Clinical trials: Acid Base Imbalance
Lactic Acidosis
Dichloroacetate Kinetics, Metabolism and Toxicology
Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern.
- Trial name
- NCT00015015
- Testing
- Dichloroacetate
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Acute Heart Failure (AHF)
Exogenous KETOne Supplements in Patients Hospitalized for Acute Heart Failure
This is a multicenter, randomized, double-blind, placebo-controlled trial to investigate the clinical efficacy of treatment with exogenous dietary ketone supplement containing 1,3-butanediol in patients hospitalized with acute…
- Trial name
- KETO-AHF (NCT06653725)
- Testing
- 1,3-butanediol
- Where
- 8 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- Aarhus University Hospital
Apgar; 0-3 at 1 Minute, Metabolic Acidosis
Autologous Stem Cells in Newborns With Oxygen Deprivation
The purpose of this study is to determine whether the plasticity of autologous intravenous application of cord blood stem cells would improve the clinical course of asphyxiated newborns.
- Conditions
- Apgar; 0-3 at 1 Minute, Metabolic Acidosis, Hypoxia, Brain, Multiple Organ Failure
- Trial name
- NCT01506258
- Testing
- Application of Stem Cells, Observation
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Distal Renal Tubular Acidosis
Study Evaluating Subjects With Distal Renal Tubular Acidosis
This is a phase 3, prospective, multicenter, randomized, double-blinded, placebo-controlled withdrawal study comparing the efficacy of ADV7103 versus placebo in preventing the development of metabolic acidosis in pediatric and…
- Trial name
- NCT03644706
- Testing
- ADV7103
- Where
- 8 sites in United States, Canada
- Volunteers
- 3 people
- Sponsor
- Advicenne Pharma
Vitamin B-12 Deficiency, Achlorhydria
Cobalamin Absorption From Fortified Food
To determine B12 bioavailability from 14C-B12 fortified bread in healthy subjects and in subjects with proton pump inhibitor induced achlorhydria.
- Trial name
- FL-72 (NCT01399164)
- Testing
- 14C-B12 fortified bread
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Diabetic Ketoacidosis
Clinical and Laboratory Parameters Associated With Different Degrees of Dehydration Among Children With Diabetic Ketoacidosis
Diabetic ketoacidosis (DKA) is a common acute complication of type 1 diabetes mellitus (T1DM). DKA is characterized by hyperglycemia, metabolic acidosis, increased levels of ketone bodies in blood and urine.
- Trial name
- NCT05383404
- Testing
- blood and urine samples
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Metabolic Acidosis
Intraoperative Cell Salvage and Postoperative Acidosis
Metabolic acidosis is a common complication that patients experience in the early postoperative period following cardiac surgery.
- Trial name
- NCT02800343
- Testing
- routine administration of 0.9% sodium chloride
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- University of Edinburgh
Ketonemia, Exercise Performance
Ketone Supplementation, Glycogen Replenishment and Time Trial Performance Following Glycogen Lowering Exercise
20 healthy trained males will volunteer to participate in this study. there will be 2 treatments: Carbohydrate- ketone supplementation and carbohydrate alone.
- Conditions
- Ketonemia, Exercise Performance, Ketosis
- Trial name
- NCT04004676
- Testing
- 20 km time trial performance, Glycogen lowering exercise
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Obesity, Inflammatory Markers
Time-Restricted Feeding
We propose to conduct a randomized 6-day isocaloric crossover feeding study in humans with prediabetes and obesity. We will study the effect of restricting the timing of caloric intake to earlier in the day (TRF) versus later in…
- Conditions
- Obesity, Inflammatory Markers, Glycemic Variation, Time Restricted Feeding
- Trial name
- TRIO (NCT04884659)
- Testing
- Time restricted feeding arm, usual feeding pattern arm
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Ketosis, Resistance Exercise
Acute Effects of Ketone Monoester Co-Ingestion With Dietary Protein on Whole-Body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Older Males
The goal of this trial is to determine if ketone monoester supplementation in conjunction with protein supplementation in the post exercise period can augment whole-body protein metabolism following resistance exercise in older…
- Conditions
- Ketosis, Resistance Exercise, Dietary Protein, Aging
- Trial name
- KET-OLD-M (NCT07884513)
- Testing
- Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- McGill University
Diabetic Ketoacidosis, Acute Kidney Injury
Risk Factors and Outcomes of Acute Kidney Injury in Patients With Diabetic Ketoacidosis at Sohag University Hospital.
Diabetic ketoacidosis (DKA), a severe complication of diabetes mellitus (DM), is the leading cause of hospitalization, morbidity and mortality in patients with DM (1).
- Trial name
- NCT05867797
- Volunteers
- 100 people
- Sponsor
- Sohag University
Metabolic Ketosis, Cognitive Impairments, Mild
The Effect of Vegetable Oil on Cognitive Functions of MCI Patients
This study explores the feasibility of applying an intervention using vegetable oils (coconut and sunflower oils) on individuals diagnosed with Mild Cognitive Impairment.
- Trial name
- DICe (NCT03727386)
- Testing
- Coconut oil, Sunflower oil
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Bournemouth University
Bone Diseases, Metabolic, Acid-Base Imbalance
Short Term Bed Rest Study: Evaluation of the Use of Artificial Gravity, Induced by Short-arm Centrifugation
Randomized cross-over design with 10 male subjects and 3 campaigns to test whether the negative effects of bed rest (6º head-down tilt) on the various systems of the body and the consequences to health of simulated weightlessness…
- Conditions
- Bone Diseases, Metabolic, Acid-Base Imbalance, Muscular Atrophy, Sprains and Strains
- Trial name
- SAG (NCT01820702)
- Testing
- Defined Training Programme
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- DLR German Aerospace Center
Time Restricted Feeding
Effect of 14:10 Time-Restricted Eating on Body Weight and Metabolic Markers
The purpose of this study is to investigate the effect of engaging in time restricted eating schedule on body weight, blood glucose, and ketones (breath acetone) in individuals with obesity.
- Trial name
- NCT04492930
- Testing
- 14:10 Regimen, 12:12 Regimen
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Jenny Craig, Inc.
Metabolic Diseases, Aging Problems
Brain Substrate Switch to Ketones and Lactate
The brain is constantly active and energetically expensive, making up a quarter of the body's energy budget despite occupying only 2% of its mass.
- Trial name
- BSS (NCT06000605)
- Testing
- Fed, Fasted
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Chronic Kidney Disease, End-stage Renal Disease
Comparison of High Versus Low Bicarbonate Hemodialysis
This study will compare hemodialysis treatment with a standard, high-bicarbonate dialysis bath versus a lower bicarbonate dialysis bath, and will compare intradialytic acid-base changes and overall control of metabolic acidosis…
- Conditions
- Chronic Kidney Disease, End-stage Renal Disease, Metabolic Acidosis
- Trial name
- NCT02098356
- Testing
- Low Bicarbonate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Albert Einstein College of Medicine
Asthma, Obesity
Nutrition for Asthmatics with Obesity
This study will test the effect of diet on asthma in individuals with obesity.
- Trial name
- NCT05222451
- Testing
- DGA Diet, MCT Diet, KETO Diet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Pennington Biomedical Research Center
Chronic Kidney Diseases, Cardiovascular Diseases
Treating Metabolic Acidosis in Chronic Kidney Disease to Prevent Adverse Kidney and Cardiovascular Outcomes
Upon completion, this project will determine if treatment of metabolic acidosis in non-diabetic study participants with reduced kidney function (chronic kidney disease [CKD] stage 3) associated with high blood pressure…
- Conditions
- Chronic Kidney Diseases, Cardiovascular Diseases, Hypertension
- Trial name
- NCT06545461
- Testing
- Fruits and Vegetables (F+V), Sodium Bicarbonate (NaHCO3), Usual Care
- Volunteers
- 108 people
- Sponsor
- Donald Wesson
Sodium Bicarbonate, Alkalosis, Metabolic
Effects of Sodium Bicarbonate Supplementation on Intermittent and Intense Task
The aim of this study was to verify if sodium bicarbonate (NaHCO3) suplementation promotes changes in the performance, muscular activity and strength of individuals trained during the intermittent and intense task .
- Conditions
- Sodium Bicarbonate, Alkalosis, Metabolic, Electromyography, Fatigue
- Trial name
- NCT03837886
- Testing
- Sodium bicarbonate, Calcium carbonate
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Metabolic Acidosis
ADVOS® Versus CVVHD in Metabolic or Mixed Acidosis
The aim of the study is to investigate the effects of ADVOS® therapy in critically ill patients with acute kidney injury, necessity of renal replacement therapy and acidosis.
- Trial name
- NCT05842369
- Testing
- ADVOS, CVVHD
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf