Clinical trials: Acquired Immune Deficiency Syndrome
Drug Use, Hepatitis
Low Dead-space Injecting Equipment Distribution Program for People Who Inject Drugs in Low- and Middle-income Countries
Implementation and evaluation of a distribution program for low dead-space syringes/needles (LDSS/N) in Armenia, Georgia, and Tanzania, Egypt, Nigeria, Vietnam, India, Ukraine, and South Africa.
- Conditions
- Drug Use, Hepatitis, Hiv
- Trial name
- NCT06395129
- Testing
- Low dead-space syringes/needles, Hepatitis C Antibody Rapid Diagnostic Test, HIV rapid Diagnostic Test
- Where
- 9 sites in Armenia, Georgia and 1 more
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Médecins du Monde
Hiv
Evaluation of (Doravirine / Lamivudine / Tenofovir Disoproxil Fumarate) (Delstrigo®) as a New Strategy for Non-occupational Post Exposure Prophylaxis, a Prospective Open Label Study
Subjects who go to emergency room for possible contact to HIV transmission receive Delstrigo as post exposition prophylaxis.
- Trial name
- DORAVIPEP (NCT04233372)
- Testing
- Delstrigo
- Where
- 2 sites in France, Spain
- Volunteers
- 399 people
- Sponsor
- Hospital Clinic of Barcelona
HIV Infections
Safety and Efficacy of ADAPTAVIR's Ability to Eliminate Treatment-Resistant Infectious Virus in Peripheral Blood Mononuclear Cells (PBMCs)
This is a 24 week placebo controlled, double-blind, 2-arm study of ADAPTAVIR, Monomeric Dala1-peptide T-amide (mDAPTA) compared to placebo, in HIV infected individuals with suppressed plasma viral loads < 200 copies/ml by highly…
- Trial name
- NCT00951743
- Testing
- Adaptavir (monomeric DAPTA)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rapid Laboratories Inc.
HIV Infection
Comparing Blood Vessel Endothelial Function in HIV-Infected People and Matched HIV-Uninfected People
The blood vessels that carry blood from the heart to the rest of the body are normally capable of relaxing and constricting when needed to provide more or less blood to the body.
- Trial name
- NCT00919724
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Indiana University
Meningitis, Cryptococcal, HIV Infections
Pilot Study of Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis
To evaluate the safety and effectiveness of fluconazole as treatment for acute cryptococcal meningitis in AIDS patients. Both newly diagnosed and relapsed patients are eligible.
- Trial name
- NCT00002076
- Testing
- Fluconazole
- Where
- 3 sites in United States
- Sponsor
- Pfizer
Adolescent Behavior, Hiv
Data-informed Stepped Care (DiSC) to Improve Adolescent HIV Outcomes (UH3)
The investigators will conduct a Phase III cluster randomized controlled trial (cRCT) to evaluate the effectiveness of the implementation of a data-informed stepped care (DiSC) intervention for HIV treatment management among…
- Trial name
- NCT05007717
- Testing
- Data-informed Stepped Care (DiSC)
- Where
- 24 sites in Kenya
- Volunteers
- 1,911 people
- Sponsor
- University of Washington
Pneumonia, Pneumocystis Carinii, HIV Infections
Comparison of Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
To compare the safety and effectiveness of an investigational drug therapy (trimetrexate plus leucovorin calcium) with that of conventional therapy (sulfamethoxazole-trimethoprim) in the treatment of moderately severe…
- Trial name
- NCT00001013
- Testing
- Trimetrexate glucuronate, Pentamidine isethionate, Sulfamethoxazole-Trimethoprim
- Where
- 23 sites in United States
- Volunteers
- 364 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS
Adolescents Living With HIV (ALWH): Social Networks, Adherence and Retention
human immunodeficiency virus / acquired immunodeficiency syndrome (HIV/AIDS) is the second leading cause of death in Africa. Adolescents living with HIV (ALWH) are at increased risk for HIV-related morbidity and mortality due to…
- Trial name
- NCT04077047
- Testing
- iEngage
- Where
- 2 sites in United States, South Africa
- Volunteers
- 60 people
- Sponsor
- Wake Forest University Health Sciences
HIV/AIDS
Village-based vs Clinic-based ART Care - a Cluster Randomized Controlled Trial in Lesotho
This cluster-randomized trial tests a differentiated care model for HIV-positive individuals not on ART during a home-based HIV testing campaign in rural Lesotho, Southern Africa.
- Trial name
- VIBRA (NCT03630549)
- Testing
- Standard of Care, Village-based ART refill
- Where
- 2 sites in Lesotho
- Volunteers
- 257 people
- Sponsor
- Niklaus Labhardt
Human Immunodeficiency Virus (HIV) Infection
Investigation Of Safety And Pharmacokinetics Following A Single Oral Dose Of 300 Mg Maraviroc In Healthy Male Japanese Volunteers
To confirm safety and pharmacokinetics of maraviroc following a single oral dose of 300 mg maraviroc in healthy male Japanese volunteers.
- Trial name
- NCT00821535
- Testing
- maraviroc (Selzentry, Celsentri)
- Where
- Singapore
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV/AIDS, Medication Adherence
Adherence Through Home Education and Nursing Assessment, Indonesia
Adherence to antiretroviral therapy (ART) drops sharply after prison release. Effective medication adherence training immediately before and after prison release may improve health outcomes and limit transmission of Human…
- Conditions
- HIV/AIDS, Medication Adherence, Substance Use
- Trial name
- ATHENA-I (NCT03397576)
- Testing
- ATHENA
- Where
- Indonesia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
HIV/AIDS, STD
Addressing the Continuum of Care Among High-risk Thai Men
Young Thai men who have sex with men (YMSM) are at high risk for HIV. However, the Thailand National HIV Strategy does not adequately cover HIV prevention for YMSM using specific methods relevant to them, and instead uses a…
- Trial name
- NCT05161689
- Testing
- HUG-M+
- Where
- 2 sites in Thailand
- Volunteers
- 636 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Hepatitis C Virus Genotype-1
A Study to Assess the Safety, Tolerability and Efficacy of TMC435 Along With Pegylated Interferon Alpha-2a (Pegasys) and Ribavirin (Copegus) Triple Therapy in Chronic Hepatitis C Genotype-1 Infected Patients Co-infected With Human Immunodeficiency Virus-Type 1
The purpose of this study is to evaluate the safety and tolerability of TMC435 along with pegylated interferon alpha-2a (PegIFNα-2a) and ribavirin (RBV) triple therapy in hepatitis C virus genotype-1 infected subjects…
- Trial name
- NCT01479868
- Testing
- TMC435, Pegylated interferon alpha-2a, Ribavirin
- Where
- 32 sites in United States, Canada and 6 more
- Volunteers
- 109 people
- Sponsor
- Janssen R&D Ireland
Infection, Human Immunodeficiency Virus
Pharmacokinetics, Safety and Tolerability Study of Abacavir/ Dolutegravir/ Lamivudine Fixed-dose Combination Tablets in Healthy Japanese Subjects
The abacavir (ABC)/dolutegravir (DTG)/lamivudine (3TC) 600 milligrams (mg)/50 mg/300 mg fixed-dose combination (FDC) tablet is currently approved in the United States (US) and Europe.
- Trial name
- NCT02539576
- Testing
- ABC/DTG/3TC FDC tablet
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Hiv, Cigarette Smoking
Cultural Adaptation and Piloting of a Smoking Cessation Intervention for Smokers With HIV
One population of tobacco users that is severely affected by the consequences of smoking is people living with HIV (PLWH). Between 40-84% of PLWH smoke, a percentage that has remained constant since the first studies of smoking…
- Trial name
- NCT03580460
- Testing
- Computer delivered smoking cessation counseling
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
HIV, AIDS
Increasing Social Support to Improve HIV Care Engagement and Adherence in St. Petersburg, Russia
Prior research has documented serious health, mental health, and social-behavioral issues among people living with HIV (PLH) in St. Petersburg.
- Trial name
- NCT02167828
- Testing
- Social Support
- Where
- 2 sites in United States, Russia
- Volunteers
- 174 people
- Sponsor
- Medical College of Wisconsin
HIV Infections, Sexually Transmitted Infections
Utilization of HIV Clinical Services in Rural India
This community-based clinical trial based in two districts of rural Maharashtra, India compares utilization of an intervention model of "fully-decentralized," or rural primary clinic-based, HIV testing and care services, with a…
- Trial name
- NCT00554567
- Testing
- HIV Testing and Care Services
- Where
- India
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Institute of Health Management, Pachod, India
HIV Infections, Sepsis
Study of MDW Levels Predicting the Development of Sepsis in Hospitalized HIV-infected Patients and Correlation With Prognosis
Sepsis is a common and critical complication in HIV-infected patients and an important marker of high risk of patient death. The widely used diagnostic criteria for sepsis still have many deficiencies and do not allow for good…
- Trial name
- NCT05036928
- Testing
- Monocyte distribution width (MDW）
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Shanghai Public Health Clinical Center
Blood Pressure, Human Immunodeficiency Virus I Infection
Managing Hypertension Among People Living With HIV
The Managing Hypertension Among People Living with HIV: An InTegrated Model (MAP-IT) a stepped wedge, cluster-randomized controlled trial to evaluate the effect of practice facilitation (PF) on the integration of a Task-Shifting…
- Conditions
- Blood Pressure, Human Immunodeficiency Virus I Infection, Acquired Immunodeficiency Syndrome, Hypertension
- Trial name
- MAP-IT (NCT05031819)
- Testing
- Nurse-led Task-Shifting Strategy for Hypertension Control (TASSH) plus Practice Facilitation.
- Where
- Nigeria
- Volunteers
- 960 people
- Sponsor
- Dr. Dike Ojji
Hiv
Scaling Up Implementation Strategies to Improve the DIAGNOSE and PREVENT Pillars for Young MSM in Florida
The purpose of this study is to evaluate the Young Adult Centered HealthForce Training (YACHT) package in 41 Florida Department of Health (FDOH) contracted Counseling, Testing, and Referral (CTR) agencies across six Florida End…
- Trial name
- YACHT (NCT06015581)
- Testing
- Workforce Development (WD) strategies, Quality Management (QM) and Mystery Shopper (MS) Feedback
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Florida State University
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