Clinical trials: Accuracy of Tissue Diagnosis
Malignant Neoplasm of Lung
Single Pulmonary Nodule Investigation
A small proportion of patients with lung cancer present with a solitary pulmonary nodule (SPN). This is an important group of patients because if it is lung cancer, presentation as a SPN represents early disease, which following…
- Trial name
- SPUtNIk (NCT02013063)
- Where
- 9 sites in United Kingdom
- Volunteers
- 375 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Breast Cancer Diagnosis
PMA Required Pivotal Multi-reader Multi-case Reader Study
A pivotal multi-reader multi-case (MRMC) study to compare the diagnostic performance of 3D Koning Breast Computed Tomography (KBCT) to that of 2D Diagnostic Mammography to support the Pre-market Approval (PMA) of KBCT by the US…
- Trial name
- NCT01952717
- Volunteers
- 236 people
- Sponsor
- Koning Corporation
Breast Cancer, Complication of Surgical Procedure
Feasibility Study to Evaluate the Use of Patient Reported Complications After Digital Consent
Patient report complication data to our best knowledge has not been studied yet in electronic consent. This study is a feasibility study to assess whether patients will reliably report their complications, the quality of this…
- Trial name
- PRC (NCT06351865)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Critical Illness, Low Peripheral Perfusion
Local Warming to Improve Pulse Oximetry Accuracy in Critically Ill Patients
Pulse oximeters are widely used in intensive care to continuously estimate the oxygen level in the blood. However, pulse oximeter measurements may be less accurate when blood flow to the fingers is poor, which is common in…
- Conditions
- Critical Illness, Low Peripheral Perfusion, Pulse Oximetry Accuracy
- Trial name
- PULSEWARM (NCT07792304)
- Testing
- Protocolized Local Warming
- Where
- 4 sites in Sweden
- Volunteers
- 240 people
- Sponsor
- Vastra Gotaland Region
Melanoma
MElanoma Research Lymph Node Prediction Implementation National_001
MERLIN_001 is a prospective registry study of a primary melanoma gene-signature to predict sentinel node (SN) status and to determine its prognostic value for more accurate staging of SN-negative melanoma patients.
- Trial name
- MERLIN_001 (NCT04759781)
- Where
- 9 sites in United States
- Volunteers
- 1,820 people
- Sponsor
- SkylineDx
Prostate Cancer
The Accuracy of Modified TTMB in the Spatial Distribution of Prostate Cancer
Investigators plan to use modified TTMB technology to puncture prostate of participants suspected prostate cancer, especially those with the first negative biopsy , but having a rising PSA.Then, Investigators will simulate the…
- Trial name
- NCT03418207
- Testing
- trans-perineal template-guided mapping biopsy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Subei People's Hospital of Jiangsu Province
Cutaneous Melanoma
Advanced Non-invasive Diagnostics for Early Cutaneous Tumor Diagnosis, Clinical-therapeutic and Economic Management
The incidence of cutaneous melanoma (MM) is increasing worldwide. The best therapeutical solution for MM is early diagnosis and efforts over the last 50 years have been directed towards early and precise diagnoses.
- Trial name
- NET-DAM (NCT04789421)
- Testing
- Clinical, dermoscopy and Reflective confocal microscopy evaluations, Clinical, dermoscopy evaluations
- Volunteers
- 3,248 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Lung Cancer, Lymphoma
Improving Genomic Profiling and Reducing Time to Cancer Treatment Via Targeted Use of Endoscopic Ultrasound
Aim: To investigate whether the novel 3rd generation FNB needle provides a better diagnostic accuracy than a standard FNA needle in EUS-B guided diagnosis of common deep seated thoracic malignancies (lung cancer and lymphoma).
- Conditions
- Lung Cancer, Lymphoma, Sarcoidosis
- Trial name
- IMPROVED (NCT06848738)
- Testing
- FNB, FNA
- Where
- 3 sites in Denmark
- Volunteers
- 362 people
- Sponsor
- Zealand University Hospital
Rheumatoid Arthritis, Fibromyalgia, Secondary
Protocol for a Diagnostic Test Accuracy of Histological Muscle and Skin Biopsies of Rheumatoid Arthritis Patients Revealing Objective Chronic Widespread Pain Phenomena Related to Fibromyalgia
Background: Chronic widespread pain is challenging in the management of the patient with rheumatoid arthritis (RA), affecting approximately one third of this patient population.
- Conditions
- Rheumatoid Arthritis, Fibromyalgia, Secondary, Widespread Chronic Pain, Muscle Disorder
- Trial name
- NCT06305026
- Testing
- Muscle- and skin biopsies
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Endometriosis, Diagnosis
Proof of Concept Study to Eval MetriDx Lab-developed Test to Identify Endometriosis-specific Bio Markers
This study is testing a way to diagnose endometriosis using a uterine tissue biopsy (similar to a pap smear) as opposed to undergoing laparoscopy surgery.
- Trial name
- NCT05698212
- Testing
- MetriDx
- Where
- 3 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hera Biotech, Inc.
Oral Premalignant Lesions as Leukoplakia and Lichen Planus, Oral Cancer
Dipeptidyl Peptidase-4 Link With Oral Cancer and Premalignant Lesions
Aim: The current study targets linking serum and salivary dipeptidyl peptidase-4 with oral squamous cell carcinoma and comparing it with potentially malignant lesions and control to validate dipeptidyl peptidase-4 as a diagnostic…
- Trial name
- NCT06087042
- Testing
- serum and unstimulated salivary samples
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Breast Cancer
Accurate, Rapid and Inexpensive MRI Protocol for Breast Cancer Screening
The purpose of this study is to test an innovative MRI breast cancer screening method in women with mammographically dense breasts as well as other women with moderately increased cancer risk.
- Trial name
- NCT04877912
- Testing
- MRI Abbreviated Scan, Abbreviated MRI Scan
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Arthritis, Rheumatoid
Optimization of Infliximab Withdrawal Strategy for Rheumatoid Arthritis
This multicenter prospective clinical trial investigates the accuracy of ultrasound to predict relapse after discontinuation of infliximab and the efficacy/safety of readministration of infliximab in patients with rheumatoid…
- Trial name
- OPTIWIT (NCT02770794)
- Testing
- Infliximab
- Where
- Japan
- Volunteers
- 211 people
- Sponsor
- Chiba University
Breast Cancer, Tumors, Breast
Assessment of Diagnostic Accuracy and Performance of Digital Breast Tomosynthesis Compared to Mammography (ADAPT)
The aim of this recruitment plan (ADAPT-BX) is to collect image and technical data on both digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM), along with other subject data including histology results…
- Trial name
- ADAPT (NCT02324205)
- Testing
- DBT and FFDM
- Where
- 3 sites in United States, France
- Volunteers
- 196 people
- Sponsor
- GE Healthcare
INFECTIONS, Skin and Subcutaneous Tissue Bacterial Infections
Study of Accuracy of New Diagnostic Technology to Guide Rapid Antibiotic Treatment for Serious Infections
This research will test a new ultra-rapid technology (called ID/AST Accelerate system) that uses a digital microscope to identify bacteria based on their growth patterns.
- Conditions
- INFECTIONS, Skin and Subcutaneous Tissue Bacterial Infections, Healthcare-associated Infection, Infection Due to Resistant Bacteria
- Trial name
- NCT02796716
- Testing
- Testing on new technology called Accelerate ID/AST system
- Where
- United States
- Volunteers
- 2,102 people
- Sponsor
- Denver Health and Hospital Authority
Breast Diseases
Comparison of Real-time and Shear Wave Elastography
Tissue elasticity is being increasingly used as diagnostic parameter, since at the macroscopic level benign breast lesions tend to be stiffer than normal breast tissue but softer than breast cancers.
- Trial name
- Elasto (NCT03487471)
- Testing
- Real-time elastography, Shear wave elastography
- Where
- Switzerland
- Volunteers
- 98 people
- Sponsor
- University Hospital, Basel, Switzerland
Gallstone
Impact on Diagnostic Accuracy of a Specific Clinical Ultrasound Practical Teaching
This research proposal is a pilot double-blind randomized control trial evaluating the impact on diagnostic accuracy of a Clinical UltraSound (CUS) teaching for gallbladder assessment using exclusively healthy volunteers for…
- Trial name
- RCTpCUS (NCT04879459)
- Testing
- Practical sessions to learn CUS exclusively on volunteers presenting a healthy gallbladder
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Acute Coronary Syndrome, Myocardial Infarction (MI)
Clinical Echocardiography and S' Wave for Early Recognition of Acute Coronary Syndrome in the Emergency Department, A Prospective Study
The goal of this prospective observational study is to assess the diagnostic accuracy of the tissue Doppler imaging (TDI) S' wave in detecting acute coronary syndrome (ACS) in adult patients presenting to the emergency department…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction (MI), Non-ST Elevation Myocardial Infarction, Unstable Angina
- Trial name
- CLEAR_ECHO (NCT06860997)
- Testing
- Tissue Doppler Imaging (TDI) S' Wave Echocardiography
- Where
- Belgium
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Melanoma, Skin Cancer
Artificial Intelligence Augmented Training in Skin Cancer Diagnostics for General Practitioners
Background: The worldwide incidence of skin cancer has been rising for 50 years, in particular the incidence of malignant melanoma has increased approx. 2-7% annually and is the most common cancer amongst Danes aged 15-34.
- Trial name
- AISC-GP (NCT04576416)
- Testing
- AI augmented training and clinical feedback
- Where
- Denmark
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Melanoma, Pigmented Lesions
Dermoscopy Augmented Histology Trial, a Randomized Controlled Trial
Pathologists provide the current gold standard in skin lesion diagnostics, most often primarily based on the interpretation of histological slides.
- Trial name
- DAHT-RCT (NCT05004792)
- Testing
- DermLoop Learn
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital