Clinical trials: Abuse Tobacco
Tobacco Use Disorder, Smoking
Low Dose Aspirin Inhibition of COX-2 Derived PGE2 in Male Smokers
Regular aspirin use has been associated with a reduction in the development of a number of different malignancies including lung cancer. The mechanism of aspirin's cancer prevention is not known.
- Trial name
- NCT01796951
- Testing
- Aspirin 325 mg daily, Celecoxib 200 mg BID
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Nicotine Dependence
Smoking Cessation Following Psychiatric Hospitalization
Smoking rates among individuals with psychiatric disorders are disproportionately higher than the general population. The majority of psychiatric hospitals ban smoking on hospital grounds, thus providing an opportunity for…
- Trial name
- NCT02204956
- Testing
- Sustained Care, Usual Care
- Where
- United States
- Volunteers
- 422 people
- Sponsor
- University of Texas at Austin
Smoking, Smoking Behaviors
Abuse Liability for Four Heated Tobacco Product (HTP) Consumables and Two HTP Devices
This is a single-site, open-label, randomized, 8-way crossover study designed to evaluate elements of abuse liability (AL), including subjective effects and physiological measures (pharmacodynamics [PD]) and plasma nicotine…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT07267195
- Testing
- Product A, Product N, Product B
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking, Smoking Behaviors
Abuse Liability of Four Modern Oral Nicotine Products
This is a single-site, open-label, randomized, 6-way crossover study designed to evaluate elements of abuse liability (AL) including subjective effects, physiological measures (pharmacodynamics [PD]), and plasma nicotine uptake…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT07685795
- Testing
- Usual Brand (UB) filtered, menthol or non-menthol combustible cigarette, Wintergreen (fleece A), 12 mg nicotine, Wintergreen (fleece A), 9 mg nicotine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Tobacco Use Disorder
Tobacco Use Among Arab American Youth
Michigan has the 10th highest smoking rate in the nation. Smoking rates are also very high in the Middle East and in Arab American families.
- Trial name
- NCT00059514
- Testing
- Modified Project Toward No Tobacco Use
- Where
- United States
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Smoking, Smoking Behaviors
Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
The study will recruit an anticipated 256 adults who currently smoke cigarettes and report a willingness to try switching to alternative, non-combustible products.
- Conditions
- Smoking, Smoking Behaviors, Nicotine Dependence
- Trial name
- NCT06077240
- Testing
- E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Yale University
Smoking Cessation, Tobacco Dependence
Smoking Cessation Intervention Including Health Navigators to Address Unmet Social Needs of Parents Who Smoke
Background: The goal of this study is to address parental smoking and social adversity, which can present an obstacle for smoking cessation, in order to decrease childhood exposure to second-hand cigarette smoke.
- Trial name
- CanCEASE-2 (NCT06651684)
- Testing
- CanCEASE with Health Navigator
- Where
- 3 sites in Canada
- Volunteers
- 1,000 people
- Sponsor
- St. Justine's Hospital
Tobacco Use Disorder
Nicotine Patch and Bupropion to Reduce Smoking Rates in Younger, Low-Income, and Minority Individuals
Nicotine addiction is a serious health problem in the United States; 46 million people smoke cigarettes, and 70% of those are trying to quit.
- Trial name
- NCT00308763
- Testing
- Nicotine Patch, Sustained Release Bupropion
- Where
- United States
- Volunteers
- 594 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Tobacco Use Disorder
Treating Schizophrenic Smokers: Effects on Craving, Cues and Withdrawal
This is a clinical research protocol to study the efficacy of combined varenicline (Chantix) and motivational interviewing (MI) for smoking cessation in a sample of smokers who have been diagnosed with schizophrenia or…
- Trial name
- NCT00781755
- Testing
- varenicline, Adaptation of Motivational Interviewing
- Where
- United States
- Sponsor
- VA Boston Healthcare System
Nicotine Dependence
A Mindfulness Based Application for Smoking Cessation
Cigarette smoking is the leading cause of preventable death and disability in the world. Although over 70% of smokers want to quit, fewer than 5% achieve this goal annually.
- Trial name
- MBSC (NCT01982110)
- Testing
- Mindfulness based smoking cessation, Behavioral Smoking Cessation intervention
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Virginia
Tobacco Dependence
Tobacco Treatment for Employable Californians, Total IMPACT Study
Previous findings indicate elevated risk for tobacco use among adults in California who are unemployed and seeking work. In a pilot study, tobacco use was associated with a longer duration of time out of work.
- Trial name
- TTEC (NCT02478697)
- Testing
- ProChange ExpertSystem
- Where
- 3 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy Smokers
Nicotine Patch - Bioequivalence Study
The purpose of this study is to evaluate the bioequivalence of a new transdermal nicotine patch to that of a reference formulation following repeated applications
- Trial name
- NCT02089308
- Testing
- Test treatment : V0116 transdermal patch, Reference treatment : Nicotine transdermal patch
- Where
- France
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Medicament
Nicotine Dependence
Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2
This study is to examine if inhaled doses of an e-cigarette flavor, alone and in combination with menthol, changes the appeal of e-cigarettes containing low and high doses of nicotine.
- Trial name
- NCT03168191
- Testing
- Nicotine, Experimental Flavor, Menthol Flavor
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Use Disorder, Smoking Cessation
Tobacco Treatment Medical Education in 10 Medical Schools
This study compares two methods of teaching the 5As (Ask, Advise, Assess, Assist, Arrange) for tobacco dependence treatment to medical students: 1) traditional medical education (TE), and 2) multi-modal education (MME).
- Trial name
- MSQuit (NCT01905618)
- Testing
- Web-based curriculum on tobacco dependence treatment, Tobacco Counseling Role Play, Preceptor Training and Teaching Medical Students
- Where
- 13 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Massachusetts, Worcester
Tobacco Use Disorder
Neural Substrates in Nicotine Withdrawal
This study will test the hypothesis that a medication called tolcapone (Brand Name: Tasmar) will help reduce cognitive problems that smokers experience when they quit.
- Trial name
- NCT01001520
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- University of Pennsylvania
Healthy Smokers
Nicotine Patch - Multidose Bioequivalence Study
The purpose of this study is to compare the relative bioavailability of nicotine following repeated applications of a new transdermal formulation to that of a reference formulation. Up to day 7
- Trial name
- NCT01658215
- Testing
- V0116 transdermal patch (Test treatment ), Nicotine transdermal patch (Reference treatment )
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Medicament
Nicotine Dependence, Alcohol Use Disorder
Combining Varenicline and Naltrexone for Smoking Cessation
This study is a double-blind, randomized clinical trial using a two group medication design consisting of the combination of VAR (1 mg twice daily) + NTX (50 mg once daily) and VAR (1 mg twice daily) + PLA (matched to NTX), for…
- Trial name
- NCT02698215
- Testing
- Varenicline, Varenicline plus Naltrexone
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- University of California, Los Angeles
Tobacco Dependence
Assessment of Biomarkers in Children to Help Parents Quit Tobacco
This randomized controlled trial will test whether adding biomarker measurement and informed outreach for tobacco smoke exposure as part of routine practice increases identification and improves treatment, effectiveness, and…
- Trial name
- ABC Quit (NCT04832659)
- Testing
- CEASE, CEASE + BIO
- Where
- United States
- Volunteers
- 865 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Copd, Smoking Cessation
Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start-II Study
Chronic Obstructive Pulmonary Disease (COPD) is caused primarily by smoking and smoking cessation is the first-line treatment for slowing disease progression.
- Conditions
- Copd, Smoking Cessation, Nicotine Dependence, Tobacco Use
- Trial name
- NCT04646174
- Testing
- Unified Protocol adapted for smoking cessation, American Lung Association self-management strategies for smoking cessation
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Rush University Medical Center
Smoking
Varenicline for Light Smokers
The purpose of this study is to determine if varenicline is effective in treating tobacco dependence in adults who smoke 5-10 cigarettes per day.
- Trial name
- ChanLight (NCT01639560)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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