Clinical trials: Acetaminophen, open to volunteers
Paracetamol Toxicity
Evaluation of Differences Between the Standered NAC Regimen Protocol and the SNAP Regimen Protocol in the Treatment of Paracetamol Toxicity for Cases Presented Early and Late to Assiut University Hospitals in Terms of Safety and Efficiecy.
Evaluation of differences between the 21 h NAC regimen protocol and the 12 h NAC regimen protocol in the treatment of paracetamol toxicity (over dose) for cases presented early and late to Assiut University Hospitals in terms of…
- Trial name
- NCT07454590
- Testing
- Evidence-based medical care for paracetamol toxicity
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Assiut University
Solid Tumors
Optimizing Ancillary Therapies With Immune Checkpoint Inhibitors for Solid Tumors (OAT ICI)
This study evaluates whether optimization of ancillary therapies can improve the efficacy of immune checkpoint therapy in participants with solid tumors.
- Trial name
- OAT ICI (NCT07661459)
- Testing
- Asprin, Loratadine, Acetaminophen Avoidance
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Val Adams
Crohn's Disease (CD), Dysmenorrhea Primary
Comparing Over the Counter Pain Medicines for Discomfort in Crohn's Disease (AVID-CD)
The purpose of this pilot study is to prepare for a larger study that will compare the effectiveness and safety of two common pain medications, ibuprofen and acetaminophen, to help treat period cramps in women with Crohn's…
- Trial name
- AVID-CD (NCT07337902)
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Pain During Intrauterine Device Insertion
The Effectiveness of Topical Prilocaine-Lidocaine Cream Plus Acetaminophen and Naproxen Compared to Lidocaine Injection Plus Acetaminophen and Naproxen to Manage Pain During IntraUterine Device Insertion
The goal of this clinical trial is to learn if two pain medications used to treat pain during intrauterine device insertions work in persons with a uterus. It will also learn about the safety of the two study medications.
- Trial name
- NCT07546370
- Testing
- Prilocaine, Lidocaine, Lidocaine HCl 1%
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Monakshi Sawhney
Hepatitis
To Evaluate the Efficacy and Safety of TYNADOTE® in the Treatment of Acetaminophen Overdose
To evaluate the efficacy and safety of TYNADOTE® in the treatment of acetaminophen overdose
- Trial name
- NCT05557448
- Testing
- TYNADOTE
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Sinew Pharma Inc.
Pelvic Inflammatory Disease, Chronic Pelvic Pain Syndrome
Clinical Trial of Acupoint Application in Improving the Sequelae of Pelvic Inflammatory Disease and Chronic Pelvic Pain
Chronic Pelvic Pain is one of the common gynecological symptoms, characterized by persistent and non periodic pain in the pelvic cavity and surrounding tissues.
- Trial name
- NCT06360965
- Testing
- Improved warm meridians and relieve pain plaster, Traditional warm meridians and relieve pain plaster
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Beijing Hospital of Integrated Traditional Chinese and Western Medicine
Acute Abdominal Pain, Acupuncture Therapy
Acupuncture Versus Compound Diclofenac Sodium for Pain Relief in Non-Traumatic Acute Abdominal
The investigators designed this clinical study to evaluate the efficacy and safety of semi-standardized acupuncture and moxibustion combined with compound diclofenac sodium injection in the emergency department (ED) compared with…
- Conditions
- Acute Abdominal Pain, Acupuncture Therapy, Acupuncture, Opioids
- Trial name
- ACU-NTAA (NCT06982755)
- Testing
- acupuncture, compound diclofenac sodium, acupuncture combined with compound diclofenac sodium
- Volunteers
- 176 people
- Sponsor
- The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
Concussion Post Syndrome, Head Trauma Injury
Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment
The IMPACT study is a randomized, double-blind clinical trial evaluating two commonly used intravenous medications - metoclopramide and acetaminophen - for treating acute post-concussion symptoms in emergency department patients…
- Trial name
- IMPACT (NCT07634393)
- Testing
- Metoclopramide 10mg, Acetaminophen
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Montefiore Medical Center
Acute Chest Pain
Intravenous Hydromorphone for the Treatment of Acute Pain
To observe the efficacy and safety of hydromorphone in the treatment of acute chest pain, and to explore the potential advantages of hydromorphone for analgesia in patients with acute chest pain, so as to provide more theoretical…
- Trial name
- NCT06949059
- Testing
- Hydromorphone
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Patent Ductus Arteriosus After Premature Birth
Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants
Patent ductus arteriosus (PDA), the most common cardiovascular complication of prematurity, is associated with higher mortality and morbidities in extremely low gestational age neonates (ELGANs, < 27+0 weeks).
- Trial name
- NCT05340582
- Testing
- Acetaminophen Injection, Ibuprofen 20 mg/mL oral suspension or Ibuprofen lysine 10 mg/mL injection solution (Neoprofen), Sodium chloride 0.9% injection
- Where
- 9 sites in Australia, Canada and 2 more
- Volunteers
- 310 people
- Sponsor
- Mount Sinai Hospital, Canada
Surgery, Pain, Post Operative
Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial
This trial is being completed to compare two commonly used options to treat pain after discharge from surgery. Participants that undergo tonsil removal, gallbladder removal, and knee scope will be eligible to enroll.
- Trial name
- CARES for Kids (NCT06671002)
- Testing
- NSAID, Opioid, Acetaminophen
- Where
- 9 sites in United States
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Cutaneous Tumors, Mohs Micrographic Surgery
Suzetrigine vs Norco-postoperative Mohs Pain
To compare suzetrigine versus hydrocodone/acetaminophen for postoperative pain control following dermatologic surgery.
- Trial name
- NCT07575230
- Testing
- Norco 5Mg-325Mg Tablet, Suzetrigine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Baylor Research Institute
Postoperative Pain, Acute Pain
Suzetrigine Versus Standard Analgesia After Skin Cancer Surgery
This randomized clinical trial will compare suzetrigine with standard analgesia for postoperative pain management after skin cancer surgery.
- Conditions
- Postoperative Pain, Acute Pain, Skin Cancer, Cutaneous Malignancy
- Trial name
- NCT07843134
- Testing
- Suzetrigine, Acetaminophen Plus Ibuprofen
- Where
- 3 sites in United States
- Volunteers
- 230 people
- Sponsor
- University of Minnesota
Postoperative Pain
Oral Versus Intravenous Acetaminophen in Lumbar Spine Surgery
The goal of this study is to compare whether oral or intravenous acetaminophen works better for pain control in patients undergoing lumbar spine fusion surgery
- Trial name
- NCT07203079
- Testing
- Acetaminophen Oral Tablet, Acetaminophen infusion
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Stanford University
Acute Liver Failure
Role of N-Acetylcysteine in Non-Acetaminophen-Induced Liver Failure
This randomized controlled trial evaluates whether oral N-acetylcysteine (NAC), given alongside standard supportive care, improves survival and reduces mortality in patients with non-acetaminophen-induced acute liver failure…
- Trial name
- NCT07765823
- Testing
- N Acetyl Cysteine, Standard supportive care
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- King Edward Medical University
Shivering, Post-Spinal Shivering
Intravenous Paracetamol Versus Magnesium Sulfate for Control of Shivering Following Spinal Anesthesia in Cesarean Section
Spinal anesthesia is widely used for cesarean deliveries, but shivering is a frequent complication that occurs in 40% to 60% of patients.
- Trial name
- NCT07855588
- Testing
- Paracetamol, Magnesium Sulfate
- Volunteers
- 90 people
- Sponsor
- Assiut University
Pediatric Disorder
Comparing the Difference in Pain Control in the Pediatric General Surgery Population: to Alternate or Combine Acetaminophen and Ibuprofen?
To examine the difference in pain control in the pediatric general surgery population alternating acetaminophen and Ibuprofen q 3 hours vs giving them simultaneous combination therapy around the clock.
- Trial name
- NCT06505148
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Baylor Research Institute
Cholecystectomy, Laparoscopic, Cholecystectomy, Robotic
Opiranserin for Minimally Invasive Cholecystectomy
The purpose of this study is to evaluate whether the combination therapy of opiranserin and acetaminophen is non-inferior to the combination of non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen for postoperative…
- Trial name
- NCT07620665
- Testing
- Opiranserin+Acetaminophen, Acetaminophen+NSAIDs
- Where
- 2 sites in South Korea
- Volunteers
- 88 people
- Sponsor
- Gangnam Severance Hospital
Post Operative Delirium, Post Operative Pain
Intravenous Acetaminophen After Cardiac Surgery - Definitive Study
Double blind, double dummy trial of the use of IV acetaminophen versus oral acetaminophen for the prevention of delirium after cardiac surgery.
- Conditions
- Post Operative Delirium, Post Operative Pain, Post-Op Complication, Post-cardiac Surgery
- Trial name
- IVACS (NCT06613178)
- Testing
- acetaminophen
- Where
- 8 sites in Canada
- Volunteers
- 1,100 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pelvic Pain
Comparing Pain Improvement for Intravenous Versus Oral Acetaminophen in Acute Pelvic Pain
The investigator team proposes a randomized, double-blind, double-dummy comparative effectiveness trial conducted in two urban emergency departments (EDs) in the Bronx, New York.
- Trial name
- PIVOTAL (NCT07595302)
- Testing
- Acetaminophen 1000mg PO, IV Acetaminophen 1000mg
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Montefiore Medical Center