Clinical trials: Acquired Immune Deficiency Syndrome
AIDS
Effect of Repeated Exposures to Compressed Air on Patients With AIDS
The exposure of human beings to markedly altered environments (ambient pressure and inhaled gas mixtures) has profound effects on their innate immune capacity to effectively combat viral illnesses.
- Trial name
- DANET1 (NCT00444847)
- Testing
- Hyperbaric chamber
- Where
- United States
- Sponsor
- Designed Altobaric Technology, Incorporated
HIV Infections, Histoplasmosis
A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis
To assess the safety of intravenous itraconazole compared to amphotericin B in HIV positive or negative persons with blastomycosis or histoplasmosis.
- Conditions
- HIV Infections, Histoplasmosis, Blastomycosis
- Trial name
- NCT00002159
- Testing
- Itraconazole, Amphotericin B
- Where
- 9 sites in United States
- Volunteers
- 60 people
- Sponsor
- Janssen, LP
HIV Infections
A Phase II Trial of rsCD4 and AZT in Patients With AIDS or Advanced AIDS Related Complex (ARC)
Part 1A: To find the dose of zidovudine (AZT) that causes less than a 50 percent drop in HIV-1 p24 antigen levels in patients with AIDS and advanced AIDS related complex (ARC); to determine the pharmacokinetics (blood levels) of…
- Trial name
- NCT00000659
- Testing
- CD4 Antigens, Zidovudine
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus
Prevention and Treatment Continuum for Youth at HIV Risk, Acutely Infected and With Established HIV Infection
This is a strategic prospective cohort study which will measure the effects of early intensive antiretroviral therapy (ART) on the establishment and persistence of HIV-1 reservoirs and HIV-1-specific immunity in acutely /recently…
- Trial name
- NCT03205696
- Testing
- Antiretrovirals
- Where
- 3 sites in United States
- Volunteers
- 101 people
- Sponsor
- University of California, Los Angeles
HIV/AIDS, Tuberculosis
Prevent TB: Choice Architecture for TPT Delivery
Background: Clinical guidelines and policies often fail to achieve high levels of delivery of intended clinical interventions. The difference in what the investigators know works and what is actually delivered at the clinic-level…
- Trial name
- NCT04466488
- Testing
- Choice Architecture
- Where
- South Africa
- Volunteers
- 50,798 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Human Immunodeficiency Virus, Cognitive Dysfunction
Computerized Cognitive Rehabilitation of Patients With Cognitive Deficits Due to the Human Immunodeficiency Virus
WHO: 24 participants with cognitive deficits due to a Human Immunodeficiency Virus (HIV) infection, able to engage in moderate physical activity.
- Trial name
- NCT06603727
- Testing
- Computerized Gaming Rehabilitation Program 1, Computerized Gaming Rehabilitation Program 2
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Human Immunodeficiency Virus (HIV), Hepatitis C (HCV)
Persuasive Health Communication Intervention for HIV/HCV
A major impediment to emergency department (ED)-based HIV/HCV screening success is that often ED patients at risk for, or later diagnosed with, HIV and HCV decline testing.
- Trial name
- NCT05968573
- Testing
- Video Format with Captions, Video Format without Captions, Health Educator
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of South Florida
HIV Infections, Human Immunodeficiency Virus
Randomized, Double-Blind Study Comparing Dexelvucitabine (DFC) to Lamivudine (3TC) in Subjects With Resistance to NRTIs, PIs, and NNRTIs
The study will compare the safety and efficacy of an investigation nucleoside analog reverse transcriptase inhibitor (NRTI), dexelvucitabine (DFC), to an approved NRTI, lamivudine (3TC) in HIV treatment-experienced patients who…
- Trial name
- DECLARE (NCT00300573)
- Testing
- Dexelvucitabine
- Where
- 11 sites in United States, Puerto Rico
- Volunteers
- 250 people
- Sponsor
- Incyte Corporation
HIV Infections
Effect of Vicriviroc on HIV Ribonucleic Acid (RNA) Levels in Cerebrospinal Fluid (Study P05241)
Vicriviroc (vye-kri-VYE-rock) is an investigational drug (not yet approved by Government Regulatory Authorities for commercial use) that belongs to a new class of drugs, called CCR5 receptor blockers.
- Trial name
- NCT00632073
- Testing
- Vicriviroc
- Volunteers
- 13 people
- Sponsor
- Merck Sharp & Dohme LLC
Hiv
COMMIT HIV Trial Nepal
Community Healthcare Workers (CHWs), who live in the communities they serve, have the potential to reach patients who poorly engage in their care.
- Trial name
- NCT04462679
- Testing
- COMMIT mHealth application
- Where
- Nepal
- Volunteers
- 86 people
- Sponsor
- Possible
Healthy Subjects, Infection, Human Immunodeficiency Virus
Drug Interaction Study of Darunavir/Ritonavir and Lopinavir/Ritonavir on GSK2248761 PK and CYP450 Probe Drugs
The purpose of this study is to evaluate the effect of GSK2448761 on CYP450 metabolic probes and to evaluate the 2-way interaction between GSK2448761 and two ritonavir-boosted protease inhibitors that are commonly used in…
- Trial name
- NCT00920088
- Testing
- darunavir/ritonavir, lopinavir/ritonavir, Midazolam
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Blood Donors, Acquired Immunodeficiency Syndrome
KSHV Infection in Blood Donors From Texas
To determine the seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) in blood donors from Texas. Also to examine the donors' demographic characteristics and to characterize the KSHV using polymerase chain…
- Conditions
- Blood Donors, Acquired Immunodeficiency Syndrome, Blood Transfusion, Herpesvirus, Kaposi Sarcoma-Associated
- Trial name
- NCT00006310
- Sponsor
- The University of Texas Health Science Center at San Antonio
HIV/AIDS
Impact of Hyperbilirubinemia Among HIV Patients Treated With Atazanavir
The purpose of this study is to determine whether HIV patients on Atazanavir who have Hyperbilirubinemia have different outcomes from those without Hyperbilirubinemia.
- Trial name
- NCT02532673
- Volunteers
- 1,200 people
- Sponsor
- Bristol-Myers Squibb
Anal Intraepithelial Neoplasia (AIN) in HIV-infected Patients
Efficacy and Safety of TCA vs. ECA for the Treatment of AIN in HIV-positive Patients
Comparative evaluation of efficacy and safety of high-resolution anoscopy (HRA)-guided topical treatment (trichloroacetic acid, TCA) vs.
- Trial name
- TECAIN (NCT02615860)
- Testing
- Topical 85% trichloroacetic acid (TCA), Surgical electrocautery (ECA)
- Where
- Germany
- Volunteers
- 560 people
- Sponsor
- University Hospital, Essen
HIV Infections
A Randomized, Unblinded Trial of Zidovudine Versus ddC in the Treatment of Patients Status Post PCP Who Received Long-Term Zidovudine Therapy in Protocol ACTG 002
To evaluate the efficacy of AZT versus ddC in terms of survival, antiviral effects, neurological status, and health status in patients post Pneumocystis carinii pneumonia (PCP) who received long-term AZT therapy in ACTG protocol…
- Trial name
- NCT00000682
- Testing
- Zidovudine, Zalcitabine
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Penile Infection, Penile Haematoma
Evaluation of the Acceptability and Safety of the ShangRing Device for Male Circumcision in Shinyanga, Tanzania
The goal of this observational study was to evaluate the safety and acceptability of the ShangRing device for male circumcision among men in Shinyanga, Tanzania.
- Conditions
- Penile Infection, Penile Haematoma, Penile Bleeding, Deformity
- Trial name
- NCT06273696
- Testing
- ShangRing
- Where
- 2 sites in Tanzania
- Volunteers
- 575 people, healthy volunteers welcome
- Sponsor
- IntraHealth International
Infection, Human Immunodeficiency Virus
GSK706769 Repeat Dose Study
To determine safety, tolerability and Pharmacokinetics of GSK706769
- Trial name
- NCT00711386
- Testing
- GSK706769
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV, AIDS
A Pilot Study to Characterize the Pharmacokinetics of Raltegravir in the Cervicovaginal Fluids of HIV-infected Women
The purpose of this research sub-study is to learn about the levels of an antiretroviral (ARV) medication called Raltegravir, and response to HIV virus in the genital tract of HIV-positive women.
- Trial name
- NCT00774683
- Testing
- Raltegravir (Isentress®)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Kristine Patterson, MD
Streptococcal Pneumonia, HIV/AIDS
Immunogenicity and Safety of 13-valent Pneumococcal Conjugate Vaccine Among HIV-infected Adults
HIV-infected patients are 30- to 100-fold more susceptible to invasive pneumococcal diseases. Pneumococcal vaccination is the best way to decrease the large pneumococcal disease burden, but the optimal timing of vaccination is…
- Trial name
- NCT03838497
- Testing
- Prevenar13
- Volunteers
- 70 people
- Sponsor
- Korea University Guro Hospital
Human Immunodeficiency Virus, Treatment Adherence
Data Science and Qualitative Research for Decision Support in the HIV Care Cascade
The goal of this study is to determine whether clinical prediction algorithms derived using statistical machine learning methods can be used to improve patient outcomes in large HIV care programs in sub-Saharan Africa and…
- Conditions
- Human Immunodeficiency Virus, Treatment Adherence, Treatment Compliance, Patient No Show
- Trial name
- CASCADE (NCT06604663)
- Testing
- Activation of the CDSS system
- Where
- Kenya
- Volunteers
- 80,000 people
- Sponsor
- Brown University
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