Clinical trials: Acne Inversa
Hidradenitis Suppurativa (HS)
Pharmacokinetics, Safety, and Efficacy of Povorcitinib in Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa
The purpose of this study is to evaluate the pharmacokinetics, safety, and efficacy of povorcitinib in adolescent participants with moderate to severe hidradenitis suppurativa over a 54-week open-label treatment period.
- Trial name
- NCT07213973
- Testing
- Povorcitinib
- Where
- 30 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- Incyte Corporation
Hidradenitis Suppurativa, Hidradenitis
Low Dose Radiotherapy for Advanced Hidradenitis Suppurativa
To establish the safety of radiotherapy in the treatment of advanced hidradenitis suppurativa. Patients will receive radiotherapy treatment over one week and then they will be followed for the next three months.
- Trial name
- RTHS (NCT03040804)
- Testing
- Low dose Radiotherapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Montefiore Medical Center
Hidradenitis Suppurativa, Acne Inversa
Microwave Ablation in Mild Axillary Hidradenitis Suppurativa
With microwave ablation (MWA), using the heat generated from electromagnetic waves in the microwave energy spectrum, hair follicles and apocrine glands in the (hypo)dermis are ablated through thermolysis.
- Trial name
- WAVE (NCT03238469)
- Testing
- Microwave ablation
- Where
- Netherlands
- Volunteers
- 9 people
- Sponsor
- M.B.A. van Doorn
Hidradenitis Suppurativa, Acne Inversa
Intense Pulsed Light Therapy for Hidrosadenitis Suppurativa
6 monthly treatments with IPL laser in patients with Hidradenitis Suppurativa. The effect in measured on several severity scores.
- Trial name
- NCT03203122
- Testing
- IPL laser
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Zealand University Hospital
Hidradenitis, Healthy Volunteers
SAR447971 First-in-human Study
SAD20411 is a single-center, first-in-human, double-blind, randomized, placebo-controlled, sequential single ascending dose study in healthy male and/or female participants with a pilot food effect investigation.
- Trial name
- NCT07629336
- Testing
- SAR447971
- Where
- Netherlands
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Sanofi
Hidradenitis Suppurativa
A Study of Early Secukinumab Treatment in Moderate to Severe Hidradenitis Suppurativa Patients
The aim of this study is to evaluate the effectiveness of early treatment with secukinumab in patients with moderate-to-severe hidradenitis suppurativa (HS) and assess its impact on disease progression using data from multiple…
- Trial name
- EARLY-HS 2 (NCT07690319)
- Volunteers
- 186 people
- Sponsor
- Novartis Pharmaceuticals
Hidradenitis Suppurativa
Effect of Sclerotherapy on Fistulas and Sinus Tracts in Hidradenitis Suppurativa
This study evaluates the effect of hypertonic saline 23.4% injection in fistulas or sinus tracts in adult patients with hidradenitis suppurativa.
- Trial name
- NCT02805595
- Testing
- 23.4% Hypertonic saline
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Spontaneous Urticaria (CSU), Hidradenitis Suppurativa (HS)
SKIN Disease Profiling by an Exploratory, pRospective, Biomarker Study in dermatoloGY Practice (SKINERGY)
The goal of this observational study is to comprehensively profile six immune-mediated inflammatory diseases, including atopic dermatitis (AD), plaque psoriasis (PSO), hidradenitis suppurativa (HS), cutaneous T-cell lymphoma…
- Conditions
- Chronic Spontaneous Urticaria (CSU), Hidradenitis Suppurativa (HS), Psoriasis (PsO), Atopic Dermatitis (AD)
- Trial name
- SKINERGY (NCT07021495)
- Where
- 8 sites in Netherlands
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Hidradenitis Suppurativa
Hidradenitis Suppurativa Written Action Plan
This study is being conducted to evaluate if a written action plan for hidradenitis suppurativa (HS) will help patients with hidradenitis suppurativa gain a better understanding of the condition and how to manage the condition on…
- Trial name
- HSWAP (NCT04230291)
- Testing
- Verbal consultation, Written Action Plan
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Arizona
Hidradenitis Suppurativa
Brivekimig for the Treatment of Moderate to Severe Hidradenitis Suppurativa
This is a Phase 2b, global, multicenter, sequential, randomized, double-blind, placebo-controlled, parallel group, dose-ranging study in participants with moderate to severe hidradenitis suppurativa.
- Trial name
- BRIGHTEN (NCT07170917)
- Testing
- Brivekimig
- Where
- 85 sites in United States, Australia and 17 more
- Volunteers
- 208 people
- Sponsor
- Sanofi
Hidradenitis Suppurativa
A Study to Evaluate the Efficacy and Safety of Bimekizumab in Study Participants With Moderate to Severe Hidradenitis Suppurativa
The purpose of the study is to evaluate the efficacy and safety of bimekizumab in study participants with moderate to severe hidradenitis suppurativa (HS)
- Trial name
- BE HEARD I (NCT04242446)
- Testing
- Bimekizumab
- Where
- 88 sites in United States, Australia and 13 more
- Volunteers
- 505 people
- Sponsor
- UCB Biopharma SRL
Psoriasis, Alopecia Areata
Development and EValuation of an Online Intervention to Reduce Self-Stigma in People With Visible Chronic Skin disEases
This project aims to develop and evaluate an online intervention to prevent and/or reduce self-stigma in German patients with visible chronic skin diseases.
- Conditions
- Psoriasis, Alopecia Areata, Hidradenitis Suppurativa, Vitiligo
- Trial name
- DEVISE (NCT06324695)
- Testing
- HautKompass
- Where
- 12 sites in Germany
- Volunteers
- 298 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hidradenitis Suppurativa
Hidradenitis Suppurativa Prospective Observational Registry and Biospecimen Repository
Hidradenitis suppurativa (HS) is a common and debilitating skin disease that is poorly understood and understudied. As a result, little is known about disease prognosis and few effective treatments exist for this condition.
- Trial name
- HS PROGRESS (NCT04115566)
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- University of California, San Francisco
Hidradenitis Suppurativa (HS)
A Study of SPY072 in Adults With Moderate to Severe Hidradenitis Suppurativa (The SKYLIGHT Trial)
This Phase 2 study will test whether the investigational medicine, SPY072, improves hidradenitis suppurativa (HS) in adults with moderate to severe disease receiving advanced standard of care treatment.
- Trial name
- NCT07766005
- Testing
- SPY072, bimekizumab
- Where
- 34 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- Spyre Therapeutics, Inc.
Hidradenitis Suppurativa (HS)
Hidradenitis Suppurativa Wound Care
The objective of this case series is to monitor time and outcome of healing of wounds associated with HS using Endoform [ovine forestomach], Hydrofera Blue [methylene blue and gentian violet], and Hypafix tape.
- Trial name
- NCT04354012
- Testing
- methylene blue, gentian violet, and ovine forestomach wound dressings
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Wake Forest University Health Sciences
Hidradenitis Suppurativa (HS)
Radiotherapy for Refractory Hidradenitis Suppurativa
The goal of this clinical trial is to learn if high-dose radiotherapy can provide sustained disease relief in moderate to severe, treatment resistant Hidradenitis suppurativa patients; could include any of the following: any…
- Trial name
- RADIANTSUPPoRT (NCT07414550)
- Testing
- Radiated axilla
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Thomas Jefferson University
Hidradenitis Suppurativa
Intralesional Diode Laser Treatment of Fistulas in Hidradenitis Suppurativa
Hidradenitis suppurativa (HS) is a common chronic skin disease where patients experience inflamed painful nodules and chronic suppurating tunnels under the skin that often leave mutilating scars.
- Trial name
- NCT04508374
- Testing
- 1470 nm intra-lesional diode laser treatment of right HS tunnel, 1470 nm intra-lesional diode laser treatment of left HS tunnel
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Zealand University Hospital
Hidradenitis Suppurativa
Topical Ruxolitinib 1.5% for Hidradenitis Suppurativa Treatment
Investigators hypothesize that ruxolitinib 1.5% cream is an effective therapy for HS participants through inhibition of inflammatory activity.
- Trial name
- NCT04414514
- Testing
- Ruxolitinib 1.5% Cream
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Milton S. Hershey Medical Center
Hidradenitis Suppurativa
Study to Compare Two Treatments for Axillary Hidradenitis Suppurativa: Carbon Dioxide Laser Versus Surgical Deroofing
This study compares two well-known treatment options for Stage 2 hidradenitis suppurativa: carbon dioxide (CO2) laser excision versus surgical deroofing.
- Trial name
- NCT02163746
- Testing
- CO2 (carbon dioxide) laser, Surgical Deroofing
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Hidradenitis Suppurativa, Surgical Wound
Wet-to-dry vs Petrolatum & Non-stick Dressings After Hidradenitis Suppurativa Surgery
Hidradenitis suppurativa (HS) is a chronic, severe, inflammatory skin disease associated with pain, drainage, odor, and disability characterized by recurring abscesses, nodules, and tunneling sinuses in intertriginous locations…
- Trial name
- NCT05194969
- Testing
- Wet-to-Dry Dressings, Petrolatum with Non-Stick Gauze
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of North Carolina, Chapel Hill