Clinical trials: Abuse Tobacco
Nicotine Dependence, Smoking Cessation
A Safety and Cognitive Function Study of EVP-6124 Versus Placebo in Subjects With Nicotine Dependence
This study is designed to evaluate the initial evidence for efficacy of the investigational medicine, EVP-6124, to improve smoking cessation outcomes with and without a standard taper of nicotine replacement therapy (NRT) in…
- Trial name
- NCT01480232
- Testing
- EVP-6124, NicoDerm Patch (Active), Brief Supportive and Behavioral Treatment
- Where
- United States
- Volunteers
- 345 people
- Sponsor
- A. Eden Evins
Tobacco Use Cessation, Tobacco Use Disorder
Text Messaging for Supporting Quit Attempts
This study is a preliminary research aimed to compare the feasibility and effectiveness of motivational interview (MI), Personalized text messages (TM) and usual care for outpatients, with focus on smoking cessation as the main…
- Trial name
- NCT02571244
- Testing
- Motivational Interview plus text message
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Federal University of Juiz de Fora
Nicotine Dependence
Sensitivity to Intravenous Nicotine: Genetic Moderators
To determine if the mu opioid receptor gene (OPRM1) A118G polymorphism moderates the subjective-rewarding effects of intravenous (IV) nicotine in male and female smokers.
- Trial name
- NCT00969137
- Testing
- saline, Nicotine
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Yale University
Cannabis Use, Tobacco Use Disorder
N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use
Tobacco and cannabis co-use is a common and growing public health problem, especially in states that have legalized cannabis. There are no pharmacologic treatments for co-occurring tobacco and cannabis use.
- Conditions
- Cannabis Use, Tobacco Use Disorder, Drug Use Disorder
- Trial name
- NAC_CUD-TUD (NCT04627922)
- Testing
- N-Acetyl cysteine, Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Ellen Herbst
Tobacco Use Disorder
Increasing Smoking Cessation Success Through Sleep-amplified Memory Consolidation
The goal of this subproject is to examine the hypothesized improvement of treatment with chess-based training and sleep enhancement, both together and on their own, in smokers.
- Trial name
- NCT05726045
- Testing
- Standard smoking cessation program (SCP), Cognitive remediation treatment (CRT), High-intensity interval training (HIIT evening)
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Tobacco Use, Smoking Cessation
Overcoming Nicotine Dependence to Enable Quitting
Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are…
- Conditions
- Tobacco Use, Smoking Cessation, Smoking Behaviors, Nicotine Dependence
- Trial name
- ON-DEQ (NCT05513872)
- Testing
- Nicotine Replacement Therapy (NRT) Sampling, Practice Quitting (PQ) Counseling, Motivational Interviewing (MI) Counseling
- Where
- United States
- Volunteers
- 780 people
- Sponsor
- Rush University Medical Center
Tobacco Dependence, Schizophrenia
The Appeal and Impact of E-cigarettes in Smokers With SMI
This study will evaluate behavioral and psychological appeal, toxicity, and effect of e-cigarettes on smoking behavior and nicotine addiction in chronic smokers with serious mental illness (SMI) who have failed to quit smoking.
- Conditions
- Tobacco Dependence, Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT03050853
- Testing
- E-cigarette
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Tobacco Use Disorder, Mental Illness
Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings
The study team will conduct a Multisite Randomized Controlled Trial to evaluate the advantages and disadvantages of two approaches for quitting smoking among people with serious mental illness (SMI).
- Conditions
- Tobacco Use Disorder, Mental Illness, Recurring Major Depressive Disorder, Bipolar Disorder
- Trial name
- MTQT (NCT05030272)
- Testing
- Quit on the Go App (formerly "Learn to Quit " App), Brief advice, Nicotine patch
- Where
- 3 sites in United States
- Volunteers
- 343 people
- Sponsor
- Wake Forest University Health Sciences
Nicotine Dependence
Smoking Treatment and Anxiety Management Program
The Smoking Treatment and Anxiety Management Program (STAMP) is a treatment program focused on helping people manage their anxiety while quitting smoking.
- Trial name
- STAMP (NCT01753141)
- Testing
- Cognitive Behavioral Therapy for smoking cessation, Cognitive Behavioral Therapy for smoking cessation and anxiety sensitivity reduction.
- Where
- United States
- Volunteers
- 378 people
- Sponsor
- Florida State University
Tobacco Use Disorder
Theta-burst Repetitive Transcranial Magnetic Stimulation (TBS) of the Right Inferior Frontal Gyrus for Treatment of Nicotine Dependence
The purpose of this research study is to examine the effects of theta-burst Transcranial Magnetic Stimulation on inhibitory control and smoking among adult cigarette smokers.
- Trial name
- NCT05389670
- Testing
- Continuous Theta-burst stimulation (cTBS)
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Tobacco Dependence
Healing and Empowering Alaskan Lives Towards Healthy-Hearts Study
This study aims to identify effective and cost-effective interventions for tobacco use and other risk behaviors for cardiovascular disease among Alaska Native people in rural villages.
- Trial name
- HEALTHH (NCT02137902)
- Testing
- Tobacco/Physical Activity Intervention, Diet plus BP/CHOL Intervention
- Where
- 2 sites in United States
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Stanford University
Tobacco Use Disorder
Neural Substrates in Nicotine Withdrawal
This study will test the hypothesis that a medication called tolcapone (Brand Name: Tasmar) will help reduce cognitive problems that smokers experience when they quit.
- Trial name
- NCT01001520
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- University of Pennsylvania
Tobacco Use Disorder
Comparative Abuse Liability Among African American and White Smokers
The study is a randomized crossover trial. Current smokers will complete a session with each product: usual brand cigarette, e-cigarette, and heat-not-burn.
- Trial name
- NCT04646668
- Testing
- E-cigarette and Heat not burn
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Tobacco Dependence
C-Raven, a Virtual Tobacco Cessation Intervention in the Community
In low-income housing units in Baltimore, the investigators propose to conduct a pilot two-arm hybrid type 1 effectiveness-implementation RCT comparing a) an avatar-delivered computerized intervention (CI) for tobacco cessation…
- Trial name
- NCT06545669
- Testing
- C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Nicotine Dependence
Effects of Flavors on Nicotine Reinforcement in Smokers
To examine the acute reinforcing effects of menthol, a fruit flavor (green apple) or a fruit flavor plus menthol, alone or in combination with nicotine in smokers.
- Trial name
- NCT03243630
- Testing
- IV nicotine, Menthol flavor, green apple
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Yale University
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder
Prevalence of smoking among individuals with opioid use disorder (OUD) is six-fold that of the general US adult population. The mortality rate of opioid-dependent smokers is four times that of opioid-dependent nonsmokers, and…
- Trial name
- NCT04092101
- Testing
- Cigarettes with varying nicotine content, E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Alcohol Drinking, Cigarette Smoking
Brief Voluntary Alcohol and Drug Intervention for Middle School Youth
We are currently working in 16 middle schools across Los Angeles, Santa Monica and Torrance to test out a voluntary after school program called Project CHOICE, which focuses on helping students decrease their alcohol and drug…
- Conditions
- Alcohol Drinking, Cigarette Smoking, Marijuana Smoking
- Trial name
- CHOICE (NCT01081119)
- Testing
- Project CHOICE
- Where
- United States
- Volunteers
- 6,455 people
- Sponsor
- RAND
Tobacco Dependence
Effects of Naltrexone on Nicotine Reinforcement
Despite preclinical evidence supporting the role of the endogenous opioid system in the reinforcing effects of nicotine, the efficacy of the opioid antagonist naltrexone (NTX) as a tobacco dependence treatment remains unresolved.
- Trial name
- NCT00270231
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Pennsylvania
Nicotine Dependence
Smart Olfaction App to Reduce Relapse
The proposed project aims to refine and test a novel biobehavioral smoking cessation intervention that integrates the strategic application of olfactory stimulation to reduce cigarette craving with an established smartphone-based…
- Trial name
- SOARR (NCT07007195)
- Testing
- Ad Libitum Use followed by Instructed Use of the Inspire Device, Instructed Use followed by Ad Libitum Use of the Inspire Device, Smart-T Smoking Cessation App with the Inspire Device Condition
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Houston
Nicotine Dependence
Orexin s Role in the Neurobiology of Substance Use Disorder
Study Description: Despite the availability of pharmacotherapy for some substance use disorders, relapse vulnerability is still a significant issue.
- Trial name
- NCT05630781
- Testing
- Belsomra, Methylphenidate
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
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