Clinical trials: Acidosis, Metabolic
Diabetic Ketoacidosis
A Multi-Disciplinary Technology-Based Care for Diabetic Ketoacidosis in Patients With Type 1 Diabetes
The study team proposes that use of a novel multi-disciplinary approach with continuous glucose monitoring technology can significantly improve glycemic control and reduce readmissions among those with type 1 diabetes mellitus…
- Trial name
- DKA (NCT06471322)
- Testing
- Continuous Glucose Monitoring (CGM), Standard of Care
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The Cleveland Clinic
Ketosis
Markers of Appetite Regulation During Exogenous Ketosis
The aim of this study is to investigate the relationship, if any, between markers of satiety, desire to eat, hunger, and metabolic markers of the regulation hereof during ketosis as compared with a Glucose-containing and a…
- Trial name
- MARK (NCT04156477)
- Testing
- Ketone ester, Glucose, Tap water
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Central Jutland Regional Hospital
Ketoses, Metabolic, Ketogenic Dieting
Effect of Nutritional Ketosis on Alcohol Metabolism
The research study is being conducted in health controls to better understand the effects of ketosis on brain functioning after 3 different, randomly assigned, 3-day dietary interventions and the acute effects of alcohol after…
- Conditions
- Ketoses, Metabolic, Ketogenic Dieting, Alcohol Intoxication, Magnetic Resonance Imaging
- Trial name
- KAM (NCT06065657)
- Testing
- Ketone Supplement, Control Diet, Ketogenic diet
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Post-Traumatic Stress Disorder, PTSD
Ketogenic Diet for Post-Traumatic Stress Disorder (PTSD)
This project is a prospective, single-arm, open-label feasibility study testing whether a 12-week medically supervised ketogenic diet (KD) can be implemented in adults with PTSD in Germany (N=6).
- Trial name
- NCT07415590
- Testing
- Ketogenic diet
- Where
- 2 sites in Germany
- Volunteers
- 6 people
- Sponsor
- Bundeswehr University Munich
Type1diabetes
Very Low Carbohydrate Diets and Glucagon Response in T1DM
Despite major technological advances, management of type one diabetes mellitus (T1D) remains suboptimal, putting millions of people at risk for immediate and long-term complications.
- Trial name
- NCT04200391
- Testing
- Very low carbohydrate diet
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Boston Children's Hospital
HIV Infections, Hepatitis C
Effect of a Change in HIV Therapy on Liver Steatosis, Inflammation, and Fibrosis
The purpose of this study is to look at how 2 different anti-HIV drug treatments affect the liver. The use of anti-HIV drugs like the nucleoside reverse transcriptase inhibitors (NRTIs) may be linked to liver problems like fatty…
- Trial name
- NCT00023218
- Testing
- Lopinavir/Ritonavir, Efavirenz
- Where
- 3 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Young Adults
Effects of Exogenous Ketones in Healthy Young Adults
Exogenous ketone supplements in the form of beta-hydroxybutyrate can be utilized as an alternate energy source (in place of glucose) for all cells except red blood cells.
- Trial name
- NCT03452761
- Testing
- Ketone Salts
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Augusta University
Aging
Do Ketone Drinks Improve Immune, Metabolic and Cognitive Health in Older Adults
The goal of this randomised, double-blinded, placebo-controlled trial is to investigate the immune, metabolic and cognitive effects of four weeks of daily ketone supplementation in adults aged 60 to 80 with stable health.
- Trial name
- NCT06068803
- Testing
- Ketone drink
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Bath
Obesity, Morbid, NASH
The Impact of Different Carbohydrate Restriction After a Gastric Bypass on the Ketosis and Ketoacidosis
Background: Ketosis after bariatric surgery is a metabolic process that occurs when the body breaks down fat for energy because of not getting enough carbohydrates.
- Conditions
- Obesity, Morbid, NASH, Ketosis, Keto Acidosis
- Trial name
- NCT06338969
- Testing
- Carbohydrate Restriction after a Gastric Bypass
- Where
- Kazakhstan
- Volunteers
- 150 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Kidney Transplantation
Major Activation Of NCC in Graft Urinary Exosomes
Hypertension is common disorder after renal transplantation and is associated with mortality. Calcineurin Inhibitor (CNI), by activating NCC cotransporter, may be a major determinant of hypertension, included in a "Gordon like"…
- Trial name
- MANGUE (NCT03503461)
- Testing
- exosomes analysis
- Where
- 2 sites in France, Reunion
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Mechanical Ventilation Complication
Potential Impact of the Use of the Application VentilO
Mechanical ventilation is a vital support associated with the treatment of patients with acute respiratory failure and in other indications such as surgery under general anesthesia, coma or shock.
- Trial name
- NCT05587686
- Testing
- VentilO application
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Laval University
Diabetes, Diabetic Ketoacidosis
Evaluation of a Non-invasive Brain Compliance Measurement Device
This is a research study to understand how diabetic ketoacidosis may affect the brain and learning and to see if these changes are transient or permanent.
- Trial name
- NCT01753921
- Testing
- this is not an intervention study, MRI
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Stanford University
Fetal Distress, Stillbirth
Introducing Fetal Scalp Stimulation as an Adjunct to Intermittent Auscultation in Low-Resource Settings.
This study is a pilot study taking place in Moshi, Tanzania at the Kilimanjaro Christian Medical Centre (KCMC). The study aims to introduce fetal scalp stimulation into the intermittent auscultation protocols at KCMC, and to…
- Conditions
- Fetal Distress, Stillbirth, Birth Asphyxia, Acidosis
- Trial name
- NCT02862925
- Testing
- Fetal Scalp Stimulation
- Where
- Tanzania
- Volunteers
- 550 people
- Sponsor
- Duke University
Severe Malaria
Clinical Prediction Models for Pediatric In-Hospital Death Risk in Congolese Severe Malaria Children Using Machine Learning Based-Algorithms
The goal of this observational study is to optimize the management of severe childhood malaria, based on understanding and controlling the severity factors of the disease in Congolese children aged 2 to 9 years (the age group at…
- Trial name
- NCT07355426
- Testing
- Puncture of the radial artery for instant arterial blood gaz as well as for venous biochemistry
- Where
- Democratic Republic of the Congo
- Volunteers
- 100 people
- Sponsor
- University of Kinshasa
Propionic Acidemia
Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia
This 3-part, Phase 1/2 study is designed to characterize the safety, tolerability, and pharmacological activity (as assessed by biomarker measurements) and to determine the selected dose of mRNA-3927 in participants with…
- Trial name
- NCT04159103
- Testing
- mRNA-3927
- Where
- 35 sites in United States, Canada and 6 more
- Volunteers
- 77 people
- Sponsor
- ModernaTX, Inc.
Metformin Associated Lactic Acidosis
Study of Metformin Overdose
The objective of the METINFO study is an observational single-center retrospective and descriptive study. The main objective is to estimate the real mortality rate associated to a Metformin overdose.
- Trial name
- METINFO (NCT04762966)
- Testing
- Metformin
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Metabolic Acidosis
Effect of Propofol and Sevoflurane on Lactate During Anesthesia for Pediatric Heart Catheterisation
Propofol is routinely used for general anesthesia during pediatric heart catheterisation. Propofol infusion syndrome (PRIS) is a rare, but often fatal complication mainly defined by bradycardia with progress to asystolia during…
- Trial name
- PRISCATHLAB (NCT01293266)
- Testing
- Propofol
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Schleswig-Holstein
Muscle Acidosis
The Causal Connection Between Sng and Muscle Acidosis
This proposed study suggests that peripheral tissue acidosis sensed by the somatosensory system (sngceptin) would evoke the sng perception in the brain.
- Trial name
- NCT04049253
- Testing
- Phosphate Buffer Solution
- Where
- Taiwan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Hospital
Exercise, Ultra-endurance Running
Effect of Exogenous Ketosis During Ultra-endurance Exercise
The aim of this study is to investigate the effect of oral ketone administration during and immediately after an ultramarathon. Potential changes in cognitive function (reaction time, number of errors), running performance, jump…
- Conditions
- Exercise, Ultra-endurance Running, Ketosis, Skeletal Muscle
- Trial name
- NCT05407753
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Head Trauma
Interest of Using Balanced Fluid for Infusion at the Early Phase of an Acute Cranial Trauma for Limiting Hyperchloremic Acidosis
isotonic NaCl serum is the first intent solution for infusion during the initial phase of reanimation for an acute cranial traumatism.
- Trial name
- IsoTC (NCT00847977)
- Testing
- use of a non balced fluid and of a macromolecular fluid, use of balanced crystalloids fluid and macromolecular fluid
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Nantes University Hospital