Clinical trials: Acid Base Imbalance
Respiratory Failure, Hypercapnic Acidosis
High Flow Oxygen Therapy in Patients Undergoing Bronchoscopy Under Sedation
A reduction of peripheral oxygen saturation (SpO2) commonly occurs during bronchoscopy and may be associated with both respiratory and cardiac adverse events.
- Trial name
- BroncHoFlow (NCT04728412)
- Testing
- High Flow Oxygen Therapy (HFOT)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Cardarelli Hospital
Acid Base Disorder
Effect of the Diet on Urinary Excretion of Alpha-ketoglutarate
The G coupled-protein receptors 99 (GPR99) was discovered in 2002 by Wittenberg et al. and is involved as a metabolic receptor. It has been shown that the natural ligand of GPR99 is an intermediate in the Krebs cycle…
- Trial name
- NCT01880281
- Testing
- Meat and vegetable diet
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Michel Burnier
Ketoses, Metabolic, Ketosis
Efficacy of Acute Intake of Ketones on Performance in Professional Road Cyclists
Randomized, controlled, double-blind, crossover clinical trial, depending on the product consumed, to analyze the efficacy on physical performance of a sports supplement consumed prior to and during competition or training.
- Trial name
- KETA (NCT05294939)
- Testing
- Ketone monoester, Control product consumption
- Where
- Spain
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Ketosis
Markers of Appetite Regulation During Exogenous Ketosis
The aim of this study is to investigate the relationship, if any, between markers of satiety, desire to eat, hunger, and metabolic markers of the regulation hereof during ketosis as compared with a Glucose-containing and a…
- Trial name
- MARK (NCT04156477)
- Testing
- Ketone ester, Glucose, Tap water
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Central Jutland Regional Hospital
Acidosis, Lactic
D4T or Abacavir Plus Vitamin Enhancement in HIV-Infected Patients (DAVE)
The purpose of this study is to determine the best way to treat people on d4T (stavudine) with high levels of lactic acid. Switching from d4T to abacavir will be assessed. Adding riboflavin and thiamine will also be assessed.
- Trial name
- NCT00143702
- Testing
- d4T, Abacavir, Riboflavin and Thiamine (Supplementation)
- Where
- 2 sites in Canada
- Volunteers
- 80 people
- Sponsor
- University of British Columbia
Type2diabetes, Heart Failure With Reduced Ejection Fraction
Ketones, SGLT2, HFrEF
The study team will examine the effects of elevated plasma ketone levels following initiation of SGLT2 inhibitor therapy in high-risk type 2 diabetes mellitus (T2DM) individuals with heart failure (HF) with reduced ejection…
- Trial name
- NCT06229678
- Testing
- Empagliflozin 25 MG Oral Tablet, Acipimox 250 Mg Oral Capsule
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Shock, Hemorrhagic, Shock, Traumatic
Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients
MP4OX is a novel oxygen therapeutic agent specifically developed to perfuse and oxygenate tissue at risk for ischemia and hypoxia.
- Conditions
- Shock, Hemorrhagic, Shock, Traumatic, Acidosis, Lactic
- Trial name
- NCT01004198
- Testing
- MP4OX, Ringers Lactate solution
- Where
- 13 sites in France, Germany and 2 more
- Volunteers
- 51 people
- Sponsor
- Sangart
Ketosis, Epilepsy
Market Research - Acceptability Study for New MCT Fat Products
This is a market research, observational study to evaluate the tolerability and acceptability of MCT supplements for young children, young people and adults with intractable epilepsy, GLUT-1 or PDHD from 3 years to adulthood.
- Conditions
- Ketosis, Epilepsy, Fatty Acid Oxidation Disorder, Malabsorption
- Trial name
- NCT04309214
- Testing
- MCT fats
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Dr. Schär AG / SPA
Heart Failure, Ketosis
Modulation of Circulating Levels of the Ketone Body 3-hydroxybutyrate in Patients With Chronic Heart Failure: Cardiovascular Effects
The ketone body 3-hydroxybutyrate (3-OHB) is a naturally occurring energy substrate, and is associated with increased life span and improved health.
- Conditions
- Heart Failure, Ketosis, Ketonemia
- Trial name
- KETO-KINETICS1 (NCT04443426)
- Testing
- Oral 3-hydroxybutyrate salts, Ketone Monoester
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- University of Aarhus
Chronic Kidney Disease, Metabolic Acidosis
Comparison of Standard Versus Low Bicarbonate Hemodialysis
This study will compare acid-base changes during hemodialysis treatments with a standard dialysis bath versus a lower bicarbonate dialysis bath, and aims to define the factors that limit equilibration of the bicarbonate…
- Trial name
- NCT01777178
- Testing
- Low bicarbonate dialysis
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Albert Einstein College of Medicine
Acid-Base Imbalance, Respiratory Alkalosis
Cerebrospinal Acid-base in Pregnant and Non-pregnant Fertile Women
The third trimester of pregnancy is typically characterized by the development of a marked respiratory alkalosis. The possible role of pregnancy-induced variations of cerebrospinal fluid (CSF) acid-base characteristics on the…
- Conditions
- Acid-Base Imbalance, Respiratory Alkalosis, Cerebrospinal Fluid, Pregnancy
- Trial name
- NCT03496311
- Testing
- Acid - Base characterization
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Diabetes Mellitus, Diabetes Mellitus, Type 1
The SHINE Study: Safety of Implant and Preliminary Performance of the SHINE SYSTEM in Diabetic Subjects
The objectives of SHINE study are to confirm the safety aspects of the SHINE SYSTEM. Moreover, the goal of this clinical investigation is the initial evaluation of sensor's performance by assessing sensor's ability to…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Ketoacidosis, Diabetic
- Trial name
- NCT05597605
- Testing
- The SHINE SYSTEM
- Where
- 3 sites in Belgium, France and 1 more
- Volunteers
- 6 people
- Sponsor
- Indigo Diabetes NV
ADPKD
Short Term Induction of Ketosis in PKD
Recently, it has been shown that ketose-inducing dietary interventions slow disease progression in animal models of polycystic kidney disease (PKD), even when the state of ketosis is only induced for a short period of time.
- Trial name
- RESET-PKD (NCT04472624)
- Testing
- Fasting, Ketogenic diet
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Cologne
Diabetes Mellitus, Type 2
Dosage Reduction and Acute Glycemic Complications in People With Type 2 Diabetes Who Fast During Ramadan
Every lunar year, during the month of Ramadan, Muslims abstain from food and drink between dawn and nightfall. People with type 2 diabetes who fast during Ramadan are at an increased risk of acute glycemic complications.
- Trial name
- NCT04237493
- Testing
- Metformin and Glimepiride (Low Dosage), Metformin and Vildagliptin (Low Dosage), Metformin and Insulin Glargine U100 (Low Dosage)
- Where
- Jordan
- Volunteers
- 687 people
- Sponsor
- University of Jordan
Ketosis, Hypoxia
Effect of Ketone Ester Supplementation on Sleep and Recovery in Hypoxia
This study specifically aims to elucidate the effects of IEK on sleep and recuperation in hypoxia, after training in normoxia. These conditions are in line with the widely applied live-high train-low strategy.
- Conditions
- Ketosis, Hypoxia, Sleep
- Trial name
- NCT06060093
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Diabetic Ketoacidosis, Insulin
Relapse Among Diabetic Ketoacidosis Patients Maintained Basal Bolus Insulin Administration in Combination With Continuous Intravenous Insulin Infusion VS Non Maintaining Basal Insulin Patients
This study aimed to assess intensive care unit stay and relapse among patients of Diabetic ketoacidosis (type 1 diabetes mellitus) maintained basal bolus insulin and patients non maintaining along with intervenors insulin…
- Conditions
- Diabetic Ketoacidosis, Insulin, Intensive Care Unit Stay
- Trial name
- NCT07423559
- Testing
- insulin infusion without basal insulin, insulin infusion with basal insulin, Insulin infusion with basal insulin and bolus
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Hyponatremia
Influence of Triathlon on the Electrolyte Balance
Aim of the study is examining the incidence of the occurrence of hyponatremia during a Triathlon
- Trial name
- Ironman (NCT02263586)
- Testing
- Education in nutrition
- Where
- Germany
- Volunteers
- 1,089 people, healthy volunteers welcome
- Sponsor
- University Hospital of Cologne
Acid Base Imbalance, Osmolality Disturbance
Heart-Lung Machine: Impact of the Priming Solution on Acid-Base Balance, Electrolytes and Outcome on Patients Undergoing Cardiac Surgery
Most cardiac surgery procedures requires the use of heart-lung machine. The heart-lung machine circuit needs to be filled with a fluid before connecting it to the patients circulation.
- Conditions
- Acid Base Imbalance, Osmolality Disturbance, Crystalloid Solutions, Electrolyte Changes
- Trial name
- PRIMEII (NCT07267546)
- Testing
- Ringer's Acetate 80, Plasmalyte, Ringer's Acetate no add
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Region Skane
Critical Illness, Gastro Intestinal Surgery
Undiluted and Diluted Nutrition
Adult patients after elective major abdominal surgeries who are planned to be admitted to the Intensive Care Unit (ICU) can be included in the trial. Each patient will be fed via the gastrointestinal tract.
- Conditions
- Critical Illness, Gastro Intestinal Surgery, Enteral Feeding Intolerance, Gastro-Intestinal Disorder
- Trial name
- NCT07352150
- Testing
- Enteral fluid, Intravenous fluid
- Where
- 2 sites in Poland
- Volunteers
- 80 people
- Sponsor
- John Paul II Catholic University of Lublin
Gastroenteritis Acute, Dehydration
Balanced Crystalloid vs Normal Saline in Pediatric Acute Gastroenteritis
Acute gastroenteritis (AGE) is among the most common reasons for paediatric emergency visits. Children with significant dehydration often require intravenous (IV) fluid therapy.
- Conditions
- Gastroenteritis Acute, Dehydration, Acidosis, Metabolic, Diarrhea
- Trial name
- NCT07610382
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Aydin Adnan Menderes University