Clinical trials: Acquired Immune Deficiency Syndrome
HIV Infections, Liver Toxicity
Compare to the Safety of Efavirenz and Nevirapine in Treating HIV Positive Patients With Mild Baseline Liver Function Test Impairment, and/or Hepatitis B or Hepatitis C Co-infection
The purpose of this study is to demonstrate the difference in frequency and level of liver function disturbance between patients on efavirenz based ART, and patients on nevirapine based ART in HBV and HCV co-infected patients…
- Conditions
- HIV Infections, Liver Toxicity, Hepatitis Co-infection
- Trial name
- NCT01273142
- Volunteers
- 100 people
- Sponsor
- Henan Provincial People's Hospital
Acquired Immunodeficiency Syndrome, HIV Infections
A Phase I /II Study of the Protease Inhibitor Indinavir (MK-0639) in Children With HIV Infection
This is a phase I/II study to determine the safety and tolerance of the protease inhibitor indinavir (MK-0639), alone and then in combination with HIV reverse transcriptase inhibitor therapy in children with HIV infection.
- Trial name
- NCT00001443
- Testing
- indinavir (MK-0639)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- National Cancer Institute (NCI)
HIV Infections
FREE Study: Efficacy and Toxicity of Trizivir
Antiretroviral naïve patients with <350 xE6/l CD4 cells and a HIV-viral load of > 30.000 cop/ml are started on combivir ® and Kaletra ®.
- Trial name
- NCT00405925
- Testing
- Trizivir, zidovudine,lamivudine,abacavir
- Where
- Netherlands
- Volunteers
- 207 people
- Sponsor
- Rijnstate Hospital
HIV/AIDS, Adherence, Medication
Quantification of Tenofovir Alafenamide Adherence (QUANTI-TAF)
This study is being done to evaluate the relationship between adherence to antiretroviral therapy (ART) and HIV drug concentrations in persons living with HIV (PLWH) that are taking tenofovir alafenamide (TAF).
- Trial name
- NCT04065347
- Testing
- Digital Pill
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Colorado, Denver
HIV/AIDS
PrEPared and Strong: Clinic-Based PrEP for Black MSM
Black men who have sex with men (MSM) have among the highest rates of new HIV infections of any group in the United States. Developing effective HIV prevention interventions that work with this group is a critical element of the…
- Trial name
- P&S (NCT02167386)
- Testing
- Enhanced PrEP Adherence, Standard PrEP Adherence
- Where
- 2 sites in United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV Infections
The Mochudi Prevention Project ART Protocol
The goal of the "Mochudi Prevention Project" is to reduce the number of new HIV infections in the village of Mochudi, Botswana by promoting a comprehensive package of interventions that have proven to be effective in preventing…
- Trial name
- NCT01583439
- Testing
- highly active antiretroviral therapy: Lopinavir/Ritonavir, Lamivudine, Zidovudine, Efavirenz, Tenofovir Disoproxil Fumarate, Emtricitabine
- Where
- Botswana
- Volunteers
- 11 people
- Sponsor
- Harvard School of Public Health (HSPH)
Hiv, Cancer
Cancer Prevalence and Outcomes in Individuals With HIV and AIDS: Multicenter BUHASDER Study
AIDS-defining cancers reported a 70% drop in the 1990s following the advent of triple antiretroviral therapy in the USA. With increased survival, the proportion of non-AIDS-defining cancers increases with age, making cancer a…
- Trial name
- NCT06774495
- Where
- Turkey (Türkiye)
- Volunteers
- 154 people
- Sponsor
- Kocaeli University
HIV/AIDS
HIV Awal (Early) Testing & Treatment Indonesia Project Observational Phase
This study will be one of the first to systematically evaluate strategies to improve the implementation of a T\&T strategy in a concentrated epidemic in Asia.
- Trial name
- NCT03429842
- Volunteers
- 2,071 people
- Sponsor
- Gadjah Mada University
Human Immunodeficiency Virus
Jamii Bora: A Home-Based Couples Intervention
The purpose of the study is to develop and pilot-test a home-based intervention to facilitate sate HIV testing and disclosure within pregnant couples in order to increase use of prevention-of-mother-to-child-transmission (PMTCT)…
- Trial name
- NCT02403583
- Testing
- Intervention- Home Visits
- Where
- 5 sites in Kenya
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Sexually Transmitted Diseases, Pregnancy
All About Youth: Evaluation of Sexual Risk Avoidance and Risk Reduction Programs for Middle School Students
This study will evaluate the efficacy of two curricula relative to standard care. The first is a sexual risk avoidance curriculum for middle school students that included abstinence until marriage and complies with Title V…
- Conditions
- Sexually Transmitted Diseases, Pregnancy, HIV Infections
- Trial name
- NCT00167505
- Testing
- Risk Avoidance Intervention, Risk Reduction Intervention
- Where
- United States
- Volunteers
- 1,742 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
HIV (Human Immunodeficiency Virus)
Optimizing the Efficiency and Implementation of Cash Transfers to Improve Adherence to Antiretroviral Therapy Phase II
This protocol describes a 2-arm cluster, randomized controlled trial designed to test the effectiveness of a conditional cash transfer on viral suppression at 12 months post-ART initiation among PHWHIV who have initiated ART…
- Trial name
- Afya 2 Phase2 (NCT04201353)
- Testing
- Conditional Cash Transfer
- Where
- Tanzania
- Volunteers
- 1,984 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Acquired Immunodeficiency Syndrome
A Study of Single Dose Nevirapine (NVP) Combined With Combivir® for the Prevention of Mother to Child Transmission (pMTCT) - Treatment Options Preservation Study (TOPS)
To determine whether a regimen of single dose nevirapine combined with either 4 or 7 days of Combivir®, compared to a regimen of single dose nevirapine, for the prevention of mother to child transmission can reduce the rate of…
- Trial name
- NCT00144183
- Testing
- Nevirapine (NVP), Zidovudine (ZCV), 3TC
- Where
- 5 sites in South Africa
- Volunteers
- 407 people
- Sponsor
- Boehringer Ingelheim
HIV Infections
Pharmacogenetics of Antiretroviral Drugs
In this research project, we will study the genetic determinants that influence the pharmacokinetics of antiretroviral drugs used in the treatment of diseases caused by the HIV.
- Trial name
- NCT00435656
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Drug Use, Hepatitis
Low Dead-space Injecting Equipment Distribution Program for People Who Inject Drugs in Low- and Middle-income Countries
Implementation and evaluation of a distribution program for low dead-space syringes/needles (LDSS/N) in Armenia, Georgia, and Tanzania, Egypt, Nigeria, Vietnam, India, Ukraine, and South Africa.
- Conditions
- Drug Use, Hepatitis, Hiv
- Trial name
- NCT06395129
- Testing
- Low dead-space syringes/needles, Hepatitis C Antibody Rapid Diagnostic Test, HIV rapid Diagnostic Test
- Where
- 9 sites in Armenia, Georgia and 1 more
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Médecins du Monde
Meningitis, Cryptococcal, HIV Infections
Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Maintenance Treatment for the Prevention of Relapse of Cryptococcal Meningitis in Patients With Acquired Immunodeficiency Syndrome
To compare the safety and effectiveness of fluconazole and amphotericin B as maintenance treatment for preventing the relapse of cryptococcal meningitis in patients with AIDS.
- Trial name
- NCT00002074
- Testing
- Fluconazole, Amphotericin B
- Where
- 39 sites in United States, Canada
- Sponsor
- Pfizer
HIV, AIDS
Community-based Accompaniment With Supervised Antiretrovirals in Lima, Peru
Using quantitative and qualitative data, this study will assess the impact of community accompaniment with supervised antiretrovirals (CASA) on HIV-positive individuals and community members in Lima, Peru.
- Conditions
- HIV, AIDS, HIV Infections
- Trial name
- CASA (NCT01070017)
- Testing
- DOT-HAART
- Where
- Peru
- Volunteers
- 1,244 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Mycobacterium Avium-Intracellulare Infection, HIV Infections
An Open-Label Study of the Use of Azithromycin in Patients With Symptomatic Disseminated Mycobacterium Avium-Intracellulare Complex (MAC) Infection Failing Current Therapy
To evaluate the efficacy and safety of azithromycin given chronically for the treatment of Mycobacterium avium (MAC) bacteremia in patients failing or intolerant of current available MAC therapy.
- Trial name
- NCT00002089
- Testing
- Azithromycin
- Where
- United States
- Sponsor
- Pfizer
Infection, Human Immunodeficiency Virus
GSK1265744 (Cabotegravir, CAB) for Named Patient/Compassionate Use in HIV
The goal of this compassionate use program is to provide a mechanism to supply Cabotegravir, CAB on an individual named patient basis for treatment of individuals who have no available treatment alternatives and/or limited…
- Trial name
- NCT03462810
- Testing
- cabotegravir, CAB
- Sponsor
- ViiV Healthcare
Hiv
Optimizing Reversal of HIV Latency With Combination Therapy
The ORBIT trial is part of a worldwide search for a functional cure of HIV. One such cure strategy aims to reverse HIV in the reservoir from latency by increasing cell-associated HIV-RNA, which will lead to increased antigen…
- Trial name
- ORBIT (NCT06240520)
- Testing
- Panobinostat 20 MG Oral Capsule, Pyrimethamine 200mg Oral Tablet, Lenalidomide 25 MG Oral Capsule
- Where
- 3 sites in Netherlands
- Volunteers
- 49 people
- Sponsor
- Erasmus Medical Center
HIV Infections
A Double-Blind Placebo Controlled Study To Determine the Optimal Immunopharmacological Dose Level of Isoprinosine in Immunodepressed Volunteers
The objective of this double-blind placebo-controlled study is to evaluate the effect of Isoprinosine in a group of homogenous male volunteers who present with immunologic defects relative to: Comparison of total helper and…
- Trial name
- NCT00002059
- Testing
- Inosine pranobex
- Where
- United States
- Sponsor
- Newport Pharmaceuticals International
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