Clinical trials: Acquired Immune Deficiency Syndrome
Cryptococcal Meningitis, HIV/AIDS
Clinical Outcomes of Cryptococcal Meningitis Among HIV-infected Patients in the Era of Antiretroviral Therapy
Cryptococcal meningitis is one of the most common central nervous system infections among HIV-infected patients. The outcome is generally severe.
- Trial name
- NCT02098525
- Where
- Thailand
- Volunteers
- 195 people
- Sponsor
- Mahidol University
HIV/AIDS
The Incidence and Severity of Drug Interactions Before and After Switching Antiretroviral Therapy to Bictegravir/Emtricitabine/Tenofovir Alafenamide in Treatment Experienced Patients
This study will assess changes in the incidence and severity of drug interactions before and after switching antiretroviral therapy to bictegravir/emtricitabine/tenofovir alafenamide-based regimens in treatment experienced…
- Trial name
- NCT03789968
- Testing
- bictegravir/emtricitabine/tenofovir alafenamide
- Where
- United States
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
HIV
Rwanda Selenium Supplementation Clinical Trial
Study Hypothesis: The addition of selenium supplementation to cotrimoxazole will improve CD4 counts, decrease opportunistic infections, decrease viral loads and delay the need for initiating antiretroviral therapy(ART) in Rwandan…
- Trial name
- RSST (NCT01327755)
- Testing
- Selenium
- Where
- 2 sites in Rwanda
- Volunteers
- 300 people
- Sponsor
- The Canadian College of Naturopathic Medicine
HIV, HIV - Human Immunodeficiency Virus
Intervention to Reduce HIV Related Stigma Among Pregnant and Postpartum Women
Purpose of this Study: The main purpose of this study is to adapt an existing evidence-based intervention, Project Accept Post-Test Support Services (PTSS) Module 3, specifically for pregnant and postpartum women living with HIV…
- Conditions
- HIV, HIV - Human Immunodeficiency Virus, Postpartum, Pregnancy
- Trial name
- WAT (NCT07064928)
- Testing
- Adapted Project Accept's Post-Test Support Services (PTSS) Module 3
- Where
- Ghana
- Volunteers
- 163 people
- Sponsor
- University of California, San Francisco
HIV Infections
A Treatment IND (Investigational New Drug) Protocol for the Use of Videx (2',3'-Dideoxyinosine, ddI) in Patients With Acquired Immunodeficiency Syndrome (AIDS) or AIDS- Related Complex (ARC) Who Are Intolerant to Zidovudine (Retrovir)
The objective of this treatment IND protocol is to make didanosine (ddI) available to patients with HIV infection (suffering from AIDS related complex (ARC) or AIDS) who have developed documented intolerance to zidovudine (AZT)…
- Trial name
- NCT00002028
- Testing
- Didanosine
- Where
- United States
- Sponsor
- Bristol-Myers Squibb
HIV Infections
Phase I Safety Study of Anti-HIV Immune Serum Globulin (Human)
To investigate the potential benefit of providing passive immunity with hyperimmune anti-HIV human serum.
- Trial name
- NCT00002036
- Testing
- Anti-HIV Immune Serum Globulin (Human)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Abbott
Cytomegalovirus Retinitis, HIV Infections
A Study of Two Forms of Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS
To compare the time to progression of Cytomegalovirus (CMV) retinitis among each of three doses of oral ganciclovir, as well as to intravenous therapy, when given as maintenance for 26 weeks.
- Trial name
- NCT00002330
- Testing
- Ganciclovir
- Where
- 36 sites in United States, Canada
- Volunteers
- 280 people
- Sponsor
- Roche Global Development
HIV (Human Immunodeficiency Virus)
The Eswatini Study on Neurocognitive Performance in Adolescents Living With HIV
This study explores the link between inflammatory biomarkers and neurocognitive performance in adolescents living with HIV (ALHIV) in Eswatini.
- Trial name
- NCT07165639
- Where
- Eswatini
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Eswatini Nazarene Health Institutions
HIV, HIV Infections
Measurement of Adherence to ART in HIV-Infected Children in Uganda (The CHARTA Study)
This study will compare methods of determining whether HIV-infected children take their medications.
- Trial name
- NCT00868257
- Where
- Uganda
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
HIV Infections, Acquired Immunodeficiency Syndrome
Feasibility of Measuring Immune Resp, Activation in Foreskin/Mucosa in HIV-, Uncircumcised High-HIV-risk MSM, Lima Peru
Rectal and genital sampling in HIV prevention trials permits assessments at the site of HIV entry. Yet the safety and acceptability of circumcision and sigmoidoscopy (and associated abstinence recommendations) are unknown in…
- Conditions
- HIV Infections, Acquired Immunodeficiency Syndrome, Lentivirus Infections, Retroviridae Infections
- Trial name
- HVTN 914 (NCT02630082)
- Testing
- Circumcision, Flexible sigmoidoscopy
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus, HIV
Fetal HIV Transmission Risk and Duration of Membrane Rupture
In optimally managed HIV+ women with undetectable viral loads, who are on HAART and also receiving intrapartum IV ZDV, the risk of vertical transmission of HIV is independent of the length of time of rupture of membranes.
- Trial name
- NCT01616823
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- Unity Health Toronto
Contraception, Hiv
Contraceptive/HIV Affecting Risk in Adolescents
This study will evaluate the impact of hormonal contraceptives on HIV risk associated with changes to the innate immunity in the female genital tract in a cross-sectional study.
- Trial name
- CHARA (NCT03301480)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Pittsburgh
HIV/AIDS
Mother Infant Retention for Health: MIR4Health
Linking HIV-infected pregnant women into prevention of mother to child transmission (PMTCT) services and keeping them in care is important in ensuring that both mother and infant benefit from interventions that improve maternal…
- Trial name
- MIR4HEALTH (NCT01962220)
- Testing
- Study Intervention for Retention (APFU)
- Where
- 10 sites in Kenya
- Volunteers
- 680 people
- Sponsor
- Columbia University
Cryptosporidiosis, HIV Infections
Azithromycin in the Treatment of Cryptosporidiosis in Patients With Acquired Immune Deficiency Syndrome (AIDS): A Randomized, Multi-Center, Placebo-Controlled, Double-Blind Study
To evaluate the safety and efficacy of azithromycin in the treatment of intestinal cryptosporidial infection in AIDS patients.
- Trial name
- NCT00002082
- Testing
- Azithromycin
- Where
- 4 sites in United States
- Sponsor
- Pfizer
HIV/AIDS-associated Fatigue
American Ginseng to Improve HIV-Associated Fatigue: A Randomized, Placebo-Controlled, Parallel Design, Multiple-Dose Clinical Trial
The purpose of this study is to determine whether American ginseng is effective in the treatment of HIV-associated fatigue.
- Trial name
- NCT01500096
- Testing
- American ginseng
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Johns Hopkins University
HIV Infections, Tuberculosis
A Prospective Study of Multidrug Resistance and a Pilot Study of the Safety of and Clinical and Microbiologic Response to Levofloxacin in Combination With Other Antimycobacterial Drugs for Treatment of Multidrug-Resistant Pulmonary Tuberculosis (MDRTB) in HIV-Infected Patients.
To determine the demographic, behavioral, clinical, and geographic risk factors associated with the occurrence of multidrug-resistant pulmonary tuberculosis (MDRTB).
- Trial name
- NCT00000796
- Testing
- Cycloserine, Ethionamide, Capreomycin sulfate
- Where
- 21 sites in United States
- Volunteers
- 525 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, AIDS
Massage to Increase Well-Being and Immune Function in Dominican Children Infected With HIV
The purpose of this study is to determine whether massage therapy can improve immune status and enhance well-being in children living in the Dominican Republic who are infected with HIV.
- Trial name
- NCT00070980
- Testing
- Massage therapy
- Where
- Dominican Republic
- Volunteers
- 54 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
HIV Infections
A Randomized, Parallel Arm, Comparative, Open Label, Multicenter Study of the Activity and Safety of Two Formulations of Saquinavir in Combination With Other Antiretroviral Drugs
To evaluate the antiviral activity and safety of two formulations of saquinavir in combination with licensed nucleoside antiretroviral drugs.
- Trial name
- NCT00002162
- Testing
- Saquinavir, Lamivudine, Stavudine
- Where
- 27 sites in United States, Canada
- Volunteers
- 140 people
- Sponsor
- Hoffmann-La Roche
HIV Infections
Evaluation of the Efficacy of Hydroxychloroquine in Decreasing Immune Activation in Asymptomatic HIV-infected Patients
The purpose of this pilot study is to find out if taking hydroxychloroquine will decrease immune activation (stimulation of the body's defence system) in people with early HIV infection.
- Trial name
- HCQ-01 (NCT01067417)
- Testing
- Hydroxychloroquine
- Volunteers
- 83 people
- Sponsor
- Medical Research Council
HIV-infection/Aids
Effectiveness of Peer Navigation to Link Released HIV+ Jail Inmates to HIV Care
This study will implement a peer navigation intervention to improve linkage to and retention in HIV care for inmates released from L.A. county jail into the community.
- Trial name
- LINK LA (NCT01406626)
- Testing
- Peer Navigator
- Where
- United States
- Volunteers
- 356 people
- Sponsor
- University of California, Los Angeles
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