Clinical trials: Acinetobacter Baumannii
Ventilator Associated Pneumonia
PK of BV100 in Patients VABP Suspected or Confirmed to Be Due to CRAB
A multicenter Phase 2 study to evaluate the pharmacokinetics, efficacy, and safety of intravenous BV100 combined with Polymyxin B in adult patients with VABP suspected or confirmed to be due to CRAB
- Trial name
- NCT05685615
- Testing
- BV100 plus Polymyxin B, BAT
- Where
- 16 sites in Georgia, Greece and 1 more
- Volunteers
- 39 people
- Sponsor
- BioVersys AG
Hospital-acquired Bacterial Pneumonia, Ventilator-associated Bacterial Pneumonia
A Clinical Trial to Assess the Safety and PK of OMN6 in HABP or VABP Caused by Acinetobacter Baumannii Complex
This is a phase 2a, multinational, multicenter, double-blind, randomized, placebo-controlled, dose-ranging safety, tolerability and PK study in patients with HABP (Hospital Acquired Bacterial Pneumonia) or VABP (Ventilator…
- Trial name
- NCT06087536
- Testing
- OMN6
- Where
- 15 sites in Greece, Israel
- Volunteers
- 54 people
- Sponsor
- Omnix Medical Ltd
Acinetobacter Baumannii-calcoaceticus Complex Infection (ABC)
A Study to Assess Sulbactam-durlobactam in Pediatric Patients With Acinetobacter Baumannii-calcoaceticus Complex Infection
The goal of this clinical trial is to investigate the use of Sulbactam-Durlobactam (SUL-DUR) in pediatric patients and is being conducted to collect pharmacokinetic (PK) and safety data to enable the identification of appropriate…
- Trial name
- NCT06801223
- Testing
- Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 6 hours), Sulbactam 20mg/kg-Durlobactam 20mg/kg (Every 8 hours), Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 8 hours)
- Where
- 4 sites in United States
- Volunteers
- 48 people
- Sponsor
- Innoviva Specialty Therapeutics
Acinetobacter Baumannii
Management of an Imipenem-resistant Acinetobacter Baumannii Alert in a French University Hospital
Colonization with imipenem-resistant Acinetobacter baumannii (IBA) is an unfavorable event for the patient, especially in intensive care.
- Trial name
- Baumannii (NCT06173440)
- Where
- France
- Volunteers
- 148 people
- Sponsor
- University Hospital, Strasbourg, France
Carbapenem Resistant Bacteria Infection
European Prospective Cohort Study on Enterobacteriaceae Showing Resistance to Carbapenems
Among antibiotic-resistant organisms, the Gram-negative bacteria are now the most important challenge because of the rapid worldwide spread of mechanisms conferring resistance to multiple drugs.
- Trial name
- EURECA (NCT02709408)
- Where
- 50 sites in Albania, Bulgaria and 9 more
- Volunteers
- 2,515 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Pulmonary Infection, Pneumonia, Bacterial
Eravacycline Combination Therapy for MRAB
The goal of this observational study is to learn about the eravacycline combination therapy in multidrug-resistant acinetobacter gaumannii pneumonia. The main question is to evaluate the the effectiveness and safety.
- Conditions
- Pulmonary Infection, Pneumonia, Bacterial, Acinetobacter Baumannii
- Trial name
- NCT06282835
- Testing
- Eravacycline Injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Fujian Medical University Union Hospital
Acinetobacter Bacteraemia
A Prospective Observational Study of Patients With Drug Resistant Acinetobacter Baumannii Bacteremia
Extensively and multi-drug resistant A. baumannii (AB) represent an emerging threat in hospitals locally and worldwide. There is lack of prospective comparative clinical data to guide optimal strategy for treating such…
- Trial name
- ANTI-AB (NCT01511224)
- Where
- 3 sites in Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Acinetobacter Infections
Efficacy of Colistin Monotherapy Versus Colistin Plus Minocycline for Carbapenem-Resistant A. Baumannii Infection
Acinetobacter baumannii causes severe infections (pneumonia, bacteremia, organ space) with high lethality in hospitalised critically ill patients.
- Trial name
- NCT05586815
- Testing
- Colistin, Minocycline
- Where
- Thailand
- Volunteers
- 94 people
- Sponsor
- Mahidol University
Infection Due to Carbapenem Resistant Acinetobacter
Colistin Monotherapy vs Colsitin-fosfomycine in CRAB Infection
The goal of this clinical trial is to evaluate the efficacy of colistin compared with colistin plus fosfomycin against carbapenem-resistant Acinetobacter baumanii infection in Thailand.
- Trial name
- NCT06570850
- Testing
- Colistin Sodium Methanesulfonate, Colistin Sodium Methanesulfonate plus Fosfomycin
- Where
- Thailand
- Volunteers
- 188 people
- Sponsor
- Chiang Mai University
Multi-antibiotic Resistance
Screening of Multidrug Resistant Bacteria, and the Clinical Implication for the Patient
The goal of this observational study is to evaluate the screening for multidrug resistant bacteria in patients admitted to hospitals in Scania.
- Trial name
- NCT06370299
- Testing
- (exposure of) MDR carriage
- Volunteers
- 10,000 people
- Sponsor
- Region Skane
Acinetobacter Baumannii Infection
Effects of Immune Function on Prognositic Outcome in Critical Ill Patients With Acinetobacter Baumannii Infection
The purpose of the present study is to evaluate the effects of immune function on prognositic outcome in critical ill patients with Acinetobacter baumannii infection.
- Trial name
- NCT02886637
- Testing
- None intervention
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Carbapenem-Resistant Enterobacteriaceae
Clinical Validation of the Molecular-Based GenePOC Carba Assay for the Detection and Differentiation of Carbapenemase Genes in Rectal Swab Samples.
The primary purpose of this clinical investigation is to establish the performance of the GenePOC Carba assay on the revogene. This will be achieved by comparing the test to a conventional method for detection of Carbapenemase…
- Trial name
- NCT03680898
- Testing
- Rectal swab collection
- Where
- 3 sites in United States, Canada
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Meridian Bioscience, Inc.
Carbapenem-Resistant Acinetobacter Baumannii Infection, Bloodstream Infection
Sulbactam-Durlobactam in CRAB Infection: A Real-World Cohort Study
This is a multicenter real-world observational cohort study designed to evaluate the effectiveness and safety of sulbactam-durlobactam in patients with carbapenem-resistant Acinetobacter baumannii (CRAB) infections.
- Conditions
- Carbapenem-Resistant Acinetobacter Baumannii Infection, Bloodstream Infection, Pneumonia, Sepsis
- Trial name
- SD-CRAB (NCT07601711)
- Testing
- Sulbactam-Durlobactam
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sichuan Provincial People's Hospital
Infections, Bacterial, Sepsis Bacterial
Therapeutic Options for CRAB
CRAB infections in ICUs are on the rise, leading to higher morbidity, mortality, and healthcare costs due to resistance to most antibiotics, including carbapenems.
- Trial name
- TheraCRAB (NCT06440304)
- Testing
- Fosfomycin, Eravacycline, ampicillin/sulbactam
- Where
- Croatia
- Volunteers
- 108 people
- Sponsor
- Clinical Hospital Centre Zagreb
Infections Resistant to Multiple Drugs, Bacterial Infections
Multi-Drug Resistant Organism Network
This study is specifically designed to provide observational data which can be used to help in the design of future randomized clinical trials on both therapeutics and diagnostics for MDRO infections.
- Trial name
- MDRO Network (NCT03646227)
- Testing
- Standard of Care
- Where
- 4 sites in United States, Australia and 2 more
- Volunteers
- 6,496 people
- Sponsor
- Duke University
Drug Safety
Colistin Versus Colistin Plus Fosfomycin for Infections Caused by MDR Acinetobacter Baumannii
In Siriraj Hospital, colistin alone for treatment of MDR A. baumannii contributed to mortality 45% Fosfomycin is an antimicrobial which has activity against gram-negative bacterial including MDR A.
- Trial name
- NCT01297894
- Testing
- colistin, colistin plus fosfomycin
- Where
- Thailand
- Volunteers
- 92 people
- Sponsor
- Mahidol University
Antibiotic Resistant Infection
Effectiveness and Safety of Tigecycline for Therapy of Infections Caused by Multi-Drug Resistant Acinetobacter Baumannii
30 adult hospitalized patients who have infections due to MDR Acinetobacter baumannii will be enrolled. The eligible patients will receive 100 mg of tigecycline intravenous infusion for 30 minutes followed by 50 mg every 12 hours…
- Trial name
- NCT01342731
- Testing
- Tigecycline
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Infection Control
Enhanced Room Cleaning in Intensive Care Units to Reduce Gown and Glove Contamination With Multi-drug-resistant Bacteria
The purpose of this study is to determine whether extra cleaning of frequently-contaminated surfaces in intensive care rooms is effective in preventing contamination of disposable isolation gowns and gloves with multi-drug…
- Trial name
- NCT01481935
- Testing
- Enhanced cleaning of surfaces in ICU rooms
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- University of Maryland, Baltimore
Acinetobacter Bacteraemia
Imipenem and Sulbactam in the Treatment of Imipenem-resistant Acinetobacter Baumannii Bacteremia
Infections caused by imipenem-resistant Acinetobacter baumannii are associated with high mortality and morbidity. The treatment choices for this resistant pathogen are limited.
- Trial name
- NCT01374256
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Pneumonitis, Acinetobacter Baumannii
A Study on the Combination Therapy of Eravacycline for Treating Carbapenem-Resistant Acinetobacter Baumannii Pneumonia
This study intends to evaluate the efficacy and safety of eravacycline-based combination therapy in real words for Chinese patients with CRAB pneumonia, providing data reference for clinical treatment of CRAB pneumonia.
- Trial name
- NCT06670872
- Testing
- Eravacycline combination therapy group
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Peking University Third Hospital