Clinical trials: Acquired Immune Deficiency Syndrome
HIV Infections
Effect of Antacids on the Pharmacokinetics of Raltegravir
The purpose of this study is to test whether there is a drug interaction between raltegravir (a medicine used to treat the human immunodeficiency virus or HIV) and antacids.
- Trial name
- NCT00944307
- Testing
- raltegravir, antacid
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Human Immunodeficiency Virus
3BNC117 and 10-1074 in ART-treated Individuals
The proposed study is a phase 1, open label, randomized study to evaluate the safety and antiretroviral activity of seven infusions of 3BNC117 and 10-1074, administered intravenously at 30 mg/kg dose level, in human…
- Trial name
- NCT03526848
- Testing
- 3BNC117, 10-1074, Analytical treatment interruption
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Rockefeller University
HIV/AIDS
Adolescent Master Protocol for Participants 18 Years of Age or Older - Lite
This is a prospective cohort study designed to define the impact of HIV infection and antiretroviral therapy (ART) on young adults with perinatal HIV infection as they transition to adulthood.
- Trial name
- AMP Up Lite (NCT03279185)
- Where
- 9 sites in United States
- Volunteers
- 334 people
- Sponsor
- Harvard School of Public Health (HSPH)
Mycobacterium Avium-intracellulare Infection, HIV Infections
Evaluation of Treatment for Mycobacterium Avium Complex (MAC) Infection in HIV-Infected Patients
To assess the feasibility of using culture and staining techniques to quantify tissue Mycobacterium avium Complex (MAC) burden in bone marrow.
- Trial name
- NCT00001039
- Testing
- Ethambutol hydrochloride, Clarithromycin
- Where
- 8 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
AIDS Dementia Complex, HIV-1-Associated Cognitive Motor Complex
Effect of Cenicriviroc on HIV Neurocognitive Impairment
The study hypothesis is that cenicriviroc will improve cognition in HIV infected individuals with cognitive impairment. The investigators will study the effect of cenicriviroc on cognition in 24 subjects over a 24 week period.
- Conditions
- AIDS Dementia Complex, HIV-1-Associated Cognitive Motor Complex, Human Immunodeficiency Virus
- Trial name
- NCT02128828
- Testing
- cenicriviroc
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Hawaii
HIV/AIDS, Methamphetamine Abuse
Depression Intervention Among Gay and Bisexual Men Receiving Treatment for Methamphetamine Use
This study is a single-arm, non-randomized pilot study. Eligible participants are newly enrolled participants in an outpatient methamphetamine treatment program, and study activities will take place contemporaneously with…
- Conditions
- HIV/AIDS, Methamphetamine Abuse, Depression
- Trial name
- NCT03864653
- Testing
- MoodGym
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Friends Research Institute, Inc.
HIV Infections
Spirituality and Will to Live in Patients With HIV/AIDS
This study is assessing the extent of spirituality in patients with HIV/AIDS and will determine the relationship between spirituality, health status, and the will to live.
- Trial name
- NCT00122902
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Pregnancy, HIV Infection
A Randomized Trial of IUD Versus Hormonal Contraception in HIV-infected Women in Zambia
A randomized trial of the intrauterine contraceptive device (IUD) versus user's choice hormonal contraception (injectable progestins or oral contraceptive pills) among HIV-infected, recently post-partum women in Lusaka, Zambia.
- Trial name
- NCT00336245
- Testing
- Copper T Intrauterine Contraceptive Device, Hormonal Contraception
- Volunteers
- 600 people
- Sponsor
- University of Alabama at Birmingham
HIV/AIDS
PrEPared and Strong: Clinic-Based PrEP for Black MSM
Black men who have sex with men (MSM) have among the highest rates of new HIV infections of any group in the United States. Developing effective HIV prevention interventions that work with this group is a critical element of the…
- Trial name
- P&S (NCT02167386)
- Testing
- Enhanced PrEP Adherence, Standard PrEP Adherence
- Where
- 2 sites in United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV/AIDS
A Mobile Phone Game to Prevent HIV Among Young Africans
This project will test the feasibility of an electronic game to prevent HIV among African preadolescents, delivered via inexpensive Android smart phones.
- Trial name
- NCT03054051
- Testing
- Tumaini Mobile Phone Game
- Where
- Kenya
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Emory University
HIV Infections
BASIC: Boosted Atazanavir or Saquinavir Induced Lipid Changes
The purpose of this study is to assess differences in changes in plasma lipids between patients on saquinavir/ritonavir or atazanavir/ritonavir in combination with tenofovir disoproxil fumarate and emtricitabine as a first-line…
- Trial name
- NCT00389402
- Testing
- saquinavir/ritonavir, atazanavir/ritonavir
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- International Antiviral Therapy Evaluation Center
HIV Infections
The CogNaive Study: Assessing Changes in Neurocognitive Function in Treatment Naïve HIV-1 Positive Subjects
The purpose of this study is to investigate the possibility of an association between changes in neurocognitive function, as measured by a computerised test battery, and the use of two different highly active antiretroviral…
- Trial name
- NCT00540137
- Testing
- nevirapine, atazanavir/ritonavir
- Where
- 2 sites in United Kingdom
- Volunteers
- 21 people
- Sponsor
- Imperial College London
HIV, AIDS
A Pilot Study to Characterize the Pharmacokinetics of Raltegravir in the Cervicovaginal Fluids of HIV-infected Women
The purpose of this research sub-study is to learn about the levels of an antiretroviral (ARV) medication called Raltegravir, and response to HIV virus in the genital tract of HIV-positive women.
- Trial name
- NCT00774683
- Testing
- Raltegravir (Isentress®)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Kristine Patterson, MD
Neuropathy, AIDS
Safety and Preliminary Evidence of Efficacy of Escalating Doses of Dimiracetam in AIDS Patients With Painful Neuropathy
One hundred consenting AIDS patients suffering from treatment induced painful neuropathy will be blindly randomize to Active and Placebo groups (ratio A/P = 3/2 and will receive increasing oral doses of dimiracetam starting from…
- Trial name
- NCT01135251
- Testing
- dimiracetam, sugar pill
- Where
- South Africa
- Volunteers
- 116 people
- Sponsor
- Neurotune AG
Hiv, Meningococcal Infections
Safety and Immunogenicity Following Meningococcal and Pneumococcal Immunization Among Adult People Living With HIV
MENPI is an investigator-initiated single-centre randomized controlled trial which aims to assess the efficacy and safety of meningococcal and pneumococcal vaccination in adults living with HIV receiving antiretroviral treatment.
- Conditions
- Hiv, Meningococcal Infections, Pneumococcal Infections
- Trial name
- MENPI (NCT04875819)
- Testing
- Neisseria meningitidis oligosaccharide conjugate vaccine and recombinant protein-based vaccine, 13 valent pneumococcal conjugate vaccine and 23 valent pneumococcal polysaccharide vaccine
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- Thomas Benfield
Cancer, Cardiac Anomaly
Using NPT to Evaluate Providing PPC as ELNEC-PPC WBT for Nurses
The purpose of this study is to explain the provision of palliative care at the end of life by the implementation of the ELNEC course, as WBT Program using the Normalization Process Theory, that focus attention on how complex…
- Conditions
- Cancer, Cardiac Anomaly, Cystic Fibrosis, Muscular Dystrophy
- Trial name
- ELNEC-PPC (NCT04461561)
- Testing
- end-of-life nursing education consortium-pediatric palliative care as web based-training plus usual care
- Where
- Iraq
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Altoosi University College
Virus-HIV
HIV A6 Genome In ART Unsuccessful Patients On DOR
The aim of the study is to evaluate the efficacy of Doravirine (DOR) in the second-line therapy for patients infected with HIV-1 sub-subtype A6 and its derivatives and having the mutations to previously used drugs
- Trial name
- HIV-A6-DOR (NCT05322083)
- Testing
- Doravirine
- Volunteers
- 60 people
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Alcohol Drinking, Sex, Unsafe
Alcohol and "Heat of the Moment" Sexual Decision Making
HIV transmission remains a significant public health concern, especially among men who have sex with men (MSM). Condomless anal intercourse (CAI) continues to be the major route of transmission for MSM.
- Conditions
- Alcohol Drinking, Sex, Unsafe, Hiv
- Trial name
- NCT05729256
- Testing
- Self-Regulation Intervention, Brief Advice and Information
- Where
- United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Cytomegalovirus Retinitis, HIV Infections
An Open Study of Foscarnet Treatment First Episode CMV-Retinitis in AIDS Patients
To evaluate the safety and efficacy of foscarnet induction therapy for treatment of AIDS patients experiencing their first episode of cytomegalovirus (CMV) retinitis.
- Trial name
- NCT00002039
- Testing
- Foscarnet sodium
- Where
- United States
- Sponsor
- Astra USA
HIV - Human Immunodeficiency Virus, Cognitive Symptoms
COMO: Cognition Study With HIV+ Patients (CTNPT 015)
The purpose of this study is to contribute evidence towards the potential to improve cognition in HIV+ individuals experiencing cognitive decline through personalized change in antiretroviral (ARV) medication.
- Trial name
- COMO (NCT02144688)
- Testing
- Change in antiretrovirals
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Marie-Josée Brouillette
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