Clinical trials: Abuse Liability
Electronic Cigarette Use
Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With Use of RELX ENDS Products by Smokers
This study is being conducted to evaluate nicotine uptake and exposure, the abuse liability, and puffing topography associated with the use of an electronic nicotine delivery system ENDS with tobacco- and menthol-flavored…
- Trial name
- NCT04640285
- Testing
- RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, Usual Brand Cigarette
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Cheerain HK Limited
Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders
Study to Evaluate the Likeability, Safety, and Abuse Potential of NRP 104 in Adults With Histories of Stimulant Abuse
This research is being done to evaluate if NRP104 is a safe drug. The other purpose is to learn if NRP104 produces a high and any other effects like amphetamine and other stimulant drugs that are abused.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00248092
- Testing
- NRP104
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- New River Pharmaceuticals
Tobacco Use
Evaluation of the Abuse Liability of Very Low Nicotine (VLN) Cigarettes
This study is designed to evaluate the abuse liability of very low nicotine cigarettes compared to nicotine gum and usual brand cigarettes
- Trial name
- NCT03559751
- Testing
- VLN cigarettes (A), Usual Brand Cigarettes (B), Nicotine gum (C)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- 22nd Century Group, Inc.
Narcotic Abuse, Opioid-related Disorders
Abuse Potential Assessment of Intranasally Administered EMBEDA Compared To Morphine Sulfate Controlled Release And Placebo
This was a single-dose, randomized, double-blind, placebo-controlled, 3 way crossover study designed to evaluate the relative abuse potential of crushed EMBEDA® compared to morphine sulfate CR tablets and placebo in healthy male…
- Conditions
- Narcotic Abuse, Opioid-related Disorders, Analgesia, Chronic Pain
- Trial name
- NCT01595867
- Testing
- EMBEDA - morphine sulfate/ naltrexone hydrochloride, morphine sulfate CR crushed.
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Pfizer
Smoking, Tobacco Use
CSD201001: Study to Assess Elements of Abuse Liability for Three Nicotine Pouches
This is a two-site, open-label, randomized, 5-way cross-over study designed to evaluate elements of abuse liability (AL) including subjective effects and physiological measures (pharmacodynamics [PD]) and plasma nicotine uptake…
- Conditions
- Smoking, Tobacco Use, Tobacco Smoking
- Trial name
- NCT05129657
- Testing
- Product A, Product B, Product C
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Healthy Volunteers
A Study of the Abuse Liability Potential of Samidorphan in Healthy, Non-Dependent, Recreational Opioid Users
The purpose of this study is to evaluate the abuse potential and safety of samidorphan in healthy, non-dependent, adult, recreational opioid users.
- Trial name
- NCT02218021
- Testing
- Samidorphan, Oxycodone
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Alkermes, Inc.
Abuse Potential
Evaluating the Abuse Potential of NEURONTIN® When Taken Orally in Healthy Non-drug Dependent Participants With Sedative Drug Abuse Experience
This will be a randomized, double-blind, double-dummy, placebo- and active controlled, 5 treatment, 10 sequence, 5 period crossover single dose, Williams square design study in healthy adult, non drug dependent male and female…
- Trial name
- NCT04570436
- Testing
- gabapentin 600 mg, gabapentin 1200 mg, gabapentin 1800 mg
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Viatris Specialty LLC
Smoking, Smoking Behaviors
Abuse Liability for Five Modern Oral Nicotine Products
This is a two-site, open-label, randomized, 4-way (2 arm) cross-over study designed to evaluate elements of abuse liability (AL) including subjective effects and physiological measures (pharmacodynamics [PD]) and plasma nicotine…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT07132814
- Testing
- Product A, Product B, Product C
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- RAI Services Company