon will not exhibit abuse potential when compared to placebo or a positive control (alprazolam).
- Trial name
- NCT00975481
- Testing
- dimebon, alprazolam
- Volunteers
- 36 people
- Sponsor
- Pfizer
Alcohol-Related Disorders, Anxiety Disorders
Psychosocial and Medication Treatment for Anxiety in Alcoholism
The proposed project is written as a "typical clinical practice" test and is a fully-controlled trial of a combined anxiety-focused CBT and pharmacotherapy (venlafaxine; CBT-VEN) delivered for patients with comorbid alcohol-use…
- Trial name
- NCT00248612
- Testing
- Venlafaxine, CBT, Progressive muscle relaxation therapy (PMR)
- Where
- 2 sites in United States
- Volunteers
- 162 people
- Sponsor
- Boston Medical Center
Cocaine Dependence, Cocaine Abuse
Quetiapine for the Reduction of Cocaine Use
This placebo-controlled trial will test the effectiveness of Seroquel XR™ for the treatment of cocaine dependence in non-psychotic individuals who are cocaine dependent.
- Conditions
- Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Drug Abuse
- Trial name
- AZC (NCT00631748)
- Testing
- quetiapine fumarate, Cognitive-behavioral Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Opioid-Related Disorders, Opiate Dependence
Treatment of Opioid Dependent Patients With Suboxone: Acceptability & Safety Data From Real Life Scenario (Study P05603)
The aim of this post marketing surveillance study is to investigate the retention rate after 12 months of drug dependence treatment with SUBOXONE® (buprenorphine plus naloxone) of opioid dependent patients under real life…
- Conditions
- Opioid-Related Disorders, Opiate Dependence, Drug Abuse
- Trial name
- NCT00723749
- Testing
- Buprenorphine/Naloxone
- Volunteers
- 384 people
- Sponsor
- Indivior Inc.
Attention Deficit Disorder With Hyperactivity, Conduct Disorder
Brain Indices of Stimulant Treatment in Drug-Naive Youth at Risk for Substance Use Disorder
Childhood ADHD and comorbid oppositional defiant disorder (ODD) and conduct disorder (CD) are considered risk factors for subsequent substance abuse, and youth with both ADHD and ODD/CD are at greatest risk.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Conduct Disorder, Substance Abuse
- Trial name
- NCT04170738
- Testing
- Adderall
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Jeffrey Newcorn
Cannabis Dependence
A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana
This study is investigating how N-Acetylcysteine (NAC), an over-the-counter medication, will reduce marijuana use when combined with Contingency Management, a behavioral treatment.
- Trial name
- NCT01005810
- Testing
- N-Acetylcysteine, Contingency Management
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Medical University of South Carolina
Marijuana Abuse
The Effect of Prescription Medications in Marijuana Users
A subset of heavy marijuana users have trouble quitting marijuana use and the number of those seeking treatment for problems related to marijuana is increasing.
- Trial name
- NCT00893074
- Testing
- Dronabinol 30mg/day, Dronabinol 60mg/day, Dronabinol 120mg/day
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Opioid Abuse, Opioid Dependence
Drug Interaction and Subjective Effects of Compounds for Opioid Use Disorder
The overall goal of this project is to develop initial human data on effects of novel compounds on safety (interactions with oxycodone) and efficacy (subjective response to oxycodone) in non-treatment seeking opioid use disorder…
- Conditions
- Opioid Abuse, Opioid Dependence, Opioid-Related Disorders, Opioid Use
- Trial name
- NCT03143855
- Testing
- Lorcaserin
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Virginia Commonwealth University
Substance-Related Disorders
Interactive Motivational Media for Perinatal Drug Abuse - 3
Interactive Motivational Media for Perinatal Drug Abuse
- Trial name
- NCT00230048
- Testing
- Brief computer-delivered intervention
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Wayne State University
HIV, Hepatitis Virus
Feasibility of Interventions on People Who Inject Drugs in Vietnam
This study aims at assessing the feasibility of implementing an interventional cohort of people who inject drugs in Haiphong, Viet Nam.
- Conditions
- HIV, Hepatitis Virus, Substance Abuse
- Trial name
- DRIVE-IN (NCT02573948)
- Testing
- no intervention is assessed
- Where
- Vietnam
- Volunteers
- 603 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Vitiligo, Depressive Episode
Mental Health Associations With Vitiligo
This cohort study is a large population-based study in the UK to determine the risks of comorbid mental health conditions (including depression, anxiety and other potential psychological complications of vitiligo) in adults with…
- Conditions
- Vitiligo, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorders
- Trial name
- NCT04953338
- Testing
- Exposure of mental health condtion of interest
- Where
- United Kingdom
- Volunteers
- 36,104 people, healthy volunteers welcome
- Sponsor
- Momentum Data
Substance Abuse, Intravenous, HIV
Change the Cycle: An RCT to Prevent Injection Initiation
The study will test the efficacy of a hour long, one-on-one, active listening counseling session (called Change the Cycle or CTC) aimed at reducing behaviors among active people who inject drugs (PWID) that research has found to…
- Conditions
- Substance Abuse, Intravenous, HIV, Heroin Dependence, Opioid Dependence
- Trial name
- CTC (NCT02774954)
- Testing
- Change the Cycle
- Where
- 2 sites in United States
- Volunteers
- 979 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Tobacco Use
Sugars in Cigarettes
The aim of this study is to investigate the impact of sugar levels in cigarette tobacco on cigarette abuse liability and appeal.
- Trial name
- NCT05308316
- Testing
- Cigarettes with added sucrose
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Substance Use, Substance Abuse
Family Engagement, Cross-System Linkage to Substance Use Treatment for Juvenile Probationers -- Phase 3
Developed from adapting and combining two evidence-based programs, Project CONNECT (a linkage-to-services program that targets barriers within the probation and substance abuse treatment systems) and TIES (a program that teaches…
- Conditions
- Substance Use, Substance Abuse, Substance Use Disorders, Substance-Related Disorders
- Trial name
- NCT03048552
- Testing
- Family CONNECT
- Volunteers
- 22 people
- Sponsor
- New York State Psychiatric Institute
Mental and Behavioral Disorders Due to Harmful Drug Use
HealthCall:Brief Intervention to Reduce Non-injecting Drug Use in HIV Primary Care Clinics
Among HIV-infected individuals, non-injection drug use (NIDU) is associated with poor HIV medication adherence, greater HIV/AIDS risk behaviors, and increasing non-AIDS mortality.
- Trial name
- NCT01312181
- Testing
- HealthCall and Motivational Interviewing, Motivational Interviewing (MI), HIV/AIDS health education
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Abuse of Anabolic Steroids
Intranasal Delivery of Testosterone and Its Effect on Doping Markers
Hypothesis: Intranasal administration of exogenous testosterone results in a characteristic profile during anti-doping testing, which is different than the profile seen when testosterone is administered into muscle, on skin or…
- Trial name
- Intranasal (NCT02611154)
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Utah
Marijuana Dependence
Nicotine Patch for Marijuana Withdrawal
The purpose of this 3-year trial is to test the efficacy of transdermal nicotine patch versus placebo patch on marijuana withdrawal symptoms in cannabis-dependent individuals, using a randomized, double-blind, and…
- Trial name
- NMW (NCT01400243)
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Southern Illinois University Carbondale
Alcohol Abuse, Schizophrenia
Contingency Management of Alcohol Abuse in the Severely Mentally ILL
The investigators will evaluate the efficacy of a comprehensive 12-week contingency management intervention for treating alcohol dependence for persons with severe mental illness who are seen within the context of a community…
- Conditions
- Alcohol Abuse, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- CMETG (NCT01567943)
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- University of Washington
Substance-Related Disorders
Rapid HIV Testing and Counseling in Drug Abuse Treatment
This is a randomized controlled clinical trial in which adults receiving drug abuse treatment will be recruited to participate in a multi-center HIV testing and counseling study.
- Trial name
- NCT00809445
- Testing
- On-site HIV rapid test and brief, prevention counseling, On- site HIV rapid test & information, Referral for off-site HIV testing
- Where
- 12 sites in United States
- Volunteers
- 1,281 people
- Sponsor
- University of Miami