Clinical trials: Acid Base Imbalance
Healthy
Effect of an Alpha-linolenic Acid-rich Supplement on Ketogenesis and Plasma Fatty Acids
Background: As the main alternative fuel to glucose for the brain, increased plasma ketones could potentially help compensate for brain glucose hypometabolism occurring during aging.
- Trial name
- NCT02410161
- Testing
- alpha-linolenic acid-rich supplement
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Cardiopulmonary Bypass
Comparative Analysis Between Ringer's Lactate vs Plasma Lyte-A as Cardiopulmonary Bypass Prime
Metabolic acidosis is a frequent problem in cardiopulmonary bypass. The cause is poorly understood, but it appears to be multifactorial. It is assumed to be result of hypoperfusion with resultant lactatemia.
- Trial name
- NCT03043131
- Testing
- Plasmalyte A, Ringer Lactate
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Appetite, Obesity
Exogenous Ketones and Appetite
People with obesity have different appetitive responses to stimuli compared to people without obesity. For example, people with obesity have a blunted postprandial ghrelin ('hunger' hormone) response, lower glucagon-like peptide…
- Conditions
- Appetite, Obesity, Ketones, Appetitive Behavior
- Trial name
- NCT06327464
- Testing
- Exogenous ketones
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Ketosis
Variations in Ketone Metabolism
This outcome of this study will elucidate how the phenotype of the individual modulates the KE metabolic effect. Most studies of KE have been in homogenous populations, usually young, male athletes.
- Trial name
- STAK-VKM (NCT05924295)
- Testing
- Ketone Supplement, Beverage Tolerability Questionnaire (BTQ) and satiety visual analogue scale, Blood Draw
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Gastrointestinal Infections, Ketosis
Oral Glucose Intervention for Children With Gastroenteritis and Ketosis
Fasting ketoacidosis adds morbidity to children affected by gastrointestinal infections. The investigators investigate oral glucose gel for its effectiveness in rapidly reducing ketoacidosis and for improvements in oral hydration…
- Trial name
- NCT02729870
- Testing
- Oral Glucose Gel
- Sponsor
- University of Florida
Acidosis, Oxidative Stress
Effects of Zeolite + Dolomite on Performance and Acidosis
Purpose: This study investigates the effects of dietary zeolite + dolomite on performance, exercise-induced acidosis, oxidative stress, inflammation and intestinal barrier dysfunction in trained people.
- Conditions
- Acidosis, Oxidative Stress, Inflammation
- Trial name
- NCT01831492
- Testing
- zeolite + dolomite, cellulose
- Where
- Austria
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Green Beat
Healthy
Effect of MCT Emulsification on Ketogenesis in Human Adults
Lower brain glucose uptake is present before the onset of cognitive deterioration and may increase the risk of cognitive decline in Alzheimer's disease. Ketones are the brain's main alternative energy substrates.
- Trial name
- NCT02409927
- Testing
- MCT oil 10g, MCT homogenate 10g, Control
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Kidney Failure, Chronic
Acetoacetate and Acetate Metabolism in Patients With Chronic Kidney Failure.(RENO-TEP)
The objective of this study is to nake a comparison between 11c-acetate and 11c-acetoacetate kidney uptake in chronic kidney failure patients.
- Trial name
- RENO-TEP (NCT05968391)
- Testing
- PET scan metabolic day
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Université de Sherbrooke
Alzheimer Disease, Glucose Metabolism
Feasibility Study of a Community Pilot Project for the Prevention of Alzheimer's Disease: the KetoHome Study.
The purpose of this study is to assess whether it is possible to carry out a research project with a nutritional intervention in senior's residence.
- Trial name
- KetoHome (NCT05642052)
- Testing
- low carb diet, Regular diet
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Diabetes Mellitus, Coronary Artery Disease
Metformin in Diabetic Patients Undergoing Coronary Angiography
The present study aims to evaluate the strict application of the 2018 European Society of Cardiology guidelines on myocardial revascularization, that recommends to check renal function if patients have taken metformin immediately…
- Conditions
- Diabetes Mellitus, Coronary Artery Disease, Lactic Acidosis With Diabetes Mellitus, Contrast-induced Nephropathy
- Trial name
- NO-STOP (NCT04766008)
- Testing
- Metformin
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Humanitas Hospital, Italy
Propionic Acidemia
A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study
The main purpose of this study is to evaluate the long-term safety of mRNA-3927 administered to participants with propionic acidemia (PA) who have previously participated in Study mRNA-3927-P101 (NCT04159103).
- Trial name
- NCT05130437
- Testing
- mRNA-3927
- Where
- 22 sites in United States, Canada and 6 more
- Volunteers
- 50 people
- Sponsor
- ModernaTX, Inc.
Metabolic Acidosis
Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill
The purpose of the present study is to compare the adjunct treatment of metabolic or mixed severe acidosis in the critically ill using Sodium Bicarbonate as a buffer to increase the plasma pH vs no buffering therapy.
- Trial name
- (BICAR-ICU) (NCT02476253)
- Testing
- Sodium Bicarbonate
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes Mellitus, Diabetic Ketoacidosis
Diabetic Kidney Alarm (DKA) Study
The overarching goals of this study are to determine whether tubular dysfunction (elevated urine sodium, bicarbonate and amino acids) and injury (elevated kidney injury molecule 1 [KIM-1], neutrophil gelatinase-associated…
- Trial name
- DKA (NCT03128229)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Colorado, Denver
Mitochondrial Diseases
A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease
A long-term extension study to assess the safety, tolerability and efficacy of cysteamine bitartrate delayed-release capsules (RP103) in children with inherited mitochondrial diseases who previously enrolled into study…
- Trial name
- NCT02473445
- Testing
- Cysteamine Bitartrate
- Where
- 5 sites in United States
- Volunteers
- 22 people
- Sponsor
- Amgen
Heart Failure With Preserved Ejection Fraction, Diabetes Mellitus, Type 2
Modulation of Circulating Levels of the Ketone Body 3-hydroxybutyrate in Patients With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction: Metabolic Effects. (KETO-HFpEF-Metabolic)
Heart failure (HF) is among the most common causes of death in patients with type 2 diabetes (T2D). Ketones, 3-hydroxybutyrate (3-OHB), have shown to have beneficial effects in patients with hearth failure with reduced ejection…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Diabetes Mellitus, Type 2, Ketonemia
- Trial name
- NCT05159570
- Testing
- Ketone ester
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Obesity
What is the Maximum Amount of Carbohydrates That is Still Able to Induce Ketosis and Suppress Appetite?
Two dietary approaches, very low energy diets (VLEDs) and ketogenic low carbohydrate diets (KLCDs), have the ability to suppress appetite.
- Trial name
- NCT02944253
- Testing
- Low energy diet 70 gram carbohydrates, Low energy diet 100 gram carbohydrates, Low energy diet 130 gram carbohydrates
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Hyperventilation, Chronic Idiopathic Hyperventilation
Normalizing CO2 in Chronic Hyperventilation by a Novel Breathing Mask: A Pilot Study
Background: Chronic Idiopathic Hyperventilation (CIH) is a form of dysfunctional breathing which has proven hard to treat effectively.
- Conditions
- Hyperventilation, Chronic Idiopathic Hyperventilation, Dysfunctional Breathing, Respiratory Alkalosis
- Trial name
- HVMASKE (NCT01575665)
- Testing
- Partial Rebreathing Mask
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- University of Aarhus
Diabetes Mellitus, Type 2
SGLT2 Inhibitors and Effects on Hematopoiesis, Inflammation and Metabolic Markers
Study of the response to SGLT2 inhibitors in type 2 diabetic patients with relevance to the erythropoesis and indexes of cardiorenal function.
- Trial name
- SGLT2HgB (NCT05408936)
- Testing
- SGLT2 inhibitor
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- University of Patras
Diabetic Ketoacidosis
Remote Glucose Monitoring System in Hospitalized Patients With Diabetic Ketoacidosis (DKA)
The purpose of this research study is to investigate the use of continuous glucose monitoring (CGM) device DEXCOM G6 in non-critically patients treated for diabetic emergency such as diabetic ketoacidosis (DKA).
- Trial name
- NCT05439928
- Testing
- DEXCOM G6 CGM
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- Columbia University
Ketosis, Essential Hypertension
Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity
This is a randomized, placebo-controlled, double-blinded crossover design. Nineteen patients with essential hypertension will be randomized to receive either ketone bodies (KE4) or placebo delivered by KetoneAid.
- Trial name
- (KETO-HT) (NCT06418074)
- Testing
- Ketone Monoester (KE4)
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Gødstrup Hospital