Clinical trials: Acquired Immune Deficiency Syndrome
HIV/AIDS, Dysbiosis
SHIFT: Studying HIV Immunology After Fecal Transplant
SHIFT is a randomized, longitudinal, prospective, blinded, three-arm study to determine the safety and tolerability of Fecal Microbiota Transplant (FMT) in HIV-infected participants on stable antiretroviral therapy (ART).
- Conditions
- HIV/AIDS, Dysbiosis, Inflammation
- Trial name
- SHIFT (NCT03163784)
- Testing
- Fecal Inoculum Capsule, Antibiotic
- Sponsor
- Massachusetts General Hospital
Frailty, Disability Physical
Functional Decline and QoL in People Aging with HIV in Asia
This is a multi-center prospective cross-sectional study to determine the burden of decline in intrinsic capacity and functional ability, and the prevalence of geriatric syndromes, such as frailty, and disability in adult people…
- Conditions
- Frailty, Disability Physical, HIV/AIDS
- Trial name
- NCT04212884
- Where
- 2 sites in Hong Kong
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
HIV Infections
The Effect of Stomach Acid on Foscarnet
To see if ranitidine, by reducing stomach acidity, can enhance the effectiveness of foscarnet, by making foscarnet more available to the body. Foscarnet is an antiviral compound.
- Trial name
- NCT00000964
- Testing
- Ranitidine hydrochloride, Foscarnet sodium
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS, TB - Tuberculosis
Xpert Ultra and Xpert HIV-VL in People Living With HIV
TB is increasingly diagnosed using the GeneXpert platform, which can be used for a variety of tests (not just TB). HIV viral load monitoring is required at least annually in patients on ART to detect failure of virologic…
- Conditions
- HIV/AIDS, TB - Tuberculosis, Antiretroviral Therapy, Highly Active
- Trial name
- NCT03187964
- Testing
- PLHIV Point of Care Xpert Ultra, PLHIV Point of Care Xpert VL
- Where
- South Africa
- Volunteers
- 1,053 people
- Sponsor
- University of Stellenbosch
HIV Infections
A Study of Dideoxycytidine Plus Zidovudine (AZT) in HIV-Infected Children Who Have Taken AZT
PRIMARY: To determine safety, tolerance, and pharmacokinetics of zidovudine (AZT) and zalcitabine (dideoxycytidine; ddC) when given in combination in clinically stable AZT-treated children.
- Trial name
- NCT00001032
- Testing
- Zidovudine, Zalcitabine
- Where
- 47 sites in United States, Puerto Rico
- Volunteers
- 180 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus (HIV)
The Effects of Chiropractic Care on Inflammation and Quality of Life in People Living With HIV
The main aim of this pilot trial is to investigate the feasibility of undertaking a randomized controlled trial involving adults living with HIV.
- Trial name
- HIV (NCT07466836)
- Testing
- Chiropractic Care
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tyson Perez, DC, PhD
Human Immunodeficiency Virus (HIV), Mitochondrial Diseases
Mitochondria in HIV and Aging (MITO+)
Older adults with human immunodeficiency virus (HIV) and a long history of antiretroviral therapy have more mitochondrial dysfunction- the cells that help them make energy.
- Trial name
- (MITO+) (NCT03489421)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Colorado, Denver
HIV Infections
GSK3739937 First-Time-In-Human (FTIH) Study in Healthy Volunteers
This study is a Phase 1, double-blind (sponsor-unblinded), randomized, placebo-controlled, single- and repeat-dose escalation study including a weekly oral dose (MAD) cohort and a relative bioavailability (RBA) and food effect…
- Trial name
- NCT04493684
- Testing
- GSK3739937 (PIB), GSK3739937 (Tablet)
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Distress, Depression
Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS Survivors
The purpose of this study is to determine whether psilocybin-assisted group psychotherapy is a safe and feasible treatment for demoralization in long-term AIDS survivors (LTAS).
- Conditions
- Distress, Depression, Grief
- Trial name
- NCT02950467
- Testing
- Psilocybin, Modified brief Supportive Expressive Group Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Joshua Woolley
Human Papillomavirus, Human Immunodeficiency Virus
Increasing Uptake of Evidence-Based Screening Services Through CHW-led Multi-modality Intervention
The purpose of this research study is to determine the best way to increase screening for cervical cancer, colorectal cancer, HIV, and Hepatitis C among under screened Hispanic, Haitian and African-American individuals in…
- Conditions
- Human Papillomavirus, Human Immunodeficiency Virus, Hepatitis C, ColoRectal Cancer
- Trial name
- NCT02970136
- Testing
- OraQuick Swab, Fecal Immunochemical Test, OraQuick Fingerstick
- Where
- United States
- Volunteers
- 754 people, healthy volunteers welcome
- Sponsor
- University of Miami
HIV
Using Cultural Ceremonies to Reduce Intimate Partner Violence and HIV Transmission
Violence against women (VAW), the most extreme manifestation of the unequal power balance between women and men, is a major global public health concern.
- Trial name
- NCT02311699
- Testing
- Intervention to reduce IPV and HIV
- Where
- Ethiopia
- Volunteers
- 6,800 people, healthy volunteers welcome
- Sponsor
- Abdul Latif Jameel Poverty Action Lab
Human Immunodeficiency Virus (HIV) Infection
Interventions to Improve HIV Antiretroviral Therapy Adherence
This study will explore whether financial incentives, reminders, information about HIV/AIDS and its treatment and anti-stigma counseling help improve anti-retroviral therapy (ART) adherence among HIV infected individuals in a…
- Trial name
- NCT03618511
- Testing
- Financial Incentive, Reminders, Financial Incentive and Reminders
- Where
- Mozambique
- Volunteers
- 914 people
- Sponsor
- University of Michigan
HIV Infections
A Phase I Study of Methotrexate for HIV Infection
To determine the safety and tolerance of methotrexate in HIV-infected patients. To determine the dose effective in modulating key markers of immune activation.
- Trial name
- NCT00000834
- Testing
- Lamivudine, Methotrexate, Zidovudine
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Frailty Syndrome, HIV Infections
Effectiveness of a Multifactorial Intervention in Frailty Individuals With HIV Infection: HIDRA360
The goal of this quasi-experimental before/after study without equivalent control group is to to describe the prevalence of frail, pre-fragile and robust individuals in the study group before and after a multifactorial…
- Trial name
- HIDRA360 (NCT05832164)
- Testing
- Multifactorial intervention
- Where
- Spain
- Volunteers
- 61 people
- Sponsor
- Hospital Costa del Sol
HIV Infections, AIDS
DART II - A Phase IV Study of 3 Antiretroviral Medicines in Combination, in HIV Patients Who Have Not Been Previously Treated With Antiretroviral Therapy
The purpose of this study is to evaluate whether a therapy with an all once daily regimen of stavudine extended release (d4T XR), lamivudine (3TC), and efavirenz (EFV) leads to improved outcomes, as measured by viral load, CD4…
- Trial name
- NCT00116116
- Testing
- efavirenz, stavudine extended release, lamivudine
- Where
- 10 sites in United States
- Volunteers
- 70 people
- Sponsor
- Bristol-Myers Squibb
HIV Infections
Dideoxycytidine ( Ro 24-2027 ). A Treatment Protocol for the Use of Dideoxycytidine ( ddC ) in Patients With AIDS or Advanced ARC Who Cannot Be Maintained on Zidovudine ( AZT ) Therapy.
To provide zalcitabine ( ddC ) for patients with AIDS or Advanced ARC in whom zidovudine ( AZT ) is contraindicated, or who have failed treatment with or are intolerant to AZT and to demonstrate that ddC monotherapy is safe, and…
- Trial name
- NCT00002256
- Testing
- Zalcitabine
- Where
- United States
- Sponsor
- Hoffmann-La Roche
Acquired Immune Deficiency Syndrome Virus
Immune Recovery in Advanced , ARV-naïve, HIV-1-infected Individuals Taking Dolutegravir or Ritonavir-boosted Darunavir
There are few randomized clinical trials in advanced HIV patients. This is a multicenter, randomized, open clinical trial, comparing 2 parallel groups, to compare the immunological reconstitution and the virological efficacy and…
- Trial name
- NCT02337322
- Testing
- Dolutegravir, Darunavir/r
- Where
- Spain
- Volunteers
- 104 people
- Sponsor
- Juan A. Arnaiz
HIV, AIDS Virus
HIV Testing in Pregnant Women: Evaluating an Opt-Out Testing Strategy
Mother-to-child transmission of HIV is an important but preventable mode of infection. Prevention depends on identifying pregnant women infected with HIV and offering medications during pregnancy which can dramatically decrease…
- Conditions
- HIV, AIDS Virus, Pregnancy
- Trial name
- NCT00393302
- Testing
- HIV screening in pregnancy
- Where
- Canada
- Volunteers
- 1,074 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Human Papilloma Virus Related Cervical Carcinoma
The Women's Screening and Self-Testing Program (PROMETA) Study
This proposal directly addresses the ability to safely scale-up a Screen-Triage-Treat approach to cervical cancer screening. The investigators propose to capitalize on a pool of screen-eligible women accessing routine care within…
- Trial name
- PROMETA (NCT06810739)
- Testing
- HPV DNA testing be self-collected vaginal swab
- Where
- Mozambique
- Volunteers
- 8,445 people
- Sponsor
- Tulane University
Hiv, Mental Health Issue
Striving Towards EmPowerment and Medication Adherence R01
This is a study for Black women living with HIV to test a counseling program for Black women living with HIV. This participant may be a good fit if the participant is a Black woman, living with HIV, has a history of trauma, and…
- Trial name
- NCT06463886
- Testing
- STEP-AD, Enhanced treatment as usual (E-TAU)
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Miami
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