Clinical trials: Acarbose
Type 2 Diabetes Mellitus
A Study to Learn More About How Acarbose and Metformin Work When Taken Together and How Safe They Are in Indian Patients Who Were Recently Diagnosed With Type 2 Diabetes (T2D)
The study drug, fixed dose combination of acarbose and metformin, have already been approved to take together as a treatment for type 2 diabetes (T2D).
- Trial name
- START-AM (NCT04665570)
- Testing
- BAY81-9783 (Acarbose/Metformin)
- Where
- India
- Volunteers
- 2,000 people
- Sponsor
- Bayer
Type 2 Diabetes Mellitus
Remission Evaluation of Metabolic Interventions in Type 2 Diabetes (REMIT Pilot Trial)
The purpose of this pilot trial is to determine whether an intensive treatment with insulin glargine, metformin, acarbose and lifestyle can normalize blood glucose levels in patients with recently diagnosed type 2 diabetes…
- Trial name
- NCT01181674
- Testing
- insulin glargine, metformin, acarbose
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- Population Health Research Institute
Diabetes Mellitus, Impaired Glucose Tolerance
Impact of Acarbose on Abnormal Glucose Regulation in Patients With Coronary Artery Disease (AAA Trial)
The objective of this trial is to investigate the effect of early treatment of glucose toxicity with acarbose, a drug to control postprandial hyperglycemia, on the occurence of cardiovascular events and the inhibition of…
- Conditions
- Diabetes Mellitus, Impaired Glucose Tolerance, Coronary Artery Disease
- Trial name
- NCT00858676
- Testing
- acarbose
- Where
- Japan
- Volunteers
- 150 people
- Sponsor
- Aichi Gakuin University
Diabetes Mellitus Type 2
Exercise and Acarbose in Type 2 Diabetes
The purpose of this study is to investigate the impact of exercise training, Acarbose, and the combination of exercise and Acarbose on glycemic control, body composition, insulin sensitivity and other cardiovascular risk markers…
- Trial name
- NCT01244971
- Testing
- Acarbose, Exercise, Exercise + Acarbose
- Where
- Sweden
- Volunteers
- 62 people
- Sponsor
- Karolinska Institutet
Overweight or Obesity
A Proof of Concept Trial in Overweight and Obese Patients, Investigating Effect of EMP16-02 on Body Weight (Primary)
This study is a proof of concept study to demonstrate that EMP16-02, a fixed dose combination (FDC) of orlistat and acarbose in an oral multiple-unit modified release (MR) formulation leads to a clinically relevant decrease in…
- Trial name
- NCT04521751
- Testing
- EMP16-02 120 mg orlistat/40 mg acarbose, EMP16-02 150 mg orlistat/50 mg acarbose
- Where
- 2 sites in Sweden
- Volunteers
- 156 people
- Sponsor
- Empros Pharma AB
Non-alcoholic Fatty Liver Disease
A Pilot Study of Acarbose as Treatment for Pediatric Non-alcoholic Fatty Liver Disease (NAFLD)
The objective of this study is to demonstrate a reduction of intrahepatic fat as measured with Proton Magnetic Resonance Spectroscopy after 12 weeks administration of oral acarbose.
- Trial name
- NCT00677521
- Testing
- Acarbose
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- The Hospital for Sick Children
Microalbuminuria, Microalbuminuria /Creatinine Ratios ACR
Saxagliptin's Effects on Microalbuminuria Improvement in Type 2 Diabetic Patients
This study compare the effects on microalbuminuria improvement in type 2 diabetes mellitus (T2DM) treated with saxagliptin or glimepiride.All patients received metformin and/or acarbose, and randomly receive saxagliptin (5mg/d)…
- Trial name
- NCT02462369
- Testing
- Saxagliptin, glimepiride
- Volunteers
- 88 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Diabetes Mellitus, Type 2, Obesity
Effect of Acarbose and Vildagliptin on Visceral Fat Distribution in Newly Diagnosed Type 2 Diabetes Patients
Focusing on newly diagnosed type 2 diabetes participants with overweight and obesity (24kg/m2 ≤ body mass index ≤ 30kg/m2). 50 participants per arm (acarbose \& lifestyle combination / vildagliptin \& lifestyle combination)…
- Trial name
- VISA-T2DM (NCT02999841)
- Testing
- Acarbose, Vildagliptin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University
Gestational Diabetes Mellitus in Pregnancy
Acarbose and Prandial Insulin for the Treatment of Gestational Diabetes Mellitus.
Caring for women with gestational diabetes mellitus (GDM) is very time-consuming. Therapeutic strategy includes dietary and lifestyle measures and additional insulin therapy for 15 to 40% of the women with GDM if the glycemic…
- Trial name
- ACARB-GDM (NCT03380546)
- Testing
- Acarbose, Prandial insulin
- Where
- France
- Volunteers
- 341 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Glucose Metabolism Disorders
Delineation of the Role of Glucagon-like Peptide-1 Signalling in Relation to Increased Carbohydrate Content in the Distal Small Intestines
Investigation of GLP-1 signalling in the glucose-lowering effect of increased carbohydrate content in the distal small intestines induced by alpha-glucosidase inhibition during meal ingestion in patients with type 2 diabetes
- Trial name
- AlfaEx (NCT03241303)
- Testing
- Acarbose, Exendin (9-39)
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Type 2 Diabetes
the Efficacy of Acarbose and Metformin on Blood Glucose Fluctuation When Combined With Premix Insulin
the study objective: to explore the efficacy of acarbose and metformin on glucose fluctuations as add on therapy in type 2 diabetes patients inadequately controlled with premix insulin.
- Trial name
- CGMS (NCT02438397)
- Testing
- premix insulin, metformin, Acarbose
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai 6th People's Hospital
Diabetes Mellitus, Type 2
Bioequivalence Study for Acarbose/Metformin FDC
The purpose of this study is to establish the bioequivalence (i.e. similar pharmacokinetics and pharmacodynamics characteristics) between acarbose/metformin FDC (50 mg/500 mg) and loose combination of acarbose (50 mg) and…
- Trial name
- NCT04065581
- Testing
- Acarbose/Metformin FDC(BAY81-9783), Glucobay, Glucophage
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bayer
Type 2 Diabetes
Effects of Acarbose on Endothelial Function After a Mixed Meal in Newly Diagnosed Type 2 Diabetes
Endothelial dysfunction (ED) has been suggested as a possible causal link between postprandial hyperglycemia and cardiovascular events in patients with type 2 diabetes.
- Trial name
- NCT00551954
- Testing
- acarbose
- Sponsor
- Technische Universität Dresden
Diabetes, Diabetes Complications
CGM-Guided Acarbose for Painful Diabetic Neuropathy
This Phase II pragmatic hybrid effectiveness-implementation trial tests whether acarbose, titrated using continuous glucose monitoring (CGM) to blunt post-prandial excursions, reduces 4-week pain area-under-the-curve (AUC) versus…
- Conditions
- Diabetes, Diabetes Complications, Diabetic Neuropathy
- Trial name
- NCT07436585
- Testing
- Acarbose 50 mg
- Where
- Pakistan
- Volunteers
- 170 people
- Sponsor
- Shifa International Hospital
Type 2 Diabetes Mellitus, Poor Glycemic Control
A Study for Sufficient Acarbose Decreased Glucose Excursion in Type 2 Diabetic Patients
This is a multicentre observational study to investigate the improvement in glucose fluctuation of sufficient acarbose therapy on type 2 diabetes patient with high blood glucose fluctuation
- Trial name
- FLAT (NCT03805191)
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Qilu Hospital of Shandong University
Type 2 Diabetes Mellitus
Early Diabetes Intervention Program
This is an evaluation of the effect of acarbose to delay worsening of fasting glucose control in early Type 2 diabetes mellitus.
- Trial name
- EDIP (NCT01470937)
- Testing
- Acarbose
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- Indiana University
Diabetes Mellitus, Type 2
Effects of Quercetin on Blood Sugar and Blood Vessel Function in Type 2 Diabetes.
The purpose of this study is to measure the effect of quercetin on glucose tolerance and postprandial endothelial function in comparison to placebo and Acarbose in participants with Type 2 Diabetes.
- Trial name
- NCT01839344
- Testing
- Quercetin, Acarbose
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Bastyr University
Diabetes Mellitus, Type 2
Glucose Reduction by Early Acarbose Treatment in Basal Insulin
The purpose of this study is to evaluate the efficacy and safety of acarbose in comparison with voglibose in type 2 diabetic patients whose blood glucose levels were inadequately controlled with insulin glargine alone or in…
- Trial name
- GREAN (NCT00970528)
- Testing
- Acarbose (Glucobay, BAYG5421), Voglibose (Basen)
- Where
- 11 sites in South Korea
- Volunteers
- 124 people
- Sponsor
- Bayer
Aging
Study of Acarbose in Longevity
The investigators are studying the effects of acarbose on muscle and adipose gene transcription in older adults.
- Trial name
- SAIL (NCT02953093)
- Testing
- Acarbose
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Type 2 Diabetes
A Multicenter, Randomized, Open-Label, Parallel-Controlled Clinical Study Comparing the Efficacy and Safety of Cofrogliptin Versus Acarbose in Drug-Naïve Patients With Type 2 Diabetes
This study will compare the effect and safety of cofrogliptin (HSK7653) with acarbose among people with type 2 diabetes
- Trial name
- CARAT (NCT07122102)
- Testing
- Cofrogliptin, Acarbose
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.