Clinical trials: Abuse Tobacco
Heroin Dependence, Nicotine Dependence
Pioglitazone for Heroin and for Nicotine Dependence
The goal of the proposed research is to improve the effectiveness of treatments for opioid and for nicotine dependence by testing a novel pharmacological strategy.
- Trial name
- NCT01395797
- Testing
- PIO
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Substance Related Disorder, Nicotine Dependence
Effects of Nicotine on Elements of Attentions in Smokers and Nonsmokers
Background: Many cigarette smokers claim that smoking helps them stay alert and improves their concentration, and have reported problems in attention and concentration after quitting smoking.
- Trial name
- NCT01034020
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Use, Smoking
A Facebook Intervention for Young Sexual and Gender Minority Smokers
The 2-year research plan will test the Put It Out Project (POP) in a pilot randomized trial (N=120) compared to TSP and two historical control conditions.
- Conditions
- Tobacco Use, Smoking, Tobacco Dependence, Tobacco Use Disorder
- Trial name
- POP (NCT03259360)
- Testing
- POP:, TSP:
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders
While the prevalence of smoking in the United States general population has declined over the past 50 years, there has been little to no decline among people with mental health conditions.
- Trial name
- NCT04090879
- Testing
- Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Brown University
Tobacco-Use Disorder, Schizophrenia
Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke
Many individuals with schizophrenia smoke cigarettes. Individuals in the schizophrenic population often find it difficult to quit smoking.
- Conditions
- Tobacco-Use Disorder, Schizophrenia, Psychotic Disorders
- Trial name
- NCT00307203
- Testing
- bupropion SR, Cognitive Behavioral Group Therapy, nicotine replacement therapy
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Addiction
Nicotinic Receptor Levels After Stopping Smoking
This positron emission tomography (PET) study examines the effects of 24 hours abstinence from smoking on return to availability of neuronal nicotinic receptors in slow and fast metabolizers of nicotine.
- Trial name
- NCT01704573
- Testing
- 2-[18F]-fluro-3-[2(S)-2-azethidinylmethoxy]-pyridine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Nicotine Dependence
Incentives to Promote Smoking Cessation in Low SES Women
The purpose of this study is to investigate the feasibility of a mobile-phone based contingency management (CM) intervention for smoking in low-SES women.
- Trial name
- ProjectMIST (NCT03173274)
- Testing
- Brief Motivational Intervention, Contingency Management, Non-Contingent Reinforcement
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Brown University
Tobacco Use
Evaluation of Abuse Liability of Very Low Nicotine (VLN) Mentholated Cigarettes
This study is designed to evaluate the abuse liability of mentholated very low nicotine cigarettes compared to nicotine gum and usual brand cigarettes.
- Trial name
- NCT03559725
- Testing
- VLN menthol cigarettes (A), Usual Brand Menthol Cigarettes (B), Nicotine gum (C)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- 22nd Century Group, Inc.
Electronic Nicotine Delivery System Flavors
Potential Effects of Electronic Nicotine Delivery System Flavor Regulations on African American Menthol Smokers
This study aims to better understand how the availability of electronic nicotine delivery system (aka electronic cigarettes) flavors (e.g., menthol, tobacco) impacts tobacco use behaviors, toxicant exposure, and abuse liability…
- Trial name
- RVA Flavors (NCT05023096)
- Testing
- Tobacco product administration and assessment
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Nicotine Dependence, Nicotine Vaping
Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine
In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic.
- Trial name
- NCT05962229
- Testing
- (S)-Nicotine, (R)- nicotine, Racemic nicotine
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Use Disorder
Effects of Mindfulness Meditation in Virtual Reality on Craving and Smoking Cessation
Investigators seek to propose a non-drug therapeutic alternative, namely a mindfulness meditation protocol based on virtual reality training in order to induce progressive modifications of various indicators of craving.
- Trial name
- VIREAMIND (NCT05766553)
- Testing
- Virtual reality pod, nicotine patches and chewing gum
- Where
- 3 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Henri Laborit
Tobacco Use Disorder
Increasing Smoking Cessation Success Through Sleep-amplified Memory Consolidation
The goal of this subproject is to examine the hypothesized improvement of treatment with chess-based training and sleep enhancement, both together and on their own, in smokers.
- Trial name
- NCT05726045
- Testing
- Standard smoking cessation program (SCP), Cognitive remediation treatment (CRT), High-intensity interval training (HIIT evening)
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Nicotine Dependence
Doctors' Perspective on Tobacco Addiction
ABSTRACT Aim: Our study aimed to determine the approaches of our physicians to the smoking habits of their patients other than those with pulmonary diseases.
- Trial name
- NCT06163872
- Testing
- survey study
- Where
- Turkey (Türkiye)
- Volunteers
- 941 people
- Sponsor
- Karadeniz Technical University
Nicotine Addiction
Nicotine Reinforcement and Aversion in Young Adult Light Smokers
The proposed study will examine the threshold for nicotine self-administration (NSA) using five different nicotine doses in young adult male and female non-dependent smokers (light and intermittent smokers or LITS).
- Trial name
- NCT01495819
- Testing
- Saline, Nicotine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Yale University
Tobacco Dependence, Smoking
Bupropion SR Plus Counseling for Smoking Cessation
The purpose of this study was to determine if bupropion plus counseling was more effective than bupropion alone or counseling alone in helping smokers quit smoking.
- Trial name
- NCT01621009
- Testing
- Active bupropion + counseling, Active bupropion, No counseling
- Where
- United States
- Volunteers
- 463 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Nicotine Dependence
The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence
The advent of electronic cigarette (e-cigarette) technologies represents one of the most significant developments in the last several decades, and provides a novel and promising strategy for substantially reducing the morbidity…
- Trial name
- Ecig1 (NCT02590393)
- Testing
- E-cigarettes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Nicotine Dependence
Brain Reaction to Treatment of Nicotine Dependence
The purpose of the study was to determine how the treatments for cigarette craving work. Hypothesis: During exposure to cigarette-related cues, heavy smokers will have greater reductions in regional brain activation from before…
- Trial name
- NCT00108173
- Testing
- Zyban
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- US Department of Veterans Affairs
Nicotine Use Disorder
Neural Basis of Eating Behavior in Abstinent Smokers
The purpose of this research study is to better understand why people gain weight when they quit smoking by examining food intake and changes in brain activity in smokers when they are smoking as usual compared to when they have…
- Trial name
- SIT (NCT03438188)
- Testing
- Practice Quit Attempt
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tobacco Use Behavior, Nicotine Dependence Tobacco Product
§SMOKE Nicotine and Tobacco Youth Cohort
The §SMOKE Cohort Study aims to improve understanding of tobacco and nicotine use among adolescents and young adults in Denmark.
- Conditions
- Tobacco Use Behavior, Nicotine Dependence Tobacco Product, E-Cigarette Use, Smoking ( Cigarette)
- Trial name
- NCT07910331
- Where
- Denmark
- Volunteers
- 10,000 people
- Sponsor
- University of Southern Denmark
Tobacco Use Cessation, Smoking Cessation
Treating Low-Income Smokers in the Hospital Emergency Department
This study will test the effectiveness of an Emergency Department (ED) initiated tobacco intervention which includes counseling and medication.
- Conditions
- Tobacco Use Cessation, Smoking Cessation, Smoking, Tobacco Use Disorder
- Trial name
- NCT01328431
- Testing
- Brief Intervention with NRT Initiation
- Where
- United States
- Volunteers
- 780 people
- Sponsor
- Yale University
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