Clinical trials: Acid-Base Imbalance
Ketosis
A Trial of Intravenous Fluids During Labor
The purpose of this study is to determine if intrapartum use of a glucose-containing solution will improve the outcomes in pregnant women and their babies.
- Trial name
- RARHY (NCT01110005)
- Testing
- D5 Lactated Ringer's Solution (D5LR), Lactated Ringer's Solution (LR)
- Where
- 4 sites in United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Distal Renal Tubular Acidosis
Study Evaluating Subjects With Distal Renal Tubular Acidosis
This is a phase 3, prospective, multicenter, randomized, double-blinded, placebo-controlled withdrawal study comparing the efficacy of ADV7103 versus placebo in preventing the development of metabolic acidosis in pediatric and…
- Trial name
- NCT03644706
- Testing
- ADV7103
- Where
- 8 sites in United States, Canada
- Volunteers
- 3 people
- Sponsor
- Advicenne Pharma
Healthy Adults
Ketone Production With Acute Caffeine Intake
Evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10).
- Trial name
- NCT02694601
- Testing
- Control, Caffeine low dose, Caffeine high dose
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Ketosis, Blood Glucose
The Effect of Different Ketone Supplements on β-OHB and Blood Glucose in Healthy Individuals
Ketone bodies are a fuel source and signaling molecule that are produced by your body during prolonged fasting or if you consistently eat at low-carbohydrate diet.
- Trial name
- NCT05273411
- Testing
- (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester, Beta-hydroxybutyric acid, 1,3-Butanediol
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy Adults
Comparing the Ketogenic Effect of Coconut Oil and Different MCTs
The aim of this study is to compare the ketogenic effect of coconut oil and three MCT oils (60-40 , tricaprylin and triheptanoate) on the production of ketones in healthy adults.
- Trial name
- MCT-Coco (NCT02679222)
- Testing
- Coconut oil, Coconut oil + MCT, MCT
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Diabetic Ketoacidosis
Intravenous Fluids in Adults With Diabetic Ketoacidosis in the Emergency Department
Diabetes mellitus is a common chronic disease. It is estimated that up to 40% of adults may develop diabetes in their lifetime. Patients with poorly controlled blood sugars often visit the emergency department for treatment of…
- Trial name
- BRISK-ED (NCT04926740)
- Testing
- Ringer's lactate
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Kidney Disease, Metabolic Acidosis
Bicarbonate Administration in CKD
Low serum bicarbonate levels, even within the normal laboratory range, are strongly associated with increased risks of hypertension, endothelial dysfunction, cardiovascular disease and death.
- Trial name
- NCT02915601
- Testing
- Sodium bicarbonate
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- University of Colorado, Denver
Lactic Acidosis, Blood Glucose, High
Nitroglycerin Infusion During Cardiac Surgery
Hypothermic cardiopulmonary bypass results in peripheral vasoconstriction and heparin trapping. Hypoperfusion and ischemic-reperfusion injury are associated with systemic inflammatory response, while insufficient and delayed…
- Trial name
- NCT01901419
- Testing
- Nitroglycerin infusion
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Evaluate Ketogenic Stress
An Investigation Into the Effect of Dapagliflozin on Ketogenesis in Type 1 Diabetes
The study investigations include evaluation of the acute effects of a single dose of dapagliflozin (10mg), exenatide (5µg), a combination of exenatide and dapagliflozin or placebo under insulinopenic condition and the long term…
- Trial name
- NCT02962492
- Testing
- Exenatide/Exenatide extended release, Dapagliflozin
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University at Buffalo
Alkalosis
Chronic Versus Acute Dosing of Sodium Citrate for Swimming 200m
Ingestion of sodium citrate (Na-Cit), an alkalizing agent, increases extracellular pH via liver oxidation by decreasing [H+] and increasing bicarbonate concentration (HCO3-).
- Trial name
- NCT01835912
- Testing
- Sodium Citrate Dihydrate
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Brock University
Diabetes Mellitus, Type 1
Effects of Micronutrient (Chromium) Supplementation on Diabetes
6-8% of USA population has diabetes. Intensive blood glucose control dramatically reduces the devastating complications that result from poorly controlled diabetes.
- Trial name
- NCT01709123
- Testing
- chromium niacinate
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Diabetic Ketoacidosis
Effectiveness of Subcutaneous Glargine On The Time To Closure of The Anion Gap in Patients Presenting to the Emergency Department With Diabetic Keto-acidosis
To determine if co-administration of subcutaneous (SQ)Insulin glargine in combination with intravenous (IV) insulin decreases the time to resolution of ketoacidosis and requirement for ICU admission compared to IV insulin with…
- Trial name
- GT-COG (NCT02006342)
- Testing
- Insulin Glargine, Regular Insulin
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center, Houston
Chronic Kidney Disease
Sodium Bicarbonate Supplementation in Chronic Kidney Disease Evaluation of Dose Response, Safety and Beneficial Effects
This study will enroll 25 patients with kidney disease to evaluate the effects of different doses of sodium bicarbonate (baking soda) on levels of bicarbonate in the blood, kidney function and muscle strength.
- Trial name
- NCT00888290
- Testing
- Sodium bicarbonate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Albert Einstein College of Medicine
Metabolic Acidosis, Chronic Kidney Disease
Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD
This is a pilot, randomized, double-blinded, placebo-controlled, 12-month trial of 50 patients with CKD stage 3b-4 with metabolic acidosis to examine the effect of sodium bicarbonate therapy on cognitive and cerebrovascular…
- Conditions
- Metabolic Acidosis, Chronic Kidney Disease, Cognitive Dysfunction
- Trial name
- NCT04600323
- Testing
- Sodium Bicarbonate Tablets
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Colorado, Denver
Diabetic Ketoacidosis
Cerebral Edema in Pediatric Diabetic Ketoacidosis
The purpose of this trial is to compare two different rates of fluid administration during diabetic ketoacidosis (DKA) treatment in children to determine which fluid administration rate is more beneficial for brain metabolism and…
- Trial name
- NCT00629707
- Testing
- intravenous fluid treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Davis
Metabolic Acidosis
Long-term Safety Extension to Study TRCA-301
This study is a 40-week, blinded, placebo-controlled extension of Study TRCA-301 (NCT03317444). Eligible subjects who complete the 12-week treatment period in Study TRCA-301 have the option to participate in this extension study…
- Trial name
- NCT03390842
- Testing
- TRC101
- Where
- 29 sites in United States, Bulgaria and 5 more
- Volunteers
- 196 people
- Sponsor
- Tricida, Inc.
Diabetes, Ketoacidosis
Two Bag System for Hydration in Diabetes
This is a randomized controlled trial comparing the time needed to get the conditions to space hourly controls to controls every 4 hours, using the one bag system versus the two bags system, in the initial treatment of children…
- Trial name
- NCT01631929
- Testing
- One bag, Two bags
- Where
- Argentina
- Volunteers
- 12 people
- Sponsor
- Hospital General de Niños Pedro de Elizalde