Clinical trials: Abuse
Alcohol Use Disorder, Alcohol Dependence
Tech-Enabled CM for AUD at Scale
This Phase II Small Business Innovative Research (SBIR) project is a clinical effectiveness and cost-effectiveness random controlled trial (RCT) of DynamiCare Health's innovative smartphone/smart debit card remote digital…
- Conditions
- Alcohol Use Disorder, Alcohol Dependence, Drug Dependence
- Trial name
- NCT04581499
- Testing
- DynamiCare Motivation Support Program, Untreated or Routine Care Control Group
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- DynamiCare Health
Substance Abuse
Efficacy of Centervention-ATOD: An Implementation Tool for Dissemination of Evidence-based Programs for Substance Abuse
The pilot test of Centervention-ATOD, a customizable suite of online tools specifically designed to support quality implementation and sustainability of any ATOD-EBP within real-world service settings, will evaluate whether the…
- Trial name
- CV-ATOD (NCT03084406)
- Testing
- Centervention-ATOD (CV-ATOD)
- Where
- United States
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- 3-C Institute for Social Development
Healthy Volunteers
A Study of Soticlestat in Healthy Adult Nondependent Recreational Drug Users With Central Nervous System (CNS) Depressant Experience
The main aim is to evaluate the relative abuse potential of soticlestat in healthy adults who has used central nervous system (CNS) depressants for recreational nontherapeutic reasons.
- Trial name
- NCT05602818
- Testing
- Soticlestat 300 mg, Soticlestat 600 mg, Soticlestat 900 mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Takeda
Abuse, Drug
A Trial to Evaluate the Abuse Potential of 3 Doses of GRT6005 in Adult Non-dependent Recreational Opioid Users
The primary objective of this study was to evaluate the abuse potential of single doses of cebranopadol (GRT6005) relative to hydromorphone (immediate-release formulation [IR] and placebo in 48 non-dependent recreational opioid…
- Trial name
- NCT03757559
- Testing
- Cebranopadol 100 micrograms, Cebranopadol 400 micrograms, Hydromorphone hydrochloride 4 milligrams
- Where
- Canada
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Tris Pharma, Inc.
Smoking, Tobacco Use
Modern Nicotine Oral Product Abuse Liability
This is a two-site, open-label, randomized, 8-way cross-over study designed to evaluate elements of abuse liability (AL) including subjective effects and physiological measures (pharmacodynamics [PD]) and plasma nicotine uptake…
- Trial name
- NCT06777784
- Testing
- Product A, Product B, Product C
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Cannabis Abuse
Drug-Drug Interaction Between THC and AEF0117
This trial is a single center, double blind, placebo-controlled trial in healthy male and female recreational cannabis users with placebo and AEF0117 dosed in a fixed sequence.
- Trial name
- DDI (NCT06395688)
- Testing
- 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aelis Farma
Smoking Behaviors, Smoking ( Cigarette)
A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System Product
This will be a randomized, open-label, 2-way crossover, single-site study designed to evaluate elements of abuse liability (AL), including subjective effects and physiological measures (pharmacodynamics [PD]), and plasma nicotine…
- Conditions
- Smoking Behaviors, Smoking ( Cigarette), Tobacco Use, Abuse Liability
- Trial name
- NCT07881848
- Testing
- Menthol 5%, Combustible cigarette
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Healthy
Abuse Potential of Gabapentin Taken Orally Concomitantly With Oxycodone Hydrochloride in Healthy, Non-Drug-Dependent, Recreational Opioid Users
The purpose of the present study is to assess prospectively the abuse potential of gabapentin when taken with and without oxycodone compared to placebo in healthy non-drug-dependent recreational opioid drug users under fasted…
- Trial name
- NCT07813026
- Testing
- Oxycodone 20mg, gabapentin 600 mg, Gabapentin 1200mg
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Viatris Inc.
Cocaine Abuse
ALK33BUP-101: Safety and Pharmacodynamic Effects of ALKS 33-BUP Administered Alone and When Co-administered With Cocaine
The purpose of this study is to assess the safety and tolerability of ALKS33-BUP when administered to opioid-experienced cocaine abusers.
- Trial name
- NCT01366001
- Testing
- ALKS 33-BUP, ALKS 33
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Alkermes, Inc.
Healthy Non-dependent, Recreational Sedative Users, Abuse Potential
A Study to Determine the Abuse Potential of Seltorexant Compared to Suvorexant and Zolpidem
The purpose of this study is to evaluate the abuse potential of seltorexant compared to placebo and two active comparators (zolpidem and suvorexant) in non-dependent, recreational sedative users.
- Trial name
- NCT05106153
- Testing
- Suvorexant, Zolpidem, Seltorexant
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders
Study to Evaluate the Likeability, Safety, and Abuse Potential of NRP 104 in Adults With Histories of Stimulant Abuse
This research is being done to evaluate if NRP104 is a safe drug. The other purpose is to learn if NRP104 produces a high and any other effects like amphetamine and other stimulant drugs that are abused.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00248092
- Testing
- NRP104
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- New River Pharmaceuticals
Opioid Abuse
Study of the Relative Abuse Potential of Acurox Tablets in Non-Dependent Recreational Opioid Users
The primary objective of this study is to compare the relative abuse potential of two different doses of orally administered Acurox Tablets to orally administered immediate-release (IR) oxycodone HCl tablets in non-dependent…
- Trial name
- NCT01030406
- Testing
- 40/0mg taken first, 80/0mg taken first, 40/240mg taken first
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Acura Pharmaceuticals Inc.
ADHD, Narcolepsy
Pilot Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Abuse Liability of an Abuse-Deterrent Immediate-Release Formulation (ADAIR)
This is a pilot randomized, double-blind, active-controlled, 2-treatment, crossover study to evaluate the PK, user experience and abuse liability of manipulated ADAIR compared to a manipulated commercially-available d-amphetamine…
- Trial name
- NCT04232644
- Testing
- ADAIR 10mg IR capsules, Crushed d-amphetamine sulfate IR tablets
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vallon Pharmaceuticals, Inc.
Methamphetamine-dependence, Methamphetamine Abuse
Multiple-Dose Study to Evaluate the Safety and Efficacy of IXT-m200
This Phase 2 study will evaluate the safety and efficacy of monthly intravenous doses of IXT-m200 in treatment-seeking individuals with methamphetamine (METH) use disorder.
- Trial name
- OUTLAST (NCT05034874)
- Testing
- IXT-m200
- Where
- 9 sites in United States
- Volunteers
- 61 people
- Sponsor
- InterveXion Therapeutics, LLC
Recreational Drug Use, Prescription Drug Abuse (Not Dependent)
A Study of the Abuse Potential of Lasmiditan in Participants Who Are Recreational Drug Users
The purpose of this study is to assess the abuse potential of study drug lasmiditan. Lasmiditan will be compared to a marketed benzodiazepine, alprazolam (positive control), as well as to placebo (dummy substance that looks like…
- Trial name
- NCT03286218
- Testing
- Lasmiditan, Alprazolam
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Chronic Pain
CANPAIN Feasibility Study Pragmatic Real World Trial Investigating CBMP in Chronic Pain Patients
The CANPAIN study has been devised to evaluate the efficacy and safety of a defined cannabis based medicinal product (CBMP) delivered by inhalation to patients with non cancer chronic pain attending a private clinic.
- Trial name
- CANPAIN (NCT05288010)
- Testing
- Cannabis
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Harley Street (CPC) Limited
Healthy Non-dependent, Recreational Sedative Users
Abuse Potential of Oral Gabapentin in Healthy, Non-Drug-Dependent Individuals With Recreational Sedative Drug Use Experience
The purpose of the present study is to assess prospectively the abuse potential of gabapentin compared to placebo and alprazolam in healthy non-drug-dependent recreational sedative drug users under fasted condition.
- Trial name
- NCT07777965
- Testing
- Alprazolam (Xanax), Gabapentin (Neurontin® (Registered Trademark))
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Viatris Inc.
Abuse Physical Battered Woman Syndrome
Impact of Women's Empowerment Program for Abused Pregnant Women
Although domestic violence is recognized as major threat in pregnancy, there is no intervention has been developed or test to support women in India.
- Trial name
- NCT01933555
- Testing
- Empowerment Program
- Where
- India
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Macmillan Research Group UK
Abuse Potential
An Abuse Potential Study of Orally Administered HORIZANT in Healthy, Non-dependent, Recreational Drug Users
The purpose of this study is to assess the abuse potential of gabapentin enacarbil in healthy adult, non-dependent, recreational drug users.
- Trial name
- NCT06097676
- Testing
- Alprazolam 2 mg, Gabapentin Enacarbil Immediate Release (GE-IR) 200 mg, Gabapentin Enacarbil Immediate Release (GE-IR) 450 mg
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Arbor Pharmaceuticals, Inc.
Drug Abuse
An Explorative Pilot Study of a New Mobile Phone Application Measuring Eye Parameters of Eyes in Patients With SUD
This will be a pre-market, explorative, early feasibility, pilot, controlled clinical investigation designed to collect initial clinical data for Previct Drugs.
- Trial name
- NCT05737550
- Testing
- Previct Drugs
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Kontigo Care AB