Clinical trials: Acetaminophen, open to volunteers
Surgery, Pain, Postoperative
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll.
- Trial name
- CARES (NCT05722002)
- Testing
- NSAID, Opioid, Acetaminophen
- Where
- 8 sites in United States, Canada
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Orthodontic Pain (D013850), Pain Management (D016146)
A Randomized Clinical Trial of the Effectiveness of Acupressure in Relieving Orthodontic Pain
Orthodontic treatment with fixed appliances often causes pain, which peaks within 24 hours after archwire placement and lasts for several days.
- Conditions
- Orthodontic Pain (D013850), Pain Management (D016146), Acupressure (D056351), Analgesics, Non-Narcotic (D000700)
- Trial name
- NCT06812936
- Testing
- Acetaminophen, Acupressure
- Where
- Iraq
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Analgesic Efficacy
Suzetrigine Frame Trial Comparing Suzetrigine and Acetaminophen
Local anesthetic infiltration is a primary source of acute pain during stereotactic procedures.
- Trial name
- NCT07525219
- Testing
- Suzetrigine, acetaminophen
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
Ischemic Stroke
Effect of Acetaminophen on Neurological Outcome in Acute Ischemic Stroke Patients Undergoing Endovascular Treatment
Neuro-inflammation response plays an important role in the development of acute ischemic stroke(AIS). The aim of this study was to conduct a prospective randomized controlled study on the effect of acetaminophen on long-term…
- Trial name
- ACEAIS (NCT06767969)
- Testing
- Acetaminophen
- Volunteers
- 892 people
- Sponsor
- Beijing Tiantan Hospital
Hepatitis
To Evaluate the Efficacy and Safety of TYNADOTE® in the Treatment of Acetaminophen Overdose
To evaluate the efficacy and safety of TYNADOTE® in the treatment of acetaminophen overdose
- Trial name
- NCT05557448
- Testing
- TYNADOTE
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Sinew Pharma Inc.
Pelvic Inflammatory Disease, Chronic Pelvic Pain Syndrome
Clinical Trial of Acupoint Application in Improving the Sequelae of Pelvic Inflammatory Disease and Chronic Pelvic Pain
Chronic Pelvic Pain is one of the common gynecological symptoms, characterized by persistent and non periodic pain in the pelvic cavity and surrounding tissues.
- Trial name
- NCT06360965
- Testing
- Improved warm meridians and relieve pain plaster, Traditional warm meridians and relieve pain plaster
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Beijing Hospital of Integrated Traditional Chinese and Western Medicine
Adenotonsillectomy, Postoperative Pain
Preoperative Celecoxib and Acetaminophen Versus Acetaminophen Alone for Pain Control After Pediatric Adenotonsillectomy
This is an open-label randomized study of approximately 500 pediatric patients (2-18 years of age, weighing more than 10 kg) undergoing adenotonsillectomy.
- Trial name
- NCT07870447
- Testing
- Celecoxib, Acetaminophen, Dexamethasone
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- NYU Langone Health
Pain
A Study to Evaluate Ibuprofen (IBU) 62.5 mg and Acetaminophen (APAP) 125 mg/5 ml in an Oral Liquid Suspension Fixed-Dose Combination Product in Children Aged 6 to 11 Years
The purpose of this study will be to characterize the pharmacokinetic (PK) profile of the Fixed-Dose Combination (FDC) IBU 62.5 milligram (mg)/APAP 125 mg per 5 milliliter (mL) suspension in children 6 to 11 years of age…
- Trial name
- NCT07632274
- Testing
- Test Product
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- HALEON
Mechanical Ventilation, Pediatric Acute Respiratory Failure
Optimizing Pain Treatment in Children On Mechanical Ventilation
In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure.
- Conditions
- Mechanical Ventilation, Pediatric Acute Respiratory Failure, Analgesics, Opioid, Sedation and Analgesia
- Trial name
- OPTICOM (NCT06994442)
- Testing
- Acetaminophen, Ketorolac
- Where
- 16 sites in United States
- Volunteers
- 644 people
- Sponsor
- Weill Medical College of Cornell University
Osteoarthritis, Knee, Osteoarthritis, Hip
Helping Osteoarthritis Patients to Walk With NSAID
There is a lack of effective analgesic treatments to help walking patients with painful hip/knee osteoarthritis. Our team therefore imagined a new strategy lying on a multimodal rehabilitation walking program with the help of a…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Chronic Pain
- Trial name
- PERIPATEI (NCT05761015)
- Testing
- therapeutic program including intermittent drug intake and multimodal rehabilitation program
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Clermont-Ferrand
Concussion Post Syndrome, Head Trauma Injury
Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment
The IMPACT study is a randomized, double-blind clinical trial evaluating two commonly used intravenous medications - metoclopramide and acetaminophen - for treating acute post-concussion symptoms in emergency department patients…
- Trial name
- IMPACT (NCT07634393)
- Testing
- Metoclopramide 10mg, Acetaminophen
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Montefiore Medical Center
Cholecystectomy, Laparoscopic, Cholecystectomy, Robotic
Opiranserin for Minimally Invasive Cholecystectomy
The purpose of this study is to evaluate whether the combination therapy of opiranserin and acetaminophen is non-inferior to the combination of non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen for postoperative…
- Trial name
- NCT07620665
- Testing
- Opiranserin+Acetaminophen, Acetaminophen+NSAIDs
- Where
- 2 sites in South Korea
- Volunteers
- 88 people
- Sponsor
- Gangnam Severance Hospital
Post Operative Analgesia, Tonsillectomy With or Without Adenoidectomy
Preoperative High-Dose Oral Paracetamol for Postoperative Analgesia in Children Undergoing Tonsillectomy"
This randomized clinical trial compares two different preoperative doses of oral paracetamol (acetaminophen) in children undergoing elective tonsillectomy.
- Trial name
- NCT07463482
- Testing
- Paracetamol (acetaminophen)
- Where
- Thailand
- Volunteers
- 54 people
- Sponsor
- Thammasat University
Pain Management, Postoperative Pain
PCDD Generation 1 Oral Liquid Acetaminophen Delivery Evaluation
This prospective randomized pilot study evaluates the feasibility, acceptability, and preliminary efficacy of the Patient-Controlled Dispenser and Deactivator (PCDD) Generation 1 system for patient-controlled oral liquid…
- Trial name
- NCT07765238
- Testing
- PCDD Generation 1 system
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Tonsillectomy, Adenoidectomy
Evaluating the Efficacy of Intravenous Acetaminophen (IV Tylenol) in Reducing Pain and Agitation in Pediatric Patients Undergoing Elective Tonsillectomy and/or Adenoidectomy
MetroHealth's main campus administers IV Tylenol as part of its pain management protocol for elective tonsillectomy/adenoidectomy, whereas Parma campus does not.
- Trial name
- PEACE (NCT07576985)
- Testing
- No Intervention: Observational Cohort
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- MetroHealth Medical Center
Surgery, Pain, Post Operative
Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial
This trial is being completed to compare two commonly used options to treat pain after discharge from surgery. Participants that undergo tonsil removal, gallbladder removal, and knee scope will be eligible to enroll.
- Trial name
- CARES for Kids (NCT06671002)
- Testing
- NSAID, Opioid, Acetaminophen
- Where
- 9 sites in United States
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Intrapartum Fever, Chorioamnionitis
Antipyretic Treatment for Intrapartum Fever: Dipyrone vs Acetaminophen (RCT)
Chorioamnionitis, or intraamniotic infection, is a common condition affecting 2-5% of all term births. This condition poses well-recognized maternal and neonatal risks, and entails a series of clinical management decisions…
- Trial name
- PARADIP (NCT06950840)
- Testing
- Acetaminophen, dipyrone
- Where
- Israel
- Volunteers
- 140 people
- Sponsor
- Wolfson Medical Center
Acute Liver Failure
Role of N-Acetylcysteine in Non-Acetaminophen-Induced Liver Failure
This randomized controlled trial evaluates whether oral N-acetylcysteine (NAC), given alongside standard supportive care, improves survival and reduces mortality in patients with non-acetaminophen-induced acute liver failure…
- Trial name
- NCT07765823
- Testing
- N Acetyl Cysteine, Standard supportive care
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- King Edward Medical University
Acute Liver Failure, Sepsis
Transcriptional Analysis of Mechanisms in Liver Failure and Sepsis
Context Acute liver failure (ALF) is a life-threatening condition that occurs on the background of a healthy liver. The most common cause of acute liver failure in the UK is paracetamol overdose.
- Trial name
- MAP-ALF (NCT07131969)
- Testing
- blood draw
- Where
- 7 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Cambridge
Acute Chest Pain
Intravenous Hydromorphone for the Treatment of Acute Pain
To observe the efficacy and safety of hydromorphone in the treatment of acute chest pain, and to explore the potential advantages of hydromorphone for analgesia in patients with acute chest pain, so as to provide more theoretical…
- Trial name
- NCT06949059
- Testing
- Hydromorphone
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School