Clinical trials: Acquired Immune Deficiency Syndrome
Human Immunodeficiency Virus, Dolutegravir
A Pilot Study of MONOtherapy of DOlutegravir in HIV-1 Virologically Suppressed Patients
Current HIV treatment guidelines recommend a combination of drugs for the maintenance of antiretroviral therapy (ART). Simplification is considered critical to further scale-up of treatment, to support retention in care and to…
- Conditions
- Human Immunodeficiency Virus, Dolutegravir, Monotherapy, Treatment Efficacy
- Trial name
- MONODO (NCT02572947)
- Testing
- Dolutegravir
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- Calmy Alexandra
Human Immunodeficiency Virus (HIV)
An Extension Protocol for Subjects Who Successfully Completed PRO140_CD02 or PRO140_CD02_Open Label Study
PRO 140_CD02 Extension study seeks to evaluate the long-term efficacy, safety and tolerability of PRO 140 weekly injection in combination with Optimized Background Therapy (OBT) in patients infected with Human Immunodeficiency…
- Trial name
- NCT02990858
- Testing
- PRO 140
- Volunteers
- 43 people
- Sponsor
- CytoDyn, Inc.
HIV Infections
A Phase I/II Study of the Safety, Tolerance, and Pharmacokinetics of 9-(2-Phosphonylmethoxyethyl)Adenine ( PMEA; Adefovir ) in Patients With Advanced HIV Disease.
To study the safety, tolerance, pharmacokinetics, and anti-HIV effects of PMEA ( adefovir ) when administered daily by intravenous (IV) and/or subcutaneous (SC) injection in patients with advanced HIV disease.
- Trial name
- NCT00002115
- Testing
- Adefovir
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Gilead Sciences
Herpes Simplex, HIV Infections
An Open Study of Foscarnet Treatment of Acyclovir-Resistant Herpes Simplex Virus in Patients With the Acquired Immunodeficiency Syndrome and Other Immunodeficiencies
To evaluate the safety and efficacy of intermittent intravenous (IV) foscarnet in the treatment of acyclovir-resistant herpes simplex virus (HSV) infections in AIDS patients and other immunocompromised patients.
- Trial name
- NCT00002021
- Testing
- Foscarnet sodium
- Where
- 2 sites in United States
- Sponsor
- Astra USA
HIV Infections
An Open Trial Combining Zidovudine, Interferon-alfa, and Recombinant CD4-IgG With Transplantation of Syngeneic Bone Marrow and Peripheral Blood Lymphocytes From Healthy gp160-Immunized Donors in the Treatment of Patients With HIV Infection
To restore immunologic function and virus-free state in HIV-infected patients. Based on previous studies showing temporary improvement in immune function in HIV-infected patients using peripheral lymphocyte transfers and bone…
- Trial name
- NCT00000647
- Testing
- CD4-IgG, Zidovudine, Interferon alfa-n1
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS
Storytelling Narrative Communication Intervention for Smoking Cessation in Women Living With HIV
HIV has transformed into a chronic illness due to the advent of effective treatments in the absence of a cure. As a result, the prevalence of non-AIDS defining cancers (NADCs), including lung cancer, has increased three-fold…
- Trial name
- WISE (NCT03289676)
- Testing
- Storytelling Narrative Intervention
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Boston
Human Immunodeficiency Virus
Impact of Pre-ART Blood CD4+ T Cell Level on the Rectal Reservoir in Long-term HIV-1 Treated Men
Although combined antiretroviral therapy (cART) has dramatically improved quality of life and lifespan of HIV infected individuals, it still fails to eliminate viral reservoirs.
- Trial name
- VIRECT (NCT02526940)
- Testing
- rectal biopsies, Blood samples
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Acquired Immunodeficiency Syndrome, Stress Disorders, Post-Traumatic
HIV Prevention and Care of Psychological Trauma in Vulnerable Rwandan Youth
The investigators propose a prospective single arm pilot cohort study of 100 youth (ages 15-25) to evaluate the feasibility of this project.
- Trial name
- NCT01401335
- Testing
- Questionnaires
- Where
- 2 sites in United States, Rwanda
- Volunteers
- 120 people
- Sponsor
- Stanford University
HIV/AIDS
Translation of Basic Research in Cognitive Science to HIV Risk
A randomized trial was conducted at drug diversion educational programs with a sample of 343 adult drug offenders who volunteered for the study.
- Trial name
- NCT03175250
- Testing
- Health Education, Action Plan, Memory Practice
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- Claremont Graduate University
HIV Infections, AIDS
Community-Based Model for Delivery of Antiretroviral Therapy in Cambodia
The community-based ART delivery (CAD) model will build on the existing framework to engage community action, operationalized in the current Global Fund-supported project.
- Trial name
- NCT04766710
- Testing
- Community-based ART delivery (CAD), ART multi-month dispensing (MMD)
- Where
- 3 sites in Cambodia
- Volunteers
- 4,049 people
- Sponsor
- National University of Singapore
Lymphoma, Non-Hodgkin, HIV Infections
Phase I Trial of mBACOD and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in AIDS-Associated Large Cell, Immunoblastic, and Small Non-cleaved Lymphoma
To determine the toxicity and effectiveness of adding sargramostim (recombinant granulocyte-macrophage colony stimulating factor; GM-CSF) to a standard chemotherapy drug combination (methotrexate, bleomycin, doxorubicin…
- Trial name
- NCT00000689
- Testing
- Bleomycin sulfate, Vincristine sulfate, Doxorubicin hydrochloride
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV, AIDS
HIV Indicator Diseases Survey Across Europe - UK Arm
In Europe many patients infected with HIV remain undiagnosed, although this percentage varies between 15-80% across the continent. In the UK it is estimated to be 27%.
- Conditions
- HIV, AIDS, Indicator Diseases/Indicator Conditions
- Trial name
- NCT01196468
- Testing
- HIV test (serological or salivary), Interview
- Where
- 2 sites in United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
HIV/AIDS
Behavioural Text Messages to Improve Retention in Care in South Africa
The proportion of South Africans aware of their HIV status and on treatment remains lower than optimal. The goal of this study is to rapidly determine whether text messages framed according to behavioural economics principles…
- Trial name
- NCT05010291
- Testing
- Standard of Care (SOC) text message reminder to attend clinic appointment, Loss aversion framed text message reminder to attend clinic appointment, Social norms framed text message reminder to attend clinic appointment
- Where
- South Africa
- Volunteers
- 1,541 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Acquired Immunodeficiency Syndrome, Lipodystrophy
Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected Subjects
Magnetic resonance spectroscopy (MRS) is commonly applied in medicine with 1H proton or 31-phosphorus spectra. The proton MRS is often used in evaluating the central nervous system and 31P MRS is used in muscular diseases or…
- Trial name
- NCT00172315
- Where
- Taiwan
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Hiv, Contraception Behavior
TwySHE - An Mhealth Peer-navigator Intervention to Increase PrEP and Contraceptive Use
The goal of this clinical trial is to learn if the TwySHE intervention can increase the use of HIV prevention in at-risk female university students aged 18-24 in Zambia.
- Trial name
- NCT06852508
- Testing
- TwySHE
- Where
- Zambia
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Meningitis, Cryptococcal, HIV Infections
A Pilot Study of Fluconazole Plus Flucytosine for the Treatment of AIDS Patients With Acute Cryptococcal Meningitis.
To evaluate and estimate the safety and efficacy of the combination of fluconazole and flucytosine as treatment for acute cryptococcal meningitis in patients with AIDS.
- Trial name
- NCT00002113
- Testing
- Flucytosine, Fluconazole
- Where
- 3 sites in United States
- Volunteers
- 64 people
- Sponsor
- Pfizer
HIV Infections
The Anti-HIV Effects of Saquinavir Soft Gelatin Capsules Versus Indinavir in Patients Who Have Used Saquinavir Hard Gelatin Capsules for One Year
To determine, in HIV-infected patients, whether switching to a new soft gelatin capsule formulation of saquinavir or to indinavir following prolonged use of the original hard capsule formulation of saquinavir results in an acute…
- Trial name
- NCT00000848
- Testing
- Indinavir sulfate, Saquinavir
- Where
- 16 sites in United States
- Volunteers
- 144 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus, Obesity
Adipose Tissue and Immune Activation in HIV
The prevalence of HIV-associated wasting declined dramatically with the introduction of effective antiretroviral therapy (ART), but as patients survive longer on treatment the proportion of overweight (body mass index [BMI] >25…
- Trial name
- AIAC (NCT04439448)
- Testing
- dual-energy X-ray absorptiometry (DEXA) scan, Carotid and branchial artery ultrasound, 2-hour oral glucose tolerace test
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
HIV/AIDS
ENLIGHTEN: Establishing Novel Antiretroviral (ARV) Imaging for Hair to Elucidate Non-Adherence
Purpose: Perform a 3-phase (single dose, multi dose, dose proportionality) study in healthy volunteers using daily tenofovir+emtricitabine, dolutegravir, and maraviroc dosing to quantify intra- and inter-subject variability and…
- Trial name
- ENLIGHTEN (NCT03218592)
- Testing
- Maraviroc Pill, Dolutegravir Pill, Truvada Pill
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Opioid-Related Disorders, HIV Infections
Buprenorphine and Integrated HIV Care Evaluation
The purpose of this study is to assess the feasibility, cost and effectiveness of interventions designed to integrate buprenorphine treatment for opioid dependence into HIV primary care in ten HIV care centers in the U.S.
- Conditions
- Opioid-Related Disorders, HIV Infections, AIDS
- Trial name
- NCT00124358
- Testing
- Buprenorphine, Integrated HIV care and office-based opioid dependence treatment
- Where
- 10 sites in United States
- Volunteers
- 1,350 people
- Sponsor
- The New York Academy of Medicine
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