Clinical trials: Abuse Tobacco
Tobacco Use Disorder
Comparative Abuse Liability Among African American and White Smokers
The study is a randomized crossover trial. Current smokers will complete a session with each product: usual brand cigarette, e-cigarette, and heat-not-burn.
- Trial name
- NCT04646668
- Testing
- E-cigarette and Heat not burn
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Veterans, Tobacco Use Disorder
Varenicline for Smoking Reduction in Veterans Not Ready To Quit
In order to reduce the prevalence of cigarette smoking among Veterans, it is vital that healthcare providers offer effective tobacco treatment to all Veterans who smoke, including those not ready to make a quit attempt.
- Conditions
- Veterans, Tobacco Use Disorder, Cigarette Smoking, Tobacco Dependence
- Trial name
- NCT06966362
- Testing
- Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT)
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- VA Office of Research and Development
Addiction Nicotine
Self-activation in Individuals With and Without Nicotine Dependence
The purpose of this study is to see if a non-medication intervention can increase motivation and reward processing to non-drug reward cues (for example, a picture of one's favorite food) in individuals with and without nicotine…
- Trial name
- NCT03170258
- Testing
- Neurofeedback (from fMRI and/or EEG)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Duke University
Nicotine Dependence, Cigarettes
Epidemiology and Acute Oral Effects Electronic Cigarette
Electronic cigarettes are battery-powered vaporizers which have a similar feel to tobacco smoking. They do not produce cigarette smoke but rather an aerosol, which is frequently referred to as vapor.
- Trial name
- NCT03011710
- Testing
- ProVari v2.5 (E-cigarette), Marlboro Gold (Conventional cigarette), Cigarette tip
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Tobacco Dependence, Tobacco Use Disorder
Chatbot for Online Support Groups to Treat Tobacco Addiction
Investigators will conduct a pilot RCT to test the efficacy of an intelligent chatbot to aid small, private, quit-smoking peer support groups.
- Trial name
- NCT06952725
- Testing
- online quit-smoking support group with intelligent chatbot, online quit-smoking support group with unintelligent bot
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Nicotine Dependence, Cigarette Smoking
Smoking Cessation for Smokers With Sleep Problems
This is a pilot research study examining two types of behavioral counseling along with the nicotine patch for smoking cessation.
- Conditions
- Nicotine Dependence, Cigarette Smoking, Insomnia
- Trial name
- NCT01277887
- Testing
- Cognitive-Behavioral Counseling, Smoking Cessation Counseling
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Yale University
Nicotine Use Disorder, Nicotine Dependence
Accelerated rTMS for the Reduction of Nicotine Craving
The purpose if this study is to determine if five treatments of repetitive transcranial magnetic stimulation (rTMS) can reduce craving for cigarettes in smokers.
- Trial name
- NCT03352609
- Testing
- Active rTMS with MagVenture MagPro double blind rTMS system
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical University of South Carolina
Smoking Cessation, Tobacco Dependence
Behavioral Therapy for Reduction in Smoking Craving
The objective of this pilot research is to investigate the effects of two behavioral smoking cessation programs on aspects of cue-induced cigarette craving, and to further investigate the neural bases of such effects.
- Trial name
- NCT00449293
- Testing
- standard cognitive behavioral therapy, Mindfulness Based Cognitive Therapy
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Tobacco Use Disorder/Cigarette Smoking
Working Memory Training on Delay Discounting Among Cigarette Smokers
Despite widespread awareness of significant negative health consequences, cigarette smoking remains the leading cause of preventable morbidity and mortality in the US (Creamer et al., 2019; Jamal, 2018).
- Trial name
- RTA (NCT05210608)
- Testing
- Working Memory Training + Behavioral Intervention
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Kansas Medical Center
Nicotine Dependence
Nicotine Delivery Rate and Its Abuse Potential: Impact of Menthol
A placebo-controlled study to enroll male and female tobacco smokers who will participate in five experimental sessions. subjects will be given an IV infusion of either saline or 1 mg nicotine at rapid, moderate or slow infusion…
- Trial name
- NCT03580525
- Testing
- Nicotine saline infusion 0.00mcg/kg/s, Nicotine infusion 0.24mcg/kg/s, Nicotine infusion 0.096mcg/kg/s
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Yale University
Tobacco Use Disorder, Smoking Cessation
p16 Methylation for Smoking Cessation
Smoking cessation is often difficult for smokers to achieve for a variety of reasons including: difficulty with nicotine withdrawal, failure to perceive the benefits of smoking cessation, and failure to perceive the risks…
- Conditions
- Tobacco Use Disorder, Smoking Cessation, Lung Cancer
- Trial name
- NCT01038492
- Testing
- p16 Methylation and Lung Cancer Education
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Duke University
Smoking, Nicotine Addiction
The END Perioperative Smoking Pilot Study
The purpose of this pilot randomized trial is to determine the feasibility of e-cigarettes and telephone counselling (compared to transdermal nicotine replacement and telephone counselling) as a harm-reduction tool that may lead…
- Conditions
- Smoking, Nicotine Addiction, Surgery
- Trial name
- NCT02482233
- Testing
- ENDD (NJOY), NRT (NicoDerm CQ), telephone counseling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Nicotine Dependence, Smoking Cue Reactivity
Concurrent PET D2/D3 Receptor Imaging and fMRI Smoking Cue Reactivity in Smokers
This trial aims to determine whether dopamine D3 receptors are elevated in smokers versus nonsmokers and whether correlations exist between D3 receptor binding potential (BP) and functional MRI (fMRI) reactivity to smoking cues…
- Conditions
- Nicotine Dependence, Smoking Cue Reactivity, Relapse to Smoking
- Trial name
- NCT01784016
- Testing
- [11C]-PHNO
- Where
- 3 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mclean Hospital
Tobacco Use Disorder
Smokers' Health Project: Self-Determination and Maintaining Tobacco Abstinence
These two studies will examine the role of autonomous motivation in maintained adherence. The first study will determine whether smokers are still abstinent from tobacco 32 months after starting in a previous project (Smoker's…
- Trial name
- SHP (NCT00178685)
- Testing
- Self-determination Intervention for Tobacco Dependence
- Where
- United States
- Volunteers
- 837 people
- Sponsor
- University of Rochester
Anxiety Disorders, Depression
Personalized Feedback for Distress Intolerant Smokers
This project will develop and refine a computer-delivered integrated Personalized Feedback Intervention (PFI) that directly addresses smoking and distress tolerance.
- Conditions
- Anxiety Disorders, Depression, Psychological Distress, Tobacco Dependence
- Trial name
- NCT03918031
- Testing
- PFI for Smoking & Distress Tolerance, PFI for Smoking Only
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Houston
Nicotine Use Disorder
Effects of Novel E-cigarette Constituents on Adults TCORS 3.0
This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.
- Trial name
- NCT05932745
- Testing
- E-liquid coolant (No WS-3) for non-menthol (1), E-liquid coolant (No WS-3) for low (0.1%) menthol (1), E-liquid coolant (No WS-3) for high (2.0%) menthol (1)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Yale University
Tobacco Smoking, Tobacco Withdrawal
Effectiveness of Combined Tobacco Treatment in Hospitalized Subjects
In the 20th century, tobacco caused the death of 100 million people worldwide and it is estimated that it will be responsible for 1 billion deaths in the 21st century.
- Conditions
- Tobacco Smoking, Tobacco Withdrawal, Nicotine Addiction, Nicotine Withdrawal
- Trial name
- NCT06254001
- Testing
- Bupropion, Nicotine replacement therapy (Nicotine patches)
- Where
- Mexico
- Volunteers
- 134 people
- Sponsor
- National Institute of Respiratory Diseases, Mexico
Nicotine Dependence
Doctors' Perspective on Tobacco Addiction
ABSTRACT Aim: Our study aimed to determine the approaches of our physicians to the smoking habits of their patients other than those with pulmonary diseases.
- Trial name
- NCT06163872
- Testing
- survey study
- Where
- Turkey (Türkiye)
- Volunteers
- 941 people
- Sponsor
- Karadeniz Technical University
Nicotine Dependence
Very Low-Nicotine Cigarettes in Smokers With SUD
The purpose of this study is to determine the efficacy, acceptability and unintended consequences of very low nicotine content cigarettes (VLNCC) in smokers with current or past year substance use disorders (SUD).
- Trial name
- VLNC (NCT01989507)
- Testing
- Nicotine, behavioral counseling for smoking cessation
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Brown University
Tobacco Use Disorder
Efficacy of Varenicline for Smokeless Tobacco Use in India
This study, based in India, is testing the efficacy of varenicline to help smokeless tobacco users with cessation efforts.
- Trial name
- NCT01098305
- Testing
- Varenicline, Counseling
- Where
- India
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
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